Michael J Mitchell

ResearcherID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 150

Top Venues

Nature communications

ACS nano

Proceedings of the National Academy of Sciences of the United States of America

Nano letters

University of Pennsylvania

Cornell University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania

United States

Skirkanich Assistant Professor of Innovation :: Department of Bioengineering

Massachusetts Institute of Technology Aug 01 2014

United States

Postdoctoral Fellow :: Chemical Engineering

Education History

Cornell University Aug 30 2009 - Jul 10 2014

United States

PHD :: Biomedical Engineering

Cornell University Aug 31 2009 - Jan 01 2012

United States

MSC :: Biomedical Engineering

Publications

Rohan Palanki, Emily L Han, Amanda M Murray, Rohin Maganti, Sophia Tang, Kelsey L Swingle, Dongyoon Kim, Hannah Yamagata, Hannah C Safford, Kaitlin Mrksich, William H Peranteau, Michael J Mitchell
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab on a chip 24 (16) (2024)
Rohan Palanki, John S Riley, Sourav K Bose, Valerie Luks, Apeksha Dave, Nicole Kus, Brandon M White, Adele S Ricciardi, Kelsey L Swingle, Lulu Xue, Derek C Sung, Ajay S Thatte, Hannah C Safford, Venkata S Chaluvadi, Marco D Carpenter, Emily L Han, Rohin Maganti, Alex G Hamilton, Kaitlin Mrksich, Margaret M Billingsley, Philip W Zoltick, Mohamad-Gabriel Alameh, Drew Weissman, Michael J Mitchell, William H Peranteau
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Alex G Hamilton, Michael J Mitchell
An oncolytic circular RNA therapy. Nature cancer (2024)
Emily L Han, Marshall S Padilla, Rohan Palanki, Dongyoon Kim, Kaitlin Mrksich, Jacqueline J Li, Sophia Tang, Il-Chul Yoon, Michael J Mitchell
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano letters (2024)
Ningqiang Gong, Mohamad-Gabriel Alameh, Rakan El-Mayta, Lulu Xue, Drew Weissman, Michael J Mitchell
Enhancing in situ cancer vaccines using delivery technologies. Nature reviews. Drug discovery 23 (8) (2024)
Alex G Hamilton, Michael J Mitchell
An oncolytic circular RNA therapy. Nature cancer 5 (1) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) 36 (26) (2024)
Xuexiang Han, Mohamad-Gabriel Alameh, Ningqiang Gong, Lulu Xue, Majed Ghattas, Goutham Bojja, Junchao Xu, Gan Zhao, Claude C Warzecha, Marshall S Padilla, Rakan El-Mayta, Garima Dwivedi, Ying Xu, Andrew E Vaughan, James M Wilson, Drew Weissman, Michael J Mitchell
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nature chemistry (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Gan Zhao, Lulu Xue, Hannah C Geisler, Junchao Xu, Xinyuan Li, Michael J Mitchell, Andrew E Vaughan
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano 18 (22) (2024)
Lays Cordeiro Guimaraes, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa Athaydes Seabra Ferreira, Ana Carolina Soares Braga, Leonardo Camilo de Oliveira, Maria Marta Figueiredo, Sarah Shepherd, Alex G Hamilton, Celso Martins Queiroz-Junior, Walison Nunes da Silva, Natália Jordana Alves da Silva, Marco Túllio Rodrigues Alves, Anderson Kenedy Santos, Kevin Kelton Santos de Faria, Fernanda Martins Marim, Heidge Fukumasu, Alexander Birbrair, Andréa Teixeira-Carvalho, Renato Santana de Aguiar, Michael J Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Frédéric Jean Georges Frézard, Pedro Pires Goulart Guimaraes
Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models. Nature communications 15 (1) (2024)
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nature communications 15 (1) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) (2024)
Emily L Han, Marshall S Padilla, Rohan Palanki, Dongyoon Kim, Kaitlin Mrksich, Jacqueline J Li, Sophia Tang, Il-Chul Yoon, Michael J Mitchell
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano letters 24 (5) (2024)
Gan Zhao, Lulu Xue, Hannah C Geisler, Junchao Xu, Xinyuan Li, Michael J Mitchell, Andrew E Vaughan
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano 18 (22) (2024)
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nature communications 15 (1) (2024)
