Steffen Lindert

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 51

Top Topics

Mass Spectrometry

Hypertrophic Cardiomyopathy

Top Venues

Journal of chemical information and modeling

Nature communications

The journal of physical chemistry. B

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

William T Higgins, Sandip Vibhute, Chad Bennett, Steffen Lindert
Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods. Journal of chemical information and modeling (2024)
Joshua W Powell, Chelsea A Mann, Paul D Toth, Sheri Nolan, Anja Steinert, Clarissa Ove, Justin T Seffernick, Daniel J Wozniak, Razieh Kebriaei, Steffen Lindert, Neil Osheroff, Jack C Yalowich, Mark J Mitton-Fry
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS medicinal chemistry letters 15 (8) (2024)
William T Higgins, Sandip Vibhute, Chad Bennett, Steffen Lindert
Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods. Journal of chemical information and modeling 64 (2) (2024)
David Han, Jonathan M Spehar, Dillon S Richardson, Sumudu Leelananda, Prathik Chakravarthy, Samantha Grecco, Jesse Reardon, Daniel G Stover, Chad Bennett, Gina M Sizemore, Zaibo Li, Steffen Lindert, Steven T Sizemore
The RAL Small G Proteins Are Clinically Relevant Targets in Triple Negative Breast Cancer. Cancers 16 (17) (2024)
Joshua W Powell, Chelsea A Mann, Paul D Toth, Sheri Nolan, Anja Steinert, Clarissa Ove, Justin T Seffernick, Daniel J Wozniak, Razieh Kebriaei, Steffen Lindert, Neil Osheroff, Jack C Yalowich, Mark J Mitton-Fry
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS medicinal chemistry letters 15 (8) (2024)
William T Higgins, Sandip Vibhute, Chad Bennett, Steffen Lindert
Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods. Journal of chemical information and modeling 64 (2) (2024)
William T Higgins, Sandip Vibhute, Chad Bennett, Steffen Lindert
Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods. Journal of chemical information and modeling 64 (2) (2024)
Joshua W Powell, Chelsea A Mann, Paul D Toth, Sheri Nolan, Anja Steinert, Clarissa Ove, Justin T Seffernick, Daniel J Wozniak, Razieh Kebriaei, Steffen Lindert, Neil Osheroff, Jack C Yalowich, Mark J Mitton-Fry
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS medicinal chemistry letters 15 (8) (2024)
Joshua W Powell, Chelsea A Mann, Paul D Toth, Sheri Nolan, Anja Steinert, Clarissa Ove, Justin T Seffernick, Daniel J Wozniak, Razieh Kebriaei, Steffen Lindert, Neil Osheroff, Jack C Yalowich, Mark J Mitton-Fry
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS medicinal chemistry letters 15 (8) (2024)
S M Bargeen Alam Turzo, Justin T Seffernick, Sergey Lyskov, Steffen Lindert
Predicting ion mobility collision cross sections using projection approximation with ROSIE-PARCS webserver. Briefings in bioinformatics (2023)
Eric R Hantz, Svetlana B Tikunova, Natalya Belevych, Jonathan P Davis, Peter J Reiser, Steffen Lindert
Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship. bioRxiv : the preprint server for biology (2023)
Austin M Cool, Steffen Lindert
Umbrella Sampling Simulations of Cardiac Thin Filament Reveal Thermodynamic Consequences of Troponin I Inhibitory Peptide Mutations. Journal of chemical information and modeling (2023)
Eric R Hantz, Svetlana B Tikunova, Natalya Belevych, Jonathan P Davis, Peter J Reiser, Steffen Lindert
Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship. bioRxiv : the preprint server for biology (2023)
Sravya Kovvali, Yuan Gao, Austin Cool, Steffen Lindert, Vicki H Wysocki, Charles E Bell, Venkat Gopalan
Insights Into The Catalytic Mechanism of A Bacterial Deglycase Essential For Utilization of Fructose-Lysine. Protein science : a publication of the Protein Society (2023)
Eric R Hantz, Svetlana B Tikunova, Natalya Belevych, Jonathan P Davis, Peter J Reiser, Steffen Lindert
Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship. Journal of chemical information and modeling (2023)
