David H Sherman

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Venues

Journal of the American Chemical Society

Nature chemistry

Journal of medicinal chemistry

ACS chemical biology

University of Michigan

Columbia University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Michigan

United States

Professort :: Medicinal Chemistry

University of Michigan

United States

Professor :: Chemistry, Microbiology & Immunology

University of Michigan

United States

PhD :: Life Sciences Institute

University of Michigan

United States

Associate Dean for Research and Graduate Education :: College of Pharmacy

University of Michigan

United States

Director :: Life Sciences Institute - Center for Chemical Genomics

University of Michigan

United States

Professor :: Medicinal Chemistry

University of Minnesota System

United States

Professor :: Microbiology and BioTechnology Institute

University of Minnesota System

United States

Director :: Biotechnology Training Program

University of Minnesota System

United States

Director :: Microbiology, Immunology and Cancer Biology Graduate Program

University of Minnesota Physicians

United States

Associate Professor :: Microbiology and BioTechnology Institute

University of Minnesota Physicians

United States

Director :: Microbial Physiology and Metabolic Engineering

University of Minnesota Physicians

United States

Assistant Professor :: Microbiology and BioTechnology Institute

John Innes Centre

United Kingdom

Research Scientist

Biogen Inc

United States

Research Scientist

Massachusetts Institute of Technology

United States

Post Doc

Yale University

United States

Post Doc

Education History

Columbia University

United States

PHD :: Organic Chemistry

Publications

Cory B Jenkinson, Shu-Yi Lin, Mary Villarreal, C Elizabeth Oakley, David H Sherman, Ching-Kuo Lee, Clay C C Wang, Berl R Oakley
Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. Journal of natural products 87 (7) (2024)
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification. Journal of medicinal chemistry (2024)
Colleen E Yancey, Lauren Hart, Sierra Hefferan, Osama G Mohamed, Sean A Newmister, Ashootosh Tripathi, David H Sherman, Gregory J Dick
Metabologenomics reveals strain-level genetic and chemical diversity of Microcystis secondary metabolism. mSystems 9 (7) (2024)
Cory B Jenkinson, Shu-Yi Lin, Mary Villarreal, C Elizabeth Oakley, David H Sherman, Ching-Kuo Lee, Clay C C Wang, Berl R Oakley
Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. Journal of natural products 87 (7) (2024)
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification. Journal of medicinal chemistry 67 (6) (2024)
Cory B Jenkinson, Shu-Yi Lin, Mary Villarreal, C Elizabeth Oakley, David H Sherman, Ching-Kuo Lee, Clay C C Wang, Berl R Oakley
Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. Journal of natural products (2024)
Colleen E Yancey, Lauren Hart, Sierra Hefferan, Osama G Mohamed, Sean A Newmister, Ashootosh Tripathi, David H Sherman, Gregory J Dick
Metabologenomics reveals strain-level genetic and chemical diversity of Microcystis secondary metabolism. mSystems 9 (7) (2024)
Donghui Yan, Muqing Zhou, Abhinav Adduri, Yihao Zhuang, Mustafa Guler, Sitong Liu, Hyonyoung Shin, Torin Kovach, Gloria Oh, Xiao Liu, Yuting Deng, Xiaofeng Wang, Liu Cao, David H Sherman, Pamela J Schultz, Roland D Kersten, Jason A Clement, Ashootosh Tripathi, Bahar Behsaz, Hosein Mohimani
Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS. Nature communications 15 (1) (2024)
Tyler M McCullough, Vishakha Choudhary, David L Akey, Meredith A Skiba, Steffen M Bernard, Jeffrey D Kittendorf, Jennifer J Schmidt, David H Sherman, Janet L Smith
Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation. bioRxiv : the preprint server for biology (2024)
Woonkee S Jo, Brian J Curtis, Mohammad Rehan, Maria L Adrover-Castellano, David H Sherman, Alan R Healy
N -to- S Acyl Transfer as an Enabling Strategy in Asymmetric and Chemoenzymatic Synthesis. JACS Au 4 (5) (2024)
