Yuguang Zhao

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 29

Top Topics

Structural Basis

Subarachnoid Hemorrhage

Crystal Structure

Top Venues

Journal of medicinal chemistry

Science (New York, N.Y.)

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Gareth T Powell, Ana Faro, Yuguang Zhao, Heather Stickney, Laura Novellasdemunt, Pedro Henriques, Gaia Gestri, Esther Redhouse White, Jingshan Ren, Weixian Lu, Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Quenten Schwarz, Elena Dreosti, David W Raible, Vivian Sze Wing Li, Gavin J Wright, Edith Yvonne Jones, Stephen W Wilson
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.) 384 (6695) (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Gareth T Powell, Ana Faro, Yuguang Zhao, Heather Stickney, Laura Novellasdemunt, Pedro Henriques, Gaia Gestri, Esther Redhouse White, Jingshan Ren, Weixian Lu, Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Quenten Schwarz, Elena Dreosti, David W Raible, Vivian Sze Wing Li, Gavin J Wright, Edith Yvonne Jones, Stephen W Wilson
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.) 384 (6695) (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Gareth T Powell, Ana Faro, Yuguang Zhao, Heather Stickney, Laura Novellasdemunt, Pedro Henriques, Gaia Gestri, Esther Redhouse White, Jingshan Ren, Weixian Lu, Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Quenten Schwarz, Elena Dreosti, David W Raible, Vivian Sze Wing Li, Gavin J Wright, Edith Yvonne Jones, Stephen W Wilson
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.) 384 (6695) (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Gareth T Powell, Ana Faro, Yuguang Zhao, Heather Stickney, Laura Novellasdemunt, Pedro Henriques, Gaia Gestri, Esther Redhouse White, Jingshan Ren, Weixian Lu, Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Quenten Schwarz, Elena Dreosti, David W Raible, Vivian Sze Wing Li, Gavin J Wright, Edith Yvonne Jones, Stephen W Wilson
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.) 384 (6695) (2024)
Gareth T Powell, Ana Faro, Yuguang Zhao, Heather Stickney, Laura Novellasdemunt, Pedro Henriques, Gaia Gestri, Esther Redhouse White, Jingshan Ren, Weixian Lu, Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Quenten Schwarz, Elena Dreosti, David W Raible, Vivian Sze Wing Li, Gavin J Wright, Edith Yvonne Jones, Stephen W Wilson
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.) 384 (6695) (2024)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott David Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictash, Patricia C Salinas, Jean-Paul Vincent, Edith Yvonne Jones, Paul Whiting, Paul V Fish
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. Journal of medicinal chemistry 65 (10) (2022)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Yuguang Zhao, William Mahy, Nicky J Willis, Hannah L Woodward, David Steadman, Elliott D Bayle, Benjamin N Atkinson, James Sipthorp, Luca Vecchia, Reinis R Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, Paul V Fish, Edith Yvonne Jones
Structural Analysis and Development of Notum Fragment Screening Hits. ACS chemical neuroscience 13 (13) (2022)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Daming Zhou, Ling Qin, Helen M E Duyvesteyn, Yuguang Zhao, Tzou-Yien Lin, Elizabeth E Fry, Jingshan Ren, Kuan-Ying A Huang, David I Stuart
Switching of Receptor Binding Poses between Closely Related Enteroviruses. Viruses 14 (12) (2022)
Yuguang Zhao, Sarah Jolly, Stefano Benvegnu, Edith Yvonne Jones, Paul V Fish
Small-molecule inhibitors of carboxylesterase Notum. Future medicinal chemistry 13 (11) (2021)
Yuguang Zhao, Fredrik Svensson, David Steadman, Sarah Frew, Amy Monaghan, Magda Bictash, Tiago Moreira, Rod Chalk, Weixian Lu, Paul V Fish, Edith Yvonne Jones
