Craig M Crews

ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 45

Top Venues

Journal of the American Chemical Society

ACS chemical biology

Angewandte Chemie (International ed. in English)

Nature chemical biology

Yale University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Yale University Jul 01 1995

United States

John C. Malone Professor of MCDB :: Molecular, Cellular, and Developmental Biology

Publications

Ke Li, Mackenzie W Krone, Arseniy Butrin, Michael J Bond, Brian M Linhares, Craig M Crews
Development of Ligands and Degraders Targeting MAGE-A3. Journal of the American Chemical Society (2024)
Davis H Chase, Adrian M Bebenek, Pengju Nie, Saul Jaime-Figueroa, Arseniy Butrin, Danielle A Castro, John Hines, Brian M Linhares, Craig M Crews
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury. Angewandte Chemie (International ed. in English) (2024)
Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie W Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crews
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science advances 10 (13) (2024)
Davis H Chase, Adrian M Bebenek, Pengju Nie, Saul Jaime-Figueroa, Arseniy Butrin, Danielle A Castro, John Hines, Brian M Linhares, Craig M Crews
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury. Angewandte Chemie (International ed. in English) 63 (14) (2024)
Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie W Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crews
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science advances 10 (13) (2024)
Davis H Chase, Adrian M Bebenek, Pengju Nie, Saul Jaime-Figueroa, Arseniy Butrin, Danielle A Castro, John Hines, Brian M Linhares, Craig M Crews
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury. Angewandte Chemie (International ed. in English) 63 (14) (2024)
Davis H Chase, Adrian M Bebenek, Pengju Nie, Saul Jaime-Figueroa, Arseniy Butrin, Danielle A Castro, John Hines, Brian M Linhares, Craig M Crews
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury. Angewandte Chemie (International ed. in English) 63 (14) (2024)
Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie W Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crews
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science advances 10 (13) (2024)
Kanak Raina, Chris D Forbes, Rebecca Stronk, Jonathan P Rappi, Kyle J Eastman, Samuel W Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P King, Zoe M Posner, Allison Denny, Andrew McGovern, David E Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J Mousseau, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Levi M Smith, Jinshan M Chen, Cesar A De Leon, John Hines, Katherine J Kayser-Bricker, Craig M Crews
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively. bioRxiv : the preprint server for biology (2023)
Zhenyi Hu, Po-Han Chen, Wenxue Li, Todd Douglas, John Hines, Yansheng Liu, Craig M Crews
Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality. Journal of the American Chemical Society (2023)
Kanak Raina, Chris D Forbes, Rebecca Stronk, Jonathan P Rappi, Kyle J Eastman, Samuel W Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P King, Zoe M Posner, Allison Denny, Andrew McGovern, David E Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J Mousseau, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Levi M Smith, Jinshan M Chen, Cesar A De Leon, John Hines, Katherine J Kayser-Bricker, Craig M Crews
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively. bioRxiv : the preprint server for biology (2023)
Deborah Chirnomas, Keith R Hornberger, Craig M Crews
Protein degraders enter the clinic - a new approach to cancer therapy. Nature reviews. Clinical oncology (2023)
Kanak Raina, Chris D Forbes, Rebecca Stronk, Jonathan P Rappi, Kyle J Eastman, Samuel W Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P King, Zoe M Posner, Allison Denny, Andrew McGovern, David E Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J Mousseau, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Levi M Smith, Jinshan M Chen, Cesar A De Leon, John Hines, Katherine J Kayser-Bricker, Craig M Crews
