Chaitan Khosla

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Topics

Structural Basis

Monoclonal Antibody

Induced Pluripotent Stem Cells

Top Venues

Journal of the American Chemical Society

Proceedings of the National Academy of Sciences of the United States of America

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Dillon P Cogan, Alexander M Soohoo, Muyuan Chen, Yan Liu, Krystal L Brodsky, Chaitan Khosla
Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nature chemical biology (2024)
Agnele S Sewa, Harrison A Besser, Irimpan I Mathews, Chaitan Khosla
Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Agnele S Sewa, Harrison A Besser, Irimpan I Mathews, Chaitan Khosla
Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Agnele S Sewa, Harrison A Besser, Irimpan I Mathews, Chaitan Khosla
Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Agnele S Sewa, Harrison A Besser, Irimpan I Mathews, Chaitan Khosla
Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society (2024)
Shreya Kishore, Antonio Del Rio Flores, Stephen R Lynch, Kai P Yuet, Chaitan Khosla
Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product. Journal of the American Chemical Society 146 (6) (2024)
Katarina M Guzman, Dillon P Cogan, Krystal L Brodsky, Alexander M Soohoo, Xiuyuan Li, Natalia Sevillano, Irimpan I Mathews, Khanh P Nguyen, Charles S Craik, Chaitan Khosla
Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry (2023)
Elise Loppinet, Harrison A Besser, Christina E Lee, Wei Zhang, Bianxiao Cui, Chaitan Khosla
Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. Journal of the American Chemical Society (2023)
Siavash Mashayekh, Lee M Stunkard, Maryline Kienle, Irimpan I Mathews, Chaitan Khosla
Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2). Biochemistry 61 (21) (2022)
Saborni Chakraborty, Joseph C Gonzalez, Benjamin L Sievers, Venkata Vamsee Aditya Mallajosyula, Srijoni Chakraborty, Megha Dubey, Usama Ashraf, Bowie Yik-Ling Cheng, Nimish Kathale, Kim Quyen Thi Tran, Courtney Scallan, Aanika Sinnott, Arianna Cassidy, Steven T Chen, Terri Gelbart, Fei Gao, Yarden Golan, Xuhuai Ji, Seunghee Kim-Schulze, Mary K Prahl, Stephanie L Gaw, Sacha Gnjatic, Thomas U Marron, Miriam Merad, Prabhu S Arunachalam, Scott D Boyd, Mark M Davis, Marisa K Holubar, Chaitan Khosla, Holden Terry Maecker, Yvonne Maldonado, Elizabeth D Mellins, Kari Christine Nadeau, Bali Pulendran, Upinder Singh, Aruna K Subramanian, Paul J Utz, Robert Sherwood, Sheng Zhang, Prasanna Jagannathan, Gene S Tan, Taia T Wang
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Science translational medicine 14 (635) (2022)
Jing Li, Maxim E Zaslavsky, Yapeng Su, Jing Guo, Michael J Sikora, Vincent van Unen, Asbjørn O Christophersen, Shin-Heng Chiou, Liang Chen, Jiefu Li, Xuhuai Ji, Julie Wilhelmy, Alana M McSween, Brad A Palanski, Venkata Vamsee Aditya Mallajosyula, Nathan A Bracey, Gopal Krishna R Dhondalay, Kartik Bhamidipati, Joy Pai, Lucas B Kipp, Jeffrey E Dunn, Stephen L Hauser, Jorge R Oksenberg, Ansuman T Satpathy, William H Robinson, Cornelia L Dekker, Lars M Steinmetz, Chaitan Khosla, Paul J Utz, Ludvig M Sollid, Yueh-Hsiu Chien, James R Heath, Nielsen Q Fernandez-Becker, Kari Christine Nadeau, Naresha Saligrama, Mark M Davis
KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science (New York, N.Y.) 376 (6590) (2022)
Thomas M Privalsky, Alexander M Soohoo, Jinhua Wang, Christopher T Walsh, Gerard D Wright, Eric M Gordon, Nathanael S Gray, Chaitan Khosla
Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society (2021)
Aleksandra Nivina, Sur Herrera Paredes, Hunter B Fraser, Chaitan Khosla
GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification. Proceedings of the National Academy of Sciences of the United States of America 118 (26) (2021)
Dillon P Cogan, Kaiming Zhang, Xiuyuan Li, Shanshan Li, Grigore D Pintilie, Soung Hun Roh, Charles S Craik, Wah Chiu, Chaitan Khosla
Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science (New York, N.Y.) 374 (6568) (2021)
Arek V Melkonian, Elise Loppinet, Renata Martin, Matthew Porteus, Chaitan Khosla
