Axel Kallies (A Kallies)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 36

Top Topics

Infectious Diseases

Transcription Factor

Chronic Lymphocytic Leukemia

Regulatory T Cells

Top Venues

Nature immunology

Science immunology

Nature communications

Nature reviews. Immunology

This page only lists publications with an associated author ORCID identifier.

Publications

Stefano Mangiola, M Milton, N Ranathunga, Connie Li Wai Suen, A Odainic, E Yang, W Hutchison, Alexandra L Garnham, J Iskander, Bhupinder Pal, Vijay K Yadav, Fernando J Rossello, Vincent J Carey, Martin Morgan, Sammy Bedoui, Axel Kallies, Anthony T Papenfuss
A multi-organ map of the human immune system across age, sex and ethnicity. bioRxiv : the preprint server for biology (2024)
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature immunology 25 (3) (2024)
Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y Kong, Iona S Schuster, Christopher E Andoniou, Melissa J Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca Guimaraes, Ian A Parish, Paul A Beavis, Daniel Thiele, Michael Chopin, Mariapia A Degli-Esposti, Joseph Cursons, Axel Kallies, Jai Rautela, Stephen L Nutt, Nicholas D Huntington
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature immunology (2024)
Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y Kong, Iona S Schuster, Christopher E Andoniou, Melissa J Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca Guimaraes, Ian A Parish, Paul A Beavis, Daniel Thiele, Michael Chopin, Mariapia A Degli-Esposti, Joseph Cursons, Axel Kallies, Jai Rautela, Stephen L Nutt, Nicholas D Huntington
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature immunology 25 (2) (2024)
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature immunology 25 (3) (2024)
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature immunology 25 (3) (2024)
Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y Kong, Iona S Schuster, Christopher E Andoniou, Melissa J Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca Guimaraes, Ian A Parish, Paul A Beavis, Daniel Thiele, Michael Chopin, Mariapia A Degli-Esposti, Joseph Cursons, Axel Kallies, Jai Rautela, Stephen L Nutt, Nicholas D Huntington
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature immunology 25 (2) (2024)
Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Rüdiger Klein, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science immunology 9 (93) (2024)
Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Rüdiger Klein, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science immunology 9 (93) (2024)
Stefano Mangiola, M Milton, N Ranathunga, Connie Li Wai Suen, A Odainic, E Yang, W Hutchison, Alexandra L Garnham, J Iskander, Bhupinder Pal, Vijay K Yadav, Fernando J Rossello, Vincent J Carey, Martin Morgan, Sammy Bedoui, Axel Kallies, Anthony T Papenfuss
A multi-organ map of the human immune system across age, sex and ethnicity. bioRxiv : the preprint server for biology (2024)
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature immunology 25 (3) (2024)
Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y Kong, Iona S Schuster, Christopher E Andoniou, Melissa J Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca Guimaraes, Ian A Parish, Paul A Beavis, Daniel Thiele, Michael Chopin, Mariapia A Degli-Esposti, Joseph Cursons, Axel Kallies, Jai Rautela, Stephen L Nutt, Nicholas D Huntington
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature immunology 25 (2) (2024)
Caterina Scirgolea, Rosa Sottile, Marco De Luca, Alberto Susana, Silvia Carnevale, Simone Puccio, Valentina Ferrari, Veronica Lise, Giorgia Contarini, Alice Scarpa, Eloise Scamardella, Simona Feno, Chiara Camisaschi, Gabriele De Simone, Gianluca Basso, Desiree Giuliano, Emilia Maria Cristina Mazza, Luca Gattinoni, Rahul Roychoudhuri, Emanuele Voulaz, Diletta Di Mitri, Matteo Simonelli, Agnese Losurdo, Davide Pozzi, Carlson Tsui, Axel Kallies, Sara Timo, Giuseppe Martano, Elettra Barberis, Marcello Manfredi, Maria Rescigno, Sebastien Jaillon, Enrico Lugli
NaCl enhances CD8 + T cell effector functions in cancer immunotherapy. Nature immunology (2024)
Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y Kong, Iona S Schuster, Christopher E Andoniou, Melissa J Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca Guimaraes, Ian A Parish, Paul A Beavis, Daniel Thiele, Michael Chopin, Mariapia A Degli-Esposti, Joseph Cursons, Axel Kallies, Jai Rautela, Stephen L Nutt, Nicholas D Huntington
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature immunology 25 (2) (2024)
Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Rüdiger Klein, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science immunology 9 (93) (2024)
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature immunology (2024)
Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Rüdiger Klein, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science immunology 9 (93) (2024)
Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs, Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Rüdiger Klein, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science immunology 9 (93) (2024)
Stefano Mangiola, M Milton, N Ranathunga, Connie Li Wai Suen, A Odainic, E Yang, W Hutchison, Alexandra L Garnham, J Iskander, Bhupinder Pal, Vijay K Yadav, Fernando J Rossello, Vincent J Carey, Martin Morgan, Sammy Bedoui, Axel Kallies, Anthony T Papenfuss
