Ben Capuano

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 16

Top Topics

Molecular Docking

Binding Protein

Capillary Electrophoresis

Top Venues

Journal of medicinal chemistry

ACS chemical neuroscience

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Boqun Liu, Geoff Thompson, Manuela Jörg, Nicholas Barnes, David M Thal, Arthur Christopoulos, Ben Capuano, Celine Valant, Peter J Scammells
Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders. Journal of medicinal chemistry 67 (15) (2024)
Boqun Liu, Geoff Thompson, Manuela Jörg, Nicholas Barnes, David M Thal, Arthur Christopoulos, Ben Capuano, Celine Valant, Peter J Scammells
Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders. Journal of medicinal chemistry 67 (15) (2024)
Boqun Liu, Geoff Thompson, Manuela Jörg, Nicholas Barnes, David M Thal, Arthur Christopoulos, Ben Capuano, Celine Valant, Peter J Scammells
Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders. Journal of medicinal chemistry (2024)
Luke A Adams, Lorna E Wilkinson-White, Menachem J Gunzburg, Stephen J Headey, Biswaranjan Mohanty, Martin J Scanlon, Ben Capuano, Joel P Mackay, Bradley C Doak
Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra-Terminal Domain. Journal of medicinal chemistry (2023)
Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M Thal, Manuela Jörg, Ben Capuano, Celine Valant, Peter J Scammells
The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ - Opioid Receptor. Journal of medicinal chemistry 65 (18) (2022)
Matthew C L Wakeham, Briana J Davie, David K Chalmers, Arthur Christopoulos, Ben Capuano, Celine Valant, Peter J Scammells
Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy. ACS chemical neuroscience 13 (1) (2021)
Le Vi Dinh, Aaron DeBono, Andrew N Keller, Tracy M Josephs, Karen J Gregory, Katie Leach, Ben Capuano
Development of AC265347-Inspired Calcium-Sensing Receptor Ago-Positive Allosteric Modulators. ChemMedChem 16 (22) (2021)
Tim J Fyfe, Peter J Scammells, J Robert Lane, Ben Capuano
Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor. Molecules (Basel, Switzerland) 26 (13) (2021)
Matthew R Bentley, Olga V Ilyichova, Geqing Wang, Martin L Williams, Gaurav Sharma, Wesam S Alwan, Rebecca L Whitehouse, Biswaranjan Mohanty, Peter J Scammells, Begoña Heras, Jennifer L Martin, Makrina Totsika, Ben Capuano, Bradley C Doak, Martin J Scanlon
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). Journal of medicinal chemistry 63 (13) (2020)
Cassandra Yong, Shane M Devine, Xuexin Gao, Angelina Yan, Richard Callaghan, Ben Capuano, Peter J Scammells
A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells. ChemMedChem 14 (23) (2019)
Carmen Klein Herenbrink, Ravi Verma, Herman D Lim, Anitha Kopinathan, Alastair Keen, Jeremy Shonberg, Christopher J Draper-Joyce, Peter J Scammells, Arthur Christopoulos, Jonathan A Javitch, Ben Capuano, Lei Shi, J Robert Lane
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole. ACS chemical biology 14 (8) (2019)
Tim J Fyfe, Barrie Kellam, David A Sykes, Ben Capuano, Peter J Scammells, J Robert Lane, Steven J Charlton, Shailesh N Mistry
Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor. Journal of medicinal chemistry 62 (21) (2019)
Manuela Jörg, Emma T van der Westhuizen, Elham Khajehali, Wessel A C Burger, Jonathan M White, Kwok H C Choy, Andrew B Tobin, Patrick M Sexton, Celine Valant, Ben Capuano, Arthur Christopoulos, Peter J Scammells
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity. ACS chemical neuroscience 10 (3) (2018)
Anitha Kopinathan, Christopher Draper-Joyce, Monika Szabo, Arthur Christopoulos, Peter J Scammells, J Robert Lane, Ben Capuano
Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 Receptor. Journal of medicinal chemistry 62 (1) (2018)
Tim J Fyfe, Barbara Zarzycka, Herman D Lim, Barrie Kellam, Shailesh N Mistry, Vsevolod Katritch, Peter J Scammells, J Robert Lane, Ben Capuano
A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of medicinal chemistry 62 (1) (2018)
Shane M Devine, Cassandra Yong, Dzifa Amenuvegbe, Luigi Aurelio, Divya Muthiah, Colin W Pouton, Richard Callaghan, Ben Capuano, Peter J Scammells
Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents. Journal of medicinal chemistry 61 (18) (2018)