Alex S Holehouse (Alex Holehouse)

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 91

Top Venues

bioRxiv : the preprint server for biology

Nucleic acids research

Nature structural & molecular biology

Nature microbiology

Washington University School of Medicine in St. Louis

Washington University in Saint Louis (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Washington University School of Medicine in St. Louis Jan 01 2020

United States

Assistant Professor :: Biochemistry and Molecular Biophysics

Washington University in Saint Louis Sep 01 2017 - Dec 31 2019

United States

Postdoctoral Fellow :: Center for Biological Systems Engineering

Mount Sinai Hospital

United States

Bioinformatician :: Genetics and Genomics

Education History

Washington University in Saint Louis Aug 14 2012 - Aug 31 2017

United States

PHD :: Center for Biological Systems Engineering

Imperial College London

United Kingdom

MSC :: Computing

Publications

Ju-Fang Chang, Jack H Landmann, Tien-Ching Chang, Mehmet Emrah Selli, Yangdon Tenzin, John M Warrington, Julie Ritchey, Yu-Sung Hsu, Michael Joseph Slade, Deepesh Kumar Gupta, John F Dipersio, Alex S Holehouse, Nathan Singh
Rational protein engineering to enhance MHC-independent T cell receptors. Cancer discovery (2024)
Rishav Mitra, Grace A Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, James C A Bardwell
Molecular insights into the interaction between a disordered protein and a folded RNA. bioRxiv : the preprint server for biology (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology 9 (4) (2024)
Garrett M Ginell, Ryan J Emenecker, Jeffrey M Lotthammer, Grace A Usher, Alex S Holehouse
Direct prediction of intermolecular interactions driven by disordered regions. bioRxiv : the preprint server for biology (2024)
Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse, Jennifer M Hurley
Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator. Nature communications 15 (1) (2024)
Paulette Sofía Romero-Pérez, Haley M Moran, Azeem Horani, Alexander Truong, Edgar Manriquez-Sandoval, John F Ramirez, Alec Martinez, Edith Gollub, Kara Hunter, Jeffrey M Lotthammer, Ryan J Emenecker, Thomas C Boothby, Alex S Holehouse, Stephen D Fried, Shahar Sukenik
Protein surface chemistry encodes an adaptive resistance to desiccation. bioRxiv : the preprint server for biology (2024)
Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation. Nucleic acids research (2024)
Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J Emenecker, John A Bryant, Tyler M Lee, Katelyn Sageman-Furnas, Edward G Wilkinson, Sunita Pathak, Sanjana R Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R Clay Wright, Alex S Holehouse, Max Valentín Staller, Rosangela Sozzani, Lucia C Strader
Identification of plant transcriptional activation domains. Nature (2024)
Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation. Nucleic acids research (2024)
James Lewis Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. bioRxiv : the preprint server for biology (2024)
Rishav Mitra, Grace A Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, James C A Bardwell
Molecular insights into the interaction between a disordered protein and a folded RNA. bioRxiv : the preprint server for biology (2024)
Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse, Jennifer M Hurley
Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator. Nature communications 15 (1) (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequence. Nature methods 21 (3) (2024)
Alex S Holehouse, Jhullian Alston, Andrea Soranno
Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation. Research square (2024)
Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J Emenecker, John A Bryant, Tyler M Lee, Katelyn Sageman-Furnas, Edward G Wilkinson, Sunita Pathak, Sanjana R Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R Clay Wright, Alex S Holehouse, Max Valentín Staller, Rosangela Sozzani, Lucia C Strader
Identification of plant transcriptional activation domains. Nature 632 (8023) (2024)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, Andrea Soranno
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA. Nucleic acids research 52 (5) (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology 9 (4) (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequence. Nature methods 21 (3) (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequence. Nature methods 21 (3) (2024)
Ju-Fang Chang, Jack H Landmann, Tien-Ching Chang, Mehmet Emrah Selli, Yangdon Tenzin, John M Warrington, Julie Ritchey, Yu-Sung Hsu, Michael Joseph Slade, Deepesh Kumar Gupta, John F Dipersio, Alex S Holehouse, Nathan Singh
Rational protein engineering to enhance MHC-independent T cell receptors. Cancer discovery (2024)
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik
Structural biases in disordered proteins are prevalent in the cell. Nature structural & molecular biology 31 (2) (2024)
Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J Emenecker, John A Bryant, Tyler M Lee, Katelyn Sageman-Furnas, Edward G Wilkinson, Sunita Pathak, Sanjana R Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R Clay Wright, Alex S Holehouse, Max Valentín Staller, Rosangela Sozzani, Lucia C Strader
Identification of plant transcriptional activation domains. Nature 632 (8023) (2024)
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik
Structural biases in disordered proteins are prevalent in the cell. Nature structural & molecular biology 31 (2) (2024)
Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation. Nucleic acids research (2024)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, Andrea Soranno
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA. Nucleic acids research 52 (5) (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology 9 (4) (2024)
Garrett M Ginell, Ryan J Emenecker, Jeffrey M Lotthammer, Grace A Usher, Alex S Holehouse
Direct prediction of intermolecular interactions driven by disordered regions. bioRxiv : the preprint server for biology (2024)
Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Sofia Ramero, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Disordered proteins interact with the chemical environment to tune their protective function during drying. bioRxiv : the preprint server for biology (2024)
Grace A Usher, Martin J Fossat, Alex S Holehouse
Phosphorylation of disordered proteins tunes local and global intramolecular interactions. bioRxiv : the preprint server for biology (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequences. Nature methods (2024)
Paulette Sofía Romero-Pérez, Haley M Moran, Azeem Horani, Alexander Truong, Edgar Manriquez-Sandoval, John F Ramirez, Alec Martinez, Edith Gollub, Kara Hunter, Jeffrey M Lotthammer, Ryan J Emenecker, Thomas C Boothby, Alex S Holehouse, Stephen D Fried, Shahar Sukenik
Protein surface chemistry encodes an adaptive resistance to desiccation. bioRxiv : the preprint server for biology (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequence. Nature methods 21 (3) (2024)
Rishav Mitra, Grace A Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, James C A Bardwell
Molecular insights into the interaction between a disordered protein and a folded RNA. bioRxiv : the preprint server for biology (2024)
Shraddha Kc, Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Sofia Romero, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Disordered proteins interact with the chemical environment to tune their protective function during drying. bioRxiv : the preprint server for biology (2024)
Shraddha Kc, Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Sofia Romero, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Disordered proteins interact with the chemical environment to tune their protective function during drying. bioRxiv : the preprint server for biology (2024)
Nicole DelRosso, Peter H Suzuki, Daniel Griffith, Jeffrey M Lotthammer, Borna Novak, Selin Kocalar, Maya U Sheth, Alex S Holehouse, Lacramioara Bintu, Polly Morrell Fordyce
High-throughput affinity measurements of direct interactions between activation domains and co-activators. bioRxiv : the preprint server for biology (2024)
James Lewis Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. bioRxiv : the preprint server for biology (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology 9 (4) (2024)
Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse, Jennifer M Hurley
Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator. Nature communications 15 (1) (2024)
Jhullian J Alston, Andrea Soranno, Alex S Holehouse
Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation. Research square (2024)
Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation. Nucleic acids research (2024)
Grace A Usher, Martin J Fossat, Alex S Holehouse
Phosphorylation of disordered proteins tunes local and global intramolecular interactions. bioRxiv : the preprint server for biology (2024)
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik
Structural biases in disordered proteins are prevalent in the cell. Nature structural & molecular biology 31 (2) (2024)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, Andrea Soranno
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA. Nucleic acids research 52 (5) (2024)
Shraddha Kc, Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Sofia Romero, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Disordered proteins interact with the chemical environment to tune their protective function during drying. bioRxiv : the preprint server for biology (2024)
Zongru Li, Qionghua Shen, Grace A Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai, George J Lu
Phase transition of GvpU regulates gas vesicle clustering in bacteria. Nature microbiology 9 (4) (2024)
James Lewis Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. bioRxiv : the preprint server for biology (2024)
James Lewis Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. bioRxiv : the preprint server for biology (2024)
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, Alex S Holehouse
Direct prediction of intrinsically disordered protein conformational properties from sequence. Nature methods (2024)
