Michael Decker

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 56

Top Topics

Histone Deacetylase

Neuroendocrine Tumors

Top Venues

Journal of medicinal chemistry

Chemistry (Weinheim an der Bergstrasse, Germany)

ACS chemical neuroscience

This page only lists publications with an associated author ORCID identifier.

Publications

Philipp Spatz, Xinyu Chen, Kora Reichau, Max E Huber, Saskia Mühlig, Yohji Matsusaka, Matthias Schiedel, Takahiro Higuchi, Michael Decker
Development and Initial Characterization of the First 18 F-CXCR2-Targeting Radiotracer for PET Imaging of Neutrophils. Journal of medicinal chemistry (2024)
Antonios Drakopoulos, Zsombor Koszegi, Kerstin Seier, Harald Hübner, Damien Maurel, Rémy Sounier, Sébastien Granier, Peter Gmeiner, Davide Calebiro, Michael Decker
Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors. Journal of medicinal chemistry (2024)
Sophie A M Steinmüller, Magdalena Odaybat, Giulia Galli, Davia Prischich, Matthew John Fuchter, Michael Decker
Arylazobenzimidazoles: versatile visible-light photoswitches with tuneable Z -isomer stability. Chemical science 15 (14) (2024)
Philipp Spatz, Xinyu Chen, Kora Reichau, Max E Huber, Saskia Mühlig, Yohji Matsusaka, Matthias Schiedel, Takahiro Higuchi, Michael Decker
Development and Initial Characterization of the First 18 F-CXCR2-Targeting Radiotracer for PET Imaging of Neutrophils. Journal of medicinal chemistry 67 (8) (2024)
Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Maurice
The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics 30 (6) (2024)
Antonios Drakopoulos, Zsombor Koszegi, Kerstin Seier, Harald Hübner, Damien Maurel, Rémy Sounier, Sébastien Granier, Peter Gmeiner, Davide Calebiro, Michael Decker
Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors. Journal of medicinal chemistry 67 (15) (2024)
Sophie A M Steinmüller, Magdalena Odaybat, Giulia Galli, Davia Prischich, Matthew John Fuchter, Michael Decker
Arylazobenzimidazoles: versatile visible-light photoswitches with tuneable Z -isomer stability. Chemical science 15 (14) (2024)
Thomas Zimmermann, Jiachen Feng, Luana Janaína de Campos, Lindsey A Knight, Jan Schlötzer, Yesid A Ramirez, Kevin Schwickert, Markus Zehe, Thomas B Adler, Tanja Schirmeister, Caroline Kisker, Christoph Sotriffer, Martin Conda Sheridan, Michael Decker
Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis . Journal of medicinal chemistry (2024)
Thomas Zimmermann, Jiachen Feng, Luana Janaína de Campos, Lindsey A Knight, Jan Schlötzer, Yesid A Ramirez, Kevin Schwickert, Markus Zehe, Thomas B Adler, Tanja Schirmeister, Caroline Kisker, Christoph Sotriffer, Martin Conda Sheridan, Michael Decker
Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis . Journal of medicinal chemistry 67 (13) (2024)
Alexandra Sink, Hubert Gerwe, Harald Hübner, Valérie Boivin-Jahns, Julia Fender, Kristina Lorenz, Peter Gmeiner, Michael Decker
"Photo-Adrenalines": Photoswitchable β 2 -Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (11) (2024)
Thomas Zimmermann, Jiachen Feng, Luana Janaína de Campos, Lindsey A Knight, Jan Schlötzer, Yesid A Ramirez, Kevin Schwickert, Markus Zehe, Thomas B Adler, Tanja Schirmeister, Caroline Kisker, Christoph Sotriffer, Martin Conda Sheridan, Michael Decker
Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis . Journal of medicinal chemistry 67 (13) (2024)
Alexandra Sink, Hubert Gerwe, Harald Hübner, Valérie Boivin-Jahns, Julia Fender, Kristina Lorenz, Peter Gmeiner, Michael Decker
"Photo-Adrenalines": Photoswitchable β 2 -Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (11) (2024)
Alexandra Sink, Hubert Gerwe, Harald Hübner, Valérie Boivin-Jahns, Julia Fender, Kristina Lorenz, Peter Gmeiner, Michael Decker
"Photo-Adrenalines": Photoswitchable β 2 -Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Thomas Zimmermann, Jiachen Feng, Luana Janaína de Campