R Benjamin Free

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 11

Top Topics

Prefrontal Cortex

Molecular Dynamics Simulations

Top Venues

ACS pharmacology & translational science

Journal of medicinal chemistry

ACS chemical neuroscience

Science signaling

This page only lists publications with an associated author ORCID identifier.

Publications

Comfort A Boateng, Ashley N Nilson, Rebekah Placide, Mimi L Pham, Franziska M Jakobs, Noelia M Boldizsar, Scot McIntosh, Leia S Stallings, Ivana V Korankyi, Shreya Kelshikar, Nisha Shah, Diandra Panasis, Abigail Muccilli, Maria Ladik, Brianna Maslonka, Connor McBride, Moises Ximello Sanchez, Ebrar Akca, Mohammad Alkhatib, Julianna Saez, Catherine Nguyen, Emily Kurtyan, Jacquelyn DePierro, Raymond Crowthers, Dylan Brunt, Alessandro Bonifazi, Amy Hauck Newman, Rana Rais, Barbara S Slusher, R Benjamin Free, David R Sibley, Kent D Stewart, Chun Wu, Scott E Hemby, Thomas M Keck
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder. Journal of medicinal chemistry (2023)
Marta Sánchez-Soto, Noelia M Boldizsar, Kayla A Schardien, Nora S Madaras, Blair K A Willette, Laura R Inbody, Christopher Dasaro, Amy E Moritz, Julia Drube, Raphael S Haider, R Benjamin Free, Carsten Hoffmann, David R Sibley
G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D 2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. Biomolecules 13 (10) (2023)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Vladimir M Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W Bertz, Jinbin Xu, Herman D Lim, Andrés E Dulcey, Robert H Mach, James H Woods, J Robert Lane, Lei Shi, Juan Jose Marugan, William C Wetsel, David R Sibley
Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity. ACS pharmacology & translational science 6 (1) (2022)
David R Sibley, Kathryn D Luderman, R Benjamin Free, Lei Shi
Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal transduction and targeted therapy 6 (1) (2021)
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W Logan, Claes B Wollheim, Massimo Trucco, Vijay K Yechoor, David R Sibley, Rita Bottino, Zachary Z Freyberg
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Translational psychiatry 11 (1) (2021)
Amy E Moritz, Alessandro Bonifazi, Adrian M Guerrero, Vivek Kumar, R Benjamin Free, J Robert Lane, Ravi Kumar Verma, Lei Shi, Amy Hauck Newman, David R Sibley
Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor. ACS chemical neuroscience 11 (20) (2020)
Marta Sánchez-Soto, Ravi Kumar Verma, Blair K A Willette, Elizabeth C Gonye, Annah M Moore, Amy E Moritz, Comfort A Boateng, Hideaki Yano, R Benjamin Free, Lei Shi, David R Sibley
A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity. Science signaling 13 (617) (2020)
Amy E Moritz, R Benjamin Free, Warren S Weiner, Emmanuel O Akano, Disha Gandhi, Ara Abramyan, Thomas M Keck, Marc Ferrer, Xin Hu, Noel Southall, Joseph Steiner, Jeffrey Aube, Lei Shi, Kevin J Frankowski, David R Sibley
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of medicinal chemistry 63 (10) (2020)
Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R Benjamin Free, Sean W Reilly, Robert R Luedtke, Peter Århem, Francisco Ciruela, David R Sibley, Robert H Mach, Jana Selent, Johanna Nilsson, Kristoffer Sahlholm
Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism. ACS chemical neuroscience 11 (19) (2020)
Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors. PLoS computational biology 14 (1) (2018)