Nicky J Willis

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2022
Publications (10 Years): 6

Top Topics

Atomic Force Microscopy

Top Venues

Journal of medicinal chemistry

Beilstein journal of organic chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott David Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictash, Patricia C Salinas, Jean-Paul Vincent, Edith Yvonne Jones, Paul Whiting, Paul V Fish
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. Journal of medicinal chemistry 65 (10) (2022)
Yuguang Zhao, William Mahy, Nicky J Willis, Hannah L Woodward, David Steadman, Elliott D Bayle, Benjamin N Atkinson, James Sipthorp, Luca Vecchia, Reinis R Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, Paul V Fish, Edith Yvonne Jones
Structural Analysis and Development of Notum Fragment Screening Hits. ACS chemical neuroscience 13 (13) (2022)
Benjamin N Atkinson, Nicky J Willis, Jennifer Smith, Rebecca Gill, Jody Ali, Zhou Xu, Ping-Shan Lai, Paul V Fish
Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1 H -1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step. RSC advances 12 (41) (2022)
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, Edith Yvonne Jones, Paul V Fish, Fredrik Svensson
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. Journal of medicinal chemistry 65 (1) (2021)
Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J Willis, Kathryn Gilroy, Alexander P Raven, Lynn McGarry, Johanna I Englund, Anna T Webb, Sandra Scharaw, Nadia Nasreddin, Michael C Hodder, Rachel A Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K Najumudeen, Beatrice Romagnolo, Christine Perret, Ann Caroline Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, Edith Yvonne Jones, Ari Ristimäki, Simon J Leedham, Paul V Fish, Jean-Paul Vincent, Pekka Katajisto, Owen James Sansom
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 (7863) (2021)
Nicky J Willis, Elliott D Bayle, George Papageorgiou, David Steadman, Benjamin N Atkinson, William Mahy, Paul V Fish
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent. Beilstein journal of organic chemistry 15 (2019)