Robert J Lefkowitz (Robert Lefkowitz)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 20

Top Topics

Skeletal Muscle

Cardiovascular Risk Factors

Signaling Pathway

Top Venues

Circulation research

Science (New York, N.Y.)

Science signaling

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Samuel Liu, Preston J Anderson, Sudarshan Rajagopal, Robert J Lefkowitz, Howard A Rockman
G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation research 135 (1) (2024)
Samuel Liu, Preston J Anderson, Sudarshan Rajagopal, Robert J Lefkowitz, Howard A Rockman
G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation research 135 (1) (2024)
Samuel Liu, Preston J Anderson, Sudarshan Rajagopal, Robert J Lefkowitz, Howard A Rockman
G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation research 135 (1) (2024)
Natalia Pakharukova, Brittany N Thomas, Harsh Bansia, Linus Li, Rinat R Abzalimov, Jihee Kim, Alem W Kahsai, Biswaranjan Pani, Dana K Bassford, Shibo Liu, Xingdong Zhang, Amédée Des Georges, Robert J Lefkowitz
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. bioRxiv : the preprint server for biology (2024)
Samuel Liu, Preston J Anderson, Sudarshan Rajagopal, Robert J Lefkowitz, Howard A Rockman
G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation research 135 (1) (2024)
Natalia Pakharukova, Brittany N Thomas, Harsh Bansia, Linus Li, Rinat R Abzalimov, Jihee Kim, Alem W Kahsai, Biswaranjan Pani, Dana K Bassford, Shibo Liu, Xingdong Zhang, Amédée Des Georges, Robert J Lefkowitz
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. bioRxiv : the preprint server for biology (2024)
Angus Li, Samuel Liu, Rennica Huang, Seungkirl Ahn, Robert J Lefkowitz
Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. PloS one 18 (3) (2023)
Robert J Lefkowitz, Howard A Rockman, Paul Jaehoon Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K Shenoy, Michel Bouvier, Jeffrey L Benovic, Stephen B Liggett, Robert R Ruffolo, Michael R Bristow, Milton Packer
How carvedilol does not activate β 2 -adrenoceptors. Nature communications 14 (1) (2023)
Alem W Kahsai, Kunal S Shah, Paul Jaehoon Shim, Mason A Lee, Bowie N Shreiber, Allison M Schwalb, Xingdong Zhang, Henry Y Kwon, Li-Yin Huang, Erik J Soderblom, Seungkirl Ahn, Robert J Lefkowitz
Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America 120 (43) (2023)
Paul J Utz, Mukesh K Jain, Vivian G Cheung, Brian K Kobilka, Robert J Lefkowitz, Tadataka Yamada, Victor J Dzau
Translating science to medicine: The case for physician-scientists. Science translational medicine 14 (632) (2022)
Robert J Lefkowitz, Susan G Amara
Marc G. Caron (1946-2022). Nature neuroscience 25 (9) (2022)
Anthony H Nguyen, Robert J Lefkowitz
Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. The FEBS journal 288 (8) (2021)
Conor McMahon, Dean P Staus, Laura M Wingler, Jialu Wang, Meredith A Skiba, Matthias Elgeti, Wayne L Hubbell, Howard A Rockman, Andrew C Kruse, Robert J Lefkowitz
Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America 117 (33) (2020)
Laura M Wingler, Meredith A Skiba, Conor McMahon, Dean P Staus, Alissa L W Kleinhenz, Carl-Mikael Suomivuori, Naomi R Latorraca, Ron O Dror, Robert J Lefkowitz, Andrew C Kruse
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.) 367 (6480) (2020)
Carl-Mikael Suomivuori, Naomi R Latorraca, Laura M Wingler, Stephan Eismann, Matthew C King, Alissa L W Kleinhenz, Meredith A Skiba, Dean P Staus, Andrew C Kruse, Robert J Lefkowitz, Ron O Dror
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.) 367 (6480) (2020)
Anthony H Nguyen, Alex R B Thomsen, Thomas J Cahill, Rick Huang, Li-Yin Huang, Tara Marcink, Oliver B Clarke, Søren Heissel, Ali Masoudi, Danya Ben-Hail, Fadi Samaan, Venkata P Dandey, Yong Zi Tan, Chuan Hong, Jacob P Mahoney, Sarah Triest, John Little, Xin Chen, Roger K Sunahara, Jan Steyaert, Henrik Molina, Zhiheng Yu, Amédée Des Georges, Robert J Lefkowitz
Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. Nature structural & molecular biology 26 (12) (2019)
Xiangyu Liu, Ali Masoudi, Alem W Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P Staus, Paul Jaehoon Shim, Kunio Hirata, Rishabh K Simhal, Allison M Schwalb, Paula K Rambarat, Seungkirl Ahn, Robert J Lefkowitz, Brian K Kobilka
Mechanism of β2AR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.) 364 (6447) (2019)
Jihee Kim, Chad A Grotegut, James W Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B Rosenberg, Howard A Rockman, Robert J Lefkowitz
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skeletal muscle 8 (1) (2018)
Louis M Luttrell, Jialu Wang, Bianca Plouffe, Jeffrey S Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, Christophe Gauthier, Mi-Hye Lee, Biswaranjan Pani, Jihee Kim, Seungkirl Ahn, Sudarshan Rajagopal, Eric Reiter, Michel Bouvier, Sudha K Shenoy, Stéphane A Laporte, Howard A Rockman, Robert J Lefkowitz
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science signaling 11 (549) (2018)
Minjung Choi, Dean P Staus, Laura M Wingler, Seungkirl Ahn, Biswaranjan Pani, William D Capel, Robert J Lefkowitz
G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor. Science signaling 11 (544) (2018)