George M Burslem (George Burslem)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

Science advances

Nature communications

Chemical science

RSC chemical biology

University of Pennsylvania

University of Leeds (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania Jan 01 2020

United States

Assistant Professor :: Biochemistry and Biophysics

Yale University Sep 01 2015 - Nov 30 2019

United States

Postdoctoral Researcher :: Molecular, Cellular and Developmental Biology

Education History

University of Leeds Oct 01 2011 - Jun 15 2015

United Kingdom

PHD :: Chemistry

Publications

Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Nicole R Raniszewski, Jenna N Beyer, Myles I Noel, George M Burslem
Sortase mediated protein ubiquitination with defined chain length and topology. RSC chemical biology 5 (4) (2024)
Jia-Ying Lee, Sebastian Dilones, Timothe Maujean, Mohammad Asad, Altaf Mohd, Noam Auslander, Donita C Brady, George M Burslem, Eric S Witze
A selective S-acyltransferase inhibitor suppresses tumor growth. bioRxiv : the preprint server for biology (2024)
Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Nicole R Raniszewski, Jenna N Beyer, Myles I Noel, George M Burslem
Sortase mediated protein ubiquitination with defined chain length and topology. RSC chemical biology 5 (4) (2024)
Nicole R Raniszewski, Jenna N Beyer, Myles I Noel, George M Burslem
Sortase mediated protein ubiquitination with defined chain length and topology. RSC chemical biology 5 (4) (2024)
Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Jenna N Beyer, Yevgeniy V Serebrenik, Kaitlyn Toy, Mohd Altaf Najar, Nicole R Raniszewski, Ophir Shalem, George M Burslem
Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins. bioRxiv : the preprint server for biology (2024)
Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Science advances 9 (8) (2023)
Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Science advances 9 (8) (2023)
Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Science advances 9 (8) (2023)
Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Science advances 9 (8) (2023)
Ophir Shalem, Yevgeniy Serebrenik, Deepak Mani, Timothé Maujean, George M Burslem
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics. Research square (2023)
Timothé Maujean, Prakash Kannaboina, Adam I Green, George M Burslem
Lead-oriented synthesis of epigenetic relevant scaffolds. Chemical communications (Cambridge, England) (2023)
Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau Truong, Sagar Gupta, Trenton J Winters, George M Burslem, Nikolaos G Sgourakis
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes. bioRxiv : the preprint server for biology (2023)
Jean M Etersque, Iris K Lee, Nitika Sharma, Kexiang Xu, Andrew Ruff, Justin D Northrup, Swarbhanu Sarkar, Tommy Nguyen, Richard Lauman, George M Burslem, Mark A Sellmyer
Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nature communications 14 (1) (2023)
Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau V Truong, Sagar Gupta, Trenton J Winters, Joan Font-Burgada, George M Burslem, Nikolaos G Sgourakis
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes. Proceedings of the National Academy of Sciences of the United States of America 120 (25) (2023)
Andrew C McShan, Christine A Devlin, Georgia F Papadaki, Yi Sun, Adam I Green, Giora I Morozov, George M Burslem, Erik Procko, Nikolaos G Sgourakis
TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nature chemical biology 18 (8) (2022)
Adam I Green, George M Burslem
Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres. Journal of medicinal chemistry 64 (11) (2021)
Adam I Green, George M Burslem
Photochemical synthesis of an epigenetic focused tetrahydroquinoline library. RSC medicinal chemistry 12 (10) (2021)
George M Burslem, Daniel P Bondeson, Craig M Crews
Scaffold hopping enables direct access to more potent PROTACs with in vivo activity. Chemical communications (Cambridge, England) 56 (50) (2021)
Jenna N Beyer, Nicole R Raniszewski, George M Burslem
Advances and Opportunities in Epigenetic Chemical Biology. Chembiochem : a European journal of chemical biology 22 (1) (2020)
George M Burslem, Anna Reister Schultz, Daniel P Bondeson, Christopher A Eide, Samantha L Savage Stevens, Brian J Druker, Craig M Crews
Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer research 79 (18) (2019)
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson
Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical science 9 (7) (2018)
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson
Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical science 9 (7) (2018)
George M Burslem, Jayoung Song, Xin Chen, John Hines, Craig M Crews
Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. Journal of the American Chemical Society 140 (48) (2018)
George M Burslem, Philipp Ottis, Saul Jaime-Figueroa, Alicia Morgan, Philipp M Cromm, Momar Toure, Craig M Crews
Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships. ChemMedChem 13 (15) (2018)
George M Burslem, Craig M Crews
Small-Molecule Modulation of Protein Homeostasis. Chemical reviews 117 (17) (2017)
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson
Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chemical science 8 (6) (2017)
Claire M Grison, George M Burslem, Jennifer A Miles, Ludwig K A Pilsl, David J Yeo, Zeynab Imani, Stuart L Warriner, Michael E Webb, Andrew J Wilson
Double quick, double click reversible peptide "stapling". Chemical science 8 (7) (2017)

George M Burslem.css-eqlu8i{font-size:small;padding-left:4px;} (George Burslem)

Publication Activity (10 Years)

Top Topics

Top Venues

George M Burslem (George Burslem)