Emily L Han, Marshall S Padilla, Rohan Palanki, Dongyoon Kim, Kaitlin Mrksich, Jacqueline J Li, Sophia Tang, Il-Chul Yoon, Michael J Mitchell
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano letters 24 (5) (2024)
Ningqiang Gong, Wenqun Zhong, Mohamad Gabriel Alameh, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Gan Zhao, Andrew E Vaughan, Zhiyuan Qin, Fengyuan Xu, Alex G Hamilton, Dongyoon Kim, Junchao Xu, Junhyong Kim, Xucong Teng, Jinghong Li, Xing-Jie Liang, Drew Weissman, Wei Guo, Michael J Mitchell
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nature materials (2024)
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nature communications 15 (1) (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering 8 (5) (2024)
Rohan Palanki, John S Riley, Sourav K Bose, Valerie Luks, Apeksha Dave, Nicole Kus, Brandon M White, Adele S Ricciardi, Kelsey L Swingle, Lulu Xue, Derek C Sung, Ajay S Thatte, Hannah C Safford, Venkata S Chaluvadi, Marco D Carpenter, Emily L Han, Rohin Maganti, Alex G Hamilton, Kaitlin Mrksich, Margaret M Billingsley, Philip W Zoltick, Mohamad-Gabriel Alameh, Drew Weissman, Michael J Mitchell, William H Peranteau
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) 36 (26) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano 18 (22) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano 18 (22) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) 36 (26) (2024)
Andrew R Hanna, Sarah J Shepherd, David Issadore, Michael J Mitchell
Microfluidic Generation of Diverse Lipid Nanoparticle Libraries. Nanomedicine (London, England) 19 (6) (2024)
Gan Zhao, Lulu Xue, Hannah C Geisler, Junchao Xu, Xinyuan Li, Michael J Mitchell, Andrew E Vaughan
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano (2024)
Fan Yang, Md Naushad Akhtar, Duo Zhang, Rakan El-Mayta, Junyoung Shin, Jay F Dorsey, Lin Zhang, George X Xu, Wei Guo, Stephen J Bagley, Serge Y Fuchs, Constantinos Koumenis, Justin D Lathia, Michael J Mitchell, Yanqing Gong, Yi Fan
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science advances 10 (9) (2024)
Ningqiang Gong, Mohamad-Gabriel Alameh, Rakan El-Mayta, Lulu Xue, Drew Weissman, Michael J Mitchell
Enhancing in situ cancer vaccines using delivery technologies. Nature reviews. Drug discovery (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering (2024)
Alex G Hamilton, Kelsey L Swingle, Ajay S Thatte, Alvin J Mukalel, Hannah C Safford, Margaret M Billingsley, Rakan D El-Mayta, Xuexiang Han, Benjamin E Nachod, Ryann A Joseph, Ann E Metzloff, Michael J Mitchell
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. ACS nano (2024)
Fan Yang, Md Naushad Akhtar, Duo Zhang, Rakan El-Mayta, Junyoung Shin, Jay F Dorsey, Lin Zhang, George X Xu, Wei Guo, Stephen J Bagley, Serge Y Fuchs, Constantinos Koumenis, Justin D Lathia, Michael J Mitchell, Yanqing Gong, Yi Fan
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science advances 10 (9) (2024)
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C Warzecha, Gan Zhao, Andrew E Vaughan, James M Wilson, Drew Weissman, Michael J Mitchell
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nature communications 15 (1) (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Gan Zhao, Lulu Xue, Hannah C Geisler, Junchao Xu, Xinyuan Li, Michael J Mitchell, Andrew E Vaughan
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Rohan Palanki, John S Riley, Sourav K Bose, Valerie Luks, Apeksha Dave, Nicole Kus, Brandon M White, Adele S Ricciardi, Kelsey L Swingle, Lulu Xue, Derek C Sung, Ajay S Thatte, Hannah C Safford, Venkata S Chaluvadi, Marco D Carpenter, Emily L Han, Rohin Maganti, Alex G Hamilton, Kaitlin Mrksich, Margaret M Billingsley, Philip W Zoltick, Mohamad-Gabriel Alameh, Drew Weissman, Michael J Mitchell, William H Peranteau
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Kaitlin Mrksich, Marshall S Padilla, Ryann A Joseph, Emily L Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J Mitchell
