Tad A Holak (Tad Holak)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Topics

Plasmodium Falciparum

Molecular Docking

Network Analysis

Top Venues

Molecules (Basel, Switzerland)

Journal of medicinal chemistry

ACS medicinal chemistry letters

Beilstein journal of organic chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Aleksandra Hec-Gałązka, Urszula Tyrcha, Jan Barczyński, Przemyslaw Bielski, Michał Mikitiuk, Ganna P Gudz, Radoslaw Kitel, Bogdan M Musielak, Jacek Plewka, Tomasz Sitar, Tad A Holak
Nonsymmetrically Substituted 1,1'-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction. ACS medicinal chemistry letters 15 (6) (2024)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Correction: Reyes Romero et al. Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules 2022, 27 , 8282. Molecules (Basel, Switzerland) 29 (12) (2024)
Joanna Klimek, Oskar Kruc, Joanna Ceklarz, Beata Kaminska, Bogdan M Musielak, Robin van der Straat, Alexander S S Dömling, Tad A Holak, Damian Muszak, Justyna Kalinowska-Tluscik, Łukasz Skalniak, Ewa Surmiak
C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein-Protein Interaction. Molecules (Basel, Switzerland) 29 (11) (2024)
Joanna Klimek, Oskar Kruc, Joanna Ceklarz, Beata Kaminska, Bogdan M Musielak, Robin van der Straat, Alexander S S Dömling, Tad A Holak, Damian Muszak, Justyna Kalinowska-Tluscik, Łukasz Skalniak, Ewa Surmiak
C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein-Protein Interaction. Molecules (Basel, Switzerland) 29 (11) (2024)
Joanna Klimek, Oskar Kruc, Joanna Ceklarz, Beata Kaminska, Bogdan M Musielak, Robin van der Straat, Alexander S S Dömling, Tad A Holak, Damian Muszak, Justyna Kalinowska-Tluscik, Łukasz Skalniak, Ewa Surmiak
C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein-Protein Interaction. Molecules (Basel, Switzerland) 29 (11) (2024)
Aleksandra Hec-Gałązka, Urszula Tyrcha, Jan Barczyński, Przemyslaw Bielski, Michał Mikitiuk, Ganna P Gudz, Radoslaw Kitel, Bogdan M Musielak, Jacek Plewka, Tomasz Sitar, Tad A Holak
Nonsymmetrically Substituted 1,1'-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction. ACS medicinal chemistry letters 15 (6) (2024)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Correction: Reyes Romero et al. Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules 2022, 27 , 8282. Molecules (Basel, Switzerland) 29 (12) (2024)
Ewa Surmiak, Julia Ząber, Jacek Plewka, Grzegorz Wojtanowicz, Justyna Kocik-Krol, Oskar Kruc, Damian Muszak, Ismael Rodriguez, Bogdan M Musielak, Monica Viviano, Sabrina Castellano, Łukasz Skalniak, Katarzyna Magiera-Mularz, Tad A Holak, Justyna Kalinowska-Tłuścik
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. ACS medicinal chemistry letters 15 (1) (2023)
Ewa Surmiak, Julia Ząber, Jacek Plewka, Grzegorz Wojtanowicz, Justyna Kocik-Krol, Oskar Kruc, Damian Muszak, Ismael Rodriguez, Bogdan M Musielak, Monica Viviano, Sabrina Castellano, Łukasz Skalniak, Katarzyna Magiera-Mularz, Tad A Holak, Justyna Kalinowska-Tłuścik
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. ACS medicinal chemistry letters 15 (1) (2023)
Marta A Ważyńska, Roberto Butera, Marta Requesens, Annechien Plat, Tryfon Zarganes-Tzitzikas, Constantinos G Neochoritis, Jacek Plewka, Lukasz Skalniak, Justyna Kocik-Krol, Bogdan Musielak, Katarzyna Magiera-Mularz, Ismael Rodriguez, Simon N Blok, Marco de Bruyn, Hans W Nijman, Philip H Elsinga, Tad A Holak, Alexander S S Dömling
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. Journal of medicinal chemistry (2023)
Michał Mikitiuk, Jan Barczyński, Przemysław Bielski, Marcelino Arciniega, Urszula Tyrcha, Aleksandra Hec, Andrea D Lipińska, Michał Rychłowski, Tad A Holak, Tomasz Sitar
IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins. Molecules (Basel, Switzerland) 28 (22) (2023)
