Joseph Schlessinger

Publication Activity (10 Years)

Years Active: 2020-2023
Publications (10 Years): 21

Top Topics

Fluorescence Imaging

Epidermal Growth Factor Receptor

Binding Protein

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Journal of medicinal chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Stefan G Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proceedings of the National Academy of Sciences of the United States of America 120 (13) (2023)
Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Stefan G Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proceedings of the National Academy of Sciences of the United States of America 120 (13) (2023)
Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Stefan G Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proceedings of the National Academy of Sciences of the United States of America 120 (13) (2023)
Sean P Henry, Maria-Elena Liosi, Joseph A Ippolito, Fabian S Menges, Ana S Newton, Joseph Schlessinger, William L Jorgensen
Covalent Modification of the JH2 Domain of Janus Kinase 2. ACS medicinal chemistry letters 13 (11) (2022)
Maria-Elena Liosi, Joseph A Ippolito, Sean P Henry, Stefan G Krimmer, Ana S Newton, Kara J Cutrona, Rene A Olivarez, Jyotidarsini Mohanty, Joseph Schlessinger, William L Jorgensen
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. Journal of medicinal chemistry 65 (12) (2022)
Seong J An, Alexander Anneken, Zhiqun Xi, Changseon Choi, Joseph Schlessinger, Derek Toomre
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. Proceedings of the National Academy of Sciences of the United States of America 119 (48) (2022)
Stefan G Krimmer, Joseph Schlessinger
Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants. Proceedings of the National Academy of Sciences of the United States of America 119 (50) (2022)
Mansoor Ahmed, Navjot Kaur, Qianni Cheng, Marya Shanabrough, Evgenii O Tretiakov, Tibor Harkany, Tamas L Horvath, Joseph Schlessinger
A hypothalamic pathway for Augmentor α-controlled body weight regulation. Proceedings of the National Academy of Sciences of the United States of America 119 (16) (2022)
Sean P Henry, Maria-Elena Liosi, Joseph A Ippolito, Kara J Cutrona, Stefan G Krimmer, Ana S Newton, Joseph Schlessinger, William L Jorgensen
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies. ACS medicinal chemistry letters 13 (5) (2022)
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora K Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance J Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, Julien S Baker
Design of protein-binding proteins from the target structure alone. Nature 605 (7910) (2022)
Jungmin Choi, Aranzazu Manzano, Weilai Dong, Stefania Bellone, Elena Bonazzoli, Luca Zammataro, Xiaotong Yao, Aditya Deshpande, Samir Zaidi, Adele Guglielmi, Barbara Gnutti, Nupur Nagarkatti, Joan R Tymon-Rosario, Justin Harold, Dennis Mauricio, Burak Zeybek, Gulden Menderes, Gary Altwerger, Kyung Jo Jeong, Siming Zhao, Natalia Buza, Pei Hui, Antonella Ravaggi, Eliana Bignotti, Chiara Romani, Paola Todeschini, Laura Zanotti, Franco Edoardo Odicino, Sergio Pecorelli, Laura Ardighieri, Kaya Bilguvar, Charles Matthew Quick, Dan-Arin Silasi, Gloria Shining Huang, Vaagn Andikyan, Mitchell Clark, Elena Ratner, Masoud Azodi, Marcin Imielinski, Peter E Schwartz, Ludmil B Alexandrov, Richard P Lifton, Joseph Schlessinger, Alessandro D Santin
Integrated mutational landscape analysis of uterine leiomyosarcomas. Proceedings of the National Academy of Sciences of the United States of America 118 (15) (2021)
Tongqing Li, Steven E Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X Walker, Krishna C Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A Lemmon, Joseph Schlessinger, Daryl E Klein
Structural basis for ligand reception by anaplastic lymphoma kinase. Nature 600 (7887) (2021)
Andrey V Reshetnyak, Paolo Rossi, Alexander G Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J Miller, Irit Lax, Joseph Schlessinger, Charalampos G Kalodimos
Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature 600 (7887) (2021)
Yoshihisa Suzuki, Ekaterina Kuzina, Seong J An, Francisco Tome, Jyotidarsini Mohanty, Wenxue Li, Sangwon Lee, Yansheng Liu, Irit Lax, Joseph Schlessinger
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho. Proceedings of the National Academy of Sciences of the United States of America 117 (50) (2020)
Maria-Elena Liosi, Stefan G Krimmer, Ana S Newton, Thomas K Dawson, David E Puleo, Kara J Cutrona, Yoshihisa Suzuki, Joseph Schlessinger, William L Jorgensen
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. Journal of medicinal chemistry 63 (10) (2020)
Mo Zhou, Leena Kuruvilla, Xiarong Shi, Stephen Viviano, Ian M Ahearn, Caroline R Amendola, Wenjuan Su, Sana Badri, James Mahaffey, Nicole Fehrenbacher, Jane A Skok, Joseph Schlessinger, Benjamin E Turk, David A Calderwood, Mark R Philips
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Proceedings of the National Academy of Sciences of the United States of America 117 (50) (2020)