Carsten Hoffmann (Carsten Hoffman, C Hoffmann)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Topics

Molecular Dynamics Simulations

Transcription Factor

Top Venues

Nature communications

Hepatology communications

Molecular pharmacology

Communications biology

This page only lists publications with an associated author ORCID identifier.

Publications

Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology communications 8 (4) (2024)
Edda Sofie Fabienne Matthees, Carsten Hoffmann
The Ca 2+ -sensing receptor and the pocketome: comparing nature's complexity with human intervention in receptor modulation. Signal transduction and targeted therapy 9 (1) (2024)
Edda Sofie Fabienne Matthees, Carsten Hoffmann
The Ca 2+ -sensing receptor and the pocketome: comparing nature's complexity with human intervention in receptor modulation. Signal transduction and targeted therapy 9 (1) (2024)
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology communications 8 (4) (2024)
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology communications 8 (4) (2024)
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology communications 8 (4) (2024)
Aurelien M Zarca, Ilze Adlere, Cristina P Viciano, Marta Arimont-Segura, Max Meyrath, Icaro A Simon, Jan Paul Bebelman, Dennis Laan, Hans G J Custers, Elwin Janssen, Kobus L Versteegh, Maurice C M L Buzink, Desislava N Nesheva, Reggie Bosma, Iwan J P de Esch, Henry F Vischer, Maikel Wijtmans, Martyna Szpakowska, Andy Chevigné, Carsten Hoffmann, Chris de Graaf, Barbara A Zarzycka, Albert D Windhorst, Martine J Smit, Rob Leurs
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3. Molecular pharmacology 105 (4) (2024)
Edda Sofie Fabienne Matthees, Carsten Hoffmann
The Ca 2+ -sensing receptor and the pocketome: comparing nature's complexity with human intervention in receptor modulation. Signal transduction and targeted therapy 9 (1) (2024)
Aurelien M Zarca, Ilze Adlere, Cristina P Viciano, Marta Arimont-Segura, Max Meyrath, Icaro A Simon, Jan Paul Bebelman, Dennis Laan, Hans G J Custers, Elwin Janssen, Kobus L Versteegh, Maurice C M L Buzink, Desislava N Nesheva, Reggie Bosma, Iwan J P de Esch, Henry F Vischer, Maikel Wijtmans, Martyna Szpakowska, Andy Chevigné, Carsten Hoffmann, Chris de Graaf, Barbara A Zarzycka, Albert D Windhorst, Martine J Smit, Rob Leurs
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3. Molecular pharmacology 105 (4) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology communications 8 (4) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Aurelien Zarca, Ilze Adlere, Cristina P Viciano, Marta Arimont-Segura, Max Meyrath, Icaro A Simon, Jan Paul Bebelman, Dennis Laan, Hans G J Custers, Elwin Janssen, Kobus L K Versteegh, Maurice Buzink, Desislava Nesheva, Reggie Bosma, Iwan J P de Esch, Henry Vischer, Maikel Wijtmans, Martyna Szpakowska, Andy Chevigné, Carsten Hoffmann, Chris de Graaf, Barbara A Zarzycka, Albert D Windhorst, Martine J Smit, Rob Leurs
Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist for the atypical chemokine receptor ACKR3. Molecular pharmacology (2024)
Christine S Heinz, Marcel Bermudez, Natasha Jaiswal, Carolin Große, Michael Kauk, Carsten Hoffmann, Gerhard Bringmann
Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives. Journal of natural products (2023)
Evi Kostenis, Jesús Gomeza, Elke Miess-Tanneberg, Nina Kathleen Blum, Tobias Benkel, Andy Chevigné, Carsten Hoffmann, Peter Kolb, Viacheslav O Nikolaev, Maria Waldhoer, Martyna Szpakowska, Asuka Inoue, Stefan Schulz
Reply to: How carvedilol does not activate β 2 -adrenoceptors. Nature communications 14 (1) (2023)
Raphael S Haider, Mona Reichel, Edda S F Matthees, Carsten Hoffmann
Conformational flexibility of β-arrestins - How these scaffolding proteins guide and transform the functionality of GPCRs. BioEssays : news and reviews in molecular, cellular and developmental biology (2023)
Marta Sánchez-Soto, Noelia M Boldizsar, Kayla A Schardien, Nora S Madaras, Blair K A Willette, Laura R Inbody, Christopher Dasaro, Amy E Moritz, Julia Drube, Raphael S Haider, R Benjamin Free, Carsten Hoffmann, David R Sibley
G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D 2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. Biomolecules 13 (10) (2023)
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O'Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav O Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
How Carvedilol activates β 2 -adrenoceptors. Nature communications 13 (1) (2022)
Raphael S Haider, Edda Sofie Fabienne Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells. Nature communications 13 (1) (2022)
Julia Drube, Raphael S Haider, Edda Sofie Fabienne Matthees, Mona Reichel, J Zeiner, S Fritzwanker, C Ziegler, S Barz, L Klement, J Filor, V Weitzel, A Kliewer, E Miess-Tanneberg, Evi Kostenis, Stefan Schulz, Carsten Hoffmann
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation. Nature communications 13 (1) (2022)
Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler, Julia Drube, Carsten Degenhart, Julian Engel, Jan Eicke Eickhoff, Pooja Dasgupta, Sebastian Fritzwanker, Maria Guastadisegni, Clemens Schulte, Elke Miess-Tanneberg, Hans Michael Maric, Mariana Spetea, Andrea Kliewer, Matthias Baumann, Bert Klebl, Rainer K Reinscheid, Carsten Hoffmann, Stefan Schulz
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening. Communications biology 5 (1) (2022)
Mona Reichel, Verena Weitzel, Laura Klement, Carsten Hoffmann, Julia Drube
Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots. International journal of molecular sciences 23 (3) (2022)
Ali Işbilir, Jan Möller, Marta Arimont, Vladimir Bobkov, Cristina Perpiñá-Viciano, Carsten Hoffmann, Asuka Inoue, Raimond Heukers, Chris de Graaf, Martine J Smit, Paolo Annibale, Martin J Lohse
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists. Proceedings of the National Academy of Sciences of the United States of America 117 (46) (2020)
Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos Y Schnitzler
Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nature communications 10 (1) (2019)
Marta Arimont, Carsten Hoffmann, Chris de Graaf, Rob Leurs
Chemokine Receptor Crystal Structures: What Can Be Learned from Them? Molecular pharmacology 96 (6) (2019)
Joyce Heuninck, Cristina Perpiñá Viciano, Ali Işbilir, Birgit Caspar, Davide Capoferri, Stephen J Briddon, Thierry Durroux, Stephen J Hill, Martin J Lohse, Graeme Milligan, Jean-Philippe Pin, Carsten Hoffmann
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3. Molecular pharmacology 96 (6) (2019)
Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukas Trantirek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann, Vitezslav Bryja
Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1. Nature communications 10 (1) (2019)
Shane C Wright, Maria Consuelo Alonso Cañizal, Tobias Benkel, Katharina Simon, Christian Le Gouill, Pierre Matricon, Yoon Namkung, Viktoriya Lukasheva, Gabriele M König, Stéphane A Laporte, Jens Carlsson, Evi Kostenis, Michel Bouvier, Gunnar Schulte, Carsten Hoffmann
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science signaling 11 (559) (2018)
Regina Messerer, Michael Kauk, Daniela Volpato, Maria Consuelo Alonso Canizal, Jessika Klöckner, Ulrike Zabel, Susanne Nuber, Carsten Hoffmann, Ulrike Holzgrabe
FRET Studies of Quinolone-Based Bitopic Ligands and Their Structural Analogues at the Muscarinic M1 Receptor. ACS chemical biology 12 (3) (2017)