David Steadman

Publication Activity (10 Years)

Years Active: 2018-2022
Publications (10 Years): 8

Top Topics

Capillary Electrophoresis

Transforming Growth Factor

Molecular Dynamics

Top Venues

Journal of medicinal chemistry

Beilstein journal of organic chemistry

ACS chemical neuroscience

This page only lists publications with an associated author ORCID identifier.

Publications

Yuguang Zhao, William Mahy, Nicky J Willis, Hannah L Woodward, David Steadman, Elliott D Bayle, Benjamin N Atkinson, James Sipthorp, Luca Vecchia, Reinis R Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, Paul V Fish, Edith Yvonne Jones
Structural Analysis and Development of Notum Fragment Screening Hits. ACS chemical neuroscience 13 (13) (2022)
Yuguang Zhao, Fredrik Svensson, David Steadman, Sarah Frew, Amy Monaghan, Magda Bictash, Tiago Moreira, Rod Chalk, Weixian Lu, Paul V Fish, Edith Yvonne Jones
Structural Insights into Notum Covalent Inhibition. Journal of medicinal chemistry 64 (15) (2021)
Elliott D Bayle, Fredrik Svensson, Benjamin N Atkinson, David Steadman, Nicky J Willis, Hannah L Woodward, Paul Whiting, Jean-Paul Vincent, Paul V Fish
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. Journal of medicinal chemistry 64 (8) (2021)
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, Edith Yvonne Jones, Paul V Fish, Fredrik Svensson
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. Journal of medicinal chemistry 65 (1) (2021)
William Mahy, Mikesh Patel, David Steadman, Hannah L Woodward, Benjamin N Atkinson, Fredrik Svensson, Nicky J Willis, Alister Flint, Dimitra Papatheodorou, Yuguang Zhao, Luca Vecchia, Reinis R Ruza, James Hillier, Sarah Frew, Amy Monaghan, Artur Costa, Magda Bictash, Magnus W Walter, Edith Yvonne Jones, Paul V Fish
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. Journal of medicinal chemistry 63 (17) (2020)
Nicky J Willis, Elliott D Bayle, George Papageorgiou, David Steadman, Benjamin N Atkinson, William Mahy, Paul V Fish
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent. Beilstein journal of organic chemistry 15 (2019)
Benjamin N Atkinson, David Steadman, Yuguang Zhao, James Sipthorp, Luca Vecchia, Reinis R Ruza, Fiona Jeganathan, Georgie Lines, Sarah Frew, Amy Monaghan, Svend Kjær, Magda Bictash, Edith Yvonne Jones, Paul V Fish
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. MedChemComm 10 (8) (2019)
Jonathan Powell, Filipa Mota, David Steadman, Christelle Soudy, Jeremy T Miyauchi, Stuart Crosby, Ashley Jarvis, Tifelle Reisinger, Natalie Winfield, Graham Evans, Aled Finniear, Tamas Yelland, Yi-Tai Chou, A W Edith Chan, Andrew O'Leary, Lili Cheng, Dan Liu, Constantina Fotinou, Carla Milagre, John F Martin, Haiyan Jia, Paul Frankel, Snezana Djordjevic, Stella E Tsirka, Ian C Zachary, David L Selwood
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. Journal of medicinal chemistry 61 (9) (2018)