Stephen G Withers

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Venues

ACS chemical biology

Nature communications

Nature

Angewandte Chemie (International ed. in English)

Univ of Bristol (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Univ of Bristol Sep 01 1971 - Sep 18 1977

United Kingdom

PHD :: Chemistry

Publications

Jacob F Wardman, Stephen G Withers
Carbohydrate-active enzyme (CAZyme) discovery and engineering via (Ultra)high-throughput screening. RSC chemical biology 5 (7) (2024)
Jacob F Wardman, Stephen G Withers
Carbohydrate-active enzyme (CAZyme) discovery and engineering via (Ultra)high-throughput screening. RSC chemical biology 5 (7) (2024)
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J Worrall, Harry Brumer, Natalie C J Strynadka, Stephen G Withers
An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature 631 (8019) (2024)
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J Worrall, Harry Brumer, Natalie C J Strynadka, Stephen G Withers
An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature (2024)
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J Worrall, Harry Brumer, Natalie C J Strynadka, Stephen G Withers
An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature 631 (8019) (2024)
Serena MacMillan, Sarah A Hosgood, Léonie Walker-Panse, Peter Rahfeld, Spencer S MacDonald, Jayachandran N Kizhakkedathu, Stephen G Withers, Michael L Nicholson
Enzymatic conversion of human blood group A kidneys to universal blood group O. Nature communications 15 (1) (2024)
Serena MacMillan, Sarah A Hosgood, Léonie Walker-Panse, Peter Rahfeld, Spencer S MacDonald, Jayachandran N Kizhakkedathu, Stephen G Withers, Michael L Nicholson
Enzymatic conversion of human blood group A kidneys to universal blood group O. Nature communications 15 (1) (2024)
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J Worrall, Harry Brumer, Natalie C J Strynadka, Stephen G Withers
An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature (2024)
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J Worrall, Harry Brumer, Natalie C J Strynadka, Stephen G Withers
An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature 631 (8019) (2024)
Serena MacMillan, Sarah A Hosgood, Léonie Walker-Panse, Peter Rahfeld, Spencer S MacDonald, Jayachandran N Kizhakkedathu, Stephen G Withers, Michael L Nicholson
Enzymatic conversion of human blood group A kidneys to universal blood group O. Nature communications 15 (1) (2024)
Renuka Kadirvelraj, Bhargavi M Boruah, Shuo Wang, Digantkumar Chapla, Chin Huang, Annapoorani Ramiah, Kieran L Hudson, Anthony R Prudden, Geert-Jan Boons, Stephen G Withers, Zachary A Wood, Kelley W Moremen
Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9. Nature chemical biology (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology (2023)
Jacob F Wardman, Lyann Sim, Jennifer Liu, Teresa A Howard, Andreas Geissner, Phillip M Danby, Alisdair B Boraston, Warren W Wakarchuk, Stephen G Withers
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins. Nature chemical biology (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology 18 (2) (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology 18 (2) (2023)
Aiko Kurimoto, Seyed Amirhossein Nasseri, Camden Hunt, Michael B Rooney, David J Dvorak, Natalie E LeSage, Ryan P Jansonius, Stephen G Withers, Curtis P Berlinguette
Bioelectrocatalysis with a palladium membrane reactor. Nature communications 14 (1) (2023)
Aiko Kurimoto, Seyed Amirhossein Nasseri, Camden Hunt, Michael B Rooney, David J Dvorak, Natalie E LeSage, Ryan P Jansonius, Stephen G Withers, Curtis P Berlinguette
Bioelectrocatalysis with a palladium membrane reactor. Nature communications 14 (1) (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology 18 (2) (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology 18 (2) (2023)
Olivia Lui, Lharbi Dridi, Emmanuel Gonzalez, Suraya Yasmine, Ryszard Kubinski, Hannah Billings, Joerg Bohlmann, Stephen G Withers, Corinne Maurice, Bastien Castagner
Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling. ACS chemical biology 18 (2) (2023)
Matthew Calvert, Ryan P Sweeney, Hong-Ming Chen, Harbir Bajwa, Seyed Amirhossein Nasseri, Davood Habibi, Stephen G Withers
