Alejandro J Vila

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 39

Top Venues

Antimicrobial agents and chemotherapy

eLife

Chemical science

mBio

Universidad Nacional de Rosario

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Universidad Nacional de Rosario Mar 09 2016

Argentina

Full Professor :: Area Biofisica - Departamento de Quimica Biologica - Facultad de Ciencias Bioquimicas y Farmaceuticas

CONICET May 02 1995

Argentina

Group Leader :: IBR (Instituto de Biologia Molecular y Celular de Rosario)

Publications

Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, Anna Cmolik, Christopher R Bethel, Yoshikazu Ishii, Salvador Iván Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo, María Fernanda Mojica
The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem. Antimicrobial agents and chemotherapy (2024)
Daisuke Ono, Anna Cmolik, Christopher R Bethel, Yoshikazu Ishii, Salvador Iván Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo, María Fernanda Mojica
The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem. Antimicrobial agents and chemotherapy 68 (8) (2024)
Daisuke Ono, Anna Cmolik, Christopher R Bethel, Yoshikazu Ishii, Salvador Iván Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo, María Fernanda Mojica
The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem. Antimicrobial agents and chemotherapy 68 (8) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, Anna Cmolik, Christopher R Bethel, Yoshikazu Ishii, Salvador Iván Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo, María Fernanda Mojica
The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem. Antimicrobial agents and chemotherapy 68 (8) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy 68 (2) (2024)
Daisuke Ono, María Fernanda Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego Martín Moreno, Alejandro J Vila, Robert A Bonomo
Structural role of K224 in taniborbactam inhibition of NDM-1. Antimicrobial agents and chemotherapy (2024)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Christophe Le Terrier, Clément Viguier, Patrice Nordmann, Alejandro J Vila, Laurent Poirel
Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor taniborbactam against metallo-β-lactamases. Antimicrobial agents and chemotherapy (2023)
Salvador Iván Drusin, Christophe Le Terrier, Laurent Poirel, Robert A Bonomo, Alejandro J Vila, Diego Martín Moreno
Structural basis of metallo-β-lactamase resistance to taniborbactam. Antimicrobial agents and chemotherapy (2023)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Lisandro J Gonzalez, Guillermo Bahr, Mariano M González, Robert A Bonomo, Alejandro J Vila
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution. Nature chemical biology (2023)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, María Fernanda Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb M Haider
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase. eLife 12 (2023)
Casin Le, Camila Pimentel, Fernando Pasteran, Marisel R Tuttobene, Tomás Subils, Jenny Escalante, Brent Nishimura, Susana Arriaga, Aimee Carranza, Vyanka Mezcord, Alejandro J Vila, Alejandra Corso, Luis A Actis, Marcelo E Tolmasky, Robert A Bonomo, Maria Soledad Ramirez
Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport. Biomedicines 10 (3) (2022)
Claudia Antonella Colque, Andrea G Albarracín Orio, Pablo Emiliano Tomatis, Gina Dotta, Diego Martín Moreno, Laura G Hedemann, Rachel A Hickman, Lea M Sommer, Sofía Feliziani, Alejandro J Moyano, Robert A Bonomo, Helle Krogh Johansen, Søren Molin, Alejandro J Vila, Andrea M Smania
Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams. mBio 13 (5) (2022)
Maria-Agustina Rossi, Timothy Palzkill, Fabio C L Almeida, Alejandro J Vila
Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions. Molecular biology and evolution 39 (10) (2022)
