Stefan Knapp (S Knapp)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 163

Top Venues

Journal of medicinal chemistry

ACS chemical biology

International journal of molecular sciences

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry 67 (3) (2024)
Andreas Krämer, Stefan Knapp
Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours. Signal transduction and targeted therapy 9 (1) (2024)
Christian J Muñoz Sosa, Christopher Lenz, Anton Hamann, Frederic Farges, Johannes Dopfer, Andreas Krämer, Veronika Cherkashyna, Andrey Tarnovskiy, Yurii S Moroz, Ewgenij Proschak, Václav Němec, Susanne Müller, Krishna Saxena, Stefan Knapp
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7. ACS chemical biology (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H M Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of medicinal chemistry 67 (6) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Marcos A Ferreira, Bruno V M Teodoro, Jéssica Emi Takarada, André da Silva Santiago, Dimitrios-Ilias Balourdas, Ann-Sofie Nilsson, Bruno Urien, Vitor M Almeida, Carina Gileadi, Priscila Z Ramos, Anita Salmazo, Stanley N S Vasconcelos, Micael Rodrigues Cunha, Susanne Müller, Stefan Knapp, Katlin Brauer Massirer, Jonathan M Elkins, Opher Gileadi, Alessandra Mascarello, Bennie B L G Lemmens, Cristiano R W Guimarães, Hatylas Azevedo, Rafael Miguez Couñago
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. Journal of medicinal chemistry 67 (11) (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology 20 (9) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry (2024)
Christian J Muñoz Sosa, Christopher Lenz, Anton Hamann, Frederic Farges, Johannes Dopfer, Andreas Krämer, Veronika Cherkashyna, Andrey Tarnovskiy, Yurii S Moroz, Ewgenij Proschak, Václav Němec, Susanne Müller, Krishna Saxena, Stefan Knapp
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7. ACS chemical biology 19 (7) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology (2024)
Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H M Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of medicinal chemistry 67 (6) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology 20 (9) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H M Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of medicinal chemistry 67 (6) (2024)
Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H M Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of medicinal chemistry (2024)
Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A Laufer, Stefan Knapp, Daniel Dauch, Alexander Titz
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles. Journal of medicinal chemistry (2024)
Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Marcos A Ferreira, Bruno V M Teodoro, Jéssica Emi Takarada, André da Silva Santiago, Dimitrios-Ilias Balourdas, Ann-Sofie Nilsson, Bruno Urien, Vitor M Almeida, Carina Gileadi, Priscila Z Ramos, Anita Salmazo, Stanley N S Vasconcelos, Micael Rodrigues Cunha, Susanne Müller, Stefan Knapp, Katlin Brauer Massirer, Jonathan M Elkins, Opher Gileadi, Alessandra Mascarello, Bennie B L G Lemmens, Cristiano R W Guimarães, Hatylas Azevedo, Rafael Miguez Couñago
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. Journal of medicinal chemistry (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (15) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Fang Li, W Felix Zhu, Claire Empel, Oleksandr Datsenko, Adarsh Kumar, Yameng Xu, Johanna H M Ehrler, Iuliana L Atodiresei, Stefan Knapp, Pavel K Mykhailiuk, Ewgenij Proschak, René M Koenigs
Photosensitization enables Pauson-Khand-type reactions with nitrenes. Science (New York, N.Y.) 383 (6682) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry 67 (3) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Lara Dötsch, Caitlin Davies, Elisabeth Hennes, Julia Schönfeld, Adarsh Kumar, Celine Da Cruz Lopes Guita, Johanna H M Ehrler, Kerstin Hiesinger, Sasikala Thavam, Petra Janning, Sonja Sievers, Stefan Knapp, Ewgenij Proschak, Slava Ziegler, Herbert Waldmann
