Mariana Spetea

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 36

Top Venues

Molecules (Basel, Switzerland)

Journal of medicinal chemistry

International journal of molecular sciences

Pharmaceuticals (Basel, Switzerland)

University of Innsbruck

József Attila University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Innsbruck Oct 01 2011

Austria

Head of the Opioid Research Group :: Institute of Pharmacy

Torrey Pines Institute for Molecular Studies

United States

Visiting Scientist

The Scripps Research Institute

United States

Visiting Scientist

University of Innsbruck Apr 01 2007 - Sep 30 2011

Austria

University Assistant :: Institute of Pharmacy

Semmelweis University

Hungary

Visiting Scientist :: Faculty of Medicine

Karolinska Institutet

Sweden

Visiting Scientist :: Department of Physiology and Pharmacology

University of Innsbruck Jan 01 2000 - Sep 30 2002

Austria

Senior Research Associate :: Institute of Pharmacy

Karolinska Institutet Jan 01 1998 - Dec 31 1999

Sweden

Post-doctoral research fellow

Education History

József Attila University Sep 01 1994 - Dec 31 1997

Hungary

PHD

University of Bucharest Oct 01 1988 - Jul 01 1993

Romania

MSC

Publications

Kristina Puls, Aina-Leonor Olivé-Marti, Siriwat Hongnak, David Lamp, Mariana Spetea, Gerhard Wolber
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. Journal of medicinal chemistry 67 (16) (2024)
Kristina Puls, Aina-Leonor Olivé-Marti, Siriwat Hongnak, David Lamp, Mariana Spetea, Gerhard Wolber
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. Journal of medicinal chemistry (2024)
Nadine Hochrainer, Pawel Serafin, Sara D'Ingiullo, Adriano Mollica, Sebastian Granica, Marek Brytan, Patrycja Kleczkowska, Mariana Spetea
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide. International journal of molecular sciences 25 (7) (2024)
Kristina Puls, Aina-Leonor Olivé-Marti, Siriwat Hongnak, David Lamp, Mariana Spetea, Gerhard Wolber
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. Journal of medicinal chemistry 67 (16) (2024)
Nadine Hochrainer, Pawel Serafin, Sara D'Ingiullo, Adriano Mollica, Sebastian Granica, Marek Brytan, Patrycja Kleczkowska, Mariana Spetea
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide. International journal of molecular sciences 25 (7) (2024)
Kristina Puls, Aina-Leonor Olivé-Marti, Siriwat Hongnak, David Lamp, Mariana Spetea, Gerhard Wolber
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. Journal of medicinal chemistry 67 (16) (2024)
Nadine Hochrainer, Pawel Serafin, Sara D'Ingiullo, Adriano Mollica, Sebastian Granica, Marek Brytan, Patrycja Kleczkowska, Mariana Spetea
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide. International journal of molecular sciences 25 (7) (2024)
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W Craven, Balazs R Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J Craik, Mariana Spetea, Tao Che, Julien S Baker, Christian W Gruber
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. Nature communications 14 (1) (2023)
Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea
Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain. Molecules (Basel, Switzerland) 28 (12) (2023)
Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea
Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain. Molecules (Basel, Switzerland) 28 (12) (2023)
Edin Muratspahić, Andrew M White, Cosmin I Ciotu, Nadine Hochrainer, Nataša Tomašević, Johannes Koehbach, Richard James Lewis, Mariana Spetea, Michael J M Fischer, David J Craik, Christian W Gruber
Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. Journal of medicinal chemistry (2023)
Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea
Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain. Molecules (Basel, Switzerland) 28 (12) (2023)
Maria Dumitrascuta, Charlotte Martin, Steven Ballet, Mariana Spetea
Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice. Molecules (Basel, Switzerland) 27 (24) (2022)
Kristina Puls, Aina-Leonor Olivé-Marti, Szymon Pach, Birgit Pinter, Filippo Erli, Gerhard Wolber, Mariana Spetea
In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist. Pharmaceuticals (Basel, Switzerland) 15 (6) (2022)
Richard M Van Rijn, Mariana Spetea
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II. Molecules (Basel, Switzerland) 27 (10) (2022)
Maria Dumitrascuta, Charlotte Martin, Steven Ballet, Mariana Spetea
Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice. Molecules (Basel, Switzerland) 27 (24) (2022)
Kristina Puls, Helmut Schmidhammer, Gerhard Wolber, Mariana Spetea
Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors. Molecules (Basel, Switzerland) 27 (3) (2022)
Maria Dumitrascuta, Charlotte Martin, Steven Ballet, Mariana Spetea
Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice. Molecules (Basel, Switzerland) 27 (24) (2022)
Maria Dumitrascuta, Charlotte Martin, Steven Ballet, Mariana Spetea
Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice. Molecules (Basel, Switzerland) 27 (24) (2022)
Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler, Julia Drube, Carsten Degenhart, Julian Engel, Jan Eicke Eickhoff, Pooja Dasgupta, Sebastian Fritzwanker, Maria Guastadisegni, Clemens Schulte, Elke Miess-Tanneberg, Hans Michael Maric, Mariana Spetea, Andrea Kliewer, Matthias Baumann, Bert Klebl, Rainer K Reinscheid, Carsten Hoffmann, Stefan Schulz
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening. Communications biology 5 (1) (2022)
Mariana Spetea, Helmut Schmidhammer
Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones. Molecules (Basel, Switzerland) 26 (18) (2021)
Maria Dumitrascuta, Marcel Bermudez, Olga Trovato, Jolien De Neve, Steven Ballet, Gerhard Wolber, Mariana Spetea
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking. Molecules (Basel, Switzerland) 26 (11) (2021)
Alok K Paul, Craig M Smith, Mohammed Rahmatullah, Veeranoot Nissapatorn, Polrat Wilairatana, Mariana Spetea, Nuri Guven, Nikolas Dietis
Opioid Analgesia and Opioid-Induced Adverse Effects: A Review. Pharmaceuticals (Basel, Switzerland) 14 (11) (2021)
Maria Dumitrascuta, Marcel Bermudez, Steven Ballet, Gerhard Wolber, Mariana Spetea
Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the mu Opioid Receptor. Molecules (Basel, Switzerland) 25 (9) (2020)
Mariana Spetea, Helmut Schmidhammer
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery. Molecules (Basel, Switzerland) 25 (23) (2020)
Helmut Schmidhammer, Filippo Erli, Elena Guerrieri, Mariana Spetea
Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities. Molecules (Basel, Switzerland) 25 (21) (2020)
Susanna Fürst, Zoltán S Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani
On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance. Molecules (Basel, Switzerland) 25 (11) (2020)
Simon Gonzalez, Maria Dumitrascuta, Emilie Eiselt, Stevany Louis, Linda Kunze, Annalisa Blasiol, Mélanie Vivancos, Santo Previti, Elke Dewolf, Charlotte Martin, Dirk Tourwé, Florine Cavelier, Louis Gendron, Philippe Sarret, Mariana Spetea, Steven Ballet
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies. Journal of medicinal chemistry 63 (21) (2020)
Jean Jacques Vanden Eynde, Arduino Aleksander Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A C Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Gennaro Chiappetta, Jean Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, Francisco Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, Maria Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdieroa, Hong Liu, Peter J H Scott, Cristóbal de Los Ríos, Luigi A Agrofoglio, Simona Collina, Rita C Guedes, Diego Muñoz-Torrero
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Molecules (Basel, Switzerland) 25 (1) (2019)
Mariana Spetea, Silvia B Rief, Tanila Ben Haddou, Monika Fink, Elka Kristeva, Harald Mittendorfer, Stefanie Haas, Nora Hummer, Valeria Follia, Elena Guerrieri, Muhammad Faheem Asim, Sonja Sturm, Helmut Schmidhammer
Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives. Journal of medicinal chemistry 62 (2) (2019)
Charlotte Martin, Maria Dumitrascuta, Morgane Mannes, Aquilino Lantero, Dominik Bucher, Katja Walker, Yannick Van Wanseele, Edith Oyen, Sophie Hernot, Ann Van Eeckhaut, Annemieke Madder, Richard Hoogenboom, Mariana Spetea, Steven Ballet
Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides. Journal of medicinal chemistry 61 (21) (2018)
Jeffrey J Liu, Kirti Sharma, Luca Zangrandi, Chongguang Chen, Sean J Humphrey, Yi-Ting Chiu, Mariana Spetea, Lee-Yuan Liu-Chen, Christoph Schwarzer, Matthias Mann
In vivo brain GPCR signaling elucidated by phosphoproteomics. Science (New York, N.Y.) 360 (6395) (2018)
Stefan M Noha, Helmut Schmidhammer, Mariana Spetea
Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists. ACS chemical neuroscience 8 (6) (2017)
Maria Dumitrascuta, Tanila Ben Haddou, Elena Guerrieri, Stefan M Noha, Lea Schläfer, Helmut Schmidhammer, Mariana Spetea
Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists. Journal of medicinal chemistry 60 (22) (2017)
Filippo Erli, Elena Guerrieri, Tanila Ben Haddou, Aquilino Lantero, Michael Mairegger, Helmut Schmidhammer, Mariana Spetea
Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. Journal of medicinal chemistry 60 (17) (2017)
Mariana Spetea, Shainnel O Eans, Michelle L Ganno, Aquilino Lantero, Michael Mairegger, Lawrence Toll, Helmut Schmidhammer, Jay P McLaughlin
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. British journal of pharmacology 174 (15) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Mariana Spetea