Carolina López, Alessio Prunotto, Guillermo Bahr, Robert A Bonomo, Lisandro J González, Matteo Dal Peraro, Alejandro J Vila
Specific Protein-Membrane Interactions Promote Packaging of Metallo-β-Lactamases into Outer Membrane Vesicles. Antimicrobial agents and chemotherapy 65 (10) (2021)
Melina M B Martínez, Robert A Bonomo, Alejandro J Vila, Paulo C Maffía, Lisandro J Gonzalez
On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1). mBio 12 (5) (2021)
Maria-Agustina Rossi, Veronica Martinez, Philip Hinchliffe, María Fernanda Mojica, Valerie Castillo, Diego Martín Moreno, Ryan Smith, Brad Spellberg, George L Drusano, Claudia Banchio, Robert A Bonomo, James Spencer, Alejandro J Vila, Graciela Mahler
2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases. Chemical science 12 (8) (2021)
Guillermo Bahr, Lisandro J González, Alejandro J Vila
Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design. Chemical reviews 121 (13) (2021)
Jonathan Szuster, Ulises A Zitare, María A Castro, Alcides J Leguto, Marcos N Morgada, Alejandro J Vila, Daniel H Murgida
CuA-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential. Chemical science 11 (24) (2020)
Antonella R Palacios, María-Agustina Rossi, Graciela S Mahler, Alejandro J Vila
Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism. Biomolecules 10 (6) (2020)
Matthew O Ross, Oriana S Fisher, Marcos N Morgada, Matthew D Krzyaniak, Michael R Wasielewski, Alejandro J Vila, Brian M Hoffman, Amy C Rosenzweig
Formation and Electronic Structure of an Atypical CuA Site. Journal of the American Chemical Society 141 (11) (2019)
Carolina Lopez, Juan A Ayala, Robert A Bonomo, Lisandro J Gonzalez, Alejandro J Vila
Protein determinants of dissemination and host specificity of metallo-β-lactamases. Nature communications 10 (1) (2019)
Estefanía Giannini, Lisandro J Gonzalez, Alejandro J Vila
A simple protocol to characterize bacterial cell-envelope lipoproteins in a native-like environment. Protein science : a publication of the Protein Society 28 (11) (2019)
María Eugenia Llases, Marcos N Morgada, Alejandro J Vila
Biochemistry of Copper Site Assembly in Heme-Copper Oxidases: A Theme with Variations. International journal of molecular sciences 20 (15) (2019)
María Eugenia Llases, María Natalia Lisa, Marcos N Morgada, Estefanía Giannini, Pedro M Alzari, Alejandro J Vila
Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for CuA assembly in Cytochrome c Oxidase. The FEBS journal 287 (4) (2019)
Marcos N Morgada, Florencia Emiliani, Kelly N Chacón, Damián Álvarez-Paggi, Daniel H Murgida, Ninian J Blackburn, Luciano Andrés Abriata, Alejandro J Vila
pH-Induced Binding of the Axial Ligand in an Engineered CuA Site Favors the πu State. Inorganic chemistry 58 (23) (2019)
Jasmine Martinez, Jennifer S Fernandez, Christine Liu, Amparo Hoard, Anthony Mendoza, Jun Nakanouchi, Nyah Rodman, Robert Courville, Marisel R Tuttobene, Carolina Lopez, Lisandro J Gonzalez, Parvin Shahrestani, Krisztina M Papp-Wallace, Alejandro J Vila, Marcelo E Tolmasky, Robert A Bonomo, Rodrigo Sieira, Maria Soledad Ramirez
Human pleural fluid triggers global changes in the transcriptional landscape of Acinetobacter baumannii as an adaptive response to stress. Scientific reports 9 (1) (2019)
Alcides J Leguto, Meghan A Smith, Marcos N Morgada, Ulises A Zitare, Daniel H Murgida, Kyle M Lancaster, Alejandro J Vila
Dramatic Electronic Perturbations of CuA Centers via Subtle Geometric Changes. Journal of the American Chemical Society 141 (3) (2019)
Andrés Espinoza-Cara, Ulises A Zitare, Damián Alvarez Paggi, Sebastián Klinke, Lisandro Horacio Otero, Daniel H Murgida, Alejandro J Vila
Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis. Chemical science 9 (32) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alejandro J Vila