Branched montbretin A mimics allow derivatisation and potent amylase inhibition. Organic & biomolecular chemistry (2023)
Feng Liu, Hong-Ming Chen, Zachary Armstrong, Stephen G Withers
Azido Groups Hamper Glycan Acceptance by Carbohydrate Processing Enzymes. ACS central science 8 (5) (2022)
Carmanah Hunter, Zhi-Zeng Gao, Hong-Ming Chen, Nicole K Thompson, Warren W Wakarchuk, Mark Nitz, Stephen G Withers, Lisa M Willis
Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid. ACS chemical biology 18 (1) (2022)
Andrés G Santana, Kyle Robinson, Chelsea Vickers, Matthew C Deen, Hong-Ming Chen, Stephen Zhou, Ben Dai, Maria Fuller, Alisdair B Boraston, David J Vocadlo, Lorne A Clarke, Stephen G Withers
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models. Angewandte Chemie (International ed. in English) 61 (38) (2022)
Carmanah Hunter, Zhi-Zeng Gao, Hong-Ming Chen, Nicole K Thompson, Warren W Wakarchuk, Mark Nitz, Stephen G Withers, Lisa M Willis
Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid. ACS chemical biology (2022)
Lyann Sim, Nicole K Thompson, Andreas Geissner, Stephen G Withers, Warren W Wakarchuk
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo. Glycobiology 32 (5) (2022)
Carmanah Hunter, Zhi-Zeng Gao, Hong-Ming Chen, Nicole K Thompson, Warren W Wakarchuk, Mark Nitz, Stephen G Withers, Lisa M Willis
Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid. ACS chemical biology 18 (1) (2022)
Spencer S Macdonald, Jose H Pereira, Feng Liu, Gregor Tegl, Andy DeGiovanni, Jacob F Wardman, Samuel Deutsch, Yasuo Yoshikuni, Paul D Adams, Stephen G Withers
A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides. ACS central science 8 (4) (2022)
Carmanah Hunter, Zhi-Zeng Gao, Hong-Ming Chen, Nicole K Thompson, Warren W Wakarchuk, Mark Nitz, Stephen G Withers, Lisa M Willis
Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid. ACS chemical biology 18 (1) (2022)
Aizhou Wang, Rafaela Vanin Pinto Ribeiro, Aadil Ali, Edson Brambate, Etienne Abdelnour-Berchtold, Vinicius S Michaelsen, Yu Zhang, Peter Rahfeld, Haisle Moon, Hemant Gokhale, Anajara Gazzalle, Prodipto Pal, Mingyao Liu, Thomas K Waddell, Christine Cserti-Gazdewich, Kathryn Tinckam, Jayachandran N Kizhakkedathu, Lori West, Shaf Keshavjee, Stephen G Withers, Marcelo Cypel
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs. Science translational medicine 14 (632) (2022)
Hong-Ming Chen, Seyed Amirhossein Nasseri, Peter Rahfeld, Jacob F Wardman, Maurits Kohsiek, Stephen G Withers
Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening. Organic & biomolecular chemistry 19 (4) (2021)
Patrick Weber, Roland C Fischer, Seyed A Nasseri, Arnold E Stütz, Martin Thonhofer, Stephen G Withers, Andreas Wolfsgruber, Tanja M Wrodnigg
New α-galactosidase-inhibiting aminohydroxycyclopentanes. RSC advances 11 (26) (2021)
Melanie A Higgins, Gregor Tegl, Spencer S MacDonald, Gregory Arnal, Harry Brumer, Stephen G Withers, Katherine S Ryan
N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes. ACS chemical biology 16 (4) (2021)
Jacob F Wardman, Peter Rahfeld, Feng Liu, Connor Morgan-Lang, Lyann Sim, Steven J Hallam, Stephen G Withers
Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen. ACS chemical biology 16 (10) (2021)
Gregor Tegl, Peter Rahfeld, Katharina Ostmann, John Hanson, Stephen G Withers
Discovery of β-N-acetylglucosaminidases from screening metagenomic libraries and their use as thioglycoligase mutants. Organic & biomolecular chemistry 19 (41) (2021)
Manuel Scherer, Andrés G Santana, Kyle Robinson, Steven Zhou, Herman S Overkleeft, Lorne Clarke, Stephen G Withers
Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease. Chemical science 12 (41) (2021)
Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J Davies, Andres Gonzalez Santana, Philipp Müller, Seyed A Nasseri, Wendy A Offen, Bettina M Pabst, Eduard Paschke, Michael Schalli, Ana Torvisco, Marion Tschernutter, Christina Tysoe, Werner Windischhofer, Stephen G Withers, Andreas Wolfsgruber, Tanja M Wrodnigg, Arnold E Stütz
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine. Molecules (Basel, Switzerland) 25 (17) (2020)
Ryan P Sweeney, Phillip M Danby, Andreas Geissner, Ryan Karimi, Jesper Brask, Stephen G Withers