Sanam Shafaatalab, Alison Y Li, Farah Jayousi, Yasaman Maaref, Saif Dababneh, Homa Hamledari, Dina Hosseini Baygi, Tiffany Barszczewski, Balwinder Ruprai, Shayan Jannati, Raghu Nagalingam, Austin M Cool, Paulina Langa, Mu Chiao, Thomas Roston, R John Solaro, Shubhayan Sanatani, Christopher Toepfer, Steffen Lindert, Philipp F Lange, Glen F Tibbits
Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C +/- During Development. bioRxiv : the preprint server for biology (2023)
Sm Bargeen Alam Turzo, Eric R Hantz, Steffen Lindert
Applications of machine learning in computer-aided drug discovery. QRB discovery 3 (2022)
Zachary C Drake, Justin T Seffernick, Steffen Lindert
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling. Nature communications 13 (1) (2022)
S M Bargeen Alam Turzo, Justin T Seffernick, Amber D Rolland, Micah T Donor, Sten Heinze, James S Prell, Vicki H Wysocki, Steffen Lindert
Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction. Nature communications 13 (1) (2022)
Justin T Seffernick, Sm Bargeen Alam Turzo, Sophie R Harvey, Yongseok Kim, Árpád Somogyi, Shir Marciano, Vicki H Wysocki, Steffen Lindert
Simulation of Energy-Resolved Mass Spectrometry Distributions from Surface-Induced Dissociation. Analytical chemistry 94 (29) (2022)
Zachary C Drake, Justin T Seffernick, Steffen Lindert
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling. Nature communications 13 (1) (2022)
Eric R Hantz, Steffen Lindert
Actives-Based Receptor Selection Strongly Increases the Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Potent Cancer Inhibitors. Journal of chemical information and modeling 62 (22) (2022)
Zachary C Drake, Justin T Seffernick, Steffen Lindert
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling. Nature communications 13 (1) (2022)
Austin M Cool, Steffen Lindert
Umbrella Sampling Simulations Measure Switch Peptide Binding and Hydrophobic Patch Opening Free Energies in Cardiac Troponin. Journal of chemical information and modeling 62 (22) (2022)
Eric R Hantz, Steffen Lindert
Computational Exploration and Characterization of Potential Calcium Sensitizing Mutations in Cardiac Troponin C. Journal of chemical information and modeling (2022)
Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E Biehn, Charles K Mobley, Monique J Rogals, Yoonkyoo Kim, Sushil K Mishra, Robert J Doerksen, Steffen Lindert, James H Prestegard, Joshua S Sharp
Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling. Communications biology 5 (1) (2022)
Jiadi He, Sm Bargeen Alam Turzo, Justin T Seffernick, Stephanie S Kim, Steffen Lindert
Prediction of Intrinsic Disorder Using Rosetta ResidueDisorder and AlphaFold2. The journal of physical chemistry. B 126 (42) (2022)
Zachary C Drake, Justin T Seffernick, Steffen Lindert
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling. Nature communications 13 (1) (2022)
Zachary C Drake, Justin T Seffernick, Steffen Lindert
Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling. Nature communications 13 (1) (2022)
Sarah E Biehn, Danielle M Picarello, Xiao Pan, Richard W Vachet, Steffen Lindert
Accounting for Neighboring Residue Hydrophobicity in Diethylpyrocarbonate Labeling Mass Spectrometry Improves Rosetta Protein Structure Prediction. Journal of the American Society for Mass Spectrometry 33 (3) (2022)
Eric R Hantz, Steffen Lindert
Adaptative Steered Molecular Dynamics Study of Mutagenesis Effects on Calcium Affinity in the Regulatory Domain of Cardiac Troponin C. Journal of chemical information and modeling 61 (6) (2021)
Sarah E Biehn, Patanachai Limpikirati, Richard W Vachet, Steffen Lindert
Utilization of Hydrophobic Microenvironment Sensitivity in Diethylpyrocarbonate Labeling for Protein Structure Prediction. Analytical chemistry 93 (23) (2021)
Yanran Lu, Sandip Vibhute, Linsen Li, Antony Okumu, Steven C Ratigan, Sheri Nolan, Jonathan L Papa, Chelsea A Mann, Anthony English, Anna Chen, Justin T Seffernick, Bryan Koci, Leonard R Duncan, Brieanna Roth, Jason E Cummings, Richard A Slayden, Steffen Lindert, Craig A McElroy, Daniel J Wozniak, Jack Yalowich, Mark J Mitton-Fry
