Ernst K Schonbrunn (Ernst Schonbrunn, Ernst Schönbrunn)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 28

Top Topics

Ankylosing Spondylitis

Dna Methylation

Tyrosine Kinase

Top Venues

Journal of medicinal chemistry

ACS chemical biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Erik B Faber, Nan Wang, Kristen John, Luxin Sun, Henry L Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M Levinson, Ernst K Schonbrunn, Jon E Hawkinson, Gunda I Georg
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. Journal of medicinal chemistry 66 (3) (2023)
Yi Liao, Sean Chin Chan, Eric A Welsh, Bin Fang, Luxin Sun, Ernst K Schonbrunn, John M Koomen, Derek R Duckett, Eric B Haura, Andrii Monastyrskyi, Uwe Rix
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS chemical biology 18 (2) (2023)
Erik B Faber, Luxin Sun, Jian Tang, Emily R Roberts, Sornakala Ganeshkumar, Nan Wang, Damien M Rasmussen, Abir Majumdar, Laura E Hirsch, Kristen John, An Yang, Hira Khalid, Jon E Hawkinson, Nicholas M Levinson, Vargheese M Chennthukuzhi, Daniel A Harki, Ernst K Schonbrunn, Gunda I Georg
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nature communications 14 (1) (2023)
Yi Liao, Sean Chin Chan, Eric A Welsh, Bin Fang, Luxin Sun, Ernst K Schonbrunn, John M Koomen, Derek R Duckett, Eric B Haura, Andrii Monastyrskyi, Uwe Rix
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS chemical biology (2023)
Yi Liao, Sean Chin Chan, Eric A Welsh, Bin Fang, Luxin Sun, Ernst K Schonbrunn, John M Koomen, Derek R Duckett, Eric B Haura, Andrii Monastyrskyi, Uwe Rix
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS chemical biology 18 (2) (2023)
Yi Liao, Sean Chin Chan, Eric A Welsh, Bin Fang, Luxin Sun, Ernst K Schonbrunn, John M Koomen, Derek R Duckett, Eric B Haura, Andrii Monastyrskyi, Uwe Rix
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS chemical biology 18 (2) (2023)
Erik B Faber, Nan Wang, Kristen John, Luxin Sun, Henry L Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M Levinson, Ernst K Schonbrunn, Jon E Hawkinson, Gunda I Georg
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. Journal of medicinal chemistry 66 (3) (2023)
Yi Liao, Sean Chin Chan, Eric A Welsh, Bin Fang, Luxin Sun, Ernst K Schonbrunn, John M Koomen, Derek R Duckett, Eric B Haura, Andrii Monastyrskyi, Uwe Rix
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS chemical biology 18 (2) (2023)
Erik B Faber, Nan Wang, Kristen John, Luxin Sun, Henry L Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M Levinson, Ernst K Schonbrunn, Jon E Hawkinson, Gunda I Georg
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. Journal of medicinal chemistry 66 (3) (2023)
Erik B Faber, Nan Wang, Kristen John, Luxin Sun, Henry L Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M Levinson, Ernst K Schonbrunn, Jon E Hawkinson, Gunda I Georg
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. Journal of medicinal chemistry (2023)
Xianghong Guan, Narsihmulu Cheryala, Rezaul Md Karim, Alice Chan, Norbert Berndt, Jun Qi, Gunda I Georg, Ernst K Schonbrunn
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. Journal of medicinal chemistry 65 (15) (2022)
Rezaul Md Karim, Leixiang Yang, Lihong Chen, Melissa J Bikowitz, Junhao Lu, Dylan Grassie, Zachary P Shultz, Justin M Lopchuk, Jiandong Chen, Ernst K Schonbrunn
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. Journal of medicinal chemistry 65 (5) (2022)
Ryan R Davis, Baoli Li, Sang Y Yun, Alice Chan, Pradeep Nareddy, Steven Gunawan, Muhammad Ayaz, Harshani R Lawrence, Gary W Reuther, Nicholas J Lawrence, Ernst K Schonbrunn
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof. Journal of medicinal chemistry 64 (4) (2021)
Rezaul Md Karim, Melissa J Bikowitz, Alice Chan, Jin-Yi Zhu, Dylan Grassie, Andreas Becker, Norbert Berndt, Steven Gunawan, Nicholas J Lawrence, Ernst K Schonbrunn
Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. Journal of medicinal chemistry 64 (21) (2021)
Alex Muthengi, Virangika K Wimalasena, Hailemichael O Yosief, Melissa J Bikowitz, Logan H Sigua, Tingjian Wang, Deyao Li, Zied Gaieb, Gagan Dhawan, Shuai Liu, Jon Erickson, Rommie Elizabeth Amaro, Ernst K Schonbrunn, Jun Qi, Wei Zhang
Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. Journal of medicinal chemistry 64 (9) (2021)
Jiewei Jiang, Logan H Sigua, Alice Chan, Prakriti Kalra, William C K Pomerantz, Ernst K Schonbrunn, Jun Qi, Gunda I Georg
Dihydropyridine Lactam Analogs Targeting BET Bromodomains. ChemMedChem 17 (1) (2021)
Huda Zahid, Caroline R Buchholz, Manjulata Singh, Michael F Ciccone, Alice Chan, Stanley Nithianantham, Ke Shi, Hideki Aihara, Marcus Fischer, Ernst K Schonbrunn, Camila O Dos Santos, Joseph W Landry, William C K Pomerantz
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. Journal of medicinal chemistry 64 (18) (2021)
Noelle M Olson, Samantha Kroc, Jorden A Johnson, Huda Zahid, Peter D Ycas, Alice Chan, Jennifer R Kimbrough, Prakriti Kalra, Ernst K Schonbrunn, William C K Pomerantz
NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex. Biochemistry 59 (20) (2020)
Rezaul Md Karim, Alice Chan, Jin-Yi Zhu, Ernst K Schonbrunn
Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. Journal of medicinal chemistry 63 (6) (2020)
Yan Chen, Jin-Yi Zhu, Kwon Ho Hong, David C Mikles, Gunda I Georg, Alex S Goldstein, John K Amory, Ernst K Schonbrunn
Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS chemical biology 13 (3) (2018)
Anand Divakaran, Siva K Talluri, Alex M Ayoub, Neeraj K Mishra, Huarui Cui, John C Widen, Norbert Berndt, Jin-Yi Zhu, Angela S Carlson, Joseph J Topczewski, Ernst K Schonbrunn, Daniel A Harki, William C K Pomerantz
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of medicinal chemistry 61 (20) (2018)
Jin-Yi Zhu, Rebecca A Cuellar, Norbert Berndt, Hee Eun Lee, Sanne H Olesen, Mathew P Martin, Jeffrey T Jensen, Gunda I Georg, Ernst K Schonbrunn
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. Journal of medicinal chemistry 60 (18) (2017)
Xingxian Gu, Vijayalaxmi Gupta, Yan Yang, Jin-Yi Zhu, Erick J Carlson, Carolyn N Paulson, Joseph S Tash, Ernst K Schonbrunn, Jon E Hawkinson, Gunda I Georg
Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2. ChemMedChem 12 (23) (2017)