Bruno Melillo

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 30

Top Venues

ACS chemical biology

Journal of the American Chemical Society

ACS infectious diseases

Nature communications

University of Pennsylvania (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Pennsylvania

United States

PHD

Publications

Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D Petroski, Jaimeen D Majmudar, Sherry Niessen, Todd VanArsdale, Adam M Gilbert, Matthew M Hayward, Al E Stewart, Andrew R Nager, Bruno Melillo, Benjamin F Cravatt
An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes. Nature chemical biology (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Evert Njomen, Rachel E Hayward, Kristen E DeMeester, Daisuke Ogasawara, Melissa M Dix, Tracey Nguyen, Paige Ashby, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells. Nature chemistry (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society (2024)
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman, Bruce K Hua, Christopher J Gerry, Guoqin Xia, Heather L Osswald, John M Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I C Tresco, Shuang Liu, Andrew G Reidenbach, Katherine S Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M Gampe, Nichola J Smith, James E Bradner, Connor W Coley, Paul A Clemons, Bruno Melillo, C Suk-Yee Hon, Johannes Ottl, Christoph E Dumelin, Jonas V Schaefer, Ann Marie E Faust, Frédéric Berst, Stuart L Schreiber, Frédéric J Zécri, Karin Briner
Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature communications 14 (1) (2023)
Yongfeng Tao, David Remillard, Ekaterina V Vinogradova, Minoru Yokoyama, Sofia Banchenko, David Schwefel, Bruno Melillo, Stuart L Schreiber, Xiaoyu Zhang, Benjamin F Cravatt
Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1". Journal of the American Chemical Society (2023)
Sebastian Shaw, Ian S Cohn, Rodrigo de Paula Baptista, Guoqin Xia, Bruno Melillo, Fiifi A Dadzie, Jessica C Kissinger, Boris Striepen
Genetic crosses within and between species of Cryptosporidium . bioRxiv : the preprint server for biology (2023)
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman, Bruce K Hua, Christopher J Gerry, Guoqin Xia, Heather L Osswald, John M Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I C Tresco, Shuang Liu, Andrew G Reidenbach, Katherine S Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M Gampe, Nichola J Smith, James E Bradner, Connor W Coley, Paul A Clemons, Bruno Melillo, C Suk-Yee Hon, Johannes Ottl, Christoph E Dumelin, Jonas V Schaefer, Ann Marie E Faust, Frédéric Berst, Stuart L Schreiber, Frédéric J Zécri, Karin Briner
Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature communications 14 (1) (2023)
Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin Tianmeng Zhao, Tony P Huang, Bingwen Lu, Gabriel M Simon, Bruno Melillo, Stuart L Schreiber, Jens Lykke-Andersen, David R Liu, Benjamin F Cravatt
Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology (2023)
Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L Schreiber, Anil K Gupta, Arnab K Chatterjee, L David Sibley
Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase. Nature communications 13 (1) (2022)
Alex Reed, Taka-Aki Ichu, Natalia Milosevich, Bruno Melillo, Michael A Schafroth, Yuka Otsuka, Louis Scampavia, Timothy P Spicer, Benjamin F Cravatt
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. ACS chemical biology 17 (6) (2022)
Yongfeng Tao, David Remillard, Ekaterina V Vinogradova, Minoru Yokoyama, Sofia Banchenko, David Schwefel, Bruno Melillo, Stuart L Schreiber, Xiaoyu Zhang, Benjamin F Cravatt
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. Journal of the American Chemical Society 144 (40) (2022)
Claudia A Jette, Christopher O Barnes, Sharon M Kirk, Bruno Melillo, Amos B Smith, Pamela J Bjorkman
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nature communications 12 (1) (2021)
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Heena Tabassum, Branko Mitasev, Francis G Fang, Stuart L Schreiber, Amit Sharma
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines. Nature communications 12 (1) (2021)
Sumiti Vinayak, Rajiv S Jumani, Peter Miller, Muhammad M Hasan, Briana I McLeod, Jayesh V Tandel, Erin E Stebbins, Jose E Teixeira, Julien Borrel, Arthur Gonse, Mingliang Zhang, Xianshui Yu, Amy Wernimont, Chris Walpole, Sean Eckley, Melissa S Love, Case W MacNamara, Manmohan Sharma, Amit Sharma, Christina A Scherer, Nobutaka Kato, Stuart L Schreiber, Bruno Melillo, Boris Striepen, Christopher D Huston, Eamon Comer
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase. Science translational medicine 12 (563) (2021)
Guoqin Xia, Zhe Zhuang, Luo-Yan Liu, Stuart L Schreiber, Bruno Melillo, Jin-Quan Yu
Ligand-Enabled β-Methylene C(sp3 )-H Arylation of Masked Aliphatic Alcohols. Angewandte Chemie (International ed. in English) 59 (20) (2020)

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Publication Activity (10 Years)

Top Topics

Top Venues

Bruno Melillo