Michel Bouvier (M Bouvier)

ResearcherID Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 75

Top Venues

Nature communications

Communications biology

Science (New York, N.Y.)

Journal of medicinal chemistry

Institute for Research in Immunology and Cancer

Université de Montréal (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Institute for Research in Immunology and Cancer Aug 01 2014

Canada

General Director

Institute for Research in Immunology and Cancer Sep 01 2005

Canada

Principal Investigator

Université de Montréal Jun 01 1997

Canada

Professor :: Biochemistry

IRICoR Apr 01 2011 - Jun 01 2015

Canada

CEO

Université de Montréal Oct 01 1997 - May 31 2005

Canada

Chairman :: Biochemistry

Université de Montréal Jun 01 1993 - May 30 1997

Canada

Associate Professor :: Biochemistry

Université de Montréal Jan 03 1989 - May 30 1993

Canada

Assistant Professor :: Biochemistry

Education History

Université de Montréal Sep 01 1979 - Dec 23 1984

Canada

PHD :: Neurological Sciences

Université de Montréal Sep 03 1976 - Apr 30 1979

Canada

BSC :: Biochemistry

Publications

Badr Sokrat, Anthony H Nguyen, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes. Communications biology 7 (1) (2024)
Badr Sokrat, Anthony H Nguyen, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes. Communications biology 7 (1) (2024)
Supriya A Gaitonde, Charlotte Avet, Mario de la Fuente Revenga, Elodie Blondel-Tepaz, Aida Shahraki, Adrian Morales Pastor, Valerij Talagayev, Patricia Robledo, Peter Kolb, Jana Selent, Javier González-Maeso, Michel Bouvier
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT 2A receptor. Molecular psychiatry (2024)
Florence Gross, Arturo Mancini, Billy Breton, Hiroyuki Kobayashi, Pedro Henrique Scarpelli Pereira, Christian Le Gouill, Michel Bouvier, Stephan Schann, Xavier Leroy, Laurent Sabbagh
EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors. Communications biology 7 (1) (2024)
Elk Kossatz, Rebeca Diez Alarcia, Supriya A Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, José Javier Meana, Patricia Robledo, Jana Selent
G protein-specific mechanisms in the serotonin 5-HT 2A receptor regulate psychosis-related effects and memory deficits. Nature communications 15 (1) (2024)
Shane C Wright, Charlotte Avet, Supriya A Gaitonde, Itziar Muneta-Arrate, Christian Le Gouill, Mireille Hogue, Billy Breton, Stefania Koutsilieri, Rebeca Diez Alarcia, Madeleine Héroux, Volker Martin Lauschke, Michel Bouvier
Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling. Science signaling 17 (841) (2024)
Elk Kossatz, Rebeca Diez Alarcia, Supriya A Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, José Javier Meana, Patricia Robledo, Jana Selent
G protein-specific mechanisms in the serotonin 5-HT 2A receptor regulate psychosis-related effects and memory deficits. Nature communications 15 (1) (2024)
Supriya A Gaitonde, Charlotte Avet, Mario de la Fuente Revenga, Elodie Blondel-Tepaz, Aida Shahraki, Adrian Morales Pastor, Valerij Talagayev, Patricia Robledo, Peter Kolb, Jana Selent, Javier González-Maeso, Michel Bouvier
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT 2A receptor. Molecular psychiatry (2024)
Badr Sokrat, Anthony H Nguyen, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes. Communications biology 7 (1) (2024)
Shane C Wright, Charlotte Avet, Supriya A Gaitonde, Itziar Muneta-Arrate, Christian Le Gouill, Mireille Hogue, Billy Breton, Stefania Koutsilieri, Rebeca Diez Alarcia, Madeleine Héroux, Volker Martin Lauschke, Michel Bouvier
Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling. Science signaling 17 (841) (2024)