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Journal of biomedical materials research. Part A (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Fan Yang, Md Naushad Akhtar, Duo Zhang, Rakan El-Mayta, Junyoung Shin, Jay F Dorsey, Lin Zhang, George X Xu, Wei Guo, Stephen J Bagley, Serge Y Fuchs, Constantinos Koumenis, Justin D Lathia, Michael J Mitchell, Yanqing Gong, Yi Fan
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science advances 10 (9) (2024)
Kaitlin Mrksich, Marshall S Padilla, Ryann A Joseph, Emily L Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J Mitchell
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Journal of biomedical materials research. Part A 112 (9) (2024)
Rohan Palanki, Emily L Han, Amanda M Murray, Rohin Maganti, Sophia Tang, Kelsey L Swingle, Dongyoon Kim, Hannah Yamagata, Hannah C Safford, Kaitlin Mrksich, William H Peranteau, Michael J Mitchell
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab on a chip 24 (16) (2024)
Kaitlin Mrksich, Marshall S Padilla, Ryann A Joseph, Emily L Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J Mitchell
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Journal of biomedical materials research. Part A 112 (9) (2024)
Thomas Anchordoquy, Natalie Artzi, Irina V Balyasnikova, Yechezkel Barenholz, Ninh M La-Beck, Jacob S Brenner, Warren W C Chan, Paolo Decuzzi, Agata A Exner, Alberto Gabizon, Biana Godin, Samuel K Lai, Twan Lammers, Michael J Mitchell, Seyed Moein Moghimi, Vladimir R Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J Serkova, Ravi Singh, Avi Schroeder, Anna A Schwendeman, Joelle P Straehla, Tambet Teesalu, Scott Tilden, Dmitri Simberg
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS nano (2024)
Lays Cordeiro Guimaraes, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa Athaydes Seabra Ferreira, Ana Carolina Soares Braga, Leonardo Camilo de Oliveira, Maria Marta Figueiredo, Sarah Shepherd, Alex G Hamilton, Celso Martins Queiroz-Junior, Walison Nunes da Silva, Natália Jordana Alves da Silva, Marco Túllio Rodrigues Alves, Anderson Kenedy Santos, Kevin Kelton Santos de Faria, Fernanda Martins Marim, Heidge Fukumasu, Alexander Birbrair, Andréa Teixeira-Carvalho, Renato Santana de Aguiar, Michael J Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Frédéric Jean Georges Frézard, Pedro Pires Goulart Guimaraes
Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models. Nature communications 15 (1) (2024)
Kaitlin Mrksich, Marshall S Padilla, Ryann A Joseph, Emily L Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J Mitchell
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Journal of biomedical materials research. Part A 112 (9) (2024)
Lays Cordeiro Guimaraes, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa Athaydes Seabra Ferreira, Ana Carolina Soares Braga, Leonardo Camilo de Oliveira, Maria Marta Figueiredo, Sarah Shepherd, Alex G Hamilton, Celso Martins Queiroz-Junior, Walison Nunes da Silva, Natália Jordana Alves da Silva, Marco Túllio Rodrigues Alves, Anderson Kenedy Santos, Kevin Kelton Santos de Faria, Fernanda Martins Marim, Heidge Fukumasu, Alexander Birbrair, Andréa Teixeira-Carvalho, Renato Santana de Aguiar, Michael J Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Frédéric Jean Georges Frézard, Pedro Pires Goulart Guimaraes
Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models. Nature communications 15 (1) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering 8 (5) (2024)
Andrew R Hanna, Sarah J Shepherd, David Issadore, Michael J Mitchell
Microfluidic generation of diverse lipid nanoparticle libraries. Nanomedicine (London, England) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) (2024)
Alexander Chan, Rebecca M Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J Bugaj, George M Burslem, Michael J Mitchell, Andrew Tsourkas
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nature communications 15 (1) (2024)
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nature communications 15 (1) (2024)
Rohan Palanki, Emily L Han, Amanda M Murray, Rohin Maganti, Sophia Tang, Kelsey L Swingle, Dongyoon Kim, Hannah Yamagata, Hannah C Safford, Kaitlin Mrksich, William H Peranteau, Michael J Mitchell
