Joshua D Rabinowitz (Joshua Rabinowitz)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 88

Top Topics

Pseudomonas Aeruginosa

Embryonic Stem Cells

Saccharomyces Cerevisiae

Top Venues

Nature metabolism

Nature chemical biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Vinh G Tran, Somesh Mishra, Sarang S Bhagwat, Saman Shafaei, Yihui Shen, Jayne L Allen, Benjamin A Crosly, Shih-I Tan, Zia Fatma, Joshua D Rabinowitz, Jeremy S Guest, Vijay Singh, Huimin Zhao
Author Correction: An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis. Nature communications 15 (1) (2024)
Sarah Cherkaoui, Lifeng Yang, Matthew J McBride, Christina S Turn, Wenyun Lu, Caroline Eigenmann, George E Allen, Olesya O Panasenko, Lu Zhang, Annette Vu, Kangning Liu, Yimei Li, Om H Gandhi, Lea Surrey, Michael Wierer, Eileen P White, Joshua D Rabinowitz, Michael D Hogarty, Raphael J Morscher
Reprogramming neuroblastoma by diet-enhanced polyamine depletion. bioRxiv : the preprint server for biology (2024)
Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology (2024)
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel R Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nature communications 15 (1) (2024)
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel R Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nature communications 15 (1) (2024)
Doan Van Khanh, Timothy S Luongo, Thato T Ts'olo, Won Dong Lee, David W Frederick, Sarmistha Mukherjee, Gabriel K Adzika, Caroline E Perry, Ryan B Gaspar, Nicole Walker, Megan C Blair, Nicole Bye, James G Davis, Corey D Holman, Qingwei Chu, Lin Wang, Joshua D Rabinowitz, Daniel P Kelly, Thomas P Cappola, Kenneth B Margulies, Joseph A Baur
Cardiac NAD + depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nature cardiovascular research (2024)
Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology 9 (5) (2024)
Yihui Shen, Hoang V Dinh, Edward R Cruz, Zihong Chen, Caroline R Bartman, Tianxia Xiao, Catherine M Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, Vinh G Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D Maranas, Martin Wühr, Joshua D Rabinowitz
Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature chemical biology (2024)
Yihui Shen, Hoang V Dinh, Edward R Cruz, Zihong Chen, Caroline R Bartman, Tianxia Xiao, Catherine M Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, Vinh G Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D Maranas, Martin Wühr, Joshua D Rabinowitz
Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature chemical biology (2024)
Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Qian Wang, Siddhita D Mhatre, Takeshi Uenaka, Joshua Crapser, Travis E Conley, Hannah E Ennerfelt, Yoo Jin Jung, Ling Liu, Praveena Prasad, Brenita C Jenkins, Yeonglong Albert Ay, Matthew Matrongolo, Ryan Goodman, Traci Newmeyer, Kelly J Heard, Austin Kang, Edward N Wilson, Tao Yang, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Marius Wernig, Joshua D Rabinowitz, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasson
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.) 385 (6711) (2024)
Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology 9 (5) (2024)
Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Qian Wang, Siddhita D Mhatre, Takeshi Uenaka, Joshua Crapser, Travis E Conley, Hannah E Ennerfelt, Yoo Jin Jung, Ling Liu, Praveena Prasad, Brenita C Jenkins, Yeonglong Albert Ay, Matthew Matrongolo, Ryan Goodman, Traci Newmeyer, Kelly J Heard, Austin Kang, Edward N Wilson, Tao Yang, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Marius Wernig, Joshua D Rabinowitz, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasson
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.) 385 (6711) (2024)
Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology 9 (5) (2024)
Yihui Shen, Hoang V Dinh, Edward R Cruz, Zihong Chen, Caroline R Bartman, Tianxia Xiao, Catherine M Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, Vinh G Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D Maranas, Martin Wühr, Joshua D Rabinowitz
Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature chemical biology 20 (9) (2024)
Charlotte G Mann, Michael R MacArthur, Jing Zhang, Songlin Gong, Jenna E AbuSalim, Craig J Hunter, Wenyun Lu, Thomas Agius, Alban Longchamp, Florent Allagnat, Joshua D Rabinowitz, James R Mitchell, Katrien De Bock, Sarah J Mitchell
Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle. bioRxiv : the preprint server for biology (2024)
Sarah Cherkaoui, Lifeng Yang, Matthew J McBride, Christina S Turn, Wenyun Lu, Caroline Eigenmann, George E Allen, Olesya O Panasenko, Lu Zhang, Annette Vu, Kangning Liu, Yimei Li, Om H Gandhi, Lea Surrey, Michael Wierer, Eileen P White, Joshua D Rabinowitz, Michael D Hogarty, Raphael J Morscher
Reprogramming neuroblastoma by diet-enhanced polyamine depletion. bioRxiv : the preprint server for biology (2024)
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel R Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nature communications 15 (1) (2024)
Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology 9 (5) (2024)
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel R Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nature communications 15 (1) (2024)
Charlotte G Mann, Michael R MacArthur, Jing Zhang, Songlin Gong, Jenna E AbuSalim, Craig J Hunter, Wenyun Lu, Thomas Agius, Alban Longchamp, Florent Allagnat, Joshua D Rabinowitz, James R Mitchell, Katrien De Bock, Sarah J Mitchell
Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation in Muscle. bioRxiv : the preprint server for biology (2024)
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel R Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nature communications 15 (1) (2024)
Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Qian Wang, Siddhita D Mhatre, Takeshi Uenaka, Joshua Crapser, Travis E Conley, Hannah E Ennerfelt, Yoo Jin Jung, Ling Liu, Praveena Prasad, Brenita C Jenkins, Yeonglong Albert Ay, Matthew Matrongolo, Ryan Goodman, Traci Newmeyer, Kelly J Heard, Austin Kang, Edward N Wilson, Tao Yang, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Marius Wernig, Joshua D Rabinowitz, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasson
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.) 385 (6711) (2024)
Vinh G Tran, Somesh Mishra, Sarang S Bhagwat, Saman Shafaei, Yihui Shen, Jayne L Allen, Benjamin A Crosly, Shih-I Tan, Zia Fatma, Joshua D Rabinowitz, Jeremy S Guest, Vijay Singh, Huimin Zhao
Author Correction: An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis. Nature communications 15 (1) (2024)
Yihui Shen, Hoang V Dinh, Edward R Cruz, Zihong Chen, Caroline R Bartman, Tianxia Xiao, Catherine M Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, Vinh G Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D Maranas, Martin Wühr, Joshua D Rabinowitz
Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature chemical biology (2024)
Yihui Shen, Hoang V Dinh, Edward R Cruz, Zihong Chen, Caroline R Bartman, Tianxia Xiao, Catherine M Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, Vinh G Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D Maranas, Martin Wühr, Joshua D Rabinowitz
Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature chemical biology 20 (9) (2024)
Xincheng Xu, Zihong Chen, Caroline R Bartman, Xi Xing, Kellen Olszewski, Joshua D Rabinowitz
One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade. bioRxiv : the preprint server for biology (2023)
Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie E Axsom, Marc R Bornstein, Chelsea L Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature metabolism 5 (4) (2023)
Vinh G Tran, Somesh Mishra, Sarang S Bhagwat, Saman Shafaei, Yihui Shen, Jayne L Allen, Benjamin A Crosly, Shih-I Tan, Zia Fatma, Joshua D Rabinowitz, Jeremy S Guest, Vijay Singh, Huimin Zhao
An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis. Nature communications 14 (1) (2023)
Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie E Axsom, Marc R Bornstein, Chelsea L Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature metabolism 5 (4) (2023)
Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie E Axsom, Marc R Bornstein, Chelsea L Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature metabolism 5 (4) (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614 (7947) (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614 (7947) (2023)
Zhaoyue Zhang, Tara TeSlaa, Joshua D Rabinowitz
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis. Nature metabolism (2023)
Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie E Axsom, Marc R Bornstein, Chelsea L Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature metabolism 5 (4) (2023)
Bruce Culbertson, Kristle Garcia, Daniel Markett, Hosseinali Asgharian, Li Chen, Lisa Fish, Albertas Navickas, Johnny Yu, Brian Woo, Arjun Scott Nanda, Benedict Choi, Shaopu Zhou, Joshua D Rabinowitz, Hani Goodarzi
A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression. Nature cancer (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Jared H Rowe, Ilaria Elia, Osmaan Shahid, Emily F Gaudiano, Natalia E Sifnugel, Sheila Johnson, Amy G Reynolds, Megan E Fung, Shakchhi Joshi, Martin W LaFleur, Joon Seok Park, Kristen E Pauken, Joshua D Rabinowitz, Gordon J Freeman, Marcia C Haigis, Arlene H Sharpe
Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer discovery (2023)
Wenyun Lu, Noel R Park, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Melanie McReynolds, Xi Xing, Jessica Schembri, Morgan T Woolf, Joshua D Rabinowitz, Shawn M Davidson
Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism. Analytical chemistry (2023)
Tara TeSlaa, Markus Ralser, Jing Fan, Joshua D Rabinowitz
The pentose phosphate pathway in health and disease. Nature metabolism 5 (8) (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614 (7947) (2023)
Bruce Culbertson, Kristle Garcia, Daniel Markett, Hosseinali Asgharian, Li Chen, Lisa Fish, Albertas Navickas, Johnny Yu, Brian Woo, Arjun Scott Nanda, Benedict Choi, Shaopu Zhou, Joshua D Rabinowitz, Hani Goodarzi
A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression. Nature cancer (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614 (7947) (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature 614 (7947) (2023)
Taijin Lan, Sara Arastu, Samuel Wang, Jarrick Lam, Wenping Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Sherrie Hu, Michael Sun, Xuefei Luo, Jonathan M Ghergurovich, Changlong Li, Xiaoyang Su, Joshua D Rabinowitz, Eileen P White, Jessie Yanxiang Guo
G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer. bioRxiv : the preprint server for biology (2023)
Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie E Axsom, Marc R Bornstein, Chelsea L Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature metabolism 5 (4) (2023)
Caroline R Bartman, Brandon Faubert, Joshua D Rabinowitz, Ralph J DeBerardinis
Metabolic pathway analysis using stable isotopes in patients with cancer. Nature reviews. Cancer (2023)
Caroline R Bartman, Daniel R Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S R Jankowski, Laith Samarah, Noel R Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn M Davidson, Martin Wühr, Matthew G Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature (2023)
Tianxia Xiao, Artem Khan, Yihui Shen, Li Chen, Joshua D Rabinowitz
Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast. Nature chemical biology 18 (12) (2022)
Connor S R Jankowski, Joshua D Rabinowitz
Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate. Cancer research 82 (19) (2022)
Claudio F Meyer, Ciaran P Seath, Steve D Knutson, Wenyun Lu, Joshua D Rabinowitz, David W C MacMillan
Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. Journal of the American Chemical Society (2022)
Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y Feng, Yaqing Zhang, Dennie T Frederick, Lei Gu, Li Cai, John M Asara, Marina Pasca di Magliano, Genevieve M Boland, Keith T Flaherty, Kenneth D Swanson, David Liu, Joshua D Rabinowitz, Bin Zheng
Myeloid-derived itaconate suppresses cytotoxic CD8 + T cells and promotes tumour growth. Nature metabolism (2022)
Lin Wang, Xi Xing, Xianfeng Zeng, S RaElle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z Samarah, Katharine Goodwin, Lifeng Yang, Melanie R McReynolds, Xiaoxuan Li, Jeremy J Wolff, Joshua D Rabinowitz, Shawn M Davidson
Spatially resolved isotope tracing reveals tissue metabolic activity. Nature methods 19 (2) (2022)
Claudio F Meyer, Ciaran P Seath, Steve D Knutson, Wenyun Lu, Joshua D Rabinowitz, David W C MacMillan
Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. Journal of the American Chemical Society 144 (51) (2022)
Claudio F Meyer, Ciaran P Seath, Steve D Knutson, Wenyun Lu, Joshua D Rabinowitz, David W C MacMillan
Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. Journal of the American Chemical Society 144 (51) (2022)