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of medicinal chemistry 67 (6) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A Laufer, Stefan Knapp, Daniel Dauch, Alexander Titz
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles. Journal of medicinal chemistry 67 (8) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry (2023)
Alexander Strubel, Philipp Münick, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus Elmar Diefenbacher, Volker Dötsch
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell death & disease 14 (10) (2023)
Marta Sanz Murillo, Amalia Villagran Suarez, Verena Dederer, Deep Chatterjee, Jaime Alegrio Louro, Stefan Knapp, Sebastian Mathea, Andres E Leschziner
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Science advances 9 (48) (2023)
Emmanuel Deau, Mattias F Lindberg, Frédéric Miege, Didier Roche, Nicolas George, Pascal George, Andreas Krämer, Stefan Knapp, Laurent Meijer
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. Journal of medicinal chemistry (2023)
Leonore Novak, Maria Petrosino, Alessandra Pasquo, Apirat Chaikuad, Roberta Chiaraluce, Stefan Knapp, Valerio Consalvi
Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability. Cancers 15 (11) (2023)
Xiaomin Ni, Andreas C Joerger, Apirat Chaikuad, Stefan Knapp
Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction. Open biology 13 (5) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Mattias F Lindberg, Emmanuel Deau, Frédéric Miege, Marie Greverie, Didier Roche, Nicolas George, Pascal George, Laura Merlet, Julie Gavard, Sander J T Brugman, Edwin Aret, Paul Tinnemans, René de Gelder, Jan Sadownik, Eva Verhofstad, Dennis Sleegers, Sara Santangelo, Julien Dairou, Álvaro Fernandez-Blanco, Mara Dierssen, Andreas Krämer, Stefan Knapp, Laurent Meijer
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate. Journal of medicinal chemistry (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Jennifer A Amrhein, Guiqun Wang, Benedict-Tilmann Berger, Lena Marie Berger, Amalia D Kalampaliki, Andreas Krämer, Stefan Knapp, Thomas Hanke
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS medicinal chemistry letters 14 (6) (2023)
Stefan Knapp, Susanne Müller
Improving data quality in chemical biology. Nature chemical biology (2023)
Silvia Arifi, Julian A Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser, Lennart Obeser, Georg Höfner, Ewgenij Proschak, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation. Journal of the American Chemical Society (2023)
Jiong Hu, Matthias S Leisegang, Mario Looso, Maria-Kyriaki Drekolia, Janina Wittig, Janina Mettner, Christina Karantanou, Anastasia Kyselova, Gabrijela Dumbović, Xiaoming Li, Yuanyuan Li, Stefan Günther, David John, Mauro Siragusa, Sven Zukunft, James Oo, Ilka Wittig, Susanne S Hille, Andreas Weigert, Stefan Knapp, Ralf P Brandes, Oliver J Müller, Andreas Papapetropoulos, Fragiska Sigala, Gergana Dobreva, Baktybek Kojonazarov, Ingrid Fleming, Sofia-Iris Bibli
Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence. Circulation research (2023)
Chanchal Chauhan, Andreas Kraemer, Stefan Knapp, Mark Windheim, Alexey Kotlyarov, Manoj B Menon, Matthias Gaestel
5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling. Cell death discovery 9 (1) (2023)
Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D Chodera, Markus A Seeliger
Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. eLife 12 (2023)
Jun Yong Choi, Yoshihiko Noguchi, James M Alburger, Simon Bayle, Eugene Chung, Wayne Grant, Apirat Chaikuad, Stefan Knapp, Derek R Duckett, William R Roush
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ. Journal of medicinal chemistry (2023)
Janice M Reimer, Andrea M Dickey, Yu Xuan Lin, Robert G Abrisch, Sebastian Mathea, Deep Chatterjee, Elizabeth J Fay, Stefan Knapp, Matthew D Daugherty, Samara L Reck-Peterson, Andres E Leschziner
Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature structural & molecular biology (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Henner F Farin, Mohammed H Mosa, Benardina Ndreshkjana, Britta Moyo Grebbin, Birgit Ritter, Constantin Menche, Kilian B Kennel, Paul K Ziegler, Lili Szabo, Julia Bollrath, Dietmar Rieder, Birgitta E Michels, Alena Kress, Muge Bozlar, Tahmineh Darvishi, Sara Stier, Ivan-Maximiliano Kur, Katrin Bankov, Rebecca Kesselring, Stefan Fichtner-Feigl, Bernhard Brüne, Thorsten O Goetze, Salah-Eddin Al-Batran, Christian H Brandts, Wolf Otto Bechstein, Peter J Wild, Andreas Weigert, Susanne Müller, Stefan Knapp, Zlatko Trajanoski, Florian R Greten
Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses. Cancer discovery (2023)
Maria Karelou, Dionysis Kampasis, Amalia D Kalampaliki, Leentje Persoons, Andreas Krämer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K Kostakis
Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3 H )-Ones with Antiproliferative Activities. Molecules (Basel, Switzerland) 28 (23) (2023)
Sandrine Baltzer, Timur Bulatov, Christopher Schmied, Andreas Krämer, Benedict-Tilmann Berger, Andreas Oder, Ryan Walker-Gray, Christin Kuschke, Kerstin Zühlke, Jenny Eichhorst, Martin Lehmann, Stefan Knapp, John Weston, Jens Peter von Kries, Roderich D Süssmuth, Enno Klussmann
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells. International journal of molecular sciences 23 (2) (2022)
Amelie Tjaden, Apirat Chaikuad, Eric Kowarz, Rolf Marschalek, Stefan Knapp, Martin Schröder, Susanne Müller
Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening. Molecules (Basel, Switzerland) 27 (4) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
W Felix Zhu, Andreas Krämer, Stefan Knapp, Ewgenij Proschak, Victor Hernandez-Olmos
Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation. The Journal of organic chemistry 87 (5) (2022)
Javier R Balboa, Dominik J Essig, Sana Ma, Nichlas Karer, Louise S Clemmensen, Søren W Pedersen, Andreas C Joerger, Stefan Knapp, Søren Østergaard, Kristian Stro Mgaard
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. Journal of medicinal chemistry (2022)
Javier R Balboa, Dominik J Essig, Sana Ma, Nichlas Karer, Louise S Clemmensen, Søren W Pedersen, Andreas C Joerger, Stefan Knapp, Søren Østergaard, Kristian Stro Mgaard
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. Journal of medicinal chemistry 66 (1) (2022)
Angelina R Sekirnik, Jessica K Reynolds, Larissa See, Joseph P Bluck, Amy R Scorah, Cynthia Tallant, Bernadette Lee, Katarzyna B Leszczynska, Rachel L Grimley, R Ian Storer, Marta Malattia, Sara Crespillo, Sofia Caria, Stephanie Duclos, Eva-Leonne Göttgens, Stefan Knapp, Garrett M Morris, Fernanda Duarte, Philip Charles Biggin, Stuart J Conway
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. ACS chemical biology 17 (10) (2022)
Apirat Chaikuad, Rezart Zhubi, Claudia Tredup, Stefan Knapp
Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family. IUCrJ 9 (Pt 6) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Christian G Kurz, Franziska Preuss, Amelie Tjaden, Martin Cusack, Jennifer Alisa Amrhein, Deep Chatterjee, Sebastian Mathea, Lena Marie Berger, Benedict-Tilmann Berger, Andreas Krämer, Michael Weller, Tobias Weiss, Susanne Müller, Stefan Knapp, Thomas Hanke
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. Journal of medicinal chemistry 65 (11) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilmann Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Müller, Stefan Knapp
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Journal of medicinal chemistry 65 (19) (2022)
Aziz M Rangwala, Benedict-Tilmann Berger, Matthew B Robers, Stefan Knapp, Markus A Seeliger
Resistance to kinase inhibition through shortened target engagement. Molecular & cellular oncology 9 (1) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Giuseppe Faudone, Rezart Zhubi, Fatih Celik, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Design of a Potent TLX Agonist by Rational Fragment Fusion. Journal of medicinal chemistry 65 (3) (2022)