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab on a chip 24 (16) (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) 36 (26) (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering (2024)
Alex G Hamilton, Kelsey L Swingle, Ajay S Thatte, Alvin J Mukalel, Hannah C Safford, Margaret M Billingsley, Rakan D El-Mayta, Xuexiang Han, Benjamin E Nachod, Ryann A Joseph, Ann E Metzloff, Michael J Mitchell
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. ACS nano 18 (25) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Rohan Palanki, Emily L Han, Amanda M Murray, Rohin Maganti, Sophia Tang, Kelsey L Swingle, Dongyoon Kim, Hannah Yamagata, Hannah C Safford, Kaitlin Mrksich, William H Peranteau, Michael J Mitchell
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab on a chip (2024)
Ann E Metzloff, Marshall S Padilla, Ningqiang Gong, Margaret M Billingsley, Xuexiang Han, Maria Merolle, David Mai, Christian G Figueroa-Espada, Ajay S Thatte, Rebecca M Haley, Alvin J Mukalel, Alex G Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.) 36 (26) (2024)
Gan Zhao, Lulu Xue, Aaron I Weiner, Ningqiang Gong, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E Gentile, Ana N Nottingham, Maria C Basal, Susan M Lin, Terren K Niethamer, Joshua M Diamond, Christian A Bermudez, Edward Cantu, Xuexiang Han, Yaqi Cao, Mohamad Gabriel Alameh, Drew Weissman, Edward E Morrisey, Michael J Mitchell, Andrew E Vaughan
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Science translational medicine 16 (732) (2024)
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G Figueroa-Espada, Sarah J Shepherd, Alvin J Mukalel, Mohamad Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E Vaughan, Drew Weissman, Michael J Mitchell
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature communications 15 (1) (2024)
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C Warzecha, Gan Zhao, Andrew E Vaughan, James M Wilson, Drew Weissman, Michael J Mitchell
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nature communications 15 (1) (2024)
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C Warzecha, Gan Zhao, Andrew E Vaughan, James M Wilson, Drew Weissman, Michael J Mitchell
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nature communications 15 (1) (2024)
Gan Zhao, Maria E Gentile, Lulu Xue, Christopher V Cosgriff, Aaron I Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P Holcomb, Maria C Basal, Kathleen M Stewart, Joseph D Planer, Edward Cantu, Jason D Christie, Maria M Crespo, Michael J Mitchell, Nuala J Meyer, Andrew E Vaughan
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nature communications 15 (1) (2024)
Andrew R Hanna, Sarah J Shepherd, David Issadore, Michael J Mitchell
Microfluidic Generation of Diverse Lipid Nanoparticle Libraries. Nanomedicine (London, England) 19 (6) (2024)
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C Sheppard, Carl H June, Michael J Mitchell
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature biomedical engineering (2024)
Alex G Hamilton, Michael J Mitchell
An oncolytic circular RNA therapy. Nature cancer 5 (1) (2024)
Rebecca M Haley, Alexander Chan, Margaret M Billingsley, Ningqiang Gong, Marshall S Padilla, Emily H Kim, Hejia Wang, Dingzi Yin, Kirk J Wangensteen, Andrew Tsourkas, Michael J Mitchell
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. ACS applied materials & interfaces 15 (18) (2023)
Alex G Hamilton, Kelsey L Swingle, Michael J Mitchell
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS biology 21 (4) (2023)
Alex G Hamilton, Kelsey L Swingle, Michael J Mitchell
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS biology 21 (4) (2023)
Jia Nong, Patrick M Glassman, Jacob W Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia, Alvin Mukalel, Serena Omo-Lamai, Landis R Walsh, Marco E Zamora, Xijing Gong, Zhicheng Wang, Kartik Bhamidipati, Raisa Y Kiseleva, Carlos H Villa, Colin Fred Greineder, Scott E Kasner, Drew Weissman, Michael J Mitchell, Silvia Muro, Yuri Persidsky, Jacob Samuel Brenner, Vladimir R Muzykantov, Oscar A Marcos-Contreras
