Darryl B McConnell

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 30

Top Venues

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

Nature chemical biology

ChemMedChem

This page only lists publications with an associated author ORCID identifier.

Publications

Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Manfred Koegl, Simon Lucas, Laetitia J Martin, Moriz Mayer, Darryl B McConnell, Sophie Mitzner, Guido Scholz, Matthias Treu, Bernhard Wolkerstorfer, Stephan Zahn, Krzysztof M Zak, Philipp A Jaeger, Peter Ettmayer
Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays. Journal of medicinal chemistry 67 (14) (2024)
Andreas Beier, Gerald Platzer, Theresa Höfurthner, Aleksandra L Ptaszek, Roman J Lichtenecker, Leonhard Geist, Julian E Fuchs, Darryl B McConnell, Moriz Mayer, Robert Konrat
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. Journal of medicinal chemistry (2024)
Andreas Beier, Gerald Platzer, Theresa Höfurthner, Aleksandra L Ptaszek, Roman J Lichtenecker, Leonhard Geist, Julian E Fuchs, Darryl B McConnell, Moriz Mayer, Robert Konrat
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. Journal of medicinal chemistry 67 (15) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Manfred Koegl, Simon Lucas, Laetitia J Martin, Moriz Mayer, Darryl B McConnell, Sophie Mitzner, Guido Scholz, Matthias Treu, Bernhard Wolkerstorfer, Stephan Zahn, Krzysztof M Zak, Philipp A Jaeger, Peter Ettmayer
Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays. Journal of medicinal chemistry 67 (14) (2024)
Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Manfred Koegl, Simon Lucas, Laetitia J Martin, Moriz Mayer, Darryl B McConnell, Sophie Mitzner, Guido Scholz, Matthias Treu, Bernhard Wolkerstorfer, Stephan Zahn, Krzysztof M Zak, Philipp A Jaeger, Peter Ettmayer
Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays. Journal of medicinal chemistry 67 (14) (2024)
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John L Sensintaffar, Heribert Arnhof, Matthias Samwer, Plamen P Christov, Kwangho Kim, Tobias Wunberg, Norbert Schweifer, Francesca Trapani, Allison Arnold, Florian Martin, Bin Zhao, Nagaraju Miriyala, Danielle Sgubin, Stuart Fogarty, William J Moore, Gordon M Stott, Edward T Olejniczak, Harald Engelhardt, Dorothea Rudolph, Taekyu Lee, Darryl B McConnell, Stephen W Fesik
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Andreas Beier, Gerald Platzer, Theresa Höfurthner, Aleksandra L Ptaszek, Roman J Lichtenecker, Leonhard Geist, Julian E Fuchs, Darryl B McConnell, Moriz Mayer, Robert Konrat
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. Journal of medicinal chemistry 67 (15) (2024)
Andreas Gollner, Dorothea Rudolph, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Juergen Ramharter, Rolf Grempler, Jens Quant, Joerg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, Guido Boehmelt, Darryl B McConnell, Norbert Kraut, Patrizia Sini
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules. Molecular cancer therapeutics (2024)
Andreas Beier, Gerald Platzer, Theresa Höfurthner, Aleksandra L Ptaszek, Roman J Lichtenecker, Leonhard Geist, Julian E Fuchs, Darryl B McConnell, Moriz Mayer, Robert Konrat
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. Journal of medicinal chemistry 67 (15) (2024)
Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Manfred Koegl, Simon Lucas, Laetitia J Martin, Moriz Mayer, Darryl B McConnell, Sophie Mitzner, Guido Scholz, Matthias Treu, Bernhard Wolkerstorfer, Stephan Zahn, Krzysztof M Zak, Philipp A Jaeger, Peter Ettmayer
Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays. Journal of medicinal chemistry 67 (14) (2024)
Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Manfred Koegl, Simon Lucas, Laetitia J Martin, Moriz Mayer, Darryl B McConnell, Sophie Mitzner, Guido Scholz, Matthias Treu, Bernhard Wolkerstorfer, Stephan Zahn, Krzysztof M Zak, Philipp A Jaeger, Peter Ettmayer
Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays. Journal of medicinal chemistry (2024)
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B McConnell, Norbert Kraut, Piro Lito
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature (2023)
Gerald Platzer, Aleksandra L Ptaszek, Jark Böttcher, Julian E Fuchs, Leonhard Geist, Daniel Braun, Darryl B McConnell, Robert Konrat, Pedro A Sánchez-Murcia, Moriz Mayer
Ligand 1 H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution. Chemphyschem : a European journal of chemical physics and physical chemistry (2023)
Joachim Bröker, Alex G Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B McConnell, Stephen W Fesik
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. Journal of medicinal chemistry 65 (21) (2022)
Sven Brüschweiler, Julian E Fuchs, Gerd Bader, Darryl B McConnell, Robert Konrat, Moriz Mayer
A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods. ChemMedChem 16 (23) (2021)
Dirk Kessler, Moriz Mayer, Stephan K Zahn, Markus Zeeb, Simon Wöhrle, Andreas Bergner, Jens Bruchhaus, Tuncay Ciftci, Georg Dahmann, Maike Dettling, Sandra Döbel, Julian E Fuchs, Leonhard Geist, Wolfgang Hela, Christiane Kofink, Roland Kousek, Franziska Moser, Teresa Puchner, Klaus Rumpel, Maximilian Scharnweber, Patrick Werni, Bernhard Wolkerstorfer, Dennis Breitsprecher, Philipp Baaske, Mark Pearson, Darryl B McConnell, Jark Böttcher
Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods. ChemMedChem 16 (9) (2021)
Darryl B McConnell
Biotin's Lessons in Drug Design. Journal of medicinal chemistry 64 (22) (2021)
Dirk Kessler, Darryl B McConnell
The hanging heart: How KRAS lures its prey to the membrane. Proceedings of the National Academy of Sciences of the United States of America 117 (43) (2020)
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L F Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P Vellano, Jonathan C O'Connell, Rachel L Mendes, Jurgen Moll, Mark Petronczki, Timothy P Heffernan, Mark Pearson, Darryl B McConnell, Norbert Kraut
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer discovery 11 (1) (2020)
Marco H Hofmann, Rajeswaran Mani, Harald Engelhardt, Maria A Impagnatiello, Sebastian Carotta, Marc Kerenyi, Seila Lorenzo-Herrero, Jark Böttcher, Dirk Scharn, Heribert Arnhof, Andreas Zoephel, Renate Schnitzer, Thomas Gerstberger, Michael P Sanderson, Girish Rajgolikar, Swagata Goswami, Sumithira Vasu, Peter Ettmayer, Segundo González, Mark Pearson, Darryl B McConnell, Norbert Kraut, Natarajan Muthusamy, Jürgen Moll
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Molecular cancer therapeutics 19 (4) (2020)
Dirk Kessler, Andreas Bergner, Jark Böttcher, Gerhard Fischer, Sandra Döbel, Melanie Hinkel, Barbara Müllauer, Alexander Weiss-Puxbaum, Darryl B McConnell
Drugging all RAS isoforms with one pocket. Future medicinal chemistry 12 (21) (2020)
Gerald Platzer, Moriz Mayer, Andreas Beier, Sven Brüschweiler, Julian E Fuchs, Harald Engelhardt, Leonhard Geist, Gerd Bader, Julia Schörghuber, Roman J Lichtenecker, Bernhard Wolkerstorfer, Dirk Kessler, Darryl B McConnell, Robert Konrat
PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angewandte Chemie (International ed. in English) 59 (35) (2020)
