L David Sibley

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 59

Top Topics

Transcription Factor

Toxoplasma Gondii

Immune Response

Top Venues

Nature communications

ACS infectious diseases

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum . bioRxiv : the preprint server for biology (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases (2024)
Jing Xia, Wanyi Huang, Taher Uddin, L David Sibley
Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii . mBio (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum . bioRxiv : the preprint server for biology (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics 20 (6) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases (2024)
Jing Xia, Wanyi Huang, Taher Uddin, L David Sibley
Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii . mBio (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Vitul Jain, Eamon Comer, Stuart L Schreiber, Bruno Melillo, L David Sibley, Arnab K Chatterjee
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases 10 (6) (2024)
Brittany Henry, Aubrey J Phillips, L David Sibley, Alex Rosenberg
A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death. mBio (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics 20 (6) (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications 15 (1) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics 20 (6) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics 20 (6) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics 20 (6) (2024)
Abigail K Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H Witola, L David Sibley
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum . bioRxiv : the preprint server for biology (2024)
Marianna E Akey, Rui Xu, Soumya Ravindran, Lisa Funkhouser-Jones, L David Sibley
Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum. mBio (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Marianna E Akey, Rui Xu, Soumya Ravindran, Lisa Funkhouser-Jones, L David Sibley
Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum. mBio 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Marianna E Akey, Rui Xu, Soumya Ravindran, Lisa Funkhouser-Jones, L David Sibley
Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum. mBio 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Lisa J Funkhouser-Jones, Rui Xu, Georgia Wilke, Yong Fu, Lawrence A Shriefer, Heyde Makimaa, Rachel Rodgers, Elizabeth A Kennedy, Kelli L VanDussen, Thaddeus S Stappenbeck, Megan T Baldridge, L David Sibley
Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth. bioRxiv : the preprint server for biology (2023)
Marianna E Akey, Rui Xu, Soumya Ravindran, Lisa Funkhouser-Jones, L David Sibley
Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum. mBio 14 (1) (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Nicholas Rinkenberger, Alex Rosenberg, Joshua B Radke, Jaya Bhushan, Tadakimi Tomita, Louis M Weiss, L David Sibley
Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci. mBio (2023)
Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, L David Sibley
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Alex Rosenberg, L David Sibley
Epigenetic Modifiers Alter Host Cell Transcription to Promote Toxoplasma Infection. ACS infectious diseases 8 (3) (2022)
Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L Schreiber, Anil K Gupta, Arnab K Chatterjee, L David Sibley
Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase. Nature communications 13 (1) (2022)
Zhou Huang, Hejun Liu, Jay C Nix, Rui Xu, Catherine R Knoverek, Gregory R Bowman, Gaya K Amarasinghe, L David Sibley
The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nature communications 13 (1) (2022)
Yong Fu, Kevin M Brown, Nathaniel G Jones, Silvia N J Moreno, L David Sibley
Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress. eLife 10 (2021)
Sumit K Matta, Nicholas Rinkenberger, Ildiko R Dunay, L David Sibley
Toxoplasma gondii infection and its implications within the central nervous system. Nature reviews. Microbiology 19 (7) (2021)
Nicholas Rinkenberger, Michael E Abrams, Sumit K Matta, John W Schoggins, Neal M Alto, L David Sibley
Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection. eLife 10 (2021)
Rui Xu, Yaoyu Feng, Lihua Xiao, L David Sibley
Insulinase-like Protease 1 Contributes to Macrogamont Formation in Cryptosporidium parvum. mBio 12 (2) (2021)
Jaya Bhushan, Joshua B Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J Lenschow, Herbert W Virgin, L David Sibley
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells. mBio 11 (5) (2020)
Kelli L VanDussen, Lisa J Funkhouser-Jones, Marianna E Akey, Deborah A Schaefer, Kevin Ackman, Michael W Riggs, Thaddeus S Stappenbeck, L David Sibley
Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. mBio 11 (6) (2020)
Roxane Tussiwand, Michael S Behnke, Nicole M Kretzer, Gary E Grajales-Reyes, Theresa L Murphy, Robert D Schreiber, Kenneth M Murphy, L David Sibley
An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3. mSphere 5 (4) (2020)
James W Janetka, Allen T Hopper, Ziping Yang, Jennifer Barks, Mary Savari Dhason, Qiuling Wang, L David Sibley
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis. Journal of medicinal chemistry 63 (11) (2020)
Allen T Hopper, Adam Brockman, Andy Wise, Julie Gould, Jennifer Barks, Joshua B Radke, L David Sibley, Yongmao Zou, Stephen Thomas
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. Journal of medicinal chemistry 62 (3) (2019)
Lisa L Drewry, L David Sibley
The hitchhiker's guide to parasite dissemination. Cellular microbiology 21 (11) (2019)
Lisa L Drewry, Nathaniel G Jones, Quiling Wang, Michael D Onken, Mark J Miller, L David Sibley
The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration. Nature microbiology 4 (11) (2019)
Derek J Theisen, Jesse T Davidson, Carlos G Briseño, Marco Gargaro, Elvin J Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R Brickner, Wandy L Beatty, Herbert W Virgin, William E Gillanders, Nima Mosammaparast, Michael S. Diamond, L David Sibley, Wayne M Yokoyama, Robert D Schreiber, Theresa L Murphy, Kenneth M Murphy
WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science (New York, N.Y.) 362 (6415) (2019)
Michael P Barrett, Dennis E Kyle, L David Sibley, Joshua B Radke, Rick L Tarleton
Protozoan persister-like cells and drug treatment failure. Nature reviews. Microbiology 17 (10) (2019)
Joshua B Radke, Kimberly L Carey, Subrata Shaw, Shailesh R Metkar, Carol Mulrooney, Jennifer P Gale, Joshua A Bittker, Robert Hilgraf, Eamon Comer, Stuart L Schreiber, Herbert W Virgin, Jose R Perez, L David Sibley
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth. ACS infectious diseases 4 (10) (2018)
Joshua B Radke, Jeremy N Burrows, Daniel E Goldberg, L David Sibley
Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro. ACS infectious diseases 4 (8) (2018)
Zi T Wang, Shiv K Verma, Jitender P Dubey, L David Sibley
The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat. PLoS pathogens 13 (3) (2017)
Shaojun Long, Bryan Anthony, Lisa L Drewry, L David Sibley
A conserved ankyrin repeat-containing protein regulates conoid stability, motility and cell invasion in Toxoplasma gondii. Nature communications 8 (1) (2017)
Shaojun Long, Kevin M Brown, Lisa L Drewry, Bryan Anthony, Isabelle Q H Phan, L David Sibley
Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii. PLoS pathogens 13 (5) (2017)
Florentine U Rutaganira, Jennifer Barks, Mary Savari Dhason, Qiuling Wang, Michael S Lopez, Shaojun Long, Joshua B Radke, Nathaniel G Jones, Amarendar R Maddirala, James W Janetka, Majida El Bakkouri, Raymond Hui, Kevan M Shokat, L David Sibley
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. Journal of medicinal chemistry 60 (24) (2017)