Vsevolod Katritch (Vsevolod Katrich)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 73

Top Topics

Structural Basis

Crystal Structure

Top Venues

Nature communications

Research square

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jae-Kyung Hyun, Vsevolod Katritch, Kwang-Pyo Kim, Yunje Cho
Constitutive activation mechanism of a class C GPCR. Nature structural & molecular biology (2024)
Jordy Homing Lam, Aiichiro Nakano, Vsevolod Katritch
Scalable computation of anisotropic vibrations for large macromolecular assemblies. Nature communications 15 (1) (2024)
Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jae-Kyung Hyun, Vsevolod Katritch, Kwang-Pyo Kim, Yunje Cho
Constitutive activation mechanism of a class C GPCR. Nature structural & molecular biology 31 (4) (2024)
Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jae-Kyung Hyun, Vsevolod Katritch, Kwang-Pyo Kim, Yunje Cho
Constitutive activation mechanism of a class C GPCR. Nature structural & molecular biology 31 (4) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Spyros P Nikas, Lipin Ji, Yingpeng Liu, Markos-Orestis Georgiadis, Amey Dopeshwarkar, Alex Straiker, Shalley N Kudalkar, Anastasiia V Sadybekov, Michaela Dvorakova, Vsevolod Katritch, Ken Mackie, Lawrence J Marnett, Alexandros Makriyannis
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2. ACS medicinal chemistry letters 15 (6) (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Václav Havel, Andrew C Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E Pintar, Christopher Hwu, Rohini S Ople, Najah Abi-Gerges, Saheem A Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A Javitch, Susruta Majumdar, Scott E Hemby, Dalibor Sames
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models. Nature communications 15 (1) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Spyros P Nikas, Lipin Ji, Yingpeng Liu, Markos-Orestis Georgiadis, Amey Dopeshwarkar, Alex Straiker, Shalley N Kudalkar, Anastasiia V Sadybekov, Michaela Dvorakova, Vsevolod Katritch, Ken Mackie, Lawrence J Marnett, Alexandros Makriyannis
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2. ACS medicinal chemistry letters 15 (6) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Jordy Homing Lam, Aiichiro Nakano, Vsevolod Katritch
Scalable computation of anisotropic vibrations for large macromolecular assemblies. Nature communications 15 (1) (2024)
Jordy Homing Lam, Aiichiro Nakano, Vsevolod Katritch
Scalable computation of anisotropic vibrations for large macromolecular assemblies. Nature communications 15 (1) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology (2024)
Sandra Arroyo-Urea, Antonina L Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site. Nature communications 15 (1) (2024)
Sandra Arroyo-Urea, Antonina L Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket. Research square (2023)
Javier García-Nafría, Sandra Arroyo-Urea, Antonina Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket. Research square (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Anastasiia V Sadybekov, Vsevolod Katritch
Computational approaches streamlining drug discovery. Nature 616 (7958) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Yasmin Aydin, Thore Böttke, Jordy Homing Lam, Stefan Ernicke, Anna Fortmann, Maik Tretbar, Barbara Zarzycka, Vsevolod V Gurevich, Vsevolod Katritch, Irene Coin
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nature communications 14 (1) (2023)
Sandra Arroyo-Urea, Antonina L Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket. Research square (2023)
Anastasiia V Sadybekov, Vsevolod Katritch
Computational approaches streamlining drug discovery. Nature 616 (7958) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Yasmin Aydin, Thore Böttke, Jordy Homing Lam, Stefan Ernicke, Anna Fortmann, Maik Tretbar, Barbara Zarzycka, Vsevolod V Gurevich, Vsevolod Katritch, Irene Coin
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nature communications 14 (1) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Anastasiia V Sadybekov, Vsevolod Katritch
Computational approaches streamlining drug discovery. Nature 616 (7958) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature (2023)
Yasmin Aydin, Thore Böttke, Jordy Homing Lam, Stefan Ernicke, Anna Fortmann, Maik Tretbar, Barbara Zarzycka, Vsevolod V Gurevich, Vsevolod Katritch, Irene Coin
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nature communications 14 (1) (2023)
Yasmin Aydin, Thore Böttke, Jordy Homing Lam, Stefan Ernicke, Anna Fortmann, Maik Tretbar, Barbara Zarzycka, Vsevolod V Gurevich, Vsevolod Katritch, Irene Coin
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nature communications 14 (1) (2023)
Sandra Arroyo-Urea, Antonina L Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket. Research square (2023)