Elk Kossatz, Rebeca Diez Alarcia, Supriya A Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, José Javier Meana, Patricia Robledo, Jana Selent
G protein-specific mechanisms in the serotonin 5-HT 2A receptor regulate psychosis-related effects and memory deficits. Nature communications 15 (1) (2024)
Florence Gross, Arturo Mancini, Billy Breton, Hiroyuki Kobayashi, Pedro Henrique Scarpelli Pereira, Christian Le Gouill, Michel Bouvier, Stephan Schann, Xavier Leroy, Laurent Sabbagh
EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors. Communications biology 7 (1) (2024)
Badr Sokrat, Anthony H Nguyen, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes. Communications biology 7 (1) (2024)
Badr Sokrat, Anthony H Nguyen, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes. Communications biology 7 (1) (2024)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Shane C Wright, Aikaterini Motso, Stefania Koutsilieri, Christian Michel Beusch, Pierre Sabatier, Alessandro Berghella, Élodie Blondel-Tepaz, Kimberley Mangenot, Ioannis Pittarokoilis, Despoina-Christina Sismanoglou, Christian Le Gouill, Jesper Velgaard Olsen, Roman A Zubarev, Nevin A Lambert, Alexander Sebastian Hauser, Michel Bouvier, Volker Martin Lauschke
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics. Nature communications 14 (1) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Robert J Lefkowitz, Howard A Rockman, Paul Jaehoon Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K Shenoy, Michel Bouvier, Jeffrey L Benovic, Stephen B Liggett, Robert R Ruffolo, Michael R Bristow, Milton Packer
How carvedilol does not activate β 2 -adrenoceptors. Nature communications 14 (1) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Elissa A Fink, Jun Xu, Harald Hübner, Joao M Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothée Weikert, Maximilian F Schmidt, Chase M Webb, Nataliya A Tolmachova, Yurii S Moroz, Xi Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P Jacobson, John J Irwin, Michel Bouvier, Yang Du, Brian K Shoichet, Allan I Basbaum, Peter Gmeiner
Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor. Science (New York, N.Y.) 377 (6614) (2022)
Bianca Plouffe, Angeliki Karamitri, Tilman Flock, Jonathan M Gallion, Shane Houston, Carole A Daly, Amélie Bonnefond, Jean-Luc Guillaume, Christian Le Gouill, Phillipe Froguel, Olivier Lichtarge, Xavier Deupi, Ralf Jockers, Michel Bouvier
Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants. ACS pharmacology & translational science 5 (2) (2022)
E Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L Posy, Victor R Guarino, Jeremy M Richter, Jianqing Li, Anuradha Gupta, Vetrichelvan Muthalagu, T J Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A Gordon, Ruth R Wexler, Anne Marinier
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. Journal of medicinal chemistry 65 (13) (2022)
Steve Reynaud, Suli-Anne Laurin, Justyna Ciolek, Peggy Barbe, Anne-Cécile Van Baelen, Michaël Susset, Florian Blondel, Marine Ghazarian, Julia Boeri, Margot Vanden Driessche, Grégory Upert, Gilles Mourier, Pascal Kessler, Laure Konnert, Rémy Beroud, Mathilde Keck, Denis Servent, Michel Bouvier, Nicolas Gilles
From a Cone Snail Toxin to a Competitive MC4R Antagonist. Journal of medicinal chemistry 65 (18) (2022)
Janik B Hedderich, Margherita Persechino, Katharina Becker, Franziska Marie Heydenreich, Torben Gutermuth, Michel Bouvier, Moritz Bünemann, Peter Kolb
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites. Nature communications 13 (1) (2022)
