Haytham O Tawfik (Haytham Tawfik)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 43

Top Topics

Molecular Docking

Breast Cancer Cells

Papillary Thyroid

Toxoplasma Gondii

Top Venues

Journal of medicinal chemistry

Journal of enzyme inhibition and medicinal chemistry

Molecules (Basel, Switzerland)

This page only lists publications with an associated author ORCID identifier.

Publications

Salma M Hefny, Tarek F El-Moselhy, Nabaweya El-Din, Simone Giovannuzzi, Thamer Bin Traiki, Mansoor-Ali Vaali-Mohammed, Ahmed M El-Dessouki, Koki Yamaguchi, Masaharu Sugiura, Moataz A Shaldam, Claudiu T Supuran, Maha-Hamadien Abdulla, Wagdy M Eldehna, Haytham O Tawfik
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro , In Vivo , and In Silico Investigations of Coumarin-Based Thiazoles. Journal of medicinal chemistry (2024)
Omnia Montaser, Mona El-Aasr, Haytham O Tawfik, Wesam S Meshrif, Hanaa Elbrense
Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L. Journal of experimental zoology. Part A, Ecological and integrative physiology (2024)
Omnia Montaser, Mona El-Aasr, Haytham O Tawfik, Wesam S Meshrif, Hanaa Elbrense
Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L. Journal of experimental zoology. Part A, Ecological and integrative physiology 341 (6) (2024)
Haytham O Tawfik, Mohamed M Saleh, Andrea Ammara, Eman F Khaleel, Rehab Badi, Yomna T T Khater, Rabab Ahmed Rasheed, Ahmed A Attia, Salma M Hefny, Eslam B Elkaeed, Alessio Nocentini, Claudiu T Supuran, Wagdy M Eldehna, Moataz A Shaldam
Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. Journal of medicinal chemistry 67 (2) (2024)
Haytham O Tawfik, Mohamed M Saleh, Andrea Ammara, Eman F Khaleel, Rehab Badi, Yomna T T Khater, Rabab Ahmed Rasheed, Ahmed A Attia, Salma M Hefny, Eslam B Elkaeed, Alessio Nocentini, Claudiu T Supuran, Wagdy M Eldehna, Moataz A Shaldam
Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. Journal of medicinal chemistry (2024)
Salma M Hefny, Tarek F El-Moselhy, Nabaweya El-Din, Simone Giovannuzzi, Thamer Bin Traiki, Mansoor-Ali Vaali-Mohammed, Ahmed M El-Dessouki, Koki Yamaguchi, Masaharu Sugiura, Moataz A Shaldam, Claudiu T Supuran, Maha-Hamadien Abdulla, Wagdy M Eldehna, Haytham O Tawfik
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro , In Vivo , and In Silico Investigations of Coumarin-Based Thiazoles. Journal of medicinal chemistry 67 (9) (2024)
Ahmed Sabt, Haytham O Tawfik, Eman F Khaleel, Rehab Mustafa Badi, Hoda Atef Abdelsattar Ibrahim, Eslam B Elkaeed, Wagdy M Eldehna
An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review. Molecular diversity (2024)
Heba A Elsebaie, Mohamed S Nafie, Haytham O Tawfik, Amany Belal, Mohammed M Ghoneim, Ahmad J Obaidullah, Salwa Shaaban, Abdelmoneim A Ayed, Mohamed El-Naggar, Ahmed B M Mehany, Moataz A Shaldam
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies. RSC medicinal chemistry 15 (7) (2024)
Haytham O Tawfik, Mohamed M Saleh, Andrea Ammara, Eman F Khaleel, Rehab Badi, Yomna T T Khater, Rabab Ahmed Rasheed, Ahmed A Attia, Salma M Hefny, Eslam B Elkaeed, Alessio Nocentini, Claudiu T Supuran, Wagdy M Eldehna, Moataz A Shaldam
Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. Journal of medicinal chemistry 67 (2) (2024)
Heba A Elsebaie, Mohamed S Nafie, Haytham O Tawfik, Amany Belal, Mohammed M Ghoneim, Ahmad J Obaidullah, Salwa Shaaban, Abdelmoneim A Ayed, Mohamed El-Naggar, Ahmed B M Mehany, Moataz A Shaldam
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies. RSC medicinal chemistry 15 (7) (2024)
Ahmed Ali Al-Karmalawy, Mai H A Mousa, Marwa Sharaky, Mai A E Mourad, Ahmed M El-Dessouki, Amir O Hamouda, Radwan Alnajjar, Abdelmoneim A Ayed, Moataz A Shaldam, Haytham O Tawfik
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of medicinal chemistry 67 (1) (2023)
