Rachel J Harding

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Venues

Journal of medicinal chemistry

Nature chemical biology

F1000Research

Science advances

University of Toronto

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto

Canada

Postdoctoral Fellow :: Structural Genomics Consortium

Publications

Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology (2024)
Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen Lester Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith
Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles. Science advances 10 (29) (2024)
Merveille Eguida, Guillaume Bret, François Sindt, Fengling Li, Irene Chau, Suzanne Ackloo, Cheryl Arrowsmith, Albina Bolotokova, Pegah Ghiabi, Elisa Gibson, Levon Halabelian, Scott Houliston, Rachel J Harding, Ashley Hutchinson, Peter Loppnau, Sumera Perveen, Almagul Seitova, Hong Zeng, Matthieu Schapira, Didier Rognan
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2. Journal of chemical information and modeling (2024)
Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology (2024)
Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology 20 (8) (2024)
Merveille Eguida, Guillaume Bret, François Sindt, Fengling Li, Irene Chau, Suzanne Ackloo, Cheryl Arrowsmith, Albina Bolotokova, Pegah Ghiabi, Elisa Gibson, Levon Halabelian, Scott Houliston, Rachel J Harding, Ashley Hutchinson, Peter Loppnau, Sumera Perveen, Almagul Seitova, Hong Zeng, Matthieu Schapira, Didier Rognan
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2. Journal of chemical information and modeling 64 (13) (2024)
Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Sara Gonzalez Bolivar, Renu Chandrasekaran, Kathleen Southern, Aled M Edwards, Rachel J Harding, Carl Laflamme, null null, null null
A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence. F1000Research 13 (2024)
Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen Lester Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith
Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles. Science advances 10 (29) (2024)
Mandeep K Mann, Esther Wolf, Madhushika Silva, Haejin Angela Kwak, Brian Wilson, Albina Bolotokova, Derek J Wilson, Rachel J Harding, Matthieu Schapira
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle. ACS omega 9 (1) (2023)
Rachel J Harding, Ivan Franzoni, Mandeep K Mann, Magdalena M Szewczyk, Bijan Mirabi, Renato Ferreira de Freitas, Dominic D G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A Juarez-Ornelas, Randy Sanichar, Rachel J Baker, Christian Dank, Peter J Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H Arrowsmith
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6. Journal of medicinal chemistry (2023)
Rachel J Harding, Patrick Bermudez, Alexander Bernier, Michael J S Beauvais, Pierre Bellec, Sean L Hill, Agâh Karakuzu, Bartha M Knoppers, Paul Pavlidis, Jean-Baptiste Poline, Jane Roskams, Nikola Stikov, Jessica Stone, Stephen Strother, null null, Alan C Evans
The Canadian Open Neuroscience Platform-An open science framework for the neuroscience community. PLoS computational biology 19 (7) (2023)
Mandeep K Mann, Esther Wolf, Madhushika Silva, Haejin Angela Kwak, Brian Wilson, Albina Bolotokova, Derek J Wilson, Rachel J Harding, Matthieu Schapira
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle. ACS omega 9 (1) (2023)
Mandeep K Mann, Carlos A Zepeda-Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Ahmed M Aman, Peter Loppnau, Yanjun Li, Brian Wilson, Cheryl H Arrowsmith, Rima Al-Awar, Rachel J Harding, Matthieu Schapira
Structure-Activity Relationship of USP5 Inhibitors. Journal of medicinal chemistry 64 (20) (2021)
Mandeep K Mann, Carlos A Zepeda-Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Ahmed M Aman, Peter Loppnau, Yanjun Li, Brian Wilson, Cheryl H Arrowsmith, Rima Al-Awar, Rachel J Harding, Matthieu Schapira
Correction to "Structure-Activity Relationship of USP5 Inhibitors". Journal of medicinal chemistry 65 (1) (2021)
Rachel J Harding, Justin C Deme, Johannes F Hevler, Sem Tamara, Alexander Lemak, Jeffrey P Cantle, Magdalena M Szewczyk, Nola Begeja, Siobhan Goss, Xiao-Bing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B Carroll, Albert J R Heck, Susan M Lea, Cheryl H Arrowsmith
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Communications biology 4 (1) (2021)
Rachel J Harding, Peter Loppnau, Suzanne Ackloo, Alexander Lemak, Ashley Hutchinson, Brittany Hunt, Alex S Holehouse, Jolene C Ho, Lixin Fan, Leticia Toledo-Sherman, Alma Seitova, Cheryl H Arrowsmith
Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems. The Journal of biological chemistry 294 (17) (2019)
Matthieu Schapira, null null, Rachel J Harding
Open laboratory notebooks: good for science, good for society, good for scientists. F1000Research 8 (2019)
Matthieu Schapira, null null, Rachel J Harding
Open laboratory notebooks: good for science, good for society, good for scientists. F1000Research (2019)
Rachel J Harding
Open notebook science can maximize impact for rare disease projects. PLoS biology 17 (1) (2019)
Mandeep K Mann, Ivan Franzoni, Renato Ferreira de Freitas, Wolfram Tempel, Scott Houliston, Leanna Smith, Masoud Vedadi, Cheryl H Arrowsmith, Rachel J Harding, Matthieu Schapira
Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. Journal of medicinal chemistry 62 (22) (2019)
Renato Ferreira de Freitas, Rachel J Harding, Ivan Franzoni, Mani Ravichandran, Mandeep K Mann, Hui Ouyang, Mark Lautens, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Matthieu Schapira
Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. Journal of medicinal chemistry 61 (10) (2018)
Rachel J Harding, Renato Ferreira de Freitas, Patrick M Collins, Ivan Franzoni, Mani Ravichandran, Hui Ouyang, Kevin A Juarez-Ornelas, Mark Lautens, Matthieu Schapira, Frank von Delft, Vjayaratnam Santhakumar, Cheryl H Arrowsmith
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. Journal of medicinal chemistry 60 (21) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Rachel J Harding