Leah E Cowen (Nicole Robbins)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 60

Top Venues

Nature communications

mBio

Clinical microbiology reviews

G3 (Bethesda, Md.)

Bright Angel Therapeutics

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Bright Angel Therapeutics

Canada

Chief Scientific Officer

University of Toronto Jul 01 2016

Canada

Professor & Chair :: Molecular Genetics

University of Toronto Jul 01 2012 - Jun 30 2016

Canada

Associate Professor & Associate Chair :: Molecular Genetics

University of Toronto Jan 01 2007 - Jun 30 2012

Canada

Assistant Professor :: Molecular Genetics

Publications

Emma Lash, Corinne Maufrais, Guilhem Janbon, Nicole Robbins, Lydia Herzel, Leah E Cowen
The spliceosome impacts morphogenesis in the human fungal pathogen Candida albicans . mBio 15 (8) (2024)
Jessie MacAlpine, Martin Daniel-Ivad, Daniela Atere, Bradley Laflamme, Nicole Robbins, William Wiley Navarre, Justin R Nodwell, Luke Whitesell, Leah E Cowen
Reply to: Lactobacillus species do not produce 1-acetyl-β-carboline. Nature communications 15 (1) (2024)
Aiman Farheen, Nicola T Case, Jessie MacAlpine, Ci Fu, Nicole Robbins, Leah E Cowen
The putative prenyltransferase Nus1 is required for filamentation in the human fungal pathogen Candida albicans. G3 (Bethesda, Md.) 14 (8) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Emma Lash, Corinne Maufrais, Guilhem Janbon, Nicole Robbins, Lydia Herzel, Leah E Cowen
The spliceosome impacts morphogenesis in the human fungal pathogen Candida albicans . mBio 15 (8) (2024)
Sara Fallah, Dustin Duncan, Kyle D Reichl, Michael J Smith, Wenyu Wang, John A Porco, Lauren E Brown, Luke Whitesell, Leah E Cowen
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans . Microbiology spectrum 12 (4) (2024)
Sara Fallah, Dustin Duncan, Kyle D Reichl, Michael J Smith, Wenyu Wang, John A Porco, Lauren E Brown, Luke Whitesell, Leah E Cowen
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans . Microbiology spectrum 12 (4) (2024)
Emma Lash, Corinne Maufrais, Guilhem Janbon, Nicole Robbins, Lydia Herzel, Leah E Cowen
The spliceosome impacts morphogenesis in the human fungal pathogen Candida albicans . mBio 15 (8) (2024)
Aiman Farheen, Nicola T Case, Jessie MacAlpine, Ci Fu, Nicole Robbins, Leah E Cowen
The Putative Prenyltransferase Nus1 is Required for Filamentation in the Human Fungal Pathogen Candida albicans. G3 (Bethesda, Md.) (2024)
Sara Fallah, Dustin Duncan, Kyle D Reichl, Michael J Smith, Wenyu Wang, John A Porco, Lauren E Brown, Luke Whitesell, Leah E Cowen
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans . Microbiology spectrum (2024)
Aiman Farheen, Nicola T Case, Jessie MacAlpine, Ci Fu, Nicole Robbins, Leah E Cowen
The putative prenyltransferase Nus1 is required for filamentation in the human fungal pathogen Candida albicans. G3 (Bethesda, Md.) 14 (8) (2024)
Jessica Knox, Andrew R Burns, Brittany Cooke, Savina R Cammalleri, Megan Kitner, Justin Ching, Jack M P Castelli, Emily Puumala, Jamie Snider, Emily J Koury, James Bryant Collins, Salma Geissah, James E Dowling, Erik C Andersen, Igor Stagljar, Leah E Cowen, Mark Lautens, Inga Zasada, Peter J Roy
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation. Nature communications 15 (1) (2024)
Jessica Knox, Andrew R Burns, Brittany Cooke, Savina R Cammalleri, Megan Kitner, Justin Ching, Jack M P Castelli, Emily Puumala, Jamie Snider, Emily J Koury, James Bryant Collins, Salma Geissah, James E Dowling, Erik C Andersen, Igor Stagljar, Leah E Cowen, Mark Lautens, Inga Zasada, Peter J Roy
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation. Nature communications 15 (1) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Sara Fallah, Dustin Duncan, Kyle D Reichl, Michael J Smith, Wenyu Wang, John A Porco, Lauren E Brown, Luke Whitesell, Leah E Cowen
