Tamara Tchkonia (T Tchkonia, Tamar Tchkonia)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 32

Top Venues

Nature cancer

Obesity (Silver Spring, Md.)

Research square

Communications biology

Mayo Clinic

Moscow State University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Mayo Clinic

United States

Reserach Scientist :: Kogod Center On Aging

Boston University School of Medicine

United States

Instructor :: Evance Department of Medicine

Boston University School of Medicine

United States

research Associate :: Evance Department of Medicine

Boston University School of Medicine

United States

Post-Doct fellow :: Evance Department of Medicine

Ivane Javakhishvili Tbilisi State University

Georgia

Associate Proffessor/ Docent :: Molecular biology

Ivane Javakhishvili Tbilisi State University

Georgia

research Scientist, :: Developmental Biology

Education History

Moscow State University Jan 11 1985 - Oct 10 1991

Russia

PHD :: Molecular Biology

Ivane Javakhishvili Tbilisi State University Sep 01 1977 - May 20 1982

Georgia

MSC :: Biochemistry

Publications

Joshua N Farr, Elizabeth J Atkinson, Sara J Achenbach, Tammie L Volkman, Amanda J Tweed, Stephanie J Vos, Ming Ruan, Jad G Sfeir, Matthew T Drake, Dominik Saul, Madison L Doolittle, Irina Bancos, Kai Yu, Tamara Tchkonia, Nathan K LeBrasseur, James L Kirkland, David G Monroe, Sundeep Khosla
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nature medicine (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan I Macura, Tamara Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology 7 (1) (2024)
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan I Macura, Tamara Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology 7 (1) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer 5 (3) (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fátima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer (2024)
Masayoshi Suda, Karl H Paul, Utkarsh Tripathi, Tohru Minamino, Tamara Tchkonia, James L Kirkland
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction. Endocrine reviews (2024)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) 31 (6) (2023)
Jessica Murphy, Bjorn T Tam, James L Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A Tsoukas, José A Morais, Sylvia Santosa
Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss. Obesity (Silver Spring, Md.) (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L Doolittle, Jad G Sfeir, Japneet Kaur, Elizabeth J Atkinson, James R Edwards, R Graham G Russell, Robert J Pignolo, James L Kirkland, Tamara Tchkonia, Laura J Niedernhofer, David G Monroe, Nathan K LeBrasseur, Joshua N Farr, Paul D Robbins, Sundeep Khosla
In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers. bioRxiv : the preprint server for biology (2023)
Cecile Riviere-Cazaux, Lucas P Carlstrom, Bryan J Neth, Ian E Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A Mansour, Bipasha Mukherjee, Arthur E Warrington, Susan C Short, Thomas von Zglinicki, Desmond A Brown, Sandeep Burma, Tamara Tchkonia, Marissa J Schafer, Darren J Baker, Sani H Kizilbash, James L Kirkland, Terry C Burns
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence. NPJ precision oncology 7 (1) (2023)
Mitzi M Gonzales, Valentina R Garbarino, Tiffany F Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia J Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E Orr
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial. Nature medicine (2023)
Miranda E Orr, Mitzi Gonzales, Valentina Garbarino, Tiffany Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C Petersen, Tamara Tchkonia, James L Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease. Research square (2023)
Xu Zhang, Vesselina M Pearsall, Chase M Carver, Elizabeth J Atkinson, Benjamin D S Clarkson, Ethan M Grund, Michelle Baez-Faria, Kevin D Pavelko, Jennifer M Kachergus, Thomas A White, Renee K Johnson, Courtney S Malo, Alan M Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O Johnson, Zachariah P Tritz, Cori E Fain, Roman H Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L Kirkland, Aaron J Johnson, Charles L Howe, E Aubrey Thompson, Nathan K LeBrasseur, Marissa J Schafer
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance. Nature communications 13 (1) (2022)
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J Atkinson, Madison L Doolittle, Xu Zhang, Nathan K LeBrasseur, Robert J Pignolo, Paul D Robbins, Laura J Niedernhofer, Yuji Ikeno, Diana Jurk, João F Passos, LaTonya J Hickson, Ailing Xue, David G Monroe, Tamara Tchkonia, James L Kirkland, Joshua N Farr, Sundeep Khosla
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nature communications 13 (1) (2022)
Selim Chaib, Tamara Tchkonia, James L Kirkland
Cellular senescence and senolytics: the path to the clinic. Nature medicine 28 (8) (2022)
Ritesh K Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamara Tchkonia, James L Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Blüher, Ulf Smith
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH. Nature metabolism 4 (8) (2022)
Christina D Camell, Matthew J Yousefzadeh, Yi Zhu, Larissa G P Langhi Prata, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Peng Cheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christina L Inman, Kurt O Johnson, Stephanie H Cholensky, Timothy W Carlson, Nathan K LeBrasseur, Sundeep Khosla, M Gerard O'Sullivan, David B Allison, Stephen C Jameson, Alexander Meves, Ming Li, Y S Prakash, Sergio E Chiarella, Sara E Hamilton, Tamara Tchkonia, Laura J Niedernhofer, James L Kirkland, Paul D Robbins
Senolytics reduce coronavirus-related mortality in old mice. Science (New York, N.Y.) 373 (6552) (2021)
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D Pavelko, David Dolan, Helen L Reeves, Sushma Grellscheid, Colin H Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamara Tchkonia, James L Kirkland, Diana Jurk, Derek A Mann, João F Passos
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. The EMBO journal 40 (9) (2021)
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan I Macura, Tamara Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology 4 (1) (2021)
J L Kirkland, Tamara Tchkonia
Senolytic drugs: from discovery to translation. Journal of internal medicine 288 (5) (2020)
Claudia C S Chini, Eduardo Nunes Chini, Gina M Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C de Oliveira, Lilian Sales Gomez, Kelly A Hogan, Mariana G Tarragó, Amrutesh S Puranik, Guillermo Agorrody, Katie L Thompson, Kevin Dang, Starlynn Clarke, Bennett G Childs, Karina S Kanamori, Micaela A Witte, Paola Vidal, Anna L Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R McReynolds, Connor S R Jankowski, Tamara Tchkonia, James L Kirkland, John M Sedivy, Jan M van Deursen, Darren J Baker, Wim van Schooten, Joshua D Rabinowitz, Joseph A Baur, Eduardo Nunes Chini
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nature metabolism 2 (11) (2020)

Tamara Tchkonia (T Tchkonia, Tamar Tchkonia)

Publication Activity (10 Years)

Top Topics

Top Venues