Charlotte Avet, Arturo Mancini, Billy Breton, Christian Le Gouill, Alexander Sebastian Hauser, Claire Normand, Hiroyuki Kobayashi, Florence Gross, Mireille Hogue, Viktoriya Lukasheva, Stéphane St-Onge, Marilyn Carrier, Madeleine Héroux, Sandra Morissette, Eric B Fauman, Jean-Philippe Fortin, Stephan Schann, Xavier Leroy, David E Gloriam, Michel Bouvier
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs. eLife 11 (2022)
Kévin Leguay, Barbara Decelle, Islam E Elkholi, Michel Bouvier, Jean-François Coté, Sébastien Carréno
Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry. The Journal of cell biology 221 (6) (2022)
Justine S Paradis, Xiang Feng, Brigitte Murat, Jefferson Roberts, Badr Sokrat, Martyna Szpakowska, Mireille Hogue, Nick D Bergkamp, Franziska M Heydenreich, Martine J Smit, Andy Chevigné, Michel Bouvier, Patrick Barth
Computationally designed GPCR quaternary structures bias signaling pathway activation. Nature communications 13 (1) (2022)
Kien Tran, Xavier Sainsily, Jérôme Côté, David Coquerel, Pierre Couvineau, Sabrina Saibi, Lounès Haroune, Élie Besserer-Offroy, Joël Flynn-Robitaille, Martin Resua Rojas, Alexandre Murza, Jean-Michel Longpré, Mannix Auger-Messier, Olivier Lesur, Michel Bouvier, Eric Marsault, Pierre-Luc Boudreault, Philippe Sarret
Size-Reduced Macrocyclic Analogues of [Pyr 1 ]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. Journal of medicinal chemistry 65 (1) (2022)
John A Lupisella, Stéphane St-Onge, Marilyn Carrier, Erica M Cook, Tao Wang, Chi Sum, Gayani Fernando, Kendra Apgar, Rongan Zhang, Nancy Carson, Bradley J Snyder, Carol S Ryan, Xiuying Ma, Elizabeth A Dierks, Sean Little, Ellen K Kick, Nicholas R Wurtz, Michel Bouvier, Madeleine Héroux, Ricardo A Garcia
Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction. ACS pharmacology & translational science 5 (10) (2022)
Peter Kolb, Terry Kenakin, Stephen P H Alexander, Marcel Bermudez, Laura M Bohn, Christian S Breinholt, Michel Bouvier, Stephen J Hill, Evi Kostenis, Kirill A Martemyanov, Rick R Neubig, H Ongun Onaran, Sudarshan Rajagopal, Bryan L Roth, Jana Selent, Arun K Shukla, Martha E Sommer, David E Gloriam
Community guidelines for GPCR ligand bias: IUPHAR review 32. British journal of pharmacology 179 (14) (2022)
Alexander Sebastian Hauser, Charlotte Avet, Claire Normand, Arturo Mancini, Asuka Inoue, Michel Bouvier, David E Gloriam
Common coupling map advances GPCR-G protein selectivity. eLife 11 (2022)
Franziska Marie Heydenreich, Bianca Plouffe, Aurélien Rizk, Dalibor Milić, Joris Zhou, Billy Breton, Christian Le Gouill, Asuka Inoue, Michel Bouvier, Dmitry B Veprintsev
Michaelis-Menten Quantification of Ligand Signaling Bias Applied to the Promiscuous Vasopressin V2 Receptor. Molecular pharmacology 102 (3) (2022)
Elodie Blondel-Tepaz, Marie Leverve, Badr Sokrat, Justine S Paradis, Milena Kosic, Kusumika Saha, Cédric Auffray, Evelyne Lima-Fernandes, Alessia Zamborlini, Anne Poupon, Louis Gaboury, Jane Findlay, George S Baillie, Hervé Enslen, Michel Bouvier, Stephane Angers, Stefano Marullo, Mark G H Scott
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis. Oncogene 40 (12) (2021)
Philipp M Tschaikner, Dominik Regele, Ruth Röck, Willi Salvenmoser, Dirk Meyer, Michel Bouvier, Stephan Geley, Eduard Stefan, Pia Aanstad
Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish. Development (Cambridge, England) 148 (4) (2021)
Jenna Giubilaro, Doris A Schuetz, Tomasz M Stepniewski, Yoon Namkung, Etienne Khoury, Mónica Lara-Márquez, Shirley Campbell, Alexandre Beautrait, Sylvain Armando, Olivier Radresa, Jean Duchaine, Nathalie Lamarche-Vane, Audrey Claing, Jana Selent, Michel Bouvier, Anne Marinier, Stéphane A Laporte