Claudio F Meyer, Ciaran P Seath, Steve D Knutson, Wenyun Lu, Joshua D Rabinowitz, David W C MacMillan
Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. Journal of the American Chemical Society 144 (51) (2022)
Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J Brown, Ben Z Stanger, Joshua D Rabinowitz, Xiaolu Yang
G6PD-mediated increase in de novo NADP + biosynthesis promotes antioxidant defense and tumor metastasis. Science advances 8 (29) (2022)
Laura Poillet-Perez, Daniel W Sharp, Yang Yang, Saurabh V Laddha, Maria Ibrahim, Praveen K Bommareddy, Zhixian Sherrie Hu, Joshua Vieth, Michael Haas, Marcus W Bosenberg, Joshua D Rabinowitz, Jian Cao, Jun-Lin Guan, Shridar Ganesan, Chang S Chan, Janice M Mehnert, Edmund C Lattime, Eileen P White
Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nature cancer 2 (9) (2022)
Xiaoxuan Li, Sheng Hui, Emily T Mirek, William O Jonsson, Tracy G Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang, Joshua D Rabinowitz
Circulating metabolite homeostasis achieved through mass action. Nature metabolism 4 (1) (2022)
Li Chen, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, Antonio D Muscarella, Yihui Shen, Alexis Cowan, Melanie R McReynolds, Brandon J Kennedy, Ashley M Lato, Shawn R Campagna, Mona Singh, Joshua D Rabinowitz
Metabolite discovery through global annotation of untargeted metabolomics data. Nature methods 18 (11) (2021)
Hongyu Ding, Zihong Chen, Katherine Wu, Shih Ming Huang, Warren L Wu, Sarah E Leboeuf, Ray G Pillai, Joshua D Rabinowitz, Thales Papagiannakopoulos
Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Science advances 7 (47) (2021)
Zhaoyue Zhang, Tara TeSlaa, Xincheng Xu, Xianfeng Zeng, Lifeng Yang, Gang Xing, Gregory J Tesz, Michelle F Clasquin, Joshua D Rabinowitz
Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nature metabolism (2021)
Sophia Hsin-Jung Li, Michel Nofal, Lance R Parsons, Joshua D Rabinowitz, Zemer Gitai
Monitoring mammalian mitochondrial translation with MitoRiboSeq. Nature protocols 16 (6) (2021)
Jonathan M Ghergurovich, Xincheng Xu, Joshua Z Wang, Lifeng Yang, Rolf-Peter Ryseck, Lin Wang, Joshua D Rabinowitz
Methionine synthase supports tumour tetrahydrofolate pools. Nature metabolism 3 (11) (2021)
Caroline R Bartman, Tara TeSlaa, Joshua D Rabinowitz
Quantitative flux analysis in mammals. Nature metabolism 3 (7) (2021)
Paras S Minhas, Amira Latif-Hernandez, Melanie R McReynolds, Aarooran S Durairaj, Qian Wang, Amanda Rubin, Amit U Joshi, Joy Q He, Esha Gauba, Ling Liu, Congcong Wang, Miles H Linde, Yuki Sugiura, Peter K Moon, Ravi Majeti, Makoto Suematsu, Daria-Mochly Rosen, Irving L Weissman, Frank M Longo, Joshua D Rabinowitz, Katrin I Andreasson
Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature 590 (7844) (2021)
Cholsoon Jang, Shogo Wada, Steven Yang, Bridget Gosis, Xianfeng Zeng, Zhaoyue Zhang, Yihui Shen, Gina Lee, Zoltan Arany, Joshua D Rabinowitz
The small intestine shields the liver from fructose-induced steatosis. Nature metabolism 2 (7) (2020)
Laura Poillet-Perez, Daniel W Sharp, Yang Yang, Saurabh V Laddha, Maria Ibrahim, Praveen K Bommareddy, Zhixian Sherrie Hu, Joshua Vieth, Michael Haas, Marcus W Bosenberg, Joshua D Rabinowitz, Jian Cao, Jun-Lin Guan, Shridar Ganesan, Chang S Chan, Janice M Mehnert, Edmund C Lattime, Eileen P White
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nature cancer 1 (9) (2020)
Juan Carlos García-Cañaveras, Olga Lancho, Gregory S Ducker, Jonathan M Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D Rabinowitz
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia 35 (2) (2020)
Joshua D Rabinowitz, Sven Enerbäck
Lactate: the ugly duckling of energy metabolism. Nature metabolism 2 (7) (2020)
Danielle Murashige, Cholsoon Jang, Michael D Neinast, Jonathan J Edwards, Alexis Cowan, Matthew C Hyman, Joshua D Rabinowitz, David S Frankel, Zoltan Arany
Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science (New York, N.Y.) 370 (6514) (2020)
Timothy S Luongo, Jared M Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R Bornstein, Paul Oliphint, Lin Wang, Melanie R McReynolds, Marie E Migaud, Joshua D Rabinowitz, F Bradley Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A Cambronne, Joseph A Baur
SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature 588 (7836) (2020)