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik
Structural biases in disordered proteins are prevalent in the cell. Nature structural & molecular biology (2024)
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik
Structural biases in disordered proteins are prevalent in the cell. Nature structural & molecular biology 31 (2) (2024)
Alex S Holehouse, Jhullian Alston, Andrea Soranno
Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation. Research square (2024)
Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J Emenecker, John A Bryant, Tyler M Lee, Katelyn Sageman-Furnas, Edward G Wilkinson, Sunita Pathak, Sanjana R Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R Clay Wright, Alex S Holehouse, Max Valentín Staller, Rosangela Sozzani, Lucia C Strader
Identification of plant transcriptional activation domains. Nature 632 (8023) (2024)
Jhullian J Alston, Andrea Soranno, Alex S Holehouse
Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation. bioRxiv : the preprint server for biology (2023)
Jared M Lalmansingh, Alex T Keeley, Kiersten M Ruff, Rohit V Pappu, Alex S Holehouse
SOURSOP: A Python package for the analysis of simulations of intrinsically disordered proteins. bioRxiv : the preprint server for biology (2023)
Alex S Holehouse, Ryan Emenecker, Karina Guadalupe, Nora Shamoon, Shahar Sukenik
Sequence-ensemble-function relationships for disordered proteins in live cells. Research square (2023)
Steven Boeynaems, X Rosa Ma, Vivian Yeong, Garrett M Ginell, Jian-Hua Chen, Jacob A Blum, Lisa Nakayama, Anushka Sanyal, Adam Briner, Delphi Van Haver, Jarne Pauwels, Axel Ekman, Hermann Broder Schmidt, Kousik Sundararajan, Lucas Porta, Keren Lasker, Carolyn A Larabell, Mirian A F Hayashi, Anshul Kundaje, Francis Impens, Allie C Obermeyer, Alex S Holehouse, Aaron D Gitler
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease. bioRxiv : the preprint server for biology (2023)
Ryan J Emenecker, Karina Guadalupe, Nora M Shamoon, Shahar Sukenik, Alex S Holehouse
Sequence-ensemble-function relationships for disordered proteins in live cells. bioRxiv : the preprint server for biology (2023)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, Andrea Soranno
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA. Nucleic acids research (2023)
Alex S Holehouse, Birthe B Kragelund
The molecular basis for cellular function of intrinsically disordered protein regions. Nature reviews. Molecular cell biology (2023)
Stephen P Plassmeyer, Alex S Holehouse
Stress granules offer first aid for leaky organelles. Nature (2023)
Jhullian J Alston, Garrett M Ginell, Andrea Soranno, Alex S Holehouse
The Analytical Flory Random Coil Is a Simple-to-Use Reference Model for Unfolded and Disordered Proteins. The journal of physical chemistry. B (2023)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, Andrea Soranno
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA. Nucleic acids research (2023)
Jared M Lalmansingh, Alex T Keeley, Kiersten M Ruff, Rohit V Pappu, Alex S Holehouse
SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins. Journal of chemical theory and computation (2023)
Jhullian J Alston, Garrett M Ginell, Andrea Soranno, Alex S Holehouse
The analytical Flory random coil is a simple-to-use reference model for unfolded and disordered proteins. bioRxiv : the preprint server for biology (2023)
J Ignacio Gutierrez, Gregory P Brittingham, Yonca Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt
SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence. eLife 11 (2022)
Keren Lasker, Steven Boeynaems, Vinson Lam, Daniel Scholl, Emma Stainton, Adam Briner, Maarten Jacquemyn, Dirk Daelemans, Ashok Deniz, Elizabeth Villa, Alex S Holehouse, Aaron D Gitler, Lucy Shapiro
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems. Nature communications 13 (1) (2022)
Garrett M Ginell, Alex S Holehouse
Hyperphosphorylation tunes TDP-43 solubility. The EMBO journal 41 (8) (2022)
Ryan J Emenecker, Alex S Holehouse
Intrinsically disordered CO 2 sensors. Nature cell biology 24 (7) (2022)
Nicolás S González-Foutel, Juliana Glavina, Wade M Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amelie Barozet, Nicolás A Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E Sánchez, Gonzalo de Prat-Gay, Juan Cortes, Pau Bernadó, Rohit V Pappu, Alex S Holehouse, Gary W Daughdrill, Lucía Beatriz Chemes
Conformational buffering underlies functional selection in intrinsically disordered protein regions. Nature structural & molecular biology 29 (8) (2022)
E Sethe Burgie, Zachary T K Gannam, Katrice E McLoughlin, Christopher D Sherman, Alex S Holehouse, Robert J Stankey, Richard David Vierstra
Differing biophysical properties underpin the unique signaling potentials within the plant phytochrome photoreceptor families. Proceedings of the National Academy of Sciences of the United States of America 118 (22) (2021)