A multi-organ map of the human immune system across age, sex and ethnicity. bioRxiv : the preprint server for biology (2024)
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G Whitney, Annabell Bachem, Alexandru Odainic, Carolien E van de Sandt, Thi H O Nguyen, Thomas Myles Ashhurst, Kayla R Wilson, Clare V L Oates, Linden J Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S Gabriel, Wolfgang Kastenmüller, Christian Kurts, Sarah L Londrigan, Axel Kallies, Katherine Kedzierska, Paul J Hertzog, Eicke Latz, Yu-Chen E Chen, Kristen J Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif-Erik Sander, Birgit Sawitzki, Joachim L Schultze, Susanne V Schmidt, Sammy Bedoui
CD4 + T cell calibration of antigen-presenting cells optimizes antiviral CD8 + T cell immunity. Nature immunology (2023)
Simone L Park, Susan N Christo, Alexandria C Wells, Luke C Gandolfo, Ali Zaid, Yannick O Alexandre, Thomas N Burn, Jan Schroeder, Nicholas Collins, Seong-Ji Han, Stephane M Guillaume, Maximilien Evrard, Clara Castellucci, Brooke Davies, Maleika Osman, Andreas Obers, Keely M McDonald, Huimeng Wang, Scott N Mueller, George Kannourakis, Stuart P Berzins, Lisa A Mielke, Francis R Carbone, Axel Kallies, Terence P Speed, Yasmine Belkaid, Laura K Mackay
Divergent molecular networks program functionally distinct CD8 + skin-resident memory T cells. Science (New York, N.Y.) 382 (6674) (2023)
Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S Gabriel, David Chisanga, Konrad Knöpper, Daniel T Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L Nutt, Dietmar Zehn, Ian A Parish, Wolfgang Kastenmüller, Wei Shi, Veit R Buchholz, Axel Kallies
MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature 609 (7926) (2022)
Charis E Teh, Simon P Preston, Alissa K Robbins, Michael D Stutz, James P Cooney, Michelle P Clark, Antonia N Policheni, Cody C Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C Rankin, Peggy P Teh, Gabrielle T Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel H D Gray
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage. Science immunology 7 (69) (2022)
Daniel T Utzschneider, Axel Kallies
Human effector T cells express TOX-Not so "TOX"ic after all. Science immunology 5 (49) (2022)
Mayura V Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van Der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nüssing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, Fabio Luciani, Joseph A Trapani, Ricky W Johnstone, Axel Kallies, Christopher C Goodnow, Ian A Parish
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance. Nature communications 12 (1) (2021)
Jack D Chan, Junyun Lai, Clare Y Slaney, Axel Kallies, Paul A Beavis, Phillip K Darcy
Cellular networks controlling T cell persistence in adoptive cell therapy. Nature reviews. Immunology 21 (12) (2021)
Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, William R Heath, Florent Ginhoux, Terence P Speed, Francis R Carbone, Axel Kallies, Laura K Mackay
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nature immunology 22 (9) (2021)
Kevin Man, Axel Kallies, Ajithkumar Vasanthakumar
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis. Cellular & molecular immunology (2021)
Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X Shi, Michael A Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S Anstee, Boris Reljić, Sarah S Gabriel, Tirta M Djajawi, Chris D Riffkin, Brandon J Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David Arthur Stroud, Ashish Bajel, Ruth M Kluck, Steven W Lane, Marie Schoumacher, Sébastien Banquet, Ian J Majewski, Andreas Strasser, Andrew W Roberts, David Ching Siang Huang, Fiona C Brown, Gemma L Kelly, Andrew H Wei
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood 137 (20) (2021)
Marco A Ataide, Karl Komander, Konrad Knöpper, Annika E Peters, Hao Wu, Sarah Eickhoff, Tea Gogishvili, Justus Weber, Anika Grafen, Axel Kallies, Natalio Garbi, Hermann Einsele, Michael Hudecek, Georg Gasteiger, Michael Hölzel, Martin Vaeth, Wolfgang Kastenmüller
BATF3 programs CD8+ T cell memory. Nature immunology 21 (11) (2020)
Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Aaron T L Lun, Wei Shi, Axel Kallies
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. Nature communications 11 (1) (2020)
Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies
Early precursor T cells establish and propagate T cell exhaustion in chronic infection. Nature immunology 21 (10) (2020)
Christian U Blank, W Nicholas Haining, Werner Held, Patrick G Hogan, Axel Kallies, Enrico Lugli, Rachel C Lynn, Mary Philip, Anjana Rao, Nicholas P Restifo, Andrea Schietinger, Ton N M Schumacher, Pamela L Schwartzberg, Arlene H Sharpe, Daniel E Speiser, E John Wherry, Benjamin A Youngblood, Dietmar Zehn
Defining 'T cell exhaustion'. Nature reviews. Immunology 19 (11) (2019)
Axel Kallies, Dietmar Zehn, Daniel T Utzschneider
Precursor exhausted T cells: key to successful immunotherapy? Nature reviews. Immunology 20 (2) (2019)
Christina Lückel, Felix S R Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nature communications 10 (1) (2019)
Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric J C Gálvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang, Andrey A Kruglov, Mir-Farzin Mashreghi, Wei Shi, Till Strowig, Sascha Rutz, Axel Kallies, Alexander Scheffold
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis. Nature immunology 20 (4) (2019)