Caroline A Heckman (Caroline Heckman)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Acute Myeloid Leukemia

Multiple Myeloma

Machine Learning

Tyrosine Kinase

Top Venues

Signal transduction and targeted therapy

This page only lists publications with an associated author ORCID identifier.

Publications

Samuli Eldfors, Joseph Saad, Nemo Koi Ikonen, Disha Malani, Markus Vähä-Koskela, Bjorn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A Heckman
Monosomy 7/del(7q) Cause Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia. Blood advances (2024)
Mehdi Mirzaie, Elham Gholizadeh, Juho J Miettinen, Filipp Ianevski, Tanja Ruokoranta, Jani Saarela, Mikko Manninen, Susanna Miettinen, Caroline A Heckman, Mohieddin Jafari
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling. Oncogenesis 13 (1) (2024)
Caroline A Heckman
A menin-KMT2A inhibitor to overcome resistance. Blood 144 (11) (2024)
Tero Satomaa, Henna Pynnönen, Olli Aitio, Jukka O Hiltunen, Virve Pitkänen, Tuula Lähteenmäki, Titta Kotiranta, Annamari Heiskanen, Anna-Liisa Hänninen, Ritva Niemelä, Jari Helin, Heikki Kuusanmäki, Ida Vänttinen, Ramji Rathod, Anni I Nieminen, Emrah Yatkin, Caroline A Heckman, Mika Kontro, Juhani Saarinen
Targeting CD33+ acute myeloid leukemia with GLK-33, a lintuzumab-auristatin conjugate with a wide therapeutic window. Molecular cancer therapeutics (2024)
Samuli Eldfors, Joseph Saad, Nemo Ikonen, Disha Malani, Markus Vähä-Koskela, Bjorn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A Heckman
Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia. Blood advances 8 (7) (2024)
Mehdi Mirzaie, Elham Gholizadeh, Juho J Miettinen, Filipp Ianevski, Tanja Ruokoranta, Jani Saarela, Mikko Manninen, Susanna Miettinen, Caroline A Heckman, Mohieddin Jafari
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling. Oncogenesis 13 (1) (2024)
Tero Satomaa, Henna Pynnönen, Olli Aitio, Jukka O Hiltunen, Virve Pitkänen, Tuula Lähteenmäki, Titta Kotiranta, Annamari Heiskanen, Anna-Liisa Hänninen, Ritva Niemelä, Jari Helin, Heikki Kuusanmäki, Ida Vänttinen, Ramji Rathod, Anni I Nieminen, Emrah Yatkin, Caroline A Heckman, Mika Kontro, Juhani Saarinen
Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window. Molecular cancer therapeutics 23 (8) (2024)
Samuli Eldfors, Joseph Saad, Nemo Ikonen, Disha Malani, Markus Vähä-Koskela, Bjorn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A Heckman
Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia. Blood advances 8 (7) (2024)
Angeliki Katsenou, Roisin O'Farrell, Paul Dowling, Caroline A Heckman, Peter O'Gorman, Despina Bazou
Using Proteomics Data to Identify Personalized Treatments in Multiple Myeloma: A Machine Learning Approach. International journal of molecular sciences 24 (21) (2023)
Katie Dunphy, Despina Bazou, Michael Henry, Paula Meleady, Juho J Miettinen, Caroline A Heckman, Paul Dowling, Peter O'Gorman
Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures. Cancers 15 (15) (2023)
Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsán, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig, Csaba Bödör, John Gribben, Caroline A Heckman, Jude Fitzgibbon, Pedro Rodriguez Cutillas
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Signal transduction and targeted therapy 8 (1) (2023)
Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsán, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig, Csaba Bödör, John Gribben, Caroline A Heckman, Jude Fitzgibbon, Pedro Rodriguez Cutillas
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Signal transduction and targeted therapy 8 (1) (2023)
Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsán, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig, Csaba Bödör, John Gribben, Caroline A Heckman, Jude Fitzgibbon, Pedro Rodriguez Cutillas
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Signal transduction and targeted therapy 8 (1) (2023)
Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsán, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig, Csaba Bödör, John Gribben, Caroline A Heckman, Jude Fitzgibbon, Pedro Rodriguez Cutillas