David W Sanders, Chanelle C Jumper, Paul J Ackerman, Dan Bracha, Anita Donlic, Hahn Kim, Devin Kenney, Ivan Castello-Serrano, Saori Suzuki, Tomokazu Tamura, Alexander H Tavares, Mohsan Saeed, Alex S Holehouse, Alexander Ploss, Ilya Levental, Florian Douam, Robert F Padera, Bruce D Levy, Clifford P Brangwynne
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. eLife 10 (2021)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Sukrit Singh, Melissa D Stuchell-Brereton, Michael D Ward, Maxwell I Zimmerman, Neha Vithani, Daniel Griffith, Jason A Wagoner, Gregory R Bowman, Kathleen B Hall, Andrea Soranno, Alex S Holehouse
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. Nature communications 12 (1) (2021)
Daniel Griffith, Alex S Holehouse
PARROT is a flexible recurrent neural network framework for analysis of large protein datasets. eLife 10 (2021)
Alex S Holehouse, Garrett M Ginell, Daniel Griffith, Elvan Böke
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates. Biochemistry 60 (47) (2021)
Natalie E Stenzoski, Junjie Zou, Andrea Piserchio, Ranajeet Ghose, Alex S Holehouse, Daniel P Raleigh
The Cold-Unfolded State Is Expanded but Contains Long- and Medium-Range Contacts and Is Poorly Described by Homopolymer Models. Biochemistry 59 (36) (2020)
Erik W Martin, Alex S Holehouse, Ivan Peran, Mina Farag, J Jeremías Incicco, Anne Bremer, Christy R R Grace, Andrea Soranno, Rohit V Pappu, Tanja Mittag
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains. Science (New York, N.Y.) 367 (6478) (2020)
Alex S Holehouse, Shahar Sukenik
Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning. Journal of chemical theory and computation 16 (3) (2020)
Andrea E Rawlings, Panah Liravi, Sybilla Corbett, Alex S Holehouse, Sarah S Staniland
Investigating the ferric ion binding site of magnetite biomineralisation protein Mms6. PloS one 15 (2) (2020)
Jason D Fernandes, Sarvenaz Sarabipour, Christopher T Smith, Natalie M Niemi, Nafisa M Jadavji, Ariangela J Kozik, Alex S Holehouse, Vikas Pejaver, Orsolya Symmons, Alexandre Wilson Bisson Filho, Amanda Haage
A survey-based analysis of the academic job market. eLife 9 (2020)
David Moses, Feng Yu, Garrett M Ginell, Nora M Shamoon, Patrick S Koenig, Alex S Holehouse, Shahar Sukenik
Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment. The journal of physical chemistry letters 11 (23) (2020)
Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Sukrit Singh, Melissa D Stuchell-Brereton, Michael D Ward, Maxwell I Zimmerman, Neha Vithani, Daniel Griffith, Jason A Wagoner, Gregory R Bowman, Kathleen B Hall, Andrea Soranno, Alex S Holehouse
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. bioRxiv : the preprint server for biology (2020)
Rachel J Harding, Peter Loppnau, Suzanne Ackloo, Alexander Lemak, Ashley Hutchinson, Brittany Hunt, Alex S Holehouse, Jolene C Ho, Lixin Fan, Leticia Toledo-Sherman, Alma Seitova, Cheryl H Arrowsmith
Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems. The Journal of biological chemistry 294 (17) (2019)
Steven Boeynaems, Alex S Holehouse, Venera Weinhardt, Denes Kovacs, Joris Van Lindt, Carolyn Larabell, Ludo Van Den Bosch, Rachel J Hagey, Peter S Tompa, Rohit V Pappu, Aaron D Gitler
Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties. Proceedings of the National Academy of Sciences of the United States of America 116 (16) (2019)
Ivan Peran, Alex S Holehouse, Isaac S Carrico, Rohit V Pappu, Osman Bilsel, Daniel P Raleigh
Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions. Proceedings of the National Academy of Sciences of the United States of America 116 (25) (2019)
Titus M Franzmann, Marcus Jahnel, Andrei Pozniakovsky, Julia Mahamid, Alex S Holehouse, Elisabeth Nüske, Doris Richter, Wolfgang Baumeister, Stephan W Grill, Rohit V Pappu, Anthony A Hyman, Simon Alberti
Phase separation of a yeast prion protein promotes cellular fitness. Science (New York, N.Y.) 359 (6371) (2018)
Alex S Holehouse, Rohit V Pappu
Functional Implications of Intracellular Phase Transitions. Biochemistry 57 (17) (2018)
Ming-Tzo Wei, Shana Elbaum-Garfinkle, Alex S Holehouse, Carlos Chih-Hsiung Chen, Marina Feric, Craig B Arnold, Rodney D Priestley, Rohit V Pappu, Clifford P Brangwynne
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles. Nature chemistry 9 (11) (2017)
Vasilios Kalas, Jerome S Pinkner, Thomas J Hannan, Michael E Hibbing, Karen W Dodson, Alex S Holehouse, Hao Zhang, Niraj H Tolia, Michael L Gross, Rohit V Pappu, James Janetka, Scott J Hultgren
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions. Science advances 3 (2) (2017)
Tyler S Harmon, Alex S Holehouse, Michael K Rosen, Rohit V Pappu
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins. eLife 6 (2017)
Alexander D Barrow, Yaseelan Palarasah, Mattia Bugatti, Alex S Holehouse, Derek E Byers, Michael J Holtzman, William Vermi, Karsten Skjødt, Erika Crouch, Marco Colonna
OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. Journal of immunology (Baltimore, Md. : 1950) 194 (7) (2015)

Alex S Holehouse.css-eqlu8i{font-size:small;padding-left:4px;} (Alex Holehouse)

Publication Activity (10 Years)

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Alex S Holehouse (Alex Holehouse)