Stephen W Fesik

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 33

Top Venues

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

Biochemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Christian T Meyer, Brianna N Smith, Jing Wang, Kevin B Teuscher, Brian C Grieb, Gregory Caleb Howard, Alexander James Silver, Shelly L Lorey, Gordon M Stott, William J Moore, Taekyu Lee, Michael R Savona, April M Weissmiller, Qi Liu, Vito Quaranta, Stephen W Fesik, William P Tansey
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Ashley J Taylor, Kangsa Amporndanai, Tyson A Rietz, Bin Zhao, Anusha Thiruvaipati, Qiangqiang Wei, Taylor M South, Mackenzie M Crow, Chideraa Apakama, John L Sensintaffar, Jason Phan, Taekyu Lee, Stephen W Fesik
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ). ACS medicinal chemistry letters 15 (8) (2024)
Christian T Meyer, Brianna N Smith, Jing Wang, Kevin B Teuscher, Brian C Grieb, Gregory Caleb Howard, Alexander James Silver, Shelly L Lorey, Gordon M Stott, William J Moore, Taekyu Lee, Michael R Savona, April M Weissmiller, Qi Liu, Vito Quaranta, Stephen W Fesik, William P Tansey
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Christian T Meyer, Brianna N Smith, Jing Wang, Kevin B Teuscher, Brian C Grieb, Gregory Caleb Howard, Alexander James Silver, Shelly L Lorey, Gordon M Stott, William J Moore, Taekyu Lee, Michael R Savona, April M Weissmiller, Qi Liu, Vito Quaranta, Stephen W Fesik, William P Tansey
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Ashley J Taylor, Kangsa Amporndanai, Tyson A Rietz, Bin Zhao, Anusha Thiruvaipati, Qiangqiang Wei, Taylor M South, Mackenzie M Crow, Chideraa Apakama, John L Sensintaffar, Jason Phan, Taekyu Lee, Stephen W Fesik
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ). ACS medicinal chemistry letters 15 (8) (2024)
Kevin B Teuscher, Jonathan J Mills, Jianhua Tian, Changho Han, Kenneth M Meyers, Jiqing Sai, Taylor M South, Mackenzie M Crow, Mayme Van Meveren, John L Sensintaffar, Bin Zhao, Kangsa Amporndanai, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. Journal of medicinal chemistry (2023)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Joachim Bröker, Alex G Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B McConnell, Stephen W Fesik
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. Journal of medicinal chemistry 65 (21) (2022)
Kevin B Teuscher, Kenneth M Meyers, Qiangqiang Wei, Jonathan J Mills, Jianhua Tian, Joseph Alvarado, Jiqing Sai, Mayme Van Meveren, Taylor M South, Tyson A Rietz, Bin Zhao, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. Journal of medicinal chemistry 65 (8) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren, Taylor M South, John L Sensintaffar, Tyson A Rietz, Soumita Goswami, Jing Wang, Brian C Grieb, Shelly L Lorey, Gregory Caleb Howard, Qi Liu, William J Moore, Gordon M Stott, William P Tansey, Taekyu Lee, Stephen W Fesik
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Tyson A Rietz, Kevin B Teuscher, Jonathan J Mills, Rocco D Gogliotti, Lance T Lepovitz, W Rush Scaggs, Keisuke Yoshida, Kelvin Luong, Taekyu Lee, Stephen W Fesik
Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). Journal of medicinal chemistry 64 (19) (2021)
Bin Zhao, William G Payne, Jiqing Sai, Zhenwei Lu, Edward T Olejniczak, Stephen W Fesik
Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex. Biochemistry 59 (8) (2020)
Selena Chacón Simon, Feng Wang, Lance R Thomas, Jason Phan, Bin Zhao, Edward T Olejniczak, Jonathan D Macdonald, J Grace Shaw, Caden Schlund, William Payne, Joy Creighton, Shaun R Stauffer, Alex G Waterson, William P Tansey, Stephen W Fesik
Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry 63 (8) (2020)
