Matthias P Wymann (Matthias Wymann)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 20

Top Topics

Top Venues

Journal of medicinal chemistry

Chemical science

Nature immunology

Science signaling

This page only lists publications with an associated author ORCID identifier.

Publications

Stephen M Lanahan, Lucas Yang, Kate M Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P Wymann, Steven H Kleinstein, V Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S Abraham, Carrie L Lucas
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells. Nature immunology (2024)
Stephen M Lanahan, Lucas Yang, Kate M Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P Wymann, Steven H Kleinstein, V Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S Abraham, Carrie L Lucas
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells. Nature immunology 25 (8) (2024)
Stephen M Lanahan, Lucas Yang, Kate M Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P Wymann, Steven H Kleinstein, V Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S Abraham, Carrie L Lucas
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells. Nature immunology 25 (8) (2024)
Werner Theodor Jauslin, Matthias Schild, Thorsten Schaefer, Chiara Borsari, Clara Orbegozo, Lukas Bissegger, Saule Zhanybekova, Danilo Ritz, Alexander Schmidt, Matthias P Wymann, Dennis Gillingham
A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα. Chemical science 15 (2) (2023)
Werner Theodor Jauslin, Matthias Schild, Thorsten Schaefer, Chiara Borsari, Clara Orbegozo, Lukas Bissegger, Saule Zhanybekova, Danilo Ritz, Alexander Schmidt, Matthias P Wymann, Dennis Gillingham
A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα. Chemical science 15 (2) (2023)
Werner Theodor Jauslin, Matthias Schild, Thorsten Schaefer, Chiara Borsari, Clara Orbegozo, Lukas Bissegger, Saule Zhanybekova, Danilo Ritz, Alexander Schmidt, Matthias P Wymann, Dennis Gillingham
A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα. Chemical science 15 (2) (2023)
Stephen M Lanahan, Matthias P Wymann, Carrie L Lucas
The role of PI3Kγ in the immune system: new insights and translational implications. Nature reviews. Immunology 22 (11) (2022)
Chiara Borsari, Erhan Keles, Jacob A McPhail, Alexander Schaefer, Rohitha Sriramaratnam, Wojciech Goch, Thorsten Schaefer, Martina De Pascale, Wojciech Bal, Matthias Gstaiger, John E Burke, Matthias P Wymann
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society 144 (14) (2022)
Chiara Borsari, Erhan Keles, Andrea Treyer, Martina De Pascale, Paul Hebeisen, Matthias Hamburger, Matthias P Wymann
Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability. RSC medicinal chemistry 12 (4) (2021)
Mayumi Mori, Julie Ruer-Laventie, Wandrille Duchemin, Philippe Demougin, Tohnyui Ndinyanka Fabrice, Matthias P Wymann, Jean Pieters
Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling. Science signaling 14 (714) (2021)
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. eLife 10 (2021)
Chiara Borsari, Erhan Keles, Denise Rageot, Andrea Treyer, Thomas Bohnacker, Lukas Bissegger, Martina De Pascale, Anna Melone, Rohitha Sriramaratnam, Florent Beaufils, Matthias Hamburger, Paul Hebeisen, Wolfgang Löscher, Doriano Fabbro, Petra Hillmann, Matthias P Wymann
4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders. Journal of medicinal chemistry 63 (22) (2020)
Denise Rageot, Thomas Bohnacker, Erhan Keles, Jacob A McPhail, Reece M Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander M Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E Burke, Matthias P Wymann
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. Journal of medicinal chemistry 62 (13) (2019)
Chiara Tarantelli, Eugenio Gaudio, Petra Hillmann, Filippo Spriano, Giulio Sartori, Luca Aresu, Luciano Cascione, Denise Rageot, Ivo Kwee, Florent Beaufils, Emanuele Zucca, Anastasios Stathis, Matthias P Wymann, Vladimir Cmiljanovic, Doriano Fabbro, Francesco Bertoni
The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax. Cancers 11 (6) (2019)
Andrew J Takeda, Timothy J Maher, Yu Zhang, Stephen M Lanahan, Molly L Bucklin, Susan R Compton, Paul M Tyler, William A Comrie, Makoto Matsuda, Kenneth N Olivier, Stefania Pittaluga, Joshua J McElwee, Debra A Long Priel, Douglas B Kuhns, Roger L Williams, Peter J Mustillo, Matthias P Wymann, V Koneti Rao, Carrie L Lucas
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Nature communications 10 (1) (2019)
Gangadhara Gangadhara, Göran Dahl, Thomas Bohnacker, Rebecca Rae, Jenny Gunnarsson, Stefan Blaho, Linda Öster, Helena Lindmark, Kostas Karabelas, Nils Pemberton, Christian Tyrchan, Mickael Mogemark, Matthias P Wymann, Roger L Williams, Matthew W D Perry, Tineke Papavoine, Jens Petersen
A class of highly selective inhibitors bind to an active state of PI3Kγ. Nature chemical biology 15 (4) (2019)
Chiara Borsari, Denise Rageot, Alix Dall'Asen, Thomas Bohnacker, Anna Melone, Alexander M Sele, Eileen Jackson, Jean-Baptiste Langlois, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, Matthias P Wymann
A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. Journal of medicinal chemistry 62 (18) (2019)
Denise Rageot, Thomas Bohnacker, Anna Melone, Jean-Baptiste Langlois, Chiara Borsari, Petra Hillmann, Alexander M Sele, Florent Beaufils, Marketa Zvelebil, Paul Hebeisen, Wolfgang Löscher, John E Burke, Doriano Fabbro, Matthias P Wymann
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders. Journal of medicinal chemistry 61 (22) (2018)
Ludovic Breasson, Barbara Becattini, Claudia Sardi, Angela Molinaro, Fabio Zani, Romina Marone, Fabrizio Botindari, Mélanie Bousquenaud, Curzio Ruegg, Matthias P Wymann, Giovanni Solinas
PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Science signaling 10 (488) (2017)
Florent Beaufils, Natasa Cmiljanovic, Vladimir Cmiljanovic, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger L Williams, Denise Rageot, Matthias P Wymann
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. Journal of medicinal chemistry 60 (17) (2017)