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA. Journal of medicinal chemistry 64 (20) (2021)
Austin M Cool, Steffen Lindert
Computational Methods Elucidate Consequences of Mutations and Post-translational Modifications on Troponin I Effective Concentration to Troponin C. The journal of physical chemistry. B 125 (27) (2021)
Justin T Seffernick, Steffen Lindert
Hybrid methods for combined experimental and computational determination of protein structure. The Journal of chemical physics 153 (24) (2021)
Justin T Seffernick, Shane M Canfield, Sophie R Harvey, Vicki H Wysocki, Steffen Lindert
Prediction of Protein Complex Structure Using Surface-Induced Dissociation and Cryo-Electron Microscopy. Analytical chemistry 93 (21) (2021)
Daniel R Marzolf, Justin T Seffernick, Steffen Lindert
Protein Structure Prediction from NMR Hydrogen-Deuterium Exchange Data. Journal of chemical theory and computation 17 (4) (2021)
Sarah E Biehn, Steffen Lindert
Accurate protein structure prediction with hydroxyl radical protein footprinting data. Nature communications 12 (1) (2021)
William H Coldren, Svetlana B Tikunova, Jonathan P Davis, Steffen Lindert
Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach. Journal of chemical information and modeling 60 (7) (2020)
Jacob D Bowman, William H Coldren, Steffen Lindert
Mechanism of Cardiac Troponin C Calcium Sensitivity Modulation by Small Molecules Illuminated by Umbrella Sampling Simulations. Journal of chemical information and modeling 59 (6) (2019)
Linsen Li, Antony A Okumu, Sheri Nolan, Anthony English, Sandip Vibhute, Yanran Lu, Katherine Hervert-Thomas, Justin T Seffernick, Lovette Azap, Serena L Cole, D Shinabarger, Laura M Koeth, Steffen Lindert, Jack C Yalowich, Daniel J Wozniak, Mark J Mitton-Fry
1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition. ACS infectious diseases 5 (7) (2019)
Melanie L Aprahamian, Steffen Lindert
Utility of Covalent Labeling Mass Spectrometry Data in Protein Structure Prediction with Rosetta. Journal of chemical theory and computation 15 (5) (2019)
Justin T Seffernick, He Ren, Stephanie S Kim, Steffen Lindert
Measuring Intrinsic Disorder and Tracking Conformational Transitions Using Rosetta ResidueDisorder. The journal of physical chemistry. B 123 (33) (2019)
Sumudu P Leelananda, Steffen Lindert
Using NMR Chemical Shifts and Cryo-EM Density Restraints in Iterative Rosetta-MD Protein Structure Refinement. Journal of chemical information and modeling 60 (5) (2019)
Stephanie S Kim, Melanie L Aprahamian, Steffen Lindert
Improving inverse docking target identification with Z-score selection. Chemical biology & drug design 93 (6) (2019)
Curran A Rhodes, Patrick G Dougherty, Jahan K Cooper, Ziqing Qian, Steffen Lindert, Qi-En Wang, Dehua Pei
Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library. Journal of the American Chemical Society 140 (38) (2018)
Melanie L Aprahamian, Emily E Chea, Lisa M Jones, Steffen Lindert
Rosetta Protein Structure Prediction from Hydroxyl Radical Protein Footprinting Mass Spectrometry Data. Analytical chemistry 90 (12) (2018)
Stephanie S Kim, Justin T Seffernick, Steffen Lindert
Accurately Predicting Disordered Regions of Proteins Using Rosetta ResidueDisorder Application. The journal of physical chemistry. B 122 (14) (2018)
Jacob D Bowman, Steffen Lindert
Molecular Dynamics and Umbrella Sampling Simulations Elucidate Differences in Troponin C Isoform and Mutant Hydrophobic Patch Exposure. The journal of physical chemistry. B 122 (32) (2018)
Melanie L Aprahamian, Svetlana B Tikunova, Morgan V Price, Andres F Cuesta, Jonathan P Davis, Steffen Lindert
Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. Journal of chemical information and modeling 57 (12) (2017)
Sumudu P Leelananda, Steffen Lindert
Iterative Molecular Dynamics-Rosetta Membrane Protein Structure Refinement Guided by Cryo-EM Densities. Journal of chemical theory and computation 13 (10) (2017)