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nature communications 12 (1) (2021)
Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selent
Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical science 12 (33) (2021)
Lu Xu, Bo Chen, Hannes Schihada, Shane C Wright, Ainoleena Turku, Yiran Wu, Gye-Won Han, Maria Kowalski-Jahn, Pawel Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, Michel Bouvier, Gunnar Schulte, Tingting Wu
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell research 31 (12) (2021)
Kien Trân, Robin Van Den Hauwe, Xavier Sainsily, Pierre Couvineau, Jérôme Côté, Louise Simard, Marco Echevarria, Alexandre Murza, Alexandra Serre, Léa Théroux, Sabrina Saibi, Lounès Haroune, Jean-Michel Longpré, Olivier Lesur, Mannix Auger-Messier, Claude Spino, Michel Bouvier, Philippe Sarret, Steven Ballet, Eric Marsault
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. Journal of medicinal chemistry 64 (9) (2021)
Alexander Sebastian Hauser, Albert Jelke Kooistra, Christian Munk, Franziska Marie Heydenreich, Dmitry B Veprintsev, Michel Bouvier, M Madan Babu, David E Gloriam
GPCR activation mechanisms across classes and macro/microscales. Nature structural & molecular biology 28 (11) (2021)
Ahmed Mansour, Karim Nagi, Paul Dallaire, Viktoriya Lukasheva, Christian Le Gouill, Michel Bouvier, Graciela Pineyro
Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation. ACS pharmacology & translational science 4 (5) (2021)
Alan Hegron, Eunna Huh, Xavier Deupi, Badr Sokrat, Wenwen Gao, Christian Le Gouill, Mickaël Canouil, Mathilde Boissel, Guillaume Charpentier, Ronan Roussel, Beverley Balkau, Philippe Froguel, Bianca Plouffe, Amélie Bonnefond, Olivier Lichtarge, Ralf Jockers, Michel Bouvier
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants. ACS pharmacology & translational science 4 (5) (2021)
Shane C Wright, Viktoriya Lukasheva, Christian Le Gouill, Hiroyuki Kobayashi, Billy Breton, Samuel Mailhot-Larouche, Élodie Blondel-Tepaz, Nichelle Antunes Vieira, Claudio Miguel da Costa-Neto, Madeleine Héroux, Nevin A Lambert, Lucas Tabajara Parreiras-E-Silva, Michel Bouvier
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes. Proceedings of the National Academy of Sciences of the United States of America 118 (20) (2021)
Julian Budzinski, Simone Maschauer, Hiroyuki Kobayashi, Pierre Couvineau, Hannah Vogt, Peter Gmeiner, Anna Roggenhofer, Olaf Prante, Michel Bouvier, Dorothée Weikert
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications biology 4 (1) (2021)
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma T van der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature communications 11 (1) (2020)
Kien Trân, Alexandre Murza, Xavier Sainsily, Eugénie Delile, Pierre Couvineau, Jérôme Côté, David Coquerel, Maude Peloquin, Mannix Auger-Messier, Michel Bouvier, Olivier Lesur, Philippe Sarret, Eric Marsault
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. Journal of medicinal chemistry 64 (1) (2020)
Najeah Okashah, Shane C Wright, Kouki Kawakami, Signe Mathiasen, Joris Zhou, Sumin Lu, Jonathan A Javitch, Asuka Inoue, Michel Bouvier, Nevin A Lambert
Agonist-induced formation of unproductive receptor-G12 complexes. Proceedings of the National Academy of Sciences of the United States of America 117 (35) (2020)
Charlotte Avet, Claudio Sturino, Sébastien Grastilleur, Christian Le Gouill, Meriem Semache, Florence Gross, Louis Gendron, Youssef Bennani, Joseph A Mancini, Camil E Sayegh, Michel Bouvier
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Communications biology 3 (1) (2020)