Radoslaw Kitel, Ewa Surmiak, Jan Borggräfe, Justyna Kalinowska-Tluscik, Przemyslaw Golik, Miroslawa Czub, Wiktor Uzar, Bogdan M Musielak, Mariusz Madej, Grzegorz M Popowicz, Grzegorz Dubin, Tad A Holak
Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. Journal of medicinal chemistry (2023)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules (Basel, Switzerland) 27 (23) (2022)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules (Basel, Switzerland) 27 (23) (2022)
Stanisław Malicki, Barbara Pucelik, Edyta Żyła, Małgorzata Benedyk-Machaczka, Wojciech Gałan, Anna Golda, Alicja Sochaj-Gregorczyk, Marta Kamińska, João Crispim Encarnação, Barbara Chruścicka, Hans-Peter Marti, Tony Jialiang Chen, Katarzyna Magiera-Mularz, Bartosz Zięba, Tad A Holak, Janusz M Dąbrowski, Anna Czarna, Joanna Kozieł, Piotr Mydel, Grzegorz Dubin
Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe. Pharmaceuticals (Basel, Switzerland) 15 (6) (2022)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules (Basel, Switzerland) 27 (23) (2022)
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A Holak, Ewa Surmiak
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein. Molecules (Basel, Switzerland) 27 (23) (2022)
Shabnam Shaabani, Louis Gadina, Ewa Surmiak, Zefeng Wang, Bidong Zhang, Roberto Butera, Tryfon Zarganes-Tzitzikas, Ismael Rodriguez, Justyna Kocik-Krol, Katarzyna Magiera-Mularz, Łukasz Skalniak, Alexander S S Dömling, Tad A Holak
Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. Molecules (Basel, Switzerland) 27 (11) (2022)
Edyta Zyla, Bogdan M Musielak, Tad A Holak, Grzegorz Dubin
Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis. Molecules (Basel, Switzerland) 26 (16) (2021)
Atilio Reyes Romero, Serjey Lunev, Grzegorz M Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A Holak, Alexander S S Dömling, Matthew R Groves
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. Communications biology 4 (1) (2021)
Ewa Surmiak, Katarzyna Magiera-Mularz, Bogdan M Musielak, Damian Muszak, Justyna Kocik-Krol, Radoslaw Kitel, Jacek Plewka, Tad A Holak, Łukasz Skalniak
PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action. International journal of molecular sciences 22 (21) (2021)
Bogdan M Musielak, Weronika Janczyk, Ismael Rodriguez, Jacek Plewka, Dominik Sala, Katarzyna Magiera-Mularz, Tad A Holak
Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions. Molecules (Basel, Switzerland) 25 (13) (2020)
Ramon van der Vlag, M Yagiz Unver, Tommaso Felicetti, Aleksandra Twarda-Clapa, Fatima Kassim, Cagdas Ermis, Constantinos G Neochoritis, Bogdan M Musielak, Beata Labuzek, Alexander S S Dömling, Tad A Holak, Anna Katharina Herta Hirsch
Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination. ChemMedChem 15 (4) (2019)
Constantinos G Neochoritis, Maryam Kazemi Miraki, Eman M M Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A Holak, Alexander Dömling
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists. Beilstein journal of organic chemistry 15 (2019)
Łukasz Skalniak, Ewa Surmiak, Tad A Holak
A therapeutic patent overview of MDM2/X-targeted therapies (2014-2018). Expert opinion on therapeutic patents 29 (3) (2019)
Aleksandra Twarda-Clapa, Sylwia Krzanik, Katarzyna Kubica, Katarzyna Guzik, Beata Labuzek, Constantinos G Neochoritis, Kareem Khoury, Kaja Kowalska, Miroslawa Czub, Grzegorz Dubin, Alexander S S Dömling, Łukasz Skalniak, Tad A Holak
1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. Journal of medicinal chemistry 60 (10) (2017)
Katarzyna Guzik, Krzysztof M Zak, Przemyslaw Grudnik, Katarzyna Magiera, Bogdan Musielak, Ricarda Törner, Łukasz Skalniak, Alexander S S Dömling, Grzegorz Dubin, Tad A Holak
Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. Journal of medicinal chemistry 60 (13) (2017)