James W Janetka

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 39

Top Venues

Journal of medicinal chemistry

ChemMedChem

Journal of virology

Protein science : a publication of the Protein Society

ProteXase Therapeutics, Inc.

University of Wisconsin Madison (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

ProteXase Therapeutics, Inc. Jan 20 2017

United States

Co-founder, Board of Directors

Fimbrion Therapeutics, Inc.

United States

Co-Founder, Board of Directors

Washington University in Saint Louis School of Medicine

United States

Associate Professor :: Biochemistry and Molecular Biophysics

AstraZeneca R&D Boston

United States

Principal Scientist :: Cancer Chemistry

Vertex Pharmaceuticals Inc

United States

Staff Investigator :: Chemistry

Education History

University of Wisconsin Madison

United States

PHD :: Chemistry/Daniel Rich

University of Illinois at Urbana-Champaign

United States

BSC :: Biochemistry

Publications

Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Vishnu C Damalanka, Victoria Banas, Paolo De Bona, Maithri M Kashipathy, Kevin Battaile, Scott Lovell, James W Janetka
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. Journal of medicinal chemistry (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem 19 (8) (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem 19 (8) (2024)
Amarendar Reddy Maddirala, Jerome S Pinkner, Kevin Tamadonfar, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem 19 (8) (2024)
Edward D B Lopatto, Jerome S Pinkner, Denise A Sanick, Robert F Potter, Lily X Liu, Jesús Bazán Villicaña, Kevin O Tamadonfar, Yijun Ye, Maxwell I Zimmerman, Nathaniel C Gualberto, Karen W Dodson, James W Janetka, David A Hunstad, Scott J Hultgren
Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (39) (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem 19 (8) (2024)
Matthew W Mahoney, Jonathan Helander, Anoopjit S Kooner, Mariah Norman, Vishnu C Damalanka, Paolo De Bona, Paulina Kasperkiewicz, Wioletta Rut, Marcin Poreba, Maithri M Kashipathy, Kevin P Battaile, Scott Lovell, Anthony J O'Donoghue, Charles S Craik, Marcin Dra G, James W Janetka
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. Protein science : a publication of the Protein Society 33 (8) (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem 19 (8) (2024)
Vishnu C Damalanka, Victoria Banas, Paolo De Bona, Maithri M Kashipathy, Kevin Battaile, Scott Lovell, James W Janetka
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. Journal of medicinal chemistry 67 (6) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
Vishnu C Damalanka, Victoria Banas, Paolo De Bona, Maithri M Kashipathy, Kevin Battaile, Scott Lovell, James W Janetka
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. Journal of medicinal chemistry 67 (6) (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry 67 (5) (2024)
Matthew W Mahoney, Jonathan Helander, Anoopjit S Kooner, Mariah Norman, Vishnu C Damalanka, Paolo De Bona, Paulina Kasperkiewicz, Wioletta Rut, Marcin Poreba, Maithri M Kashipathy, Kevin P Battaile, Scott Lovell, Anthony J O'Donoghue, Charles S Craik, Marcin Dra G, James W Janetka
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. Protein science : a publication of the Protein Society 33 (8) (2024)
Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman, James W Janetka
Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. ChemMedChem (2024)
Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren, James W Janetka
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry (2024)
Matthew W Mahoney, Jonathan Helander, Anoopjit S Kooner, Mariah Norman, Vishnu C Damalanka, Paolo De Bona, Paulina Kasperkiewicz, Wioletta Rut, Marcin Poreba, Maithri M Kashipathy, Kevin P Battaile, Scott Lovell, Anthony J O'Donoghue, Charles S Craik, Marcin Dra G, James W Janetka
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. Protein science : a publication of the Protein Society 33 (8) (2024)
Vishnu C Damalanka, Victoria Banas, Paolo De Bona, Maithri M Kashipathy, Kevin Battaile, Scott Lovell, James W Janetka
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. Journal of medicinal chemistry (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Vishnu C Damalanka, Jorine J L P Voss, Matthew W Mahoney, Tina Primeau, Shunqiang Li, Lidija Klampfer, James W Janetka
Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression. Journal of medicinal chemistry 64 (24) (2021)
James W Janetka, Allen T Hopper, Ziping Yang, Jennifer Barks, Mary Savari Dhason, Qiuling Wang, L David Sibley
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis. Journal of medicinal chemistry 63 (11) (2020)
Vishnu C Damalanka, Scott A Wildman, James W Janetka
Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin. MedChemComm 10 (9) (2019)
Rahul Tyagi, Mostafa A Elfawal, Scott A Wildman, Jon Helander, Christina A Bulman, Judy Sakanari, Bruce A Rosa, Paul J Brindley, James W Janetka, Raffi V Aroian, Makedonka Mitreva
Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. Scientific reports 9 (1) (2019)
Amarendar Reddy Maddirala, Roger Klein, Jerome S Pinkner, Vasilios Kalas, Scott J Hultgren, James W Janetka
Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design. Journal of medicinal chemistry 62 (2) (2019)
Vishnu C Damalanka, Zhenfu Han, Partha Karmakar, Anthony J O'Donoghue, Florencia La Greca, Tommy Kim, Shishir M Pant, Jonathan Helander, Juha Klefström, Charles S Craik, James W Janetka
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. Journal of medicinal chemistry 62 (2) (2019)
Agostinho G Rocha, Antonietta Franco, Andrzej M Krezel, Jeanne M Rumsey, Justin M Alberti, William C Knight, Nikolaos Biris, Emmanouil Zacharioudakis, James W Janetka, Robert H Baloh, Richard N Kitsis, Daria-Mochly Rosen, R Reid Townsend, Evripidis Gavathiotis, Gerald W Dorn
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science (New York, N.Y.) 360 (6386) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

James W Janetka