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma T van der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature communications 10 (1) (2019)
Hiroyuki Kobayashi, Louis-Philippe Picard, Anne-Marie Schönegge, Michel Bouvier
Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells. Nature protocols 14 (4) (2019)
Wang Wang, Mengcheng Shen, Conrad Fischer, Ratnadeep Basu, Saugata Hazra, Pierre Couvineau, Manish Paul, Faqi Wang, Sandra Toth, Doran S Mix, Marko Poglitsch, Norma P Gerard, Michel Bouvier, John C Vederas, Josef M Penninger, Zamaneh Kassiri, Gavin Y Oudit
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proceedings of the National Academy of Sciences of the United States of America 116 (26) (2019)
Michael M Miller, Jacques Banville, Todd J Friends, Mark Gagnon, Jon J Hangeland, Jean-François Lavallée, Alain Martel, Harold O'Grady, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L Posy, Nick J Allegretto, Victor R Guarino, David G Harden, Timothy W Harper, Karen Hartl, Jonathan Josephs, Sarah Malmstrom, Carol Watson, Yanou Yang, Ge Zhang, Pancras Wong, Jing Yang, Michel Bouvier, Dietmar A Seiffert, Ruth R Wexler, R Michael Lawrence, E Scott Priestley, Anne Marinier
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy. Journal of medicinal chemistry 62 (16) (2019)
Daniele Bolognini, Natasja Barki, Adrian J Butcher, Brian D Hudson, Eugenia Sergeev, Colin Molloy, Catherine E Moss, Sophie J Bradley, Christian Le Gouill, Michel Bouvier, Andrew B Tobin, Graeme Milligan
Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nature chemical biology 15 (5) (2019)
Markus Stanek, Louis-Philippe Picard, Maximilian F Schmidt, Jonas M Kaindl, Harald Hübner, Michel Bouvier, Dorothée Weikert, Peter Gmeiner
Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. Journal of medicinal chemistry 62 (10) (2019)
David Cotnoir-White, Mohamed El Ezzy, Pierre-Luc Boulay, Marieke Rozendaal, Michel Bouvier, Etienne Gagnon, Sylvie Mader
Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect. Proceedings of the National Academy of Sciences of the United States of America 115 (11) (2018)
Shane C Wright, Maria Consuelo Alonso Cañizal, Tobias Benkel, Katharina Simon, Christian Le Gouill, Pierre Matricon, Yoon Namkung, Viktoriya Lukasheva, Gabriele M König, Stéphane A Laporte, Jens Carlsson, Evi Kostenis, Michel Bouvier, Gunnar Schulte, Carsten Hoffmann
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science signaling 11 (559) (2018)
M Young, T Dahoun, B Sokrat, C Arber, K M Chen, Michel Bouvier, P Barth
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 115 (27) (2018)
Noumeira Hamoud, Viviane Tran, Takahiro Aimi, Wataru Kakegawa, Sylvie Lahaie, Marie-Pier Thibault, Ariane Pelletier, G William Wong, In-San Kim, Artur Kania, Michisuke Yuzaki, Michel Bouvier, Jean-François Coté
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion. Nature communications 9 (1) (2018)
Yoon Namkung, Christian Le Gouill, Sahil Kumar, Yubo Cao, Larissa B Teixeira, Viktoriya Lukasheva, Jenna Giubilaro, Sarah C Simões, Jean-Michel Longpré, Dominic Devost, Terence E Hébert, Graciela Piñeyro, Richard Leduc, Claudio Miguel da Costa-Neto, Michel Bouvier, Stéphane A Laporte
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors. Science signaling 11 (559) (2018)
Louis M Luttrell, Jialu Wang, Bianca Plouffe, Jeffrey S Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, Christophe Gauthier, Mi-Hye Lee, Biswaranjan Pani, Jihee Kim, Seungkirl Ahn, Sudarshan Rajagopal, Eric Reiter, Michel Bouvier, Sudha K Shenoy, Stéphane A Laporte, Howard A Rockman, Robert J Lefkowitz
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science signaling 11 (549) (2018)