Dirk Kessler, Andreas Gollner, Michael Gmachl, Andreas Mantoulidis, Laetitia J Martin, Andreas Zoephel, Moriz Mayer, David Covini, Silke Fischer, Thomas Gerstberger, Teresa Gmaschitz, Craig Goodwin, Peter Greb, Daniela Häring, Wolfgang Hela, Johann Hoffmann, Jale Karolyi-Oezguer, Petr Knesl, Stefan Kornigg, Manfred Koegl, Roland Kousek, Lyne Lamarre, Franziska Moser, Silvia Munico-Martinez, Christoph Peinsipp, Jason Phan, Jörg Rinnenthal, Jiqing Sai, Christian Salamon, Yvonne Scherbantin, Katharina Schipany, Renate Schnitzer, Andreas Schrenk, Bernadette Sharps, Gabriella Siszler, Qi Sun, Alex Waterson, Bernhard Wolkerstorfer, Markus Zeeb, Mark Pearson, Stephen W Fesik, Darryl B McConnell
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers. Proceedings of the National Academy of Sciences of the United States of America 117 (7) (2020)
Andreas Bergner, Xiaoling Cockcroft, Gerhard Fischer, Andreas Gollner, Wolfgang Hela, Roland Kousek, Andreas Mantoulidis, Laetitia J Martin, Moriz Mayer, Barbara Müllauer, Gabriella Siszler, Bernhard Wolkerstorfer, Dirk Kessler, Darryl B McConnell
KRAS Binders Hidden in Nature. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (52) (2019)
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Mark Petronczki, Markus Zeeb, Nikolai Mischerikow, Abdellah Allali-Hassani, Magdalena M Szewczyk, Fengling Li, Steven Kennedy, Masoud Vedadi, Dalia Barsyte-Lovejoy, Peter J Brown, Kilian V M Huber, Catherine M Rogers, Carrow I Wells, Oleg Fedorov, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Heribert Arnhof, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Maja Corcokovic, Bernadette Sharps, Sandra Winkler, Daniela Häring, Xiao-Ling Cockcroft, Julian E Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Thomas Gerstberger, Guido Boehmelt, Christopher R Vakoc, Cheryl H Arrowsmith, Mark Pearson, Darryl B McConnell
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology 15 (8) (2019)
William Farnaby, Manfred Koegl, Michael J Roy, Claire Whitworth, Emelyne Diers, Nicole Trainor, David Zollman, Steffen Steurer, Jale Karolyi-Oezguer, Carina Riedmueller, Teresa Gmaschitz, Johannes Wachter, Christian Dank, Michael Galant, Bernadette Sharps, Klaus Rumpel, Elisabeth Traxler, Thomas Gerstberger, Renate Schnitzer, Oliver Petermann, Peter Greb, Harald Weinstabl, Gerd Bader, Andreas Zoephel, Alexander Weiss-Puxbaum, Katharina Ehrenhöfer-Wölfer, Simon Wöhrle, Guido Boehmelt, Joerg Rinnenthal, Heribert Arnhof, Nicola Wiechens, Meng-Ying Wu, Tom Owen-Hughes, Peter Ettmayer, Mark Pearson, Darryl B McConnell, Alessio Ciulli
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nature chemical biology 15 (7) (2019)
Dirk Kessler, Michael Gmachl, Andreas Mantoulidis, Laetitia J Martin, Andreas Zoephel, Moriz Mayer, Andreas Gollner, David Covini, Silke Fischer, Thomas Gerstberger, Teresa Gmaschitz, Craig Goodwin, Peter Greb, Daniela Häring, Wolfgang Hela, Johann Hoffmann, Jale Karolyi-Oezguer, Petr Knesl, Stefan Kornigg, Manfred Koegl, Roland Kousek, Lyne Lamarre, Franziska Moser, Silvia Munico-Martinez, Christoph Peinsipp, Jason Phan, Jörg Rinnenthal, Jiqing Sai, Christian Salamon, Yvonne Scherbantin, Katharina Schipany, Renate Schnitzer, Andreas Schrenk, Bernadette Sharps, Gabriella Siszler, Qi Sun, Alex Waterson, Bernhard Wolkerstorfer, Markus Zeeb, Mark Pearson, Stephen W Fesik, Darryl B McConnell
Drugging an undruggable pocket on KRAS. Proceedings of the National Academy of Sciences of the United States of America 116 (32) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Darryl B McConnell