Fredrik Svensson

ORCID

Publication Activity (10 Years)

Years Active: 2016-2022
Publications (10 Years): 22

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

Chemical research in toxicology

Journal of cheminformatics

University College London

Uppsala University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University College London Aug 06 2018

United Kingdom

Senior Research Associate :: ARUK DDI

University of Cambridge Nov 09 2015 - Aug 04 2018

United Kingdom

Postdoctoral Research Fellow :: Department of Chemistry

Uppsala Universitet Jan 11 2011 - Oct 31 2015

Sweden

PhD Student :: Department of Medicinal Chemistry

Education History

Uppsala University Jan 01 2011 - Oct 01 2015

Sweden

PHD

Publications

Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott David Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictash, Patricia C Salinas, Jean-Paul Vincent, Edith Yvonne Jones, Paul Whiting, Paul V Fish
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. Journal of medicinal chemistry 65 (10) (2022)
Yuguang Zhao, Fredrik Svensson, David Steadman, Sarah Frew, Amy Monaghan, Magda Bictash, Tiago Moreira, Rod Chalk, Weixian Lu, Paul V Fish, Edith Yvonne Jones
Structural Insights into Notum Covalent Inhibition. Journal of medicinal chemistry 64 (15) (2021)
Ulf Norinder, Ola Spjuth, Fredrik Svensson
Synergy conformal prediction applied to large-scale bioactivity datasets and in federated learning. Journal of cheminformatics 13 (1) (2021)
Jin Zhang, Ulf Norinder, Fredrik Svensson
Deep Learning-Based Conformal Prediction of Toxicity. Journal of chemical information and modeling 61 (6) (2021)
Elliott D Bayle, Fredrik Svensson, Benjamin N Atkinson, David Steadman, Nicky J Willis, Hannah L Woodward, Paul Whiting, Jean-Paul Vincent, Paul V Fish
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. Journal of medicinal chemistry 64 (8) (2021)
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, Edith Yvonne Jones, Paul V Fish, Fredrik Svensson
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. Journal of medicinal chemistry 65 (1) (2021)
Ulf Norinder, Ola Spjuth, Fredrik Svensson
Using Predicted Bioactivity Profiles to Improve Predictive Modeling. Journal of chemical information and modeling 60 (6) (2020)
Henriëtte M G Willems, Stephane De Cesco, Fredrik Svensson
Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources. Journal of medicinal chemistry 63 (18) (2020)
William Mahy, Mikesh Patel, David Steadman, Hannah L Woodward, Benjamin N Atkinson, Fredrik Svensson, Nicky J Willis, Alister Flint, Dimitra Papatheodorou, Yuguang Zhao, Luca Vecchia, Reinis R Ruza, James Hillier, Sarah Frew, Amy Monaghan, Artur Costa, Magda Bictash, Magnus W Walter, Edith Yvonne Jones, Paul V Fish
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. Journal of medicinal chemistry 63 (17) (2020)
William Mahy, Nicky J Willis, Yuguang Zhao, Hannah L Woodward, Fredrik Svensson, James Sipthorp, Luca Vecchia, Reinis R Ruza, James Hillier, Svend Kjær, Sarah Frew, Amy Monaghan, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, E Yvonne Jones, Paul V Fish
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. Journal of medicinal chemistry 63 (21) (2020)
Ulf Norinder, Ola Spjuth, Fredrik Svensson
Correction to "Using Predicted Bioactivity Profiles to Improve Predictive Modeling". Journal of chemical information and modeling 60 (12) (2020)
Ines A Smit, Avid M Afzal, Chad H G Allen, Fredrik Svensson, Thierry Hanser, Andreas Bender
Systematic Analysis of Protein Targets Associated with Adverse Events of Drugs from Clinical Trials and Postmarketing Reports. Chemical research in toxicology 34 (2) (2020)
Gabriel H S Dreiman, Magda Bictash, Paul V Fish, Lewis Griffin, Fredrik Svensson
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding. SLAS discovery : advancing life sciences R & D 26 (2) (2020)
Samar Y Mahmoud, Fredrik Svensson, Azedine Zoufir, Dezső Módos, Avid M Afzal, Andreas Bender
Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods. Chemical research in toxicology 33 (1) (2019)
Ulf Norinder, Fredrik Svensson
Multitask Modeling with Confidence Using Matrix Factorization and Conformal Prediction. Journal of chemical information and modeling 59 (4) (2019)
Jin Zhang, Daniel Mucs, Ulf Norinder, Fredrik Svensson
LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity-Application to the Tox21 and Mutagenicity Data Sets. Journal of chemical information and modeling 59 (10) (2019)
Fredrik Svensson, Azedine Zoufir, Samar Mahmoud, Avid M Afzal, Ines Smit, Kathryn A Giblin, Peter J Clements, Jerome T Mettetal, Amy Pointon, James S Harvey, Nigel Greene, Richard V Williams, Andreas Bender
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity. Chemical research in toxicology 31 (11) (2018)
Fredrik Svensson, Natalia Aniceto, Ulf Norinder, Isidro Cortes-Ciriano, Ola Spjuth, Lars Carlsson, Andreas Bender
Conformal Regression for Quantitative Structure-Activity Relationship Modeling-Quantifying Prediction Uncertainty. Journal of chemical information and modeling 58 (5) (2018)
Fredrik Svensson, Avid M Afzal, Ulf Norinder, Andreas Bender
Maximizing gain in high-throughput screening using conformal prediction. Journal of cheminformatics 10 (1) (2018)
Fredrik Svensson, Ulf Norinder, Andreas Bender
Improving Screening Efficiency through Iterative Screening Using Docking and Conformal Prediction. Journal of chemical information and modeling 57 (3) (2017)
Fredrik Svensson, Andreas Bender, David Bailey
Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors. Journal of medicinal chemistry 61 (4) (2017)
Fredrik Svensson, Ulf Norinder, Andreas Bender
Modelling compound cytotoxicity using conformal prediction and PubChem HTS data. Toxicology research 6 (1) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Fredrik Svensson