Javier R Balboa, Dominik J Essig, Sana Ma, Nichlas Karer, Louise S Clemmensen, Søren W Pedersen, Andreas C Joerger, Stefan Knapp, Søren Østergaard, Kristian Stro Mgaard
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. Journal of medicinal chemistry 66 (1) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Ranjan Kumar Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H Schmidt, Deep Chatterjee, Joshua A David, Els Pardon, Thomas U Schwartz, Stefan Knapp, Eileen J Kennedy, Jan Steyaert, Friedrich W Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Deep Chatterjee, Franziska Preuss, Verena Dederer, Stefan Knapp, Sebastian Mathea
Structural Aspects of LIMK Regulation and Pharmacology. Cells 11 (1) (2022)
Milan Hluchý, Pavla Gajdušková, Ruiz De Los Mozos Igor, Michal Rájecký, Michael Kluge, Benedict-Tilmann Berger, Zuzana Slabá, David Potěšil, Elena Weiβ, Jernej Ule, Zbyněk Zdráhal, Stefan Knapp, Kamil Paruch, Caroline C Friedel, Dalibor Blazek
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. Nature 609 (7928) (2022)
Ricardo A M Serafim, André da Silva Santiago, Martin P Schwalm, Zexi Hu, Caio V Dos Reis, Jessica E Takarada, Priscila Mezzomo, Katlin B Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan A Laufer, Rafael Miguez Couñago, Alexander Titz
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. Journal of medicinal chemistry 65 (4) (2022)
Vanesa Nozal, Loreto Martínez-González, Marta Gomez-Almeria, Claudia Gonzalo-Consuegra, Paula Santana, Apirat Chaikuad, Eva Pérez-Cuevas, Stefan Knapp, Daniel Lietha, David Ramírez, Sabrina Petralla, Barbara Monti, Carmen Gil, Angeles Martín-Requero, Valle Palomo, Eva de Lago, Ana Martinez
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. Journal of medicinal chemistry 65 (2) (2022)
Julian Laux, Michael Forster, Laura Riexinger, Anna Schwamborn, Jamil Guezguez, Christina Pokoj, Mark Kudolo, Lena Marie Berger, Stefan Knapp, Dieter Schollmeyer, Jan Guse, Michael Burnet, Stefan A Laufer
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells. ACS pharmacology & translational science 5 (8) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry (2022)
Václav Němec, Martin Peter Schwalm, Susanne Müller, Stefan Knapp
PROTAC degraders as chemical probes for studying target biology and target validation. Chemical Society reviews 51 (18) (2022)
Jennifer A Amrhein, Tyler S Beyett, William W Feng, Andreas Krämer, Janik Weckesser, Ilse K Schaeffner, Jaimin K Rana, Pasi A Jänne, Michael J Eck, Stefan Knapp, Thomas Hanke
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. Journal of medicinal chemistry 65 (23) (2022)
Nadilly Bonagas, Nina M S Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C Green, Karl S A Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R Scaletti, Christoffer Bengtsson, Cynthia B J Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E Krokan, Per I Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J Homan, Thomas Helleday
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature cancer 3 (2) (2022)
Javier R Balboa, Dominik J Essig, Sana Ma, Nichlas Karer, Louise S Clemmensen, Søren W Pedersen, Andreas C Joerger, Stefan Knapp, Søren Østergaard, Kristian Stro Mgaard
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. Journal of medicinal chemistry 66 (1) (2022)
Alexander Strubel, Philipp Münick, Apirat Chaikuad, Birgit Dreier, Jonas Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Stefan Knapp, Andreas Plückthun, Volker Dötsch
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell death and differentiation (2022)
Ricardo A M Serafim, Fiona J Sorrell, Benedict-Tilmann Berger, Ross J Collins, Stanley N S Vasconcelos, Katlin B Massirer, Stefan Knapp, James Bennett, Oleg Fedorov, Hitesh Patel, William J Zuercher, Jonathan M Elkins
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. Journal of medicinal chemistry 64 (18) (2021)

Stefan Knapp.css-eqlu8i{font-size:small;padding-left:4px;} (S Knapp)

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Stefan Knapp (S Knapp)