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans . Microbiology spectrum 12 (4) (2024)
Emma Lash, Corinne Maufrais, Guilhem Janbon, Nicole Robbins, Lydia Herzel, Leah E Cowen
The spliceosome impacts morphogenesis in the human fungal pathogen Candida albicans . mBio (2024)
Jessie MacAlpine, Martin Daniel-Ivad, Daniela Atere, Bradley Laflamme, Nicole Robbins, William Wiley Navarre, Justin R Nodwell, Luke Whitesell, Leah E Cowen
Reply to: Lactobacillus species do not produce 1-acetyl-β-carboline. Nature communications 15 (1) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews (2024)
Aiman Farheen, Nicola T Case, Jessie MacAlpine, Ci Fu, Nicole Robbins, Leah E Cowen
The putative prenyltransferase Nus1 is required for filamentation in the human fungal pathogen Candida albicans. G3 (Bethesda, Md.) 14 (8) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen
Advancements and challenges in antifungal therapeutic development. Clinical microbiology reviews 37 (1) (2024)
Jessica Knox, Andrew R Burns, Brittany Cooke, Savina R Cammalleri, Megan Kitner, Justin Ching, Jack M P Castelli, Emily Puumala, Jamie Snider, Emily J Koury, James Bryant Collins, Salma Geissah, James E Dowling, Erik C Andersen, Igor Stagljar, Leah E Cowen, Mark Lautens, Inga Zasada, Peter J Roy
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation. Nature communications 15 (1) (2024)
Sara Fallah, Dustin Duncan, Kyle D Reichl, Michael J Smith, Wenyu Wang, John A Porco, Lauren E Brown, Luke Whitesell, Leah E Cowen
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans . Microbiology spectrum 12 (4) (2024)
Jessie MacAlpine, Martin Daniel-Ivad, Daniela Atere, Bradley Laflamme, Nicole Robbins, William Wiley Navarre, Justin R Nodwell, Luke Whitesell, Leah E Cowen
Reply to: Lactobacillus species do not produce 1-acetyl-β-carboline. Nature communications 15 (1) (2024)
Emma Lash, Victoria Prudent, Peter J Stogios, Alexei Savchenko, Suzanne M Noble, Nicole Robbins, Leah E Cowen
Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. mBio (2023)
Lewis Marquez, Yunjin Lee, Dustin Duncan, Luke Whitesell, Leah E Cowen, Cassandra Quave
Potent Antifungal Activity of Penta- O -galloyl-β-d-Glucose against Drug-Resistant Candida albicans , Candida auris , and Other Non- albicans Candida Species. ACS infectious diseases (2023)
Zhongle Liu, Jessie MacAlpine, Nicole Robbins, Leah E Cowen
Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1. mSphere (2023)
Zhongle Liu, Pauline Basso, Saif Hossain, Sean D Liston, Nicole Robbins, Luke Whitesell, Suzanne M Noble, Leah E Cowen
Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. Nature communications 14 (1) (2023)
Rana Abdelaziz, Justin M Di Trani, Henok Sahile, Lea Mann, Adrian Richter, Zhongle Liu, Stephanie A Bueler, Leah E Cowen, John L Rubinstein, Peter Imming
Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII 2 CIV 2 Supercomplex Binding, and In Vitro Antimycobacterial Activity. ACS omega 8 (21) (2023)
Jessie MacAlpine, Zhongle Liu, Saif Hossain, Luke Whitesell, Leah E Cowen
DYRK-family kinases regulate Candida albicans morphogenesis and virulence through the Ras1/PKA pathway. mBio (2023)
Nicola T Case, Johannes Westman, Michael T Hallett, Jonathan Plumb, Aiman Farheen, Michelle E Maxson, Jessie MacAlpine, Sean D Liston, Bernhard Hube, Leah E Cowen, Luke Whitesell, Sergio Grinstein
Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages. mBio (2023)
Andrew R Burns, Rachel J Baker, Megan Kitner, Jessica Knox, Brittany Cooke, Jonathan R Volpatti, Aditya S Vaidya, Emily Puumala, Bruna M Palmeira, Elizabeth M Redman, Jamie Snider, Sagar Marwah, Sai W Chung, Margaret H MacDonald, Jens Tiefenbach, Chun Hu, Qi Xiao, Constance A M Finney, Henry M Krause, Sonya A MacParland, Igor Stagljar, John S Gilleard, Leah E Cowen, Susan L F Meyer, Sean R Cutler, James E Dowling, Mark Lautens, Inga Zasada, Peter J Roy
Selective control of parasitic nematodes using bioactivated nematicides. Nature (2023)
Saif Hossain, Nicole Robbins, Leah E Cowen
The GARP complex is required for filamentation in Candida albicans. Genetics 222 (4) (2022)
Nicola T Case, Judith Berman, David S Blehert, Robert A Cramer, Christina A Cuomo, Cameron R Currie, Iuliana V Ene, Matthew C Fisher, Lillian K Fritz-Laylin, Aleeza Cara Gerstein, N Louise Glass, Neil A R Gow, Sarah Jane Gurr, Chris Todd Hittinger, Tobias M Hohl, Iliyan D Iliev, Timothy Y James, Hailing Jin, Bruce S Klein, James W Kronstad, Jeffrey M Lorch, Victoria McGovern, Aaron P Mitchell, Julie A Segre, Rebecca S Shapiro, Donald C Sheppard, Anita Sil, Jason E Stajich, Eva Holtgrewe Stukenbrock, John W Taylor, Dawn A Thompson, Gerard D Wright, Joseph Heitman, Leah E Cowen
The future of fungi: threats and opportunities. G3 (Bethesda, Md.) 12 (11) (2022)
Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika M Borek, Leah E Cowen, Alexei Savchenko
Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans . Life science alliance 5 (8) (2022)
Nicole M Revie, Kali R Iyer, Michelle E Maxson, Jiabao Zhang, Su Yan, Caroline M Fernandes, Kirsten J Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S Shapiro, David R Andes, Gerard D Wright, Justin R Nodwell, Maurizio Del Poeta, Martin D Burke, Luke Whitesell, Nicole Robbins, Leah E Cowen
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. Nature communications 13 (1) (2022)
Emily Puumala, Olga Zaslaver, Amy Chen, Dustin Duncan, Meea Fogal, Rebecca S Shapiro, Mohammad T Mazhab-Jafari, Luke Whitesell, J Rafael Montenegro-Burke, Nicole Robbins, Leah E Cowen
The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis. mBio (2022)
Sang Hu Kim, Luke Steere, Yong-Kang Zhang, Cari McGregor, Chris Hahne, Yasheen Zhou, Chunliang Liu, Yan Cai, Haibo Zhou, Xuefei Chen, Emily Puumala, Dustin Duncan, Gerard D Wright, C Tony Liu, Luke Whitesell, Leah E Cowen
Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. ACS chemical biology 17 (6) (2022)
Sabine Ottilie, Madeline R Luth, Erich Hellemann, Gregory M Goldgof, Eddy Vigil, Prianka Kumar, Andrea L Cheung, Miranda J Song, Karla P Godinez-Macias, Krypton Carolino, Jennifer Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle V LeBlanc, Luke Whitesell, Jake Schenken, Felicia Gunawan, Reysha Patel, Joshua Smith, Melissa S Love, Roy M Williams, Case W McNamara, William H Gerwick, Trey Ideker, Yo Suzuki, Dyann F Wirth, Amanda K Lukens, Patricia M Kane, Leah E Cowen, Jacob D Durrant, Elizabeth A Winzeler
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Communications biology 5 (1) (2022)
Antonia C Du Bois, Alice Xue, Chester Pham, Nicole M Revie, Kirsten J Meyer, Yoko Yashiroda, Charles Boone, Justin R Nodwell, Peter Stogios, Alexei Savchenko, Nicole Robbins, Kali R Iyer, Leah E Cowen
High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11. mSphere 7 (3) (2022)
Jessie MacAlpine, Nicole Robbins, Leah E Cowen
Bacterial-fungal interactions and their impact on microbial pathogenesis. Molecular ecology (2022)
Jessie MacAlpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M Revie, Robert T Todd, Peter J Stogios, Hiram Sanchez, Teresa R O'Meara, Thomas A Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O Veri, David R Andes, Paul L Fidel, Nicole Robbins, Justin R Nodwell, Luke Whitesell, Leah E Cowen
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nature communications 12 (1) (2021)
Paul T Marcyk, Emmanuelle V LeBlanc, Douglas A Kuntz, Alice Xue, Francisco Ortiz, Richard Trilles, Stephen Bengtson, Tristan M G Kenney, David S Huang, Nicole Robbins, Noelle S Williams, Damian J Krysan, Gilbert G Privé, Luke Whitesell, Leah E Cowen, Lauren E Brown
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. Journal of medicinal chemistry 64 (2) (2021)
Kali R Iyer, Nicole M Revie, Ci Fu, Nicole Robbins, Leah E Cowen
Treatment strategies for cryptococcal infection: challenges, advances and future outlook. Nature reviews. Microbiology 19 (7) (2021)
Nicole M Revie, Leah E Cowen
Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action. ACS central science 7 (5) (2021)
Ci Fu, Xiang Zhang, Amanda O Veri, Kali R Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J Polvi, Sean D Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R O'Meara, Matthew J O'Meara, Suzanne Noble, Nicole Robbins, Chad L Myers, Leah E Cowen
Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. Nature communications 12 (1) (2021)
Kali R Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M Pimentel-Elardo, Jen L Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, Jose F Muñoz, Sang Hu Kim, John A Porco, Christina A Cuomo, Noelle S Williams, Ashraf S Ibrahim, John E Edwards, David R Andes, Justin R Nodwell, Lauren E Brown, Luke Whitesell, Nicole Robbins, Leah E Cowen
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature communications 11 (1) (2020)
Saif Hossain, Amanda O Veri, Leah E Cowen
The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling. mBio 11 (2) (2020)
Alice Xue, Nicole Robbins, Leah E Cowen
Advances in fungal chemical genomics for the discovery of new antifungal agents. Annals of the New York Academy of Sciences 1496 (1) (2020)
Emmanuelle V LeBlanc, Elizabeth J Polvi, Amanda O Veri, Gilbert G Privé, Leah E Cowen
Structure-guided approaches to targeting stress responses in human fungal pathogens. The Journal of biological chemistry 295 (42) (2020)
Sean D Liston, Luke Whitesell, Catherine A McLellan, Ralph Mazitschek, Vidmantas Petraitis, Ruta Petraitiene, Povilas Kavaliauskas, Thomas J Walsh, Leah E Cowen
Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability. Antimicrobial agents and chemotherapy 64 (10) (2020)
Sang Hu Kim, Chunliang Liu, Yasheen Zhou, Yong-Kang Zhang, Cari McGregor, Luke Steere, Brittany H Frederick, C Tony Liu, Luke Whitesell, Leah E Cowen
Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens. ACS chemical biology 15 (7) (2020)
Yunjin Lee, Emily Puumala, Nicole Robbins, Leah E Cowen
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond. Chemical reviews 121 (6) (2020)
Nicola T Case, Joseph Heitman, Leah E Cowen
The Rise of Fungi: A Report on the CIFAR Program Fungal Kingdom: Threats & Opportunities Inaugural Meeting. G3 (Bethesda, Md.) 10 (6) (2020)
Sang Hu Kim, Kali R Iyer, Lakhansing Pardeshi, José F Muñoz, Nicole Robbins, Christina A Cuomo, Koon Ho Wong, Leah E Cowen
Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance. mBio 10 (1) (2019)
Teresa R O'Meara, Matthew J O'Meara, Elizabeth J Polvi, M Reza Pourhaghighi, Sean D Liston, Zhen-Yuan Lin, Amanda O Veri, Andrew Emili, Anne-Claude Gingras, Leah E Cowen
Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen. PLoS biology 17 (7) (2019)
Elizabeth J Polvi, Amanda O Veri, Zhongle Liu, Saif Hossain, Sabrina Hyde, Sang Hu Kim, Faiza Tebbji, Adnane Sellam, Robert T Todd, Jinglin L Xie, Zhen-Yuan Lin, Cassandra J Wong, Rebecca S Shapiro, Malcolm Whiteway, Nicole Robbins, Anne-Claude Gingras, Anna Selmecki, Leah E Cowen
Functional divergence of a global regulatory complex governing fungal filamentation. PLoS genetics 15 (1) (2019)
Harley O'Connor Mount, Nicole M Revie, Robert T Todd, Kaitlin Anstett, Cathy Collins, Michael Costanzo, Charles Boone, Nicole Robbins, Anna Selmecki, Leah E Cowen
Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. PLoS genetics 14 (4) (2018)

Leah E Cowen.css-eqlu8i{font-size:small;padding-left:4px;} (Nicole Robbins)

Publication Activity (10 Years)

Top Topics

Top Venues

Leah E Cowen (Nicole Robbins)