James E Bradner

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 25

Top Venues

Nature communications

Nature chemical biology

Nature genetics

Nature medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Amelia E Hinman, Alejandro Reyes, Nicolas Pizzato, Barna D Fodor, Fabian Wu, Muluken S Belew, Xiaohong Mao, Jian Wang, Shripad Chitnis, Wei Niu, Amanda Hachey, Jennifer S Cobb, Nikolas A Savage, Ashley Burke, Joshiawa Paulk, Dustin Dovala, James Lin, Matthew C Clifton, Elizabeth Ornelas, Xiaolei Ma, Nathaniel F Ware, Carina C Sanchez, John Taraszka, Remi Terranova, Judith Knehr, Marc Altorfer, S Whitney Barnes, Rohan E J Beckwith, Jonathan M Solomon, Natalie A Dales, Andrew W Patterson, Juergen Wagner, Tewis Bouwmeester, Glenn Dranoff, Susan C Stevenson, James E Bradner
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science (New York, N.Y.) 385 (6704) (2024)
Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Amelia E Hinman, Alejandro Reyes, Nicolas Pizzato, Barna D Fodor, Fabian Wu, Muluken S Belew, Xiaohong Mao, Jian Wang, Shripad Chitnis, Wei Niu, Amanda Hachey, Jennifer S Cobb, Nikolas A Savage, Ashley Burke, Joshiawa Paulk, Dustin Dovala, James Lin, Matthew C Clifton, Elizabeth Ornelas, Xiaolei Ma, Nathaniel F Ware, Carina C Sanchez, John Taraszka, Remi Terranova, Judith Knehr, Marc Altorfer, S Whitney Barnes, Rohan E J Beckwith, Jonathan M Solomon, Natalie A Dales, Andrew W Patterson, Juergen Wagner, Tewis Bouwmeester, Glenn Dranoff, Susan C Stevenson, James E Bradner
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science (New York, N.Y.) 385 (6704) (2024)
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman, Bruce K Hua, Christopher J Gerry, Guoqin Xia, Heather L Osswald, John M Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I C Tresco, Shuang Liu, Andrew G Reidenbach, Katherine S Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M Gampe, Nichola J Smith, James E Bradner, Connor W Coley, Paul A Clemons, Bruno Melillo, C Suk-Yee Hon, Johannes Ottl, Christoph E Dumelin, Jonas V Schaefer, Ann Marie E Faust, Frédéric Berst, Stuart L Schreiber, Frédéric J Zécri, Karin Briner
Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature communications 14 (1) (2023)
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L Downey-Kopyscinski, Geoffrey M Matthews, Benjamin G Barwick, Vilas A Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M Meyers, Jordan G Bryan, Neekesh V Dharia, Paul J Hengeveld, Johanna B Brüggenthies, Huihui Tang, Andrew J Aguirre, Quinlan L Sievers, Benjamin L Ebert, Brian J Glassner, Christopher J Ott, James E Bradner, Nicholas P Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J Keats, Richard W J Groen, Nathanael S Gray, Aedin C Culhane, James M McFarland, Joshua M Dempster, Jonathan D Licht, Lawrence H Boise, William C Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S Mitsiades
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature cancer 4 (5) (2023)
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman, Bruce K Hua, Christopher J Gerry, Guoqin Xia, Heather L Osswald, John M Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I C Tresco, Shuang Liu, Andrew G Reidenbach, Katherine S Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M Gampe, Nichola J Smith, James E Bradner, Connor W Coley, Paul A Clemons, Bruno Melillo, C Suk-Yee Hon, Johannes Ottl, Christoph E Dumelin, Jonas V Schaefer, Ann Marie E Faust, Frédéric Berst, Stuart L Schreiber, Frédéric J Zécri, Karin Briner
Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature communications 14 (1) (2023)
Taylor Gill, Haichuan Wang, Raj Bandaru, Matthew A Lawlor, Chenyue Lu, Linda T Nieman, Junyan Tao, Yixian Zhang, Daniel G Anderson, David Tsai Ting, Xin Chen, James E Bradner, Christopher J Ott
Selective targeting of MYC mRNA by stabilized antisense oligonucleotides. Oncogene 40 (47) (2021)