Dongyin Guan, Ying Xiong, Trang Minh Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, Joshua D Rabinowitz, Mitchell A Lazar
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science (New York, N.Y.) 369 (6509) (2020)
Robin Green, Sonal Sonal, Lin Wang, Samuel Frederick Mock Hart, Wenyun Lu, David Skelding, Justin C Burton, Hanbing Mi, Aric Capel, Hung Alex Chen, Aaron Lin, Arvind R Subramaniam, Joshua D Rabinowitz, Wenying Shou
Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS biology 18 (8) (2020)
Steven Zhao, Cholsoon Jang, Joyce Liu, Kahealani Uehara, Michael Gilbert, Luke Izzo, Xianfeng Zeng, Sophie Trefely, Sully Fernandez, Alessandro Carrer, Katelyn D Miller, Zachary T Schug, Nathaniel W Snyder, Terence P F Gade, Paul M Titchenell, Joshua D Rabinowitz, Kathryn E Wellen
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579 (7800) (2020)
Anne C Wilke, Carmen Doebele, Alena Zindel, Kwang-Seok Lee, Sara A Rieke, Michele Ceribelli, Federico Comoglio, James D Phelan, James Q Wang, Yana Pikman, Dominique Jahn, Björn Häupl, Constanze Schneider, Sebastian Scheich, Frances A Tosto, Hanibal Bohnenberger, Philipp Stauder, Frank Schnuetgen, Mikolaj Slabicki, Zana A Coulibaly, Sebastian Wolf, Kamil Bojarczuk, Bjoern Chapuy, Christian H Brandts, Philipp Stroebel, Caroline A Lewis, Michael Engelke, Xincheng Xu, Hahn Kim, Thanh Hung Dang, Roland Schmitz, Daniel James Hodson, Kimberly Stegmaier, Henning Urlaub, Hubert Serve, Clemens A Schmitt, Fernando Kreuz, Gero Knittel, Joshua D Rabinowitz, Hans Christian Reinhardt, Matthew G Vander Heiden, Craig Thomas, Louis Michael Staudt, Thorsten Zenz, Thomas Oellerich
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood (2020)
Claudia C S Chini, Eduardo Nunes Chini, Gina M Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C de Oliveira, Lilian Sales Gomez, Kelly A Hogan, Mariana G Tarragó, Amrutesh S Puranik, Guillermo Agorrody, Katie L Thompson, Kevin Dang, Starlynn Clarke, Bennett G Childs, Karina S Kanamori, Micaela A Witte, Paola Vidal, Anna L Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R McReynolds, Connor S R Jankowski, Tamara Tchkonia, James L Kirkland, John M Sedivy, Jan M van Deursen, Darren J Baker, Wim van Schooten, Joshua D Rabinowitz, Joseph A Baur, Eduardo Nunes Chini
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nature metabolism 2 (11) (2020)
Jonathan M Ghergurovich, Juan Carlos García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H Beier, Hahn Kim, Joshua D Rabinowitz
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nature chemical biology 16 (7) (2020)
Wenyun Lu, Xi Xing, Lin Wang, Li Chen, Sisi Zhang, Melanie R McReynolds, Joshua D Rabinowitz
Improved Annotation of Untargeted Metabolomics Data through Buffer Modifications That Shift Adduct Mass and Intensity. Analytical chemistry 92 (17) (2020)
Yi Xu, Yang Zhang, Juan Carlos García-Cañaveras, Lili Guo, Mengyuan Kan, Sixiang Yu, Ian A Blair, Joshua D Rabinowitz, Xiaolu Yang
Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science (New York, N.Y.) 369 (6502) (2020)
Samantha Gokhale, Wenyun Lu, Sining Zhu, Yingying Liu, Ronald P Hart, Joshua D Rabinowitz, Ping Xie
Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 204 (2) (2019)
Lin Wang, Xi Xing, Li Chen, Lifeng Yang, Xiaoyang Su, Herschel A Rabitz, Wenyun Lu, Joshua D Rabinowitz
Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics. Analytical chemistry 91 (3) (2019)
Junyoung O Park, Lukas B Tanner, Monica H Wei, Daven B Khana, Tyler B Jacobson, Zheyun Zhang, Sara A Rubin, Sophia Hsin-Jung Li, Meytal B Higgins, David M Stevenson, Daniel Amador-Noguez, Joshua D Rabinowitz
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nature chemical biology 15 (10) (2019)
Qingkun Liu, Emily M Johnson, Rachel K Lam, Qian Wang, Hong Bo Ye, Edward N Wilson, Paras S Minhas, Ling Liu, Michelle S Swarovski, Stephanie Tran, Jing Wang, Swapnil S Mehta, Xi Yang, Joshua D Rabinowitz, Samuel S Yang, Mehrdad Shamloo, Christoph Müller, Michelle L James, Katrin I Andreasson
Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nature immunology 20 (8) (2019)
Yi-Fan Xu, Wenyun Lu, Jonathan C Chen, Sarah A Johnson, Patrick A Gibney, David G Thomas, Greg Brown, Amanda L May, Shawn R Campagna, Alexander F Yakunin, David Botstein, Joshua D Rabinowitz
Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase. ACS chemical biology 13 (10) (2018)