Philip Hinchliffe

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 16

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

mBio

Biochemistry

University of Bristol

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Bristol Jun 01 2014

United Kingdom

Senior Research Associate :: Cellular and Molecular Medicine

Publications

Valentina Villamil, Maria-Agustina Rossi, Maria F Mojica, Philip Hinchliffe, Verónica Martínez, Valerie Castillo, Cecilia Saiz, Claudia Banchio, Mario A Macías, James Spencer, Robert A Bonomo, Alejandro Vila, Diego Martín Moreno, Graciela Mahler
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. Journal of medicinal chemistry (2024)
Valentina Villamil, Maria-Agustina Rossi, Maria F Mojica, Philip Hinchliffe, Verónica Martínez, Valerie Castillo, Cecilia Saiz, Claudia Banchio, Mario A Macías, James Spencer, Robert A Bonomo, Alejandro Vila, Diego Martín Moreno, Graciela Mahler
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. Journal of medicinal chemistry 67 (5) (2024)
Valentina Villamil, Maria-Agustina Rossi, Maria F Mojica, Philip Hinchliffe, Verónica Martínez, Valerie Castillo, Cecilia Saiz, Claudia Banchio, Mario A Macías, James Spencer, Robert A Bonomo, Alejandro Vila, Diego Martín Moreno, Graciela Mahler
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. Journal of medicinal chemistry 67 (5) (2024)
Catherine L Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K Colenso, Christopher J Schofield, Adrian J Mulholland, James Spencer
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase. Journal of the American Chemical Society (2023)
Reynier Suardíaz, Emily Lythell, Philip Hinchliffe, Marc W Van der Kamp, James Spencer, Natalie Fey, Adrian J Mulholland
Catalytic mechanism of the colistin resistance protein MCR-1. Organic & biomolecular chemistry 19 (17) (2022)
Philip Hinchliffe, Catherine L Tooke, Christopher R Bethel, Benlian Wang, Christopher Arthur, Kate J Heesom, Stuart Shapiro, Daniela M Schlatzer, Krisztina M Papp-Wallace, Robert A Bonomo, James Spencer
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition. mBio 13 (3) (2022)
Philip Hinchliffe, Diego Martín Moreno, Maria-Agustina Rossi, Maria F Mojica, Veronica Martinez, Valentina Villamil, Brad Spellberg, George L Drusano, Claudia Banchio, Graciela Mahler, Robert A Bonomo, Alejandro J Vila, James Spencer
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode. ACS infectious diseases 7 (9) (2021)
Silvia Gervasoni, James Spencer, Philip Hinchliffe, Alessandro Pedretti, Franco Vairoletti, Graciela Mahler, Adrian J Mulholland
A multiscale approach to predict the binding mode of metallo beta-lactamase inhibitors. Proteins (2021)
Emily Lythell, Reynier Suardíaz, Philip Hinchliffe, Chonnikan Hanpaibool, Surawit Visitsatthawong, A Sofia F Oliveira, Eric J M Lang, Panida Surawatanawong, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol, Natalie Fey, James Spencer, Adrian J Mulholland
Resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes. Chemical communications (Cambridge, England) 56 (50) (2021)
Maria-Agustina Rossi, Veronica Martinez, Philip Hinchliffe, María Fernanda Mojica, Valerie Castillo, Diego Martín Moreno, Ryan Smith, Brad Spellberg, George L Drusano, Claudia Banchio, Robert A Bonomo, James Spencer, Alejandro J Vila, Graciela Mahler
2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases. Chemical science 12 (8) (2021)
Rebecca M Twidale, Philip Hinchliffe, James Spencer, Adrian J Mulholland
Crystallography and QM/MM Simulations Identify Preferential Binding of Hydrolyzed Carbapenem and Penem Antibiotics to the L1 Metallo-β-Lactamase in the Imine Form. Journal of chemical information and modeling (2021)
Catherine L Tooke, Philip Hinchliffe, Alen Krajnc, Adrian J Mulholland, Jürgen Brem, Christopher J Schofield, James Spencer
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition. RSC medicinal chemistry 11 (4) (2020)
Alen Krajnc, Jürgen Brem, Philip Hinchliffe, Karina Calvopiña, Tharindi D Panduwawala, Pauline A Lang, Jos J A G Kamps, Jonathan M Tyrrell, Emma Widlake, Benjamin G Saward, Timothy R Walsh, James Spencer, Christopher J Schofield
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. Journal of medicinal chemistry 62 (18) (2019)
Catherine L Tooke, Philip Hinchliffe, Pauline A Lang, Adrian J Mulholland, Jürgen Brem, Christopher J Schofield, James Spencer
Molecular Basis of Class A β-Lactamase Inhibition by Relebactam. Antimicrobial agents and chemotherapy 63 (10) (2019)
Pharit Kamsri, Chayanin Hanwarinroj, Naruedon Phusi, Thimpika Pornprom, Kampanart Chayajarus, Auradee Punkvang, Nitima Suttipanta, Potjanee Srimanote, Khomson Suttisintong, Chomphunuch Songsiriritthigul, Patchreenart Saparpakorn, Supa Hannongbua, Siriluk Rattanabunyong, Supaporn Seetaha, Kiattawee Choowongkomon, Sanya Sureram, Prasat Kittakoop, Poonpilas Hongmanee, Pitak Santanirand, Zhaoqiang Chen, Jianming Zhu, Rosemary A Blood, Yuiko Takebayashi, Philip Hinchliffe, Adrian J Mulholland, James Spencer, Pornpan Pungpo
Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography. Journal of chemical information and modeling 60 (1) (2019)
Philip Hinchliffe, Carol A Tanner, Anthony P Krismanich, Geneviève Labbé, Valerie J Goodfellow, Laura Marrone, Ahmed Y Desoky, Karina Calvopiña, Emily E Whittle, Fanxing Zeng, Matthew B Avison, Niels C Bols, Stefan Siemann, James Spencer, Gary I Dmitrienko
Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry 57 (12) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Philip Hinchliffe