An Unusual "OR" Gate for Allosteric Regulation of Mammalian Transglutaminase 2 in the Extracellular Matrix. Journal of the American Chemical Society 143 (28) (2021)
Katarina M Guzman, Kai P Yuet, Stephen R Lynch, Corey W Liu, Chaitan Khosla
Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase. The Journal of organic chemistry 86 (16) (2021)
Maja Klaus, Emanuele Rossini, Andreas Linden, Karthik S Paithankar, Matthias Zeug, Zoya Ignatova, Henning Urlaub, Chaitan Khosla, Jürgen Köfinger, Gerhard Hummer, Martin Grininger
Solution Structure and Conformational Flexibility of a Polyketide Synthase Module. JACS Au 1 (12) (2021)
Jing Li, Maxim E Zaslavsky, Yapeng Su, Michael J Sikora, Vincent van Unen, Asbjørn O Christophersen, Shin-Heng Chiou, Liang Chen, Jiefu Li, Xuhuai Ji, Julie Wilhelmy, Alana M McSween, Brad A Palanski, Venkata Vamsee Aditya Mallajosyula, Gopal Krishna R Dhondalay, Kartik Bhamidipati, Joy Pai, Lucas B Kipp, Jeffrey E Dunn, Stephen L Hauser, Jorge R Oksenberg, Ansuman T Satpathy, William H Robinson, Lars M Steinmetz, Chaitan Khosla, Paul J Utz, Ludvig M Sollid, James R Heath, Nielsen Q Fernandez-Becker, Kari Christine Nadeau, Naresha Saligrama, Mark M Davis
Human KIR + CD8 + T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19. bioRxiv : the preprint server for biology (2021)
Kai P Yuet, Corey W Liu, Stephen R Lynch, James Kuo, Wesley Michaels, Robert B Lee, Abigail E McShane, Brian L Zhong, Curt R Fischer, Chaitan Khosla
Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase. Journal of the American Chemical Society 142 (13) (2020)
Omar Santín, Kai Yuet, Chaitan Khosla, Gabriel Moncalián
Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase. Biochemistry 59 (50) (2020)
Dillon P Cogan, Xiuyuan Li, Natalia Sevillano, Irimpan I Mathews, Tsutomu Matsui, Charles S Craik, Chaitan Khosla
Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society 142 (35) (2020)
Aleksandra Nivina, Kai P Yuet, Jake Hsu, Chaitan Khosla
Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical reviews 119 (24) (2019)
Karthik Sankaranarayanan, Xirui X Antaris, Brad A Palanski, Abrahim El Gamal, Camilla M Kao, William L Fitch, Curt R Fischer, Chaitan Khosla
Tunable Enzymatic Synthesis of the Immunomodulator Lipid IVA To Enable Structure-Activity Analysis. Journal of the American Chemical Society 141 (24) (2019)
Maja Klaus, Alicia D D'Souza, Aleksandra Nivina, Chaitan Khosla, Martin Grininger
Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains. ACS chemical biology 14 (3) (2019)
Brad A Palanski, Chaitan Khosla
Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism. Biochemistry 57 (24) (2018)
Xiuyuan Li, Natalia Sevillano, Florencia La Greca, Lindsay Deis, Yu-Chen Liu, Marc C Deller, Irimpan I Mathews, Tsutomu Matsui, David E Cane, Charles S Craik, Chaitan Khosla
Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society 140 (21) (2018)
Xiuyuan Li, Natalia Sevillano, Florencia La Greca, Jake Hsu, Irimpan I Mathews, Tsutomu Matsui, Charles S Craik, Chaitan Khosla
Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry 57 (43) (2018)
Chaitan Khosla
Celiac Disease: Lessons for and from Chemical Biology. ACS chemical biology 12 (6) (2017)
Xinqiang Xie, Ashish Garg, Chaitan Khosla, David E Cane
Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society 139 (28) (2017)
Irimpan I Mathews, Kim Allison, Thomas Robbins, Artem Y Lyubimov, Monarin Uervirojnangkoorn, Axel T Brunger, Chaitan Khosla, Hasan DeMirci, Scott E McPhillips, Michael Hollenbeck, Michael Soltis, Aina E Cohen
The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry 56 (36) (2017)
Xinqiang Xie, Ashish Garg, Chaitan Khosla, David E Cane
Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society 139 (8) (2017)
Xinqiang Xie, Chaitan Khosla, David E Cane
Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society 139 (17) (2017)
Arif Wibowo, Jae Mo Park, Shie-Chau Liu, Chaitan Khosla, Daniel M Spielman
Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea. ACS chemical biology 12 (7) (2017)