Donghui Yan, Muqing Zhou, Abhinav Adduri, Yihao Zhuang, Mustafa Guler, Sitong Liu, Hyonyoung Shin, Torin Kovach, Gloria Oh, Xiao Liu, Yuting Deng, Xiaofeng Wang, Liu Cao, David H Sherman, Pamela J Schultz, Roland D Kersten, Jason A Clement, Ashootosh Tripathi, Bahar Behsaz, Hosein Mohimani
Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS. Nature communications 15 (1) (2024)
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification. Journal of medicinal chemistry (2024)
Colleen E Yancey, Lauren Hart, Sierra Hefferan, Osama G Mohamed, Sean A Newmister, Ashootosh Tripathi, David H Sherman, Gregory J Dick
Metabologenomics reveals strain-level genetic and chemical diversity of Microcystis secondary metabolism. mSystems (2024)
Donghui Yan, Muqing Zhou, Abhinav Adduri, Yihao Zhuang, Mustafa Guler, Sitong Liu, Hyonyoung Shin, Torin Kovach, Gloria Oh, Xiao Liu, Yuting Deng, Xiaofeng Wang, Liu Cao, David H Sherman, Pamela J Schultz, Roland D Kersten, Jason A Clement, Ashootosh Tripathi, Bahar Behsaz, Hosein Mohimani
Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS. Nature communications 15 (1) (2024)
Chunyi Zhao, Samuel T Slocum, David H Sherman, Brandon T Ruotolo
Time-Resolved Ion Mobility-Mass Spectrometry Reveals Structural Transitions in the Disassembly of Modular Polyketide Syntheses. Journal of the American Society for Mass Spectrometry (2024)
Woonkee S Jo, Brian J Curtis, Mohammad Rehan, Maria L Adrover-Castellano, David H Sherman, Alan R Healy
N -to- S Acyl Transfer as an Enabling Strategy in Asymmetric and Chemoenzymatic Synthesis. JACS Au 4 (5) (2024)
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification. Journal of medicinal chemistry 67 (6) (2024)
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification. Journal of medicinal chemistry 67 (6) (2024)
Colleen E Yancey, Lauren Hart, Sierra Hefferan, Osama G Mohamed, Sean A Newmister, Ashootosh Tripathi, David H Sherman, Gregory J Dick
Metabologenomics reveals strain-level genetic and chemical diversity of Microcystis secondary metabolism. mSystems 9 (7) (2024)
Chunyi Zhao, Nicholas B Borotto, Jennifer Schmidt, Kinshuk Srivastava, Andrew Lowell, Kristina Håkansson, David H Sherman, Brandon T Ruotolo
Gas-Phase Unfolding Reveals Stability Shifts Associated with Substrate Binding in Modular Polyketide Synthases. Journal of the American Society for Mass Spectrometry (2024)
Zhiwen Liu, Sebastian Rivera, Sean A Newmister, Jacob N Sanders, Qiuyue Nie, Shuai Liu, Fanglong Zhao, Joseph D Ferrara, Hao-Wei Shih, Siddhant Patil, Weijun Xu, Mitchell D Miller, George N Philips, Kendall N Houk, David H Sherman, Xue Gao
An NmrA-like enzyme-catalysed redox-mediated Diels-Alder cycloaddition with anti-selectivity. Nature chemistry (2023)
Zhiwen Liu, Sebastian Rivera, Sean A Newmister, Jacob N Sanders, Qiuyue Nie, Shuai Liu, Fanglong Zhao, Joseph D Ferrara, Hao-Wei Shih, Siddhant Patil, Weijun Xu, Mitchell D Miller, George N Philips, Kendall N Houk, David H Sherman, Xue Gao
An NmrA-like enzyme-catalysed redox-mediated Diels-Alder cycloaddition with anti-selectivity. Nature chemistry (2023)
Vikram V Shende, Natalia R Harris, Jacob N Sanders, Sean A Newmister, Yogan Khatri, Mohammad Movassaghi, Kendall N Houk, David H Sherman
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases. Angewandte Chemie (International ed. in English) (2023)
Zhiwen Liu, Sebastian Rivera, Sean A Newmister, Jacob N Sanders, Qiuyue Nie, Shuai Liu, Fanglong Zhao, Joseph D Ferrara, Hao-Wei Shih, Siddhant Patil, Weijun Xu, Mitchell D Miller, George N Philips, Kendall N Houk, David H Sherman, Xue Gao
An NmrA-like enzyme-catalysed redox-mediated Diels-Alder cycloaddition with anti-selectivity. Nature chemistry (2023)
Samantha P Kelly, Vikram V Shende, Autumn R Flynn, Qingyun Dan, Ying Ye, Janet L Smith, Sachiko Tsukamoto, Matthew S Sigman, David H Sherman
Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. Journal of the American Chemical Society 144 (42) (2022)
Alexander Rittner, Mirko Joppe, Jennifer J Schmidt, Lara Maria Mayer, Simon Reiners, Elia Heid, Dietmar Herzberg, David H Sherman, Martin Grininger