Yasmin Aydin, Thore Böttke, Jordy Homing Lam, Stefan Ernicke, Anna Fortmann, Maik Tretbar, Barbara Zarzycka, Vsevolod V Gurevich, Vsevolod Katritch, Irene Coin
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nature communications 14 (1) (2023)
Dongqi Zhang, Yong-Feng Liu, Saheem A Zaidi, Lingyi Xu, Yuting Zhan, Anqi Chen, Jiang Tao Guo, Xi-Ping Huang, Bryan L Roth, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. The EMBO journal (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Alessandro Bonifazi, Elizabeth Saab, Julie Sanchez, Antonina L Nazarova, Saheem A Zaidi, Khorshada Jahan, Vsevolod Katritch, Meritxell Canals, J Robert Lane, Amy Hauck Newman
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D 3 (D 3 R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. Journal of medicinal chemistry (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Michael J Cunningham, Hailey A Bock, Inis C Serrano, Benjamin Bechand, D J Vidyadhara, Emma M Bonniwell, David Lankri, Priscilla Duggan, Antonina L Nazarova, Andrew B Cao, Maggie M Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S Chandra, John D McCorvy, Dalibor Sames
Pharmacological Mechanism of the Non-hallucinogenic 5-HT 2A Agonist Ariadne and Analogs. ACS chemical neuroscience 14 (1) (2022)
Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth
Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nature structural & molecular biology 29 (7) (2022)
Abdelfattah Faouzi, Haoqing Wang, Saheem A Zaidi, Jeffrey F DiBerto, Tao Che, Qianhui Qu, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K Kobilka, Susruta Majumdar
Structure-based design of bitopic ligands for the µ-opioid receptor. Nature (2022)
Michael J Cunningham, Hailey A Bock, Inis C Serrano, Benjamin Bechand, D J Vidyadhara, Emma M Bonniwell, David Lankri, Priscilla Duggan, Antonina L Nazarova, Andrew B Cao, Maggie M Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S Chandra, John D McCorvy, Dalibor Sames
Pharmacological Mechanism of the Non-hallucinogenic 5-HT 2A Agonist Ariadne and Analogs. ACS chemical neuroscience 14 (1) (2022)
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D Kostagianni, Antonis D Tsiailanis, Thomas Thorne, Maria V Chatziathanasiadou, Gregory B Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie V Morse, James J Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G Tzakos, Nelofer Syed
Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma. Proceedings of the National Academy of Sciences of the United States of America 119 (32) (2022)
Michael J Cunningham, Hailey A Bock, Inis C Serrano, Benjamin Bechand, D J Vidyadhara, Emma M Bonniwell, David Lankri, Priscilla Duggan, Antonina L Nazarova, Andrew B Cao, Maggie M Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S Chandra, John D McCorvy, Dalibor Sames
Pharmacological Mechanism of the Non-hallucinogenic 5-HT 2A Agonist Ariadne and Analogs. ACS chemical neuroscience (2022)
Zenia Motiwala, Nanda Gowtham Aduri, Hamidreza Shaye, Gye Won Han, Jordy Homing Lam, Vsevolod Katritch, Vadim Cherezov, Cornelius Gati
Structural basis of GABA reuptake inhibition. Nature 606 (7915) (2022)
Yuni Kay, Linda Tsan, Elizabeth A Davis, Chen Tian, Léa Décarie-Spain, Anastasiia Sadybekov, Anna N Pushkin, Vsevolod Katritch, Scott E Kanoski, Bruce E Herring
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats. Nature communications 13 (1) (2022)
Antonina L Nazarova, Vsevolod Katritch
It all clicks together: In silico drug discovery becoming mainstream. Clinical and translational medicine 12 (4) (2022)
Michael J Cunningham, Hailey A Bock, Inis C Serrano, Benjamin Bechand, D J Vidyadhara, Emma M Bonniwell, David Lankri, Priscilla Duggan, Antonina L Nazarova, Andrew B Cao, Maggie M Calkins, Prashant Khirsariya, Christopher Hwu, Vsevolod Katritch, Sreeganga S Chandra, John D McCorvy, Dalibor Sames
Pharmacological Mechanism of the Non-hallucinogenic 5-HT 2A Agonist Ariadne and Analogs. ACS chemical neuroscience 14 (1) (2022)
Francisco O Battiti, Saheem A Zaidi, Vsevolod Katritch, Amy Hauck Newman, Alessandro Bonifazi
Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists. Journal of medicinal chemistry 64 (21) (2021)
Alessandro Bonifazi, Francisco O Battiti, Julie Sanchez, Saheem A Zaidi, Eric Bow, Mariia Makarova, Jianjing Cao, Anver Basha Shaik, Agnieszka Sulima, Kenner C Rice, Vsevolod Katritch, Meritxell Canals, J Robert Lane, Amy Hauck Newman
Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management. Journal of medicinal chemistry 64 (11) (2021)
Arman A Sadybekov, Anastasiia V Sadybekov, Yong-Feng Liu, Christos Iliopoulos-Tsoutsouvas, Xi-Ping Huang, Julie E Pickett, Blake Houser, Nilkanth Patel, Ngan K Tran, Fei Tong, Nikolai Zvonok, Manish Kumar Jain, Olena Savych, Dmytro S Radchenko, Spyros P Nikas, Nicos A Petasis, Yurii S Moroz, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds. Nature 601 (7893) (2021)
