Evi Kostenis (E Kostenis)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 38

Top Topics

Single Molecule

Molecular Docking

Top Venues

Nature communications

Communications biology

Journal of natural products

Signal transduction and targeted therapy

This page only lists publications with an associated author ORCID identifier.

Publications

Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Evi Kostenis, Lars Jürgenliemke, Judith Alenfelder
G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding. Signal transduction and targeted therapy 9 (1) (2024)
Evi Kostenis, Lars Jürgenliemke, Judith Alenfelder
G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding. Signal transduction and targeted therapy 9 (1) (2024)
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
A molecular mechanism to diversify Ca 2+ signaling downstream of Gs protein-coupled receptors. Nature communications 15 (1) (2024)
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
A molecular mechanism to diversify Ca 2+ signaling downstream of Gs protein-coupled receptors. Nature communications 15 (1) (2024)
Tim Berger, Judith Alenfelder, Sophie A M Steinmüller, Dominik Heimann, Namrata Gohain, Daniel Petras, Mingxun Wang, Robert Berger, Evi Kostenis, Raphael Reher
A MassQL-Integrated Molecular Networking Approach for the Discovery and Substructure Annotation of Bioactive Cyclic Peptides. Journal of natural products 87 (4) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Tim Berger, Judith Alenfelder, Sophie A M Steinmüller, Dominik Heimann, Namrata Gohain, Daniel Petras, Mingxun Wang, Robert Berger, Evi Kostenis, Raphael Reher
A MassQL-Integrated Molecular Networking Approach for the Discovery and Substructure Annotation of Bioactive Cyclic Peptides. Journal of natural products 87 (4) (2024)
Evi Kostenis, Lars Jürgenliemke, Judith Alenfelder
G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding. Signal transduction and targeted therapy 9 (1) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Edda Sofie Fabienne Matthees, Jenny C Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D'Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications biology 7 (1) (2024)
Tim Berger, Judith Alenfelder, Sophie A M Steinmüller, Dominik Heimann, Namrata Gohain, Daniel Petras, Mingxun Wang, Robert Berger, Evi Kostenis, Raphael Reher
A MassQL-Integrated Molecular Networking Approach for the Discovery and Substructure Annotation of Bioactive Cyclic Peptides. Journal of natural products (2024)
Max E Huber, Silas L Wurnig, Aurélien F A Moumbock, Lara Toy, Evi Kostenis, Ana Alonso Bartolomé, Martyna Szpakowska, Andy Chevigné, Stefan Günther, Finn K Hansen, Matthias Schiedel
Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1. ChemMedChem (2024)
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J Simon Wiegert, Gabriele M König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Author Correction: Selective optogenetic control of G q signaling using human Neuropsin. Nature communications 14 (1) (2023)
Evi Kostenis, Jesús Gomeza, Elke Miess-Tanneberg, Nina Kathleen Blum, Tobias Benkel, Andy Chevigné, Carsten Hoffmann, Peter Kolb, Viacheslav O Nikolaev, Maria Waldhoer, Martyna Szpakowska, Asuka Inoue, Stefan Schulz
Reply to: How carvedilol does not activate β 2 -adrenoceptors. Nature communications 14 (1) (2023)
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J Simon Wiegert, Gabriele M König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Author Correction: Selective optogenetic control of G q signaling using human Neuropsin. Nature communications 14 (1) (2023)
Max E Huber, Silas L Wurnig, Lara Toy, Corinna Weiler, Nicole Merten, Evi Kostenis, Finn K Hansen, Matthias Schiedel
Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2. Journal of medicinal chemistry (2023)
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O'Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav O Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
How Carvedilol activates β 2 -adrenoceptors. Nature communications 13 (1) (2022)
Julia Drube, Raphael S Haider, Edda Sofie Fabienne Matthees, Mona Reichel, J Zeiner, S Fritzwanker, C Ziegler, S Barz, L Klement, J Filor, V Weitzel, A Kliewer, E Miess-Tanneberg, Evi Kostenis, Stefan Schulz, Carsten Hoffmann
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation. Nature communications 13 (1) (2022)
Max E Huber, Lara Toy, Maximilian F Schmidt, Hannah Vogt, Julian Budzinski, Martin F J Wiefhoff, Nicole Merten, Evi Kostenis, Dorothée Weikert, Matthias Schiedel
A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs. Angewandte Chemie (International ed. in English) 61 (12) (2022)
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J Simon Wiegert, Gabriele M König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Selective optogenetic control of G q signaling using human Neuropsin. Nature communications 13 (1) (2022)
Takefumi Kimura, Sai P Pydi, Lei Wang, Dhanush Haspula, Yinghong Cui, Huiyan Lu, Gabriele M König, Evi Kostenis, Gregory R Steinberg, Oksana Gavrilova, Jürgen Wess