Chemoenzymatic synthesis of fluorinated polyketides. Nature chemistry 14 (9) (2022)
Rosa V Espinoza, Kersti Caddell Haatveit, S Wald Grossman, Jin Yi Tan, Caylie A McGlade, Yogan Khatri, Sean A Newmister, Jennifer J Schmidt, Marc Garcia-Borràs, John Montgomery, Kendall N Houk, David H Sherman
Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics. ACS catalysis 11 (13) (2021)
Edward Kalkreuter, Kyle S Bingham, Aaron M Keeler, Andrew N Lowell, Jennifer J Schmidt, David H Sherman, Gavin J Williams
Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase. Nature communications 12 (1) (2021)
Amy E Fraley, David H Sherman
Enzyme evolution in fungal indole alkaloid biosynthesis. The FEBS journal 287 (7) (2021)
Robert M Hohlman, David H Sherman
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity. Natural product reports 38 (9) (2021)
Song Yang, Matthew D DeMars, Jessica M Grandner, Noelle M Olson, Yojiro Anzai, David H Sherman, Kendall N Houk
Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics. Journal of the American Chemical Society 142 (42) (2020)
Aaron A Koch, Jennifer J Schmidt, Andrew N Lowell, Douglas A Hansen, Katherine M Coburn, Joseph A Chemler, David H Sherman
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases. Angewandte Chemie (International ed. in English) 59 (32) (2020)
Jennifer J Schmidt, Yogan Khatri, Scott I Brody, Catherine Zhu, Halina Pietraszkiewicz, Frederick A Valeriote, David H Sherman
A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs. ACS chemical biology 15 (2) (2020)
Amy E Fraley, Kersti Caddell Haatveit, Ying Ye, Samantha P Kelly, Sean A Newmister, Fengan Yu, Robert M Williams, Janet L Smith, Kendall N Houk, David H Sherman
Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. Journal of the American Chemical Society 142 (5) (2020)
Amy E Fraley, Hong T Tran, Samantha P Kelly, Sean A Newmister, Ashootosh Tripathi, Hikaru Kato, Sachiko Tsukamoto, Lei Du, Shengying Li, Robert M Williams, David H Sherman
Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides. Chembiochem : a European journal of chemical biology 21 (17) (2020)
Yogan Khatri, Robert M Hohlman, Johnny Mendoza, Shasha Li, Andrew N Lowell, Haruichi Asahara, David H Sherman
Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids. ACS synthetic biology 9 (6) (2020)
Mark M Painter, Gretchen E Zimmerman, Madeline S Merlino, Andrew W Robertson, Valeri H Terry, Xuefeng Ren, Megan R McLeod, Lyanne Gomez-Rodriguez, Kirsten A Garcia, Jolie A Leonard, Kay E Leopold, Andrew J Neevel, Jay Lubow, Eli Olson, Alicja Piechocka-Trocha, David R Collins, Ashootosh Tripathi, Malini Raghavan, Bruce D Walker, James H Hurley, David H Sherman, Kathleen L Collins
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 117 (38) (2020)
Jonathan R Thielman, David H Sherman, Robert M Williams
Stereoselective Synthesis of Baulamycin A. The Journal of organic chemistry 85 (5) (2020)
Shasha Li, Sean A Newmister, Andrew N Lowell, Jiachen Zi, Callie R Chappell, Fengan Yu, Robert M Hohlman, Jimmy Orjala, Robert M Williams, David H Sherman
Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases. Angewandte Chemie (International ed. in English) 59 (21) (2020)
Vikram V Shende, Yogan Khatri, Sean A Newmister, Jacob N Sanders, Petra Lindovska, Fengan Yu, Tyler J Doyon, Justin Kim, Kendall N Houk, Mohammad Movassaghi, David H Sherman
Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase. Journal of the American Chemical Society 142 (41) (2020)
Qingyun Dan, Sean A Newmister, Kimberly R Klas, Amy E Fraley, Timothy J McAfoos, Amber D Somoza, James D Sunderhaus, Ying Ye, Vikram V Shende, Fengan Yu, Jacob N Sanders, W Clay Brown, Le Zhao, Robert S Paton, K N Houk, Janet L Smith, David H Sherman, Robert M Williams
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nature chemistry 11 (11) (2019)
Cory J Knoot, Yogan Khatri, Robert M Hohlman, David H Sherman, Himadri B Pakrasi
Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973. ACS synthetic biology 8 (8) (2019)