Martin G Jaeger, Björn Schwalb, Sebastian D Mackowiak, Taras Velychko, Alexander Hanzl, Hana Imrichova, Matthias Brand, Benedikt Agerer, Someth Chorn, Behnam Nabet, Fleur M Ferguson, André C Müller, Andreas Bergthaler, Nathanael S Gray, James E Bradner, Christoph Bock, Denes Hnisz, Patrick Cramer, Georg E Winter
Selective Mediator dependence of cell-type-specifying transcription. Nature genetics 52 (7) (2020)
Behnam Nabet, Fleur M Ferguson, Bo Kyung A Seong, Miljan Kuljanin, Alan L Leggett, Mikaela L Mohardt, Amanda Robichaud, Amy S Conway, Dennis L Buckley, Joseph D Mancias, James E Bradner, Kimberly Stegmaier, Nathanael S Gray
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nature communications 11 (1) (2020)
Aline Gaub, Bilal N Sheikh, Maria Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J Bird, James E Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature communications 11 (1) (2020)
Pratiti Bandopadhayay, Frederica Piccioni, Ryan O'Rourke, Patricia Ho, Elizabeth M Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L Tiv, Andrew L Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S Cowley, Fred C Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C Hahn, Aviad Tsherniak, James E Bradner, Michael B Yaffe, Till Milde, Stefan M Pfister, Jun Qi, Monica Schenone, Steven A Carr, Keith L Ligon, Mark W Kieran, Sandro Santagata, James M Olson, Prafulla C Gokhale, Jacob D Jaffe, David E Root, Kimberly Stegmaier, Cory M Johannessen, Rameen Beroukhim
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature communications 10 (1) (2019)
David P Labbé, Giorgia Zadra, Meng Yang, Jaime M Reyes, Charles Y Lin, Stefano Cacciatore, Ericka M Ebot, Amanda L Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D Karoly, Mohammed Alshalalfa, Nicholas Erho, Ashley Ross, Edward M Schaeffer, Ewan A Gibb, Mandeep Takhar, Robert B Den, Jonathan Lehrer, R Jeffrey Karnes, Stephen J Freedland, Elai Davicioni, Daniel E Spratt, Leigh Ellis, Jacob D Jaffe, Anthony V DʼAmico, Philip W Kantoff, James E Bradner, Lorelei A Mucci, Jorge E Chavarro, Massimo Loda, Myles Brown
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program. Nature communications 10 (1) (2019)
Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F M Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y Lin, James E Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio Giacomo Galli
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma. Nature communications 10 (1) (2019)
Sara Sdelci, André Figueiredo Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G Lin, Anna Ringler, Gerald Hofstätter, Herwig P Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael K Schuster, Thomas Penz, Dennis L Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans Michael Maric, Robert Kralovics, Keiryn L Bennett, Andre C Müller, Karl Mechtler, J Formula See Text Rg Menche, James E Bradner, Georg E Winter, Kristaps Klavins, Emilio Casanova, Christoph Bock, Johannes Zuber, Stefan Kubicek
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nature genetics 51 (6) (2019)
Tanaz Sharifnia, Mathias J Wawer, Ting Chen, Qing-Yuan Huang, Barbara A Weir, Ann Sizemore, Matthew A Lawlor, Amy Goodale, Glenn S Cowley, Francisca Vazquez, Christopher J Ott, Joshua M Francis, Slim Sassi, Patricia Cogswell, Hadley E Sheppard, Tinghu Zhang, Nathanael S Gray, Paul Andrew Clarke, Julian Blagg, Paul Workman, Josh Sommer, Francis Hornicek, David E Root, William C Hahn, James E Bradner, Kwok K Wong, Paul A Clemons, Charles Y Lin, Joanne D Kotz, Stuart L Schreiber
Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature medicine 25 (2) (2019)
Qiming Duan, Sarah McMahon, Priti Anand, Hirsh Shah, Sean Thomas, Hazel T Salunga, Yu Huang, Rongli Zhang, Aarathi Sahadevan, Madeleine E Lemieux, Jonathan D Brown, Deepak Srivastava, James E Bradner, Timothy A McKinsey, Saptarsi M Haldar
BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Science translational medicine 9 (390) (2018)
Jay H Kalin, Muzhou Wu, Andrea V Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J Roberts, Justin M Roberts, Polina Prusevich, Jeliazko R Jeliazkov, Shourya S Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M Proby, Albena T Dinkova-Kostova, Wayne W Hancock, Jeffrey J Gray, James E Bradner, Sergio Valente, Antonello Mai, Nicole M Anders, Michelle A Rudek, Yong Hu, Byungwoo Ryu, John W R Schwabe, Andrea Mattevi, Rhoda M Alani, Philip A Cole
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nature communications 9 (1) (2018)
Radosław P Nowak, Stephen L DeAngelo, Dennis Buckley, Zhixiang He, Katherine A Donovan, Jian An, Nozhat Safaee, Mark P Jedrychowski, Charles M Ponthier, Mette Ishoey, Tinghu Zhang, Joseph D Mancias, Nathanael S Gray, James E Bradner, Eric S Fischer
Plasticity in binding confers selectivity in ligand-induced protein degradation. Nature chemical biology 14 (7) (2018)
Behnam Nabet, Justin M Roberts, Dennis L Buckley, Joshiawa Paulk, Shiva Dastjerdi, Annan Yang, Alan L Leggett, Michael A Erb, Matthew A Lawlor, Amanda Souza, Thomas G Scott, Sarah Vittori, Jennifer A Perry, Jun Qi, Georg E Winter, Kwok-Kin Wong, Nathanael S Gray, James E Bradner
The dTAG system for immediate and target-specific protein degradation. Nature chemical biology 14 (5) (2018)
Rhamy Zeid, Matthew A Lawlor, Evon Poon, Jaime M Reyes, Mariateresa Fulciniti, Michael A Lopez, Thomas G Scott, Behnam Nabet, Michael A Erb, Georg E Winter, Zoe Jacobson, Donald R Polaski, Kristen L Karlin, Rachel A Hirsch, Nikhil P Munshi, Thomas F Westbrook, Louis Chesler, Charles Y Lin, James E Bradner
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Nature genetics 50 (4) (2018)
Lara N Gechijian, Dennis L Buckley, Matthew A Lawlor, Jaime M Reyes, Joshiawa Paulk, Christopher J Ott, Georg E Winter, Michael A Erb, Thomas G Scott, Mousheng Xu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Nicholas P Kwiatkowski, Jennifer A Perry, Jun Qi, Nathanael S Gray, James E Bradner
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nature chemical biology 14 (4) (2018)
Shuai Liu, Hailemichael O Yosief, Lingling Dai, He Huang, Gagan Dhawan, Xiaofeng Zhang, Alex M Muthengi, Justin Roberts, Dennis L Buckley, Jennifer A Perry, Lei Wu, James E Bradner, Jun Qi, Wei Zhang
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. Journal of medicinal chemistry 61 (17) (2018)
Xiangpeng Dai, Wenjian Gan, Xiaoning Li, Shangqian Wang, Wei Zhang, Ling Huang, Shengwu Liu, Qing Zhong, Jianping Guo, Jinfang Zhang, Ting Chen, Kouhei Shimizu, Francisco Beca, Mirjam Blattner, Divya Vasudevan, Dennis L Buckley, Jun Qi, Lorenz Buser, Pengda Liu, Hiroyuki Inuzuka, Andrew H Beck, Liewei Wang, Peter J Wild, Levi A Garraway, Mark A Rubin, Christopher E Barbieri, Kwok-Kin Wong, Senthil K Muthuswamy, Jiaoti Huang, Yu Chen, James E Bradner, Wenyi Wei
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature medicine 23 (9) (2017)
Calla M Olson, Baishan Jiang, Michael A Erb, Yanke Liang, Zainab M Doctor, Zinan Z Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S Fischer, Richard A Young, James E Bradner, Georg E Winter, Nathanael S Gray
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature chemical biology 14 (2) (2017)
David Remillard, Dennis L Buckley, Joshiawa Paulk, Gerard L Brien, Matthew Sonnett, Hyuk-Soo Seo, Shiva Dastjerdi, Martin Wühr, Sirano Dhe-Paganon, Scott A Armstrong, James E Bradner
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angewandte Chemie (International ed. in English) 56 (21) (2017)
Luke W Koblan, Dennis L Buckley, Christopher J Ott, Mark E Fitzgerald, Stuart W J Ember, Jin-Yi Zhu, Shuai Liu, Justin M Roberts, David Remillard, Sarah Vittori, Wei Zhang, Ernst Schonbrunn, James E Bradner
Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET. ChemMedChem 11 (23) (2016)

James E Bradner.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

James E Bradner