Moataz A Shaldam, Hadia Almahli, Andrea Ageli, Rehab Mustafa Badi, Eman F Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, Eslam B Elkaeed, Rofaida Salem, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 38 (1) (2023)
Moataz A Shaldam, Ahmed F Khalil, Hadia Almahli, Maiy Y Jaballah, Andrea Angeli, Eman F Khaleel, Rehab Mustafa Badi, Eslam B Elkaeed, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
Identification of 3-(5-cyano-6-oxo-pyridin-2-yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity. Archiv der Pharmazie (2023)
Ahmed Ali Al-Karmalawy, Mai H A Mousa, Marwa Sharaky, Mai A E Mourad, Ahmed M El-Dessouki, Amir O Hamouda, Radwan Alnajjar, Abdelmoneim A Ayed, Moataz A Shaldam, Haytham O Tawfik
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of medicinal chemistry (2023)
Shaimaa M Aboukhatwa, Peter A Sidhom, Andrea Ageli, Claudiu T Supuran, Haytham O Tawfik
Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids. ACS omega 8 (8) (2023)
Moataz A Shaldam, Hadia Almahli, Andrea Ageli, Rehab Mustafa Badi, Eman F Khaleel, Abdelrahman I Zain-Alabdeen, Zainab M Elsayed, Eslam B Elkaeed, Rofaida Salem, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors. Journal of enzyme inhibition and medicinal chemistry 38 (1) (2023)
Faten Farouk, Ayman Abo Elmaaty, Ahmed Elkamhawy, Haytham O Tawfik, Radwan Alnajjar, Mohammed A S Abourehab, Mohamed A Saleh, Wagdy M Eldehna, Ahmed Ali Al-Karmalawy
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro , molecular docking, molecular dynamics, and SAR studies. Journal of enzyme inhibition and medicinal chemistry 38 (1) (2023)
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O Tawfik, Gaber El-Saber Batiha, Mohamed H Mahmoud, Michel De Waard, Wagdy M Eldehna, Abdel-Rahim Sayed Ibrahim
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening. Molecules (Basel, Switzerland) 28 (4) (2023)
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O Tawfik, Gaber El-Saber Batiha, Mohamed H Mahmoud, Michel De Waard, Wagdy M Eldehna, Abdel-Rahim Sayed Ibrahim
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening. Molecules (Basel, Switzerland) 28 (4) (2023)
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O Tawfik, Gaber El-Saber Batiha, Mohamed H Mahmoud, Michel De Waard, Wagdy M Eldehna, Abdel-Rahim Sayed Ibrahim
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening. Molecules (Basel, Switzerland) 28 (4) (2023)
Mahmoud G Abo Al-Hamd, Haytham O Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B M Mehany, Mervat H El-Hamamsy, Tarek F El-Moselhy
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR WT , EGFR T790M , and EGFR L858R ). Journal of enzyme inhibition and medicinal chemistry 38 (1) (2023)
Ahmed Ali Al-Karmalawy, Mai H A Mousa, Marwa Sharaky, Mai A E Mourad, Ahmed M El-Dessouki, Amir O Hamouda, Radwan Alnajjar, Abdelmoneim A Ayed, Moataz A Shaldam, Haytham O Tawfik
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of medicinal chemistry 67 (1) (2023)
Shaimaa M Aboukhatwa, Peter A Sidhom, Andrea Ageli, Claudiu T Supuran, Haytham O Tawfik
Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids. ACS omega 8 (8) (2023)
Ahmed Ali Al-Karmalawy, Mai H A Mousa, Marwa Sharaky, Mai A E Mourad, Ahmed M El-Dessouki, Amir O Hamouda, Radwan Alnajjar, Abdelmoneim A Ayed, Moataz A Shaldam, Haytham O Tawfik
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of medicinal chemistry 67 (1) (2023)
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O Tawfik, Gaber El-Saber Batiha, Mohamed H Mahmoud, Michel De Waard, Wagdy M Eldehna, Abdel-Rahim Sayed Ibrahim
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening. Molecules (Basel, Switzerland) 28 (4) (2023)