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A Zamlynny, Andreas Verras, Phieng Siliphaivanh, Jeremy Presland, Kerrie B Spencer, Stephen M Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nature communications 12 (1) (2021)
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, Andras Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. eLife 10 (2021)
Roman C Sarott, Alexander E G Viray, Patrick Pfaff, Anastasiia Sadybekov, Gabriela Rajic, Vsevolod Katritch, Erick M Carreira, James Allen Frank
Optical Control of Cannabinoid Receptor 2-Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes. Journal of the American Chemical Society 143 (2) (2021)
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch
Structure-based discovery of potent and selective melatonin receptor agonists. eLife 9 (2020)
Arman A Sadybekov, Rebecca L Brouillette, Egor Marin, Anastasiia V Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin I Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR. Biomolecules 10 (12) (2020)
Hamidreza Shaye, Andrii V Ishchenko, Jordy Homing Lam, Gye Won Han, Li Xue, Philippe Rondard, Jean-Philippe Pin, Vsevolod Katritch, Cornelius Gati, Vadim Cherezov
Structural basis of the activation of a metabotropic GABA receptor. Nature 584 (7820) (2020)
Aleksandra Luginina, Anastasiia Gusach, Egor Marin, Alexey V Mishin, Rebecca L Brouillette, Petr Popov, Anna Shiriaeva, Élie Besserer-Offroy, Jean-Michel Longpré, Elizaveta Lyapina, Andrii Ishchenko, Nilkanth Patel, Vitaly Polovinkin, Nadezhda Safronova, Andrey Bogorodskiy, Evelina Edelweiss, Hao Hu, Uwe Weierstall, Wei Liu, Alexander Batyuk, Valentin Gordeliy, Gye Won Han, Philippe Sarret, Vsevolod Katritch, Valentin I Borshchevskiy, Vadim Cherezov
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Science advances 5 (10) (2019)
Paul M Levine, Aaron T Balana, Emmanuel Sturchler, Cassandra Koole, Hiroshi Noda, Barbara Zarzycka, Eileen J Daley, Tin T Truong, Vsevolod Katritch, Thomas J Gardella, Denise Wootten, Patrick M Sexton, Patricia McDonald, Matthew R Pratt
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity. Journal of the American Chemical Society 141 (36) (2019)
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii V Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin I Borshchevskiy, Philippe Sarret, Alexey V Mishin, Vadim Cherezov
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nature communications 10 (1) (2019)
Tobias Claff, Jing Yu, Véronique Blais, Nilkanth Patel, Charlotte Martin, Li-Jie Wu, Gye Won Han, Brian J Holleran, Olivier Van der Poorten, Kate L White, Michael A Hanson, Philippe Sarret, Louis Gendron, Vadim Cherezov, Vsevolod Katritch, Steven Ballet, Zhi-Jie Liu, Christa Elisabeth Müller, Raymond C Stevens
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Science advances 5 (11) (2019)
Petr Popov, Yao Peng, Ling Shen, Raymond C Stevens, Vadim Cherezov, Zhi-Jie Liu, Vsevolod Katritch
Computational design of thermostabilizing point mutations for G protein-coupled receptors. eLife 7 (2018)
Martin Audet, Kate L White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A Hanson, Raymond C Stevens
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nature chemical biology 15 (1) (2018)
Matthew T Eddy, Zhan-Guo Gao, Philip Mannes, Nilkanth Patel, Kenneth A Jacobson, Vsevolod Katritch, Raymond C Stevens, Kurt Wüthrich
Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor. Journal of the American Chemical Society 140 (26) (2018)
Tim J Fyfe, Barbara Zarzycka, Herman D Lim, Barrie Kellam, Shailesh N Mistry, Vsevolod Katritch, Peter J Scammells, J Robert Lane, Ben Capuano
A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of medicinal chemistry 62 (1) (2018)
Wenlei Ye, Yu-Hsiang Tu, Alexander J Cooper, Zheng Zhang, Vsevolod Katritch, Emily Ruth Liman
Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers. Scientific reports 8 (1) (2018)
Matthias V Westphal, Michael A Schafroth, Roman C Sarott, Michael A Imhof, Christian P Bold, Philipp Leippe, Amey Dhopeshwarkar, Jessica M Grandner, Vsevolod Katritch, Ken Mackie, Dirk H Trauner, Erick M Carreira, James A Frank
Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling. Journal of the American Chemical Society 139 (50) (2017)
Zhong Zheng, Xi-Ping Huang, Thomas J Mangano, Rodger Zou, Xin Chen, Saheem A Zaidi, Bryan L Roth, Raymond C Stevens, Vsevolod Katritch
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor. Journal of medicinal chemistry 60 (7) (2017)
Lisa Paschold, Barbara A Zarzycka, Saheem A Zaidi, Vsevolod Katritch, Irene Coin
Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. eLife 6 (2017)