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively. bioRxiv : the preprint server for biology (2023)
Deborah Chirnomas, Keith R Hornberger, Craig M Crews
Protein degraders enter the clinic - a new approach to cancer therapy. Nature reviews. Clinical oncology 20 (4) (2023)
Dhanusha A Nalawansha, Ke Li, John Hines, Craig M Crews
Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation. Journal of the American Chemical Society 144 (12) (2022)
Kusal T G Samarasinghe, Elvira An, Miriam A Genuth, Ling Chu, Scott A Holley, Craig M Crews
OligoTRAFTACs: A generalizable method for transcription factor degradation. RSC chemical biology 3 (9) (2022)
Ke Li, Craig M Crews
PROTACs: past, present and future. Chemical Society reviews 51 (12) (2022)
Miklós Békés, David R Langley, Craig M Crews
PROTAC targeted protein degraders: the past is prologue. Nature reviews. Drug discovery 21 (3) (2022)
Jake C Swartzel, Michael J Bond, Andreas P Pintado-Urbanc, Mehana Daftary, Mackenzie W Krone, Todd Douglas, Evan J Carder, Joshua T Zimmer, Takahiro Maeda, Matthew D Simon, Craig M Crews
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC. ACS chemical biology 17 (7) (2022)
Michael J Bond, Craig M Crews
Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. RSC chemical biology 2 (3) (2021)
Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T G Samarasinghe, Lea Vogt, Neal X Rosen, Craig M Crews
Mutant-selective degradation by BRAF-targeting PROTACs. Nature communications 12 (1) (2021)
Sijin Zheng, Craig M Crews
Electrophilic Screening Platforms for Identifying Novel Covalent Ligands for E3 Ligases. Biochemistry 60 (31) (2021)
Saul Jaime-Figueroa, Michael J Bond, J Ignacio Vergara, Jake C Swartzel, Craig M Crews
Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization. The Journal of organic chemistry 86 (12) (2021)
Po-Han Chen, Zhenyi Hu, Elvira An, Ifunanya Okeke, Sijin Zheng, Xuanmeng Luo, Angela Gong, Saul Jaime-Figueroa, Craig M Crews
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS chemical biology (2021)
Warren C Fiskus, Christopher P Mill, Dimuthu Perera, Christine Birdwell, Qing Deng, Haopeng Yang, Bernardo H Lara, Nitin Jain, Jan A Burger, Alessandra Ferrajoli, John A Davis, Dyana T Saenz, Wendy Jin, Cristian Coarfa, Craig M Crews, Michael R Green, Joseph D Khoury, Kapil N Bhalla
BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma. Leukemia 35 (9) (2021)
Lucas D Sanor, Grant Parker Flowers, Craig M Crews
Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls. eLife 9 (2020)
Alexandru D Buhimschi, Craig M Crews
Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome. Biochemistry 58 (7) (2019)
Christopher P Mill, Warren C Fiskus, Courtney D DiNardo, Yimin Qian, Kanak Raina, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Tapan M Kadia, Joseph D Khoury, Dyana T Saenz, David N Saenz, Anuradha Illendula, Koichi Takahashi, Steven M Kornblau, Michael R Green, Andrew P Futreal, John H Bushweller, Craig M Crews, Kapil N Bhalla
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. Blood 134 (1) (2019)
Blake E Smith, Stephen L Wang, Saul Jaime-Figueroa, Alicia Harbin, Jing Wang, Brian D Hamman, Craig M Crews
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nature communications 10 (1) (2019)
George M Burslem, Anna Reister Schultz, Daniel P Bondeson, Christopher A Eide, Samantha L Savage Stevens, Brian J Druker, Craig M Crews
Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer research 79 (18) (2019)
Matthieu Schapira, Matthew F Calabrese, Alex N Bullock, Craig M Crews
Targeted protein degradation: expanding the toolbox. Nature reviews. Drug discovery 18 (12) (2019)
Dyana T Saenz, Warren Fiskus, Taghi Manshouri, Christopher P Mill, Yimin Qian, Kanak Raina, Kimal Rajapakshe, Cristian Coarfa, Raffaella Soldi, Prithviraj Bose, Gautam Borthakur, Tapan Mahendra Kadia, Joseph D Khoury, Lucia Masarova, Agnieszka J Nowak, Baohua Sun, David N Saenz, Steven M Kornblau, Steve Horrigan, Sunil Sharma, Peng Qiu, Craig M Crews, Srdan Verstovsek, Kapil N Bhalla
Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML. Leukemia 33 (6) (2018)
Philipp M Cromm, Kusal T G Samarasinghe, John Hines, Craig M Crews
Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. Journal of the American Chemical Society 140 (49) (2018)
Alexandru D Buhimschi, Haley A Armstrong, Momar Toure, Saul Jaime-Figueroa, Timothy L Chen, Amy M Lehman, Jennifer A Woyach, Amy J Johnson, John C Byrd, Craig M Crews
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry 57 (26) (2018)
George M Burslem, Jayoung Song, Xin Chen, John Hines, Craig M Crews
Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. Journal of the American Chemical Society 140 (48) (2018)
John Hines, Schan Lartigue, Hanqing Dong, Yimin Qian, Craig M Crews
MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer research 79 (1) (2018)
Xiaohui Zhang, Hans C Lee, Fazal Shirazi, Veerabhadran Baladandayuthapani, Heather Lin, Isere Kuiatse, Hua Wang, Richard J Jones, Zuzana Berkova, Ram Kumar Singh, Jing Lu, Yimin Qian, Kanak Raina, Kevin G Coleman, Craig M Crews, Bingzong Li, Huihan Wang, Yared Hailemichael, Sheeba K Thomas, Zhiqiang Wang, R Eric Davis, Robert Z Orlowski
Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma. Leukemia 32 (10) (2018)
Jemilat Salami, Shanique Alabi, Ryan R Willard, Nick J Vitale, Jing Wang, Hanqing Dong, Meizhong Jin, Donald P McDonnell, Andrew P Crew, Taavi K Neklesa, Craig M Crews
Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Communications biology 1 (2018)
Craig M Crews
Inducing Protein Degradation as a Therapeutic Strategy. Journal of medicinal chemistry 61 (2) (2017)
Philipp Ottis, Craig M Crews
Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy. ACS chemical biology 12 (4) (2017)
Grant Parker Flowers, Lucas D Sanor, Craig M Crews
Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration. eLife 6 (2017)
Andrew P Crew, Kanak Raina, Hanqing Dong, Yimin Qian, Jing Wang, Dominico Vigil, Yevgeniy V Serebrenik, Brian D Hamman, Alicia Morgan, Caterina Ferraro, Kam Siu, Taavi K Neklesa, James D Winkler, Kevin G Coleman, Craig M Crews
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. Journal of medicinal chemistry 61 (2) (2017)
Philipp Ottis, Momar Toure, Philipp M Cromm, Eunhwa Ko, Jeffrey L Gustafson, Craig M Crews
Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS chemical biology 12 (10) (2017)
George M Burslem, Craig M Crews
Small-Molecule Modulation of Protein Homeostasis. Chemical reviews 117 (17) (2017)
Jemilat Salami, Craig M Crews
Waste disposal-An attractive strategy for cancer therapy. Science (New York, N.Y.) 355 (6330) (2017)
Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, Afjal H Miah, Katie E Mulholland, Natasha Routly, Dennis L Buckley, Jeffrey L Gustafson, Nico Zinn, Paola Grandi, Satoko Shimamura, Giovanna Bergamini, Maria Faelth-Savitski, Marcus Bantscheff, Carly Cox, Deborah A Gordon, Ryan R Willard, John J Flanagan, Linda N Casillas, Bartholomew J Votta, Willem den Besten, Kristoffer Famm, Laurens Kruidenier, Paul S Carter, John D Harling, Ian Churcher, Craig M Crews
Catalytic in vivo protein knockdown by small-molecule PROTACs. Nature chemical biology 11 (8) (2015)
Ting Xie, Sang Min Lim, Kenneth D Westover, Michael E Dodge, Dalia Ercan, Scott B Ficarro, Durga Udayakumar, Deepak Gurbani, Hyun Seop Tae, Steven M Riddle, Taebo Sim, Jarrod A Marto, Pasi A Jänne, Craig M Crews, Nathanael S Gray
Pharmacological targeting of the pseudokinase Her3. Nature chemical biology 10 (12) (2014)
Kanak Raina, Devin J Noblin, Yevgeniy V Serebrenik, Alison Adams, Connie Zhao, Craig M Crews
Targeted protein destabilization reveals an estrogen-mediated ER stress response. Nature chemical biology 10 (11) (2014)

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Publication Activity (10 Years)

Top Topics

Top Venues

Craig M Crews