Development of an active site titration reagent for α-amylases. Chemical science 12 (2) (2020)
Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Laura I de Eugenio, Andrés G Santana, Lara Bejarano-Muñoz, Zach W B Armstrong, Juan Antonio Méndez-Líter, Juan Luis Asensio, Alicia Prieto, Stephen G Withers, Francisco Javier Cañada, Maria Jesus Martinez
Thioglycoligase derived from fungal GH3 β-xylosidase is a multi-glycoligase with broad acceptor tolerance. Nature communications 11 (1) (2020)
Andreas Wolfsgruber, Martin Thonhofer, Patrick Weber, Seyed A Nasseri, Roland C Fischer, Michael Schalli, Arnold E Stütz, Stephen G Withers, Tanja M Wrodnigg
N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase. Molecules (Basel, Switzerland) 25 (20) (2020)
Rianne A G Harmsen, Berit Bjugan Aam, Jogi Madhuprakash, Anne Grethe Hamre, Ethan D Goddard-Borger, Stephen G Withers, Vincent G H Eijsink, Morten Sørlie
Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine. Biochemistry 59 (48) (2020)
Gregor Tegl, John Hanson, Hong-Ming Chen, David H Kwan, Andrés G Santana, Stephen G Withers
Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International ed. in English) 58 (6) (2019)
Peter Rahfeld, Jacob F Wardman, Kevin Mehr, Drew Huff, Connor Morgan-Lang, Hong-Ming Chen, Steven J Hallam, Stephen G Withers
Prospecting for microbial α-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase. The Journal of biological chemistry 294 (44) (2019)
Zhizeng Gao, Olga G Ovchinnikova, Bo-Shun Huang, Feng Liu, David E Williams, Raymond J Andersen, Todd L Lowary, Chris Whitfield, Stephen G Withers
High-Throughput "FP-Tag" Assay for the Identification of Glycosyltransferase Inhibitors. Journal of the American Chemical Society 141 (6) (2019)
Peter Rahfeld, Lyann Sim, Haisle Moon, Iren Constantinescu, Connor Morgan-Lang, Steven James Hallam, Jayachandran N Kizhakkedathu, Stephen G Withers
An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nature microbiology 4 (9) (2019)
Christina R Tysoe, Sami Caner, Matthew B Calvert, Anna Win-Mason, Gary D Brayer, Stephen G Withers
Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase. Chemical science 10 (48) (2019)
Christina Tysoe, Stephen G Withers
Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α-Amylase. Biochemistry 57 (37) (2018)
Sandra Irmisch, Seohyun Jo, Christopher R Roach, Sharon Jancsik, Macaire Man Saint Yuen, Lufiani L Madilao, Mark O'Neil-Johnson, Russell B Williams, Stephen G Withers, Joerg Bohlmann
Discovery of UDP-Glycosyltransferases and BAHD-Acyltransferases Involved in the Biosynthesis of the Antidiabetic Plant Metabolite Montbretin A. The Plant cell 30 (8) (2018)
Zhizeng Gao, Andrew J Thompson, James C Paulson, Stephen G Withers
Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases. Angewandte Chemie (International ed. in English) 57 (41) (2018)
Seyed Amirhossein Nasseri, Leo Betschart, Daria Opaleva, Peter Rahfeld, Stephen G Withers
A Mechanism-Based Approach to Screening Metagenomic Libraries for Discovery of Unconventional Glycosidases. Angewandte Chemie (International ed. in English) 57 (35) (2018)
Patrick Weber, Seyed A Nasseri, Bettina M Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G Withers, Tanja M Wrodnigg, Arnold E Stütz
Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols. Molecules (Basel, Switzerland) 23 (3) (2018)
Miriam P Kötzler, Kyle Robinson, Hong-Ming Chen, Mark Okon, Lawrence P McIntosh, Stephen G Withers
Modulating the Nucleophile of a Glycoside Hydrolase through Site-Specific Incorporation of Fluoroglutamic Acids. Journal of the American Chemical Society 140 (26) (2018)
Tianmeng Duo, Kyle Robinson, Ian R Greig, Hong-Ming Chen, Brian O Patrick, Stephen G Withers
Remarkable Reactivity Differences between Glucosides with Identical Leaving Groups. Journal of the American Chemical Society 139 (44) (2017)
Phillip M Danby, Stephen G Withers
Glycosyl Cations versus Allylic Cations in Spontaneous and Enzymatic Hydrolysis. Journal of the American Chemical Society 139 (31) (2017)

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Publication Activity (10 Years)

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Stephen G Withers