Jianhua Tian, Kevin B Teuscher, Erin R Aho, Joseph R Alvarado, Jonathan J Mills, Kenneth M Meyers, Rocco D Gogliotti, Changho Han, Jonathan D Macdonald, Jiqing Sai, J Grace Shaw, John L Sensintaffar, Bin Zhao, Tyson A Rietz, Lance R Thomas, William G Payne, William J Moore, Gordon M Stott, Jumpei Kondo, Masahiro Inoue, Robert J Coffey, William P Tansey, Shaun R Stauffer, Taekyu Lee, Stephen W Fesik
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. Journal of medicinal chemistry 63 (2) (2020)
Dhruba Sarkar, Edward T Olejniczak, Jason Phan, Jesse A Coker, Jiqing Sai, Allison Arnold, Yugandhar Beesetty, Alex G Waterson, Stephen W Fesik
Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. Journal of medicinal chemistry 63 (15) (2020)
Lance R Thomas, Clare M Adams, Stephen W Fesik, Christine M Eischen, William P Tansey
Targeting MYC through WDR5. Molecular & cellular oncology 7 (2) (2020)
Jonathan D Macdonald, Selena Chacón Simon, Changho Han, Feng Wang, J Grace Shaw, Jennifer E Howes, Jiqing Sai, Joannes P Yuh, Demarco Camper, Bethany M Alicie, Joseph Alvarado, Sameer Nikhar, William Payne, Erin R Aho, Joshua A Bauer, Bin Zhao, Jason Phan, Lance R Thomas, Olivia W Rossanese, William P Tansey, Alex G Waterson, Shaun R Stauffer, Stephen W Fesik
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. Journal of medicinal chemistry 62 (24) (2019)
Taekyu Lee, Plamen P Christov, Subrata Shaw, James C Tarr, Bin Zhao, Nagarathanam Veerasamy, Kyu Ok Jeon, Jonathan J Mills, Zhiguo Bian, John L Sensintaffar, Allison L Arnold, Stuart A Fogarty, Evan Perry, Haley E Ramsey, Rebecca S Cook, Melinda Hollingshead, Myrtle Davis Millin, Kyung-Min Lee, Brian Koss, Amit Budhraja, Joseph T Opferman, Kwangho Kim, Carlos L Arteaga, William J Moore, Edward T Olejniczak, Michael R Savona, Stephen W Fesik
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. Journal of medicinal chemistry 62 (8) (2019)
Denis T Akan, Jennifer E Howes, Jiqing Sai, Allison L Arnold, Yugandhar Beesetty, Jason Phan, Edward T Olejniczak, Alex G Waterson, Stephen W Fesik
Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses. ACS chemical biology 14 (3) (2019)
Bin Zhao, Allison L Arnold, Marcelle A Coronel, Joyce H Lee, Taekyu Lee, Edward T Olejniczak, Stephen W Fesik
Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors. Biochemistry 57 (32) (2018)
Subrata Shaw, Zhiguo Bian, Bin Zhao, James C Tarr, Nagarathanam Veerasamy, Kyu Ok Jeon, Johannes Belmar, Allison L Arnold, Stuart A Fogarty, Evan Perry, John L Sensintaffar, DeMarco V Camper, Olivia W Rossanese, Taekyu Lee, Edward T Olejniczak, Stephen W Fesik
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. Journal of medicinal chemistry 61 (6) (2018)
Feng Wang, Kyu Ok Jeon, James M Salovich, Jonathan D Macdonald, Joseph Alvarado, Rocco D Gogliotti, Jason Phan, Edward T Olejniczak, Qi Sun, Shidong Wang, DeMarco Camper, Joannes P Yuh, J Grace Shaw, Jiqing Sai, Olivia W Rossanese, William P Tansey, Shaun R Stauffer, Stephen W Fesik
Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry 61 (13) (2018)
Jason R Abbott, Timothy R Hodges, R Nathan Daniels, Pratiq A Patel, J Phillip Kennedy, Jennifer E Howes, Denis T Akan, Michael C Burns, Jiqing Sai, Tammy Sobolik, Yugandhar Beesetty, Taekyu Lee, Olivia W Rossanese, Jason Phan, Alex G Waterson, Stephen W Fesik
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. Journal of medicinal chemistry 61 (14) (2018)
Timothy R Hodges, Jason R Abbott, Andrew J Little, Dhruba Sarkar, James M Salovich, Jennifer E Howes, Denis T Akan, Jiqing Sai, Allison L Arnold, Carrie Browning, Michael C Burns, Tammy Sobolik, Qi Sun, Yugandhar Beesetty, Jesse A Coker, Dirk Scharn, Heinz Stadtmueller, Olivia W Rossanese, Jason Phan, Alex G Waterson, Darryl B McConnell, Stephen W Fesik
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Journal of medicinal chemistry 61 (19) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Stephen W Fesik