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O Tawfik, Gaber El-Saber Batiha, Mohamed H Mahmoud, Michel De Waard, Wagdy M Eldehna, Abdel-Rahim Sayed Ibrahim
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening. Molecules (Basel, Switzerland) 28 (4) (2023)
Haytham O Tawfik, Amany Belal, Mohammad A S Abourehab, Andrea Ageli, Alessandro Bonardi, Claudiu T Supuran, Mervat H El-Hamamsy
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Ahmed Ali Al-Karmalawy, Mohamed S Nafie, Moataz A Shaldam, Ayman Abo Elmaaty, Samar A Antar, Anwar A El-Hamaky, Mohamed A Saleh, Ahmed Elkamhawy, Haytham O Tawfik
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. Journal of medicinal chemistry 66 (1) (2022)
Haytham O Tawfik, Anwar A El-Hamaky, Eman A El-Bastawissy, Kirill A Shcherbakov, Alexander V Veselovsky, Yulia A Gladilina, Dmitry D Zhdanov, Mervat H El-Hamamsy
New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer. Pharmaceuticals (Basel, Switzerland) 15 (4) (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Wagdy M Eldehna, Amany Elsayed Ragab
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies. Metabolites 13 (1) (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Wagdy M Eldehna, Amany Elsayed Ragab
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies. Metabolites 13 (1) (2022)
Ahmed Ali Al-Karmalawy, Mohamed S Nafie, Moataz A Shaldam, Ayman Abo Elmaaty, Samar A Antar, Anwar A El-Hamaky, Mohamed A Saleh, Ahmed Elkamhawy, Haytham O Tawfik
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. Journal of medicinal chemistry (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Wagdy M Eldehna, Amany Elsayed Ragab
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies. Metabolites 13 (1) (2022)
Mona El-Aasr, Toshihiro Nohara, Tsuyushi Ikeda, Sally E Abu-Risha, Engy Elekhnawy, Haytham O Tawfik, Nagwa Shoeib, Ghada Attia
LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound. Natural product research (2022)
Haytham O Tawfik, Moataz A Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, Sara T Al-Rashood, Claudiu T Supuran, Wagdy M Eldehna
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Mohamed H Saad, Tarek F El-Moselhy, Nabaweya S El-Din, Ahmed B M Mehany, Amany Belal, Mohammad A S Abourehab, Haytham O Tawfik, Mervat H El-Hamamsy
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Wagdy M Eldehna, Amany Elsayed Ragab
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies. Metabolites 13 (1) (2022)
Moataz A Shaldam, Haytham O Tawfik, Heba Mohamed Elmansi, Fathalla Belal, Koki Yamaguchi, Masaharu Sugiura, Galal Magdy
Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent. Journal of biomolecular structure & dynamics (2022)
Ahmed Ali Al-Karmalawy, Mohamed S Nafie, Moataz A Shaldam, Ayman Abo Elmaaty, Samar A Antar, Anwar A El-Hamaky, Mohamed A Saleh, Ahmed Elkamhawy, Haytham O Tawfik
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. Journal of medicinal chemistry 66 (1) (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Amany Elsayed Ragab
Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di- C -glucoside from Cycas rumphii Miq. Cultivated in Egypt. Plants (Basel, Switzerland) 11 (21) (2022)
Ahmed Ali Al-Karmalawy, Mohamed S Nafie, Moataz A Shaldam, Ayman Abo Elmaaty, Samar A Antar, Anwar A El-Hamaky, Mohamed A Saleh, Ahmed Elkamhawy, Haytham O Tawfik
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. Journal of medicinal chemistry 66 (1) (2022)
Hosam M El-Seadawy, Kamilia A Abo El-Seoud, Mona El-Aasr, Haytham O Tawfik, Wagdy M Eldehna, Amany Elsayed Ragab
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies. Metabolites 13 (1) (2022)
Mervat H El-Hamamsy, Nabaweya A Sharafeldin, Tarek F El-Moselhy, Haytham O Tawfik
Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors. Archiv der Pharmazie 353 (8) (2020)