Lauren E Brown

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 21

Top Topics

Candida Albicans

Top Venues

Nature communications

The Journal of organic chemistry

Journal of medicinal chemistry

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Zihao Wang, Ritesh P Thakare, Shalaka Chitale, Alok K Mishra, Stanley I Goldstein, Alice C Fan, Rui Li, Lihua Julie Zhu, Lauren E Brown, Regina Cencic, Sidong Huang, Michael R Green, Nahum Sonenberg, Sunil K Malonia, John A Porco
Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS central science 10 (8) (2024)
Zihao Wang, Ritesh P Thakare, Shalaka Chitale, Alok K Mishra, Stanley I Goldstein, Alice C Fan, Rui Li, Lihua Julie Zhu, Lauren E Brown, Regina Cencic, Sidong Huang, Michael R Green, Nahum Sonenberg, Sunil K Malonia, John A Porco
Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS central science 10 (8) (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Alexandra M Millimaci, Richard V Trilles, James H McNeely, Lauren E Brown, Aaron B Beeler, John A Porco
Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of organic chemistry (2023)
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A Porco, Christine A Iacobuzio-Donahue, Nikolaus Schultz, David A Tuveson, David C Lyden, David P Kelsen, Ruth Scherz-Shouval
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature communications 13 (1) (2022)
Stacey L Lehman, Theresa Wechsler, Kayla Schwartz, Lauren E Brown, John A Porco, William G Devine, Nahum Sonenberg, Uma T Shankavaram, Kevin Camphausen, Philip J Tofilon
Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity. Molecular cancer therapeutics 21 (9) (2022)
Paul T Marcyk, Emmanuelle V LeBlanc, Douglas A Kuntz, Alice Xue, Francisco Ortiz, Richard Trilles, Stephen Bengtson, Tristan M G Kenney, David S Huang, Nicole Robbins, Noelle S Williams, Damian J Krysan, Gilbert G Privé, Luke Whitesell, Leah E Cowen, Lauren E Brown
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. Journal of medicinal chemistry 64 (2) (2021)
Wenqing Xu, Lauren E Brown, John A Porco
Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of organic chemistry 86 (23) (2021)
Kali R Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M Pimentel-Elardo, Jen L Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, Jose F Muñoz, Sang Hu Kim, John A Porco, Christina A Cuomo, Noelle S Williams, Ashraf S Ibrahim, John E Edwards, David R Andes, Justin R Nodwell, Lauren E Brown, Luke Whitesell, Nicole Robbins, Leah E Cowen
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature communications 11 (1) (2020)
Oshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H Katz, Rona Yaeger, Ido Laish, John A Porco, Erik Sahai, Dror S Shouval, David P Kelsen, Ruth Scherz-Shouval
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature communications 11 (1) (2020)
Richard Trilles, Dmitri Beglov, Qiujia Chen, Hongzhen He, Randall Wireman, April Reed, Spandan Chennamadhavuni, James S Panek, Lauren E Brown, Sandor Vajda, John A Porco, Mark R Kelley, Millie M Georgiadis
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. Journal of medicinal chemistry 62 (4) (2019)
Xuan Zhang, Chengfeng Bi, Ting Lu, Weiwei Zhang, Ting Yue, Cheng Wang, Tian Tian, Xiaoyan Zhang, Yuhua Huang, Matthew Lunning, Xinbao Hao, Lauren E Brown, William G Devine, Julie M Vose, John A Porco, Kai Fu
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia 34 (1) (2019)
Wenhan Zhang, Jennifer Chu, Andrew M Cyr, Han Yueh, Lauren E Brown, Tony T Wang, Jerry Pelletier, John A Porco
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society 141 (32) (2019)
Wenhan Zhang, Shufeng Liu, Rayelle I Maiga, Jerry Pelletier, Lauren E Brown, Tony T Wang, John A Porco
Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. Journal of the American Chemical Society 141 (3) (2019)
Luke Whitesell, Nicole Robbins, David S Huang, Catherine A McLellan, Tanvi Shekhar-Guturja, Emmanuelle V LeBlanc, Catherine S Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L Xie, Damian J Krysan, Susan Lindquist, John A Porco, Utpal Tatu, Lauren E Brown, Juan C Pizarro, Leah E Cowen
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature communications 10 (1) (2019)
David S Huang, Emmanuelle V LeBlanc, Tanvi Shekhar-Guturja, Nicole Robbins, Damian J Krysan, Juan C Pizarro, Luke Whitesell, Leah E Cowen, Lauren E Brown
Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors. Journal of medicinal chemistry 63 (5) (2019)
Rayelle Itoua Maïga, Regina Cencic, Jennifer Chu, Daniel D Waller, Lauren E Brown, William G Devine, Wenhan Zhang, Michael Sebag, John A Porco, Jerry Pelletier
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific reports 9 (1) (2019)
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa A Yao, Faith Gorton, Junwei Shi, Craig J Thomas, Lauren E Brown, John A Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature communications 10 (1) (2019)
Spandan Chennamadhavuni, James S Panek, John A Porco, Lauren E Brown
Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a One-Pot Intramolecular aza-Michael/Lactamization Sequence. The Journal of organic chemistry 83 (24) (2018)