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Signal transduction and targeted therapy 8 (1) (2023)
Alisa Olkinuora, Taina T Nieminen, Suvi P M Douglas, Anni Kauppinen, Mika Kontro, Juho Väänänen, Matti Kankainen, Ari Ristimäki, Markus Mäkinen, Päivi Lahermo, Caroline A Heckman, Janna Saarela, Milla K Ahola, Anna Lepistö, Heikki Järvinen, Jukka-Pekka Mecklin, Outi Kilpivaara, Ulla Wartiovaara-Kautto, Kimmo Porkka, Päivi Peltomäki
Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia. Leukemia (2023)
Sini Luoma, Philipp Sergeev, Komal Kumar Javarappa, Tiina J Öhman, Markku Varjosalo, Marjaana Säily, Pekka Anttila, Marja Sankelo, Partanen Anu, Anne Nihtinen, Caroline A Heckman, Raija Silvennoinen
Deep Immune Profiling of Multiple Myeloma at Diagnosis and under Lenalidomide Maintenance Therapy. Cancers 15 (9) (2023)
Sini Luoma, Philipp Sergeev, Komal Kumar Javarappa, Tiina J Öhman, Markku Varjosalo, Marjaana Säily, Pekka Anttila, Marja Sankelo, Partanen Anu, Anne Nihtinen, Caroline A Heckman, Raija Silvennoinen
Deep Immune Profiling of Multiple Myeloma at Diagnosis and under Lenalidomide Maintenance Therapy. Cancers 15 (9) (2023)
Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Maria Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Otto Vilhelm Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho J Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko A I Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A Heckman, Mohamed El Missiry
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia. Blood (2022)
Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Maria Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Otto Vilhelm Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho J Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko A I Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A Heckman, Mohamed El Missiry
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia. Blood (2022)
Aarif M N Batcha, Nele Buckup, Stefanos A Bamopoulos, Vindi Jurinovic, Maja Rothenberg-Thurley, Hanna Gittinger, Bianka Ksienzyk, Annika Dufour, Stephanie Schneider, Mika Kontro, Joseph Saad, Caroline A Heckman, Cristina M Sauerland, Dennis Görlich, Wolfgang E Berdel, Bernhard Wörmann, Utz Krug, Jan Braess, Ulrich Robert Mansmann, Wolfgang Hiddemann, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML. Blood advances (2022)
Weikaixin Kong, Liye He, Jie Zhu, Oscar Brück, Kimmo Porkka, Caroline A Heckman, Sujie Zhu, Tero Aittokallio
An immunity and pyroptosis gene-pair signature predicts overall survival in acute myeloid leukemia. Leukemia 36 (10) (2022)
Saara Laukkanen, Alexandra Veloso, Chuan Yan, Laura Oksa, Eric J Alpert, Daniel Do, Noora Hyvärinen, Karin McCarthy, Abhinav Adhikari, Qiqi Yang, Sowmya Iyer, Sara P Garcia, Annukka Pello, Tanja Ruokoranta, Sanni Moisio, Sadiksha Adhikari, Jeffrey A Yoder, Kayleigh Gallagher, Lauren Whelton, James R Allen, Alexander H Jin, Siebe Loontiens, Merja Heinäniemi, Michelle Kelliher, Caroline A Heckman, Olli Lohi, David M Langenau
Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia. Blood 140 (17) (2022)
William Grey, Ana Rio-Machin, Pedro Casado, Eva Grönroos, Sara Ali, Juho J Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A Heckman, Charles Swanton, Pedro Rodriguez Cutillas, John G Gribben, Jude Fitzgibbon, Dominique Bonnet
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia. Science translational medicine 14 (650) (2022)
Ujunwa Cynthia Okoye-Okafor, Komal K Javarappa, Dimitrios Tsallos, Joseph Saad, Daozheng Yang, Chi Zhang, Lumie Benard, Victor J Thiruthuvanathan, Sally L Cole, Stephen B Ruiz, Madhuri Tatiparthy, Gaurav Choudhary, Stefanie DeFronzo, Boris A Bartholdy, Celine Pallaud, Pedro Marques Ramos, Aditi Shastri, Amit K Verma, Caroline A Heckman, Britta Will
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine. The Journal of experimental medicine 219 (11) (2022)
Arjen Gebraad, Roope Ohlsbom, Juho J Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N Nupponen, Caroline A Heckman, Susanna Miettinen
Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen. Cells 11 (9) (2022)
Mohieddin Jafari, Mehdi Mirzaie, Jie Bao, Farnaz Barneh, Shuyu Zheng, Johanna Eriksson, Caroline A Heckman, Jing Tang
Bipartite network models to design combination therapies in acute myeloid leukaemia. Nature communications 13 (1) (2022)
Marja Hakkarainen, Jessica R Koski, Caroline A Heckman, Pekka Anttila, Raija Silvennoinen, Juha Lievonen, Outi Kilpivaara, Ulla Waitiovaara-Kautto
A germline exome analysis reveals harmful POT1 variants in multiple myeloma patients and families. EJHaem 3 (4) (2022)
Juho J Miettinen, Romika Kumari, Gunnhildur Asta Traustadottir, Maiju-Emilia Huppunen, Philipp Sergeev, Muntasir M Majumder, Alexander Schepsky, Thorarinn Gudjonsson, Juha Lievonen, Despina Bazou, Paul Dowling, Peter O Gorman, Ana Slipicevic, Pekka Anttila, Raija Silvennoinen, Nina N Nupponen, Fredrik Lehmann, Caroline A Heckman
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen. Cancers 13 (7) (2021)
Brian S White, Suleiman A Khan, Mike J Mason, Muhammad Ammad-Ud-Din, Swapnil Potdar, Disha Malani, Heikki Kuusanmäki, Brian J Druker, Caroline A Heckman, Olli Kallioniemi, Stephen E Kurtz, Kimmo Porkka, Cristina E Tognon, Jeffrey W Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia. NPJ precision oncology 5 (1) (2021)
Disha Malani, Ashwini Kumar, Oscar Bruck, Mika Kontro, Bhagwan Yadav, Monica Hellesøy, Heikki Kuusanmaki, Olli Dufva, Matti Kankainen, Samuli Eldfors, Swapnil Potdar, Jani Saarela, Laura Turunen, Alun Parsons, Imre Vastrik, Katja Kivinen, Janna Saarela, Riikka Raty, Minna Lehto, Maija Wolf, Bjorn Tore Gjertsen, Mohamed El Missiry, Tero Aittokallio, Krister Wennerberg, Caroline A Heckman, Olli Kallioniemi, Kimmo Porkka
Implementing a functional precision medicine tumor board for acute myeloid leukemia. Cancer discovery (2021)
Romika Kumari, Muntasir Mamun Majumder, Juha Lievonen, Raija Silvennoinen, Pekka Anttila, Nina N Nupponen, Fredrik Lehmann, Caroline A Heckman
Prognostic significance of esterase gene expression in multiple myeloma. British journal of cancer 124 (8) (2021)
Ashwini Kumar, Sadiksha Adhikari, Matti Kankainen, Caroline A Heckman
Comparison of Structural and Short Variants Detected by Linked-Read and Whole-Exome Sequencing in Multiple Myeloma. Cancers 13 (6) (2021)
Paul Dowling, Ciara Tierney, Katie Dunphy, Juho J Miettinen, Caroline A Heckman, Despina Bazou, Peter O'Gorman
Identification of Protein Biomarker Signatures for Acute Myeloid Leukemia (AML) Using Both Nontargeted and Targeted Approaches. Proteomes 9 (4) (2021)
Aleksandr Ianevski, Evgeny Kulesskiy, Klara Krpina, Guofeng Lou, Yahyah Aman, Andrii Bugai, Koit Aasumets, Yevhen Akimov, Daria Bulanova, Kiira Gildemann, Albert F Arutyunyan, Olga Yu Susova, Alexei L Zhuze, Ping Ji, Wei Wang, Toril Holien, Marit Bugge, Eva Zusinaite, Valentyn Oksenych, Hilde Lysvand, Joachim M Gerhold, Magnar Bjørås, Pål Johannsen, Anders Waage, Caroline A Heckman, Evandro Fei Fang, Denis E Kainov
Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis. Cancers 12 (6) (2020)
Alina Malyutina, Muntasir Mamun Majumder, Wenyu Wang, Alberto Pessia, Caroline A Heckman, Jing Tang
Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer. PLoS computational biology 15 (5) (2019)
Komal K Javarappa, Dimitrios Tsallos, Caroline A Heckman
A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow. SLAS discovery : advancing life sciences R & D 23 (7) (2018)
Riikka Karjalainen, Tea Pemovska, Mihaela Popa, Minxia Liu, Komal K Javarappa, Muntasir M Majumder, Bhagwan Yadav, David Tamborero, Jing Tang, Dmitrii Bychkov, Mika Kontro, Alun Parsons, Minna Suvela, Mireia Mayoral Safont, Kimmo Porkka, Tero Aittokallio, Olli Kallioniemi, Emmet McCormack, Bjørn T Gjertsen, Krister Wennerberg, Jonathan Knowles, Caroline A Heckman
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML. Blood 130 (6) (2017)