Sebastian Jarosch

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 31

Top Topics

Stem Cell Transplantation

Acute Lymphoblastic Leukemia

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Christoph H Mayr, Diana Santacruz, Sebastian Jarosch, Marina Bleck, John Dalton, Angela McNabola, Charlotte Lempp, Lavinia Neubert, Berenice Rath, Jan C Kamp, Danny D Jonigk, Mark P Kühnel, Holger Schlüter, Alexander Klimowicz, Jonas Martin Doerr, Alec Dick, Fidel Ramírez, Matthew-James Thomas
Spatial transcriptomic characterization of pathologic niches in IPF. Science advances 10 (32) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Juergen Ruland, Marcel R M van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer (2024)
Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature 629 (8011) (2024)
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Juergen Ruland, Marcel R M van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer (2024)
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Juergen Ruland, Marcel R M van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer 5 (1) (2024)
Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature 629 (8011) (2024)
Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature 629 (8011) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature (2024)
Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Juergen Ruland, Marcel R M van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer 5 (1) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Juergen Ruland, Marcel R M van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer 5 (1) (2024)
Christoph H Mayr, Diana Santacruz, Sebastian Jarosch, Marina Bleck, John Dalton, Angela McNabola, Charlotte Lempp, Lavinia Neubert, Berenice Rath, Jan C Kamp, Danny D Jonigk, Mark P Kühnel, Holger Schlüter, Alexander Klimowicz, Jonas Martin Doerr, Alec Dick, Fidel Ramírez, Matthew-James Thomas
Spatial transcriptomic characterization of pathologic niches in IPF. Science advances 10 (32) (2024)
Sebastian B Lacher, Janina Dörr, Gustavo Pereira de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J Rudolph, Nadine Spranger, Matteo Morotti, Alizee J Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H Busch, Veit R Buchholz, Percy A Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan Philipp Böttcher
PGE 2 limits effector expansion of tumour-infiltrating stem-like CD8 + T cells. Nature 629 (8011) (2024)
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin-Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan Philipp Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature 627 (8003) (2024)
Sarah Dötsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Füsun Gökmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Čičin Šain, Elvira D'Ippolito, Dirk H Busch
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Sarah Dötsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Füsun Gökmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Čičin Šain, Elvira D'Ippolito, Dirk H Busch
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Sarah Dötsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Füsun Gökmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Čičin Šain, Elvira D'Ippolito, Dirk H Busch
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Sarah Dötsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Füsun Gökmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Čičin Šain, Elvira D'Ippolito, Dirk H Busch
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Sarah Dötsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Füsun Gökmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Čičin Šain, Elvira D'Ippolito, Dirk H Busch
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression. Proceedings of the National Academy of Sciences of the United States of America 120 (10) (2023)
Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S Gabriel, David Chisanga, Konrad Knöpper, Daniel T Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L Nutt, Dietmar Zehn, Ian A Parish, Wolfgang Kastenmüller, Wei Shi, Veit R Buchholz, Axel Kallies
MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature 609 (7926) (2022)
Laura M Mateyka, Philipp M Strobl, Sebastian Jarosch, Sebastian J C Scheu, Dirk H Busch, Elvira D'Ippolito
Gene Signatures of T-Cell Activation Can Serve as Predictors of Functionality for SARS-CoV-2-Specific T-Cell Receptors. Vaccines 10 (10) (2022)
Anna Purcarea, Sebastian Jarosch, Jack Barton, Simon Grassmann, Ludwig Pachmayr, Elvira D'Ippolito, Monika Hammel, Anna Hochholzer, Karolin I Wagner, Joost H van den Berg, Veit R Buchholz, John B A G Haanen, Dirk H Busch, Kilian Schober
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity. Science immunology 7 (74) (2022)
David S Fischer, Meshal Ansari, Karolin I Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H Mayr, Maximilian Strunz, Niklas J Lang, Elvira D'Ippolito, Monika Hammel, Laura Mateyka, Simone Weber, Lisa S Wolff, Klaus Witter, Isis E Fernandez, Gabriela Leuschner, Katrin Milger, Marion Frankenberger, Lorenz Nowak, Katharina Heinig-Menhard, Ina Koch, Mircea G Stoleriu, Anne Hilgendorff, Jürgen Behr, Andreas Pichlmair, Benjamin Schubert, Fabian Joachim Theis, Dirk H Busch, Herbert B Schiller, Kilian Schober
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'. Nature communications 12 (1) (2021)
Michael Hiltensperger, Eduardo Beltrán, Ravi Kant, Sofia Tyystjärvi, Gildas Lepennetier, Helena Domínguez Moreno, Isabel J Bauer, Simon Grassmann, Sebastian Jarosch, Kilian Schober, Veit R Buchholz, Selin Kenet, Christiane Gasperi, Rupert Öllinger, Roland Rad, Andreas Muschaweckh, Christopher Sie, Lilian Aly, Benjamin Knier, Garima Garg, Ali M Afzali, Lisa Ann Gerdes, Tania Kümpfel, Soeren Franzenburg, Naoto Kawakami, Bernhard Hemmer, Dirk H Busch, Thomas Misgeld, Klaus Dornmair, Thomas Korn
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nature immunology 22 (7) (2021)