Structural Insights into Notum Covalent Inhibition. Journal of medicinal chemistry 64 (15) (2021)
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, Edith Yvonne Jones, Paul V Fish, Fredrik Svensson
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. Journal of medicinal chemistry 65 (1) (2021)
Yuguang Zhao, Jingshan Ren, James Hillier, Weixian Lu, Edith Yvonne Jones
Caffeine inhibits Notum activity by binding at the catalytic pocket. Communications biology 3 (1) (2020)
Yuguang Zhao, Daming Zhou, Tao Ni, Dimple Karia, Abhay Kotecha, Xiangxi Wang, Zihe Rao, Edith Yvonne Jones, Elizabeth E Fry, Jingshan Ren, David I Stuart
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nature communications 11 (1) (2020)
Daming Zhou, Helen M E Duyvesteyn, Cheng-Pin Chen, Chung-Guei Huang, Ting-Hua Chen, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Che Ma, Jiandong Huo, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Pranav N M Shah, Tiong Kit Tan, Pramila Rijal, Robert F Donat, Kerry Godwin, Karen R Buttigieg, Julia A Tree, Julika Radecke, Neil G Paterson, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R Screaton, Miles W Carroll, Javier Gilbert Jaramillo, Michael L Knight, William S James, Raymond J Owens, James H Naismith, Alain R Townsend, Elizabeth E Fry, Yuguang Zhao, Jingshan Ren, David I Stuart, Kuan-Ying A Huang
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nature structural & molecular biology 27 (10) (2020)
William Mahy, Mikesh Patel, David Steadman, Hannah L Woodward, Benjamin N Atkinson, Fredrik Svensson, Nicky J Willis, Alister Flint, Dimitra Papatheodorou, Yuguang Zhao, Luca Vecchia, Reinis R Ruza, James Hillier, Sarah Frew, Amy Monaghan, Artur Costa, Magda Bictash, Magnus W Walter, Edith Yvonne Jones, Paul V Fish
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. Journal of medicinal chemistry 63 (17) (2020)
Jiandong Huo, Audrey Le Bas, Reinis R Ruza, Helen M E Duyvesteyn, Halina Mikolajek, Tomas Malinauskas, Tiong Kit Tan, Pramila Rijal, Maud Dumoux, Philip N Ward, Jingshan Ren, Daming Zhou, Peter J Harrison, Miriam Weckener, Daniel K Clare, Vinod K Vogirala, Julika Radecke, Lucile Moynié, Yuguang Zhao, Javier Gilbert Jaramillo, Michael L Knight, Julia A Tree, Karen R Buttigieg, Naomi Coombes, Michael J Elmore, Miles W Carroll, Loic Carrique, Pranav N M Shah, William S James, Alain R Townsend, David I Stuart, Raymond J Owens, James H Naismith
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nature structural & molecular biology 27 (9) (2020)
Yuguang Zhao, Jingshan Ren, James Hillier, Margaret Jones, Weixian Lu, Edith Yvonne Jones
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. Journal of pineal research 68 (2) (2020)
William Mahy, Nicky J Willis, Yuguang Zhao, Hannah L Woodward, Fredrik Svensson, James Sipthorp, Luca Vecchia, Reinis R Ruza, James Hillier, Svend Kjær, Sarah Frew, Amy Monaghan, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, E Yvonne Jones, Paul V Fish
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. Journal of medicinal chemistry 63 (21) (2020)
Yuguang Zhao, Jingshan Ren, James Hillier, Weixian Lu, E Yvonne Jones
Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. Journal of medicinal chemistry 63 (6) (2020)
Daming Zhou, Yuguang Zhao, Abhay Kotecha, Elizabeth E Fry, James T Kelly, Xiangxi Wang, Zihe Rao, David J Rowlands, Jingshan Ren, David I Stuart
Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2. Nature microbiology 4 (3) (2018)
Trine V Vendelboe, Pernille Harris, Yuguang Zhao, Thomas S Walter, Karl Harlos, Kamel El Omari, Hans E M Christensen
The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution. Science advances 2 (4) (2016)