Adipocyte G q signaling is a regulator of glucose and lipid homeostasis in mice. Nature communications 13 (1) (2022)
Cornelia Hermes, René Richarz, Daniel A Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa Elisabeth Müller, Evi Kostenis, Gabriele M König, Max Cruesemann
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359. Nature communications 12 (1) (2021)
Thomas A Longden, Amreen Mughal, Grant W Hennig, Osama F Harraz, Bo Shui, Frank K Lee, Jane C Lee, Shaun Reining, Michael I Kotlikoff, Gabriele M König, Evi Kostenis, David Hill-Eubanks, Mark T Nelson
Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries. Science advances 7 (30) (2021)
Wiebke Hanke, Julian Patt, Judith Alenfelder, Jan H Voss, Mitja M Zdouc, Stefan Kehraus, Jung Bong Kim, Goran V Grujičić, Vigneshwaran Namasivayam, Raphael Reher, Christa Elisabeth Müller, Evi Kostenis, Max Cruesemann, Gabriele M König
Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives. Journal of natural products 84 (7) (2021)
Jan Wenzel, Cathrin E Hansen, Carla Bettoni, Miriam A Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten Alexander Wagner, Markus Schwaninger
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. Proceedings of the National Academy of Sciences of the United States of America 117 (3) (2020)
Max Meyrath, Martyna Szpakowska, Julian Zeiner, Laurent Massotte, Myriam P Merz, Tobias Benkel, Katharina Simon, Jochen Ohnmacht, Jonathan David Turner, Rejko Krüger, Vincent Seutin, Markus Ollert, Evi Kostenis, Andy Chevigné
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nature communications 11 (1) (2020)
Caroline Coombs, Antonios Georgantzoglou, Hazel A Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Author Correction: Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish. Nature communications 11 (1) (2020)
Jim Küppers, Tobias Benkel, Suvi Annala, Kenichi Kimura, Lisa Reinelt, Bernd K Fleischmann, Evi Kostenis, Michael Gütschow
Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gαq -Protein Ligands. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (55) (2020)
Alex D White, Frédéric G Jean-Alphonse, Fei Fang, Karina A Peña, Shi Liu, Gabriele M König, Asuka Inoue, Despoina Aslanoglou, Samuel H Gellman, Evi Kostenis, Kunhong Xiao, Jean-Pierre Vilardaga
Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR. Proceedings of the National Academy of Sciences of the United States of America 117 (13) (2020)
Jim Küppers, Tobias Benkel, Suvi Annala, Gregor Schnakenburg, Evi Kostenis, Michael Gütschow
BIM-46174 fragments as potential ligands of G proteins. MedChemComm 10 (10) (2019)
Caroline Coombs, Antonios Georgantzoglou, Hazel A Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish. Nature communications 10 (1) (2019)
Suvi Annala, Xiaodong Feng, Naveen Shridhar, Funda Eryilmaz, Julian Patt, JuHee Yang, Eva M Pfeil, Rodolfo Daniel Cervantes-Villagrana, Asuka Inoue, Felix Häberlein, Tanja Slodczyk, Raphael Reher, Stefan Kehraus, Stefania Monteleone, Ramona Schrage, Nina Heycke, Ulrike Rick, Sandra Engel, Alexander Pfeifer, Peter Kolb, Gabriele König, Moritz Bünemann, Thomas Tüting, José Vázquez-Prado, Jorge Silvio Gutkind, Evelyn Gaffal, Evi Kostenis
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. Science signaling 12 (573) (2019)
Younis Baqi, Thanigaimalai Pillaiyar, Aliaa Abdelrahman, Olesja Kaufmann, Samer Alshaibani, Muhammad Rafehi, Saman Ghasimi, Rhalid Akkari, Kirsten Ritter, Katharina Simon, Andreas Spinrath, Evi Kostenis, Qiang Zhao, Meryem Köse, Vigneshwaran Namasivayam, Christa Elisabeth Müller
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. Journal of medicinal chemistry 61 (18) (2018)
Shane C Wright, Maria Consuelo Alonso Cañizal, Tobias Benkel, Katharina Simon, Christian Le Gouill, Pierre Matricon, Yoon Namkung, Viktoriya Lukasheva, Gabriele M König, Stéphane A Laporte, Jens Carlsson, Evi Kostenis, Michel Bouvier, Gunnar Schulte, Carsten Hoffmann
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science signaling 11 (559) (2018)
Rodolfo Daniel Cervantes-Villagrana, Sendi Rafael Adame-García, Irving García-Jiménez, Víctor Manuel Color-Aparicio, Yarely Mabell Beltrán-Navarro, Gabriele M König, Evi Kostenis, Guadalupe Reyes-Cruz, J Silvio Gutkind, José Vázquez-Prado
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins. The Journal of biological chemistry 294 (2) (2018)
Michaela Matthey, Richard Roberts, Alexander Seidinger, Annika Simon, Ralf Schröder, Markus Kuschak, Suvi Annala, Gabriele M König, Christa E Müller, Ian P Hall, Evi Kostenis, Bernd K Fleischmann, Daniela Wenzel
Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Science translational medicine 9 (407) (2018)
Raphael Reher, Toni Kühl, Suvi Annala, Tobias Benkel, Desireé Kaufmann, Britta Nubbemeyer, Justin Patrick Odhiambo, Pascal Heimer, Charlotte Anneke Bäuml, Stefan Kehraus, Max Cruesemann, Evi Kostenis, Daniel Tietze, Gabriele M König, Diana Imhof
Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies. ChemMedChem 13 (16) (2018)