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. ACS nano (2023)
Stefan R Torborg, Olivera Grbovic-Huezo, Anupriya Singhal, Matilda Holm, Katherine Wu, Xuexiang Han, Yu-Jui Ho, Caj Haglund, Michael J Mitchell, Scott W Lowe, Lukas E Dow, Kenneth L Pitter, Francisco J Sánchez Rivera, Andre Levchenko, Tuomas Tammela
Solid tumor growth depends on an intricate equilibrium of malignant cell states. bioRxiv : the preprint server for biology (2023)
Junchao Xu, Na Yan, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J Mitchell, Yinlong Zhang, Guangjun Nie
Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents. Circulation research (2023)
Hannah C Safford, Kelsey L Swingle, Hannah C Geisler, Alex G Hamilton, Ajay S Thatte, Aditi A Ghalsasi, Margaret M Billingsley, Mohamad-Gabriel Alameh, Drew Weissman, Michael J Mitchell
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Small (Weinheim an der Bergstrasse, Germany) (2023)
Christian G Figueroa-Espada, Pedro P G Guimarães, Rachel S Riley, Lulu Xue, Karin Wang, Michael J Mitchell
siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy. Cellular and molecular bioengineering 16 (4) (2023)
Rebecca M Haley, Alexander Chan, Margaret M Billingsley, Ningqiang Gong, Marshall S Padilla, Emily H Kim, Hejia Wang, Dingzi Yin, Kirk J Wangensteen, Andrew Tsourkas, Michael J Mitchell
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. ACS applied materials & interfaces 15 (18) (2023)
Junchao Xu, Na Yan, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J Mitchell, Yinlong Zhang, Guangjun Nie
Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents. Circulation research 132 (3) (2023)
Kelsey L Swingle, Hannah C Safford, Hannah C Geisler, Alex G Hamilton, Ajay S Thatte, Margaret M Billingsley, Ryann A Joseph, Kaitlin Mrksich, Marshall S Padilla, Aditi A Ghalsasi, Mohamad Gabriel Alameh, Drew Weissman, Michael J Mitchell
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. Journal of the American Chemical Society 145 (8) (2023)
Alex G Hamilton, Kelsey L Swingle, Michael J Mitchell
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS biology 21 (4) (2023)
Alex G Hamilton, Kelsey L Swingle, Michael J Mitchell
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS biology 21 (4) (2023)
Ghazal Bashiri, Marshall S Padilla, Kelsey L Swingle, Sarah J Shepherd, Michael J Mitchell, Karin Wang
Nanoparticle protein corona: from structure and function to therapeutic targeting. Lab on a chip 23 (6) (2023)
Ningqiang Gong, Alex G Hamilton, Michael J Mitchell
A hydrogel-entrapped live virus immunization. Nature biomedical engineering (2023)
Alex G Hamilton, Kelsey L Swingle, Ryann A Joseph, David Mai, Ningqiang Gong, Margaret M Billingsley, Mohamad-Gabriel Alameh, Drew Weissman, Neil C Sheppard, Carl H June, Michael J Mitchell
Lonizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Advanced healthcare materials (2023)
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M Billingsley, Rakan El-Mayta, Sarah J Shepherd, Mohamad Gabriel Alameh, Drew Weissman, Michael J Mitchell
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nature communications 14 (1) (2023)
Kelsey L Swingle, Hannah C Safford, Hannah C Geisler, Alex G Hamilton, Ajay S Thatte, Margaret M Billingsley, Ryann A Joseph, Kaitlin Mrksich, Marshall S Padilla, Aditi A Ghalsasi, Mohamad Gabriel Alameh, Drew Weissman, Michael J Mitchell
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. Journal of the American Chemical Society 145 (8) (2023)
Ghazal Bashiri, Marshall S Padilla, Kelsey L Swingle, Sarah J Shepherd, Michael J Mitchell, Karin Wang
Nanoparticle protein corona: from structure and function to therapeutic targeting. Lab on a chip 23 (6) (2023)
Kelsey L Swingle, Hannah C Safford, Hannah C Geisler, Alex G Hamilton, Ajay S Thatte, Margaret M Billingsley, Ryann A Joseph, Kaitlin Mrksich, Marshall S Padilla, Aditi A Ghalsasi, Mohamad Gabriel Alameh, Drew Weissman, Michael J Mitchell
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. Journal of the American Chemical Society 145 (8) (2023)

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Michael J Mitchell