Matthew D DeMars, Nathan L Samora, Song Yang, Marc Garcia-Borràs, Jacob N Sanders, Kendall N Houk, Larissa M Podust, David H Sherman
Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450. The Journal of biological chemistry 294 (44) (2019)
Tyler S Beyett, Amy E Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C Coleman, Akito Eguchi, Alisa Glukhova, Qiuyan Chen, Robert M Williams, Walter J Koch, David H Sherman, John Joseph Grubb Tesmer
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America 116 (32) (2019)
Edward Kalkreuter, Jared M CroweTipton, Andrew N Lowell, David H Sherman, Gavin J Williams
Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units. Journal of the American Chemical Society 141 (5) (2019)
Kevin J McDonnell, Joseph A Chemler, Phillip L Bartels, Elizabeth O'Brien, Monica L Marvin, Janice Ortega, Ralph H Stern, Leon Raskin, Guo-Min Li, David H Sherman, Jacqueline K Barton, Stephen B Gruber
A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster. Nature chemistry 10 (8) (2018)
Meredith A Skiba, Andrew P Sikkema, Nathan A Moss, Andrew N Lowell, Min Su, Rebecca M Sturgis, Lena Gerwick, William H Gerwick, David H Sherman, Janet L Smith
Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS chemical biology 13 (6) (2018)
Meredith A Skiba, Marissa M Bivins, John R Schultz, Steffen M Bernard, William D Fiers, Qingyun Dan, Sarang Kulkarni, Peter Wipf, William H Gerwick, David H Sherman, Courtney C Aldrich, Janet L Smith
Structural Basis of Polyketide Synthase O-Methylation. ACS chemical biology 13 (12) (2018)
Ashootosh Tripathi, Sung Ryeol Park, Andrew P Sikkema, Hyo Je Cho, Jianfeng Wu, Brian Lee, Chuanwu Xi, Janet L Smith, David H Sherman
A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ. Chembiochem : a European journal of chemical biology 19 (15) (2018)
Sean A Newmister, Shasha Li, Marc Garcia-Borràs, Jacob N Sanders, Song Yang, Andrew N Lowell, Fengan Yu, Janet L Smith, Robert M Williams, K N Houk, David H Sherman
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nature chemical biology 14 (4) (2018)
Jia-Hui Tay, Alonso J Argüelles, Matthew D DeMars, Paul M Zimmerman, David H Sherman, Pavel Nagorny
Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis. Journal of the American Chemical Society 139 (25) (2017)
Meredith A Skiba, Andrew P Sikkema, Nathan A Moss, Collin L Tran, Rebecca M Sturgis, Lena Gerwick, William H Gerwick, David H Sherman, Janet L Smith
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS chemical biology 12 (12) (2017)
Andrew N Lowell, Matthew D DeMars, Samuel T Slocum, Fengan Yu, Krithika Anand, Joseph A Chemler, Nisha Korakavi, Jennifer K Priessnitz, Sung Ryeol Park, Aaron A Koch, Pamela J Schultz, David H Sherman
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. Journal of the American Chemical Society 139 (23) (2017)
Hikaru Kato, Takashi Nakahara, Kayo Sugimoto, Kanae Matsuo, Ippei Kagiyama, Jens C Frisvad, David H Sherman, Robert M Williams, Sachiko Tsukamoto
Correction to "Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications". Organic letters 20 (1) (2017)
Douglas A Hansen, Aaron A Koch, David H Sherman
Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides. Journal of the American Chemical Society 139 (38) (2017)
Drew R Tietz, Larissa M Podust, David H Sherman, Thomas C Pochapsky
Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry 56 (21) (2017)
Aaron A Koch, Douglas A Hansen, Vikram V Shende, Lawrence R Furan, Kendall N Houk, Gonzalo Jiménez-Osés, David H Sherman
A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst. Journal of the American Chemical Society 139 (38) (2017)
Amy E Fraley, Marc Garcia-Borràs, Ashootosh Tripathi, Dheeraj Khare, Eduardo V Mercado-Marin, Hong Tran, Qingyun Dan, Gabrielle P Webb, Katharine R Watts, Phillip Crews, Richmond Sarpong, Robert M Williams, Janet L Smith, Kendall N Houk, David H Sherman
Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids. Journal of the American Chemical Society 139 (34) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

David H Sherman