Franziska Mende, Cecilie Hundahl, Bianca Plouffe, Louise Julie Skov, Bjørn Sivertsen, Andreas Nygaard Madsen, Michael Lückmann, Thi Ai Diep, Stefan Offermanns, Thomas Michael Frimurer, Michel Bouvier, Birgitte Holst
Translating biased signaling in the ghrelin receptor system into differential in vivo functions. Proceedings of the National Academy of Sciences of the United States of America 115 (43) (2018)
Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, Jean-Luc Guillaume, Alan Hegron, Mathilde Boissel, Mickaël Canouil, Claudia Langenberg, Nicholas J Wareham, Christian Le Gouill, Viktoriya Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Science signaling 11 (545) (2018)
Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma T van der Westhuizen, Jacob P Mahoney, João P G L M Rodrigues, Thomas J Mildorf, Ron O Dror, David E Shaw, Michel Bouvier, Els Pardon, Jan Steyaert, Roger K Sunahara, William I Weis, Cheng Zhang, Brian K Kobilka
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist. Nature chemical biology 14 (11) (2018)
Louis-Philippe Picard, Anne Marie Schönegge, Martin J Lohse, Michel Bouvier
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Communications biology 1 (2018)
Anne-Marie Schönegge, Jonathan Gallion, Louis-Philippe Picard, Angela D Wilkins, Christian Le Gouill, Martin Audet, Wayne Stallaert, Martin J Lohse, Marek Kimmel, Olivier Lichtarge, Michel Bouvier
Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity. Nature communications 8 (1) (2017)
Alexandre Beautrait, Justine S Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M Heydenreich, Etienne Khoury, Martin Audet, Philippe P Roux, Dmitry B Veprintsev, Stéphane A Laporte, Michel Bouvier
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nature communications 8 (2017)
Larissa B Teixeira, Lucas T Parreiras-E-Silva, Thiago Bruder-Nascimento, Diego A Duarte, Sarah C Simões, Rafael M Costa, Deisy Y Rodríguez, Pedro A B Ferreira, Carlos A A Silva, Emiliana P Abrao, Eduardo B Oliveira, Michel Bouvier, Rita C Tostes, Claudio M Costa-Neto
Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy. Scientific reports 7 (1) (2017)
Yoon Namkung, Christian Le Gouill, Viktoria Lukashova, Hiroyuki Kobayashi, Mireille Hogue, Etienne Khoury, Mideum Song, Michel Bouvier, Stéphane A Laporte
Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET. Nature communications 7 (2016)
Thorsten Fritzius, Rostislav Turecek, Riad Seddik, Hiroyuki Kobayashi, Jim Tiao, Pascal D Rem, Michaela Metz, Michaela Kralikova, Michel Bouvier, Martin Gassmann, Bernhard Bettler
KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (5) (2016)
Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Daniela Wenzel, Katrin M Büllesbach, Tobias Bald, Asuka Inoue, Yuji Shinjo, Ségolène Galandrin, Naveen Shridhar, Michael Hesse, Manuel Grundmann, Nicole Merten, Thomas H Charpentier, Matthew Martz, Adrian J Butcher, Tanja Slodczyk, Sylvain Armando, Maike Effern, Yoon Namkung, Laura Jenkins, Velten Horn, Anne Stößel, Harald Dargatz, Daniel Tietze, Diana Imhof, Céline Galés, Christel Drewke, Christa E Müller, Michael Hölzel, Graeme Milligan, Andrew B Tobin, Jesús Gomeza, Henrik G Dohlman, John Sondek, T Kendall Harden, Michel Bouvier, Stéphane A Laporte, Junken Aoki, Bernd K Fleischmann, Klaus Mohr, Gabriele M König, Thomas Tüting, Evi Kostenis
The experimental power of FR900359 to study Gq-regulated biological processes. Nature communications 6 (2015)

Michel Bouvier.css-eqlu8i{font-size:small;padding-left:4px;} (M Bouvier)

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Michel Bouvier (M Bouvier)