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Dirk Kessler

ORCID

Publication Activity (10 Years)

Years Active: 2019-2022
Publications (10 Years): 9

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature chemical biology

ChemMedChem

Angewandte Chemie (International ed. in English)

Boehringer Ingelheim RCV GmbH und Co KG

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Boehringer Ingelheim RCV GmbH und Co KG

Austria

Scientific Director :: Medicinal Chemistry

Publications

Joachim Bröker, Alex G Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B McConnell, Stephen W Fesik
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. Journal of medicinal chemistry 65 (21) (2022)
Dirk Kessler, Moriz Mayer, Stephan K Zahn, Markus Zeeb, Simon Wöhrle, Andreas Bergner, Jens Bruchhaus, Tuncay Ciftci, Georg Dahmann, Maike Dettling, Sandra Döbel, Julian E Fuchs, Leonhard Geist, Wolfgang Hela, Christiane Kofink, Roland Kousek, Franziska Moser, Teresa Puchner, Klaus Rumpel, Maximilian Scharnweber, Patrick Werni, Bernhard Wolkerstorfer, Dennis Breitsprecher, Philipp Baaske, Mark Pearson, Darryl B McConnell, Jark Böttcher
Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods. ChemMedChem 16 (9) (2021)
Daniel B Grabarczyk, Olga A Petrova, Luiza Deszcz, Robert Kurzbauer, Paul Murphy, Juraj Ahel, Antonia Vogel, Rebeca Gogova, Victoria Faas, Darja Kordic, Alexander Schleiffer, Anton Meinhart, Richard Imre, Anita Lehner, Jana Neuhold, Gerd Bader, Peggy Stolt-Bergner, Jark Böttcher, Bernhard Wolkerstorfer, Gerhard Fischer, Irina Grishkovskaya, David Haselbach, Dirk Kessler, Tim Clausen
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nature chemical biology 17 (10) (2021)
Dirk Kessler, Darryl B McConnell
The hanging heart: How KRAS lures its prey to the membrane. Proceedings of the National Academy of Sciences of the United States of America 117 (43) (2020)
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L F Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P Vellano, Jonathan C O'Connell, Rachel L Mendes, Jurgen Moll, Mark Petronczki, Timothy P Heffernan, Mark Pearson, Darryl B McConnell, Norbert Kraut
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer discovery 11 (1) (2020)
Dirk Kessler, Andreas Bergner, Jark Böttcher, Gerhard Fischer, Sandra Döbel, Melanie Hinkel, Barbara Müllauer, Alexander Weiss-Puxbaum, Darryl B McConnell
Drugging all RAS isoforms with one pocket. Future medicinal chemistry 12 (21) (2020)
Gerald Platzer, Moriz Mayer, Andreas Beier, Sven Brüschweiler, Julian E Fuchs, Harald Engelhardt, Leonhard Geist, Gerd Bader, Julia Schörghuber, Roman J Lichtenecker, Bernhard Wolkerstorfer, Dirk Kessler, Darryl B McConnell, Robert Konrat
PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angewandte Chemie (International ed. in English) 59 (35) (2020)
Dirk Kessler, Andreas Gollner, Michael Gmachl, Andreas Mantoulidis, Laetitia J Martin, Andreas Zoephel, Moriz Mayer, David Covini, Silke Fischer, Thomas Gerstberger, Teresa Gmaschitz, Craig Goodwin, Peter Greb, Daniela Häring, Wolfgang Hela, Johann Hoffmann, Jale Karolyi-Oezguer, Petr Knesl, Stefan Kornigg, Manfred Koegl, Roland Kousek, Lyne Lamarre, Franziska Moser, Silvia Munico-Martinez, Christoph Peinsipp, Jason Phan, Jörg Rinnenthal, Jiqing Sai, Christian Salamon, Yvonne Scherbantin, Katharina Schipany, Renate Schnitzer, Andreas Schrenk, Bernadette Sharps, Gabriella Siszler, Qi Sun, Alex Waterson, Bernhard Wolkerstorfer, Markus Zeeb, Mark Pearson, Stephen W Fesik, Darryl B McConnell
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers. Proceedings of the National Academy of Sciences of the United States of America 117 (7) (2020)
Andreas Bergner, Xiaoling Cockcroft, Gerhard Fischer, Andreas Gollner, Wolfgang Hela, Roland Kousek, Andreas Mantoulidis, Laetitia J Martin, Moriz Mayer, Barbara Müllauer, Gabriella Siszler, Bernhard Wolkerstorfer, Dirk Kessler, Darryl B McConnell
KRAS Binders Hidden in Nature. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (52) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Dirk Kessler