Lukas Grätz

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 21

Top Topics

Structural Basis

Top Venues

Nature communications

ACS pharmacology & translational science

Scientific reports

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Julien Bous, Julia Kinsolving, Lukas Grätz, Magdalena M Scharf, Jan Hendrik Voß, Berkay Selçuk, Ogün Adebali, Gunnar Schulte
Structural basis of frizzled 7 activation and allosteric regulation. Nature communications 15 (1) (2024)
Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Santa Veikšina, Carina Höring, Albert O Gattor, Laura J Humphrys, Christoph Müller, Nataliya Archipowa, Johannes Köckenberger, Markus R Heinrich, Roger Jan Kutta, Ago Rinken, Max Keller
Illuminating Neuropeptide Y Y 4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools. ACS pharmacology & translational science 7 (4) (2024)
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
A molecular mechanism to diversify Ca 2+ signaling downstream of Gs protein-coupled receptors. Nature communications 15 (1) (2024)
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
A molecular mechanism to diversify Ca 2+ signaling downstream of Gs protein-coupled receptors. Nature communications 15 (1) (2024)
Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Santa Veikšina, Carina Höring, Albert O Gattor, Laura J Humphrys, Christoph Müller, Nataliya Archipowa, Johannes Köckenberger, Markus R Heinrich, Roger Jan Kutta, Ago Rinken, Max Keller
Illuminating Neuropeptide Y Y 4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools. ACS pharmacology & translational science 7 (4) (2024)
Lukas Grätz, Jan Hendrik Voß, Gunnar Schulte
Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs. ACS sensors (2024)
Julien Bous, Julia Kinsolving, Lukas Grätz, Magdalena M Scharf, Jan Hendrik Voß, Berkay Selçuk, Ogün Adebali, Gunnar Schulte
Structural basis of frizzled 7 activation and allosteric regulation. Nature communications 15 (1) (2024)
Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Santa Veikšina, Carina Höring, Albert O Gattor, Laura J Humphrys, Christoph Müller, Nataliya Archipowa, Johannes Köckenberger, Markus R Heinrich, Roger Jan Kutta, Ago Rinken, Max Keller
Illuminating Neuropeptide Y Y 4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools. ACS pharmacology & translational science 7 (4) (2024)
Lukas Grätz, Maria Kowalski-Jahn, Magdalena M Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A Lambert, David E Gloriam, Gunnar Schulte
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nature communications 14 (1) (2023)
Lukas Grätz, Joanna J Sajkowska-Kozielewicz, Janine Wesslowski, Julia Kinsolving, Lloyd J Bridge, Katja Petzold, Gary Davidson, Gunnar Schulte, Pawel Kozielewicz
NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model. British journal of pharmacology (2023)
Carl-Fredrik Bowin, Pawel Kozielewicz, Lukas Grätz, Maria Kowalski-Jahn, Hannes Schihada, Gunnar Schulte
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction. Science signaling 16 (779) (2023)
Maris-Johanna Tahk, Jane Torp, Mohammed A S Ali, Dmytro Fishman, Leopold Parts, Lukas Grätz, Christoph Müller, Max Keller, Santa Veiksina, Tõnis Laasfeld, Ago Rinken
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M 4 muscarinic receptors? Open biology 12 (6) (2022)
Lisa Schindler, Jutta Moosbauer, Daniel Schmidt, Thilo Spruss, Lukas Grätz, Steffen Lüdeke, Frank Hofheinz, Sebastian Meister, Bernd Echtenacher, Günther Bernhardt, Jens Pietzsch, Dirk Hellwig, Max Keller
Development of a Neurotensin-Derived 68 Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS 1 Receptor-Expressing Tumors. Cancers 14 (19) (2022)
Lukas Grätz, Christoph Müller, Andrea Pegoli, Lisa Schindler, Günther Bernhardt, Timo Littmann
Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs. ACS pharmacology & translational science 5 (11) (2022)
Adam Konieczny, Marcus Conrad, Fabian J Ertl, Jakob Gleixner, Albert O Gattor, Lukas Grätz, Maximilian F Schmidt, Eduard Neu, Anselm H C Horn, David Wifling, Peter Gmeiner, Timothy Clark, Heinrich Sticht, Max Keller
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants. Journal of medicinal chemistry 64 (22) (2021)
Lukas Grätz, Katharina Tropmann, Merlin Bresinsky, Christoph Müller, Guenther Bernhardt, Steffen Pockes
Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells. Scientific reports 11 (1) (2021)
Lukas Grätz, Katharina Tropmann, Merlin Bresinsky, Christoph Müller, Guenther Bernhardt, Steffen Pockes
Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells. Scientific reports 11 (1) (2021)
Carina Höring, Ulla Seibel-Ehlert, Katharina Tropmann, Lukas Grätz, Denise Mönnich, Sebastian Pitzl, Guenther Bernhardt, Steffen Pockes, Andrea Strasser
A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes. International journal of molecular sciences 21 (22) (2020)
Lukas Grätz, Katharina Tropmann, Merlin Bresinsky, Christoph Müller, Guenther Bernhardt, Steffen Pockes
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells. Scientific reports 10 (1) (2020)
Corinna G Gruber, Andrea Pegoli, Christoph Müller, Lukas Grätz, Xueke She, Max Keller
Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity. RSC medicinal chemistry 11 (7) (2020)
Lisa Forster, Lukas Grätz, Denise Mönnich, Günther Bernhardt, Steffen Pockes
A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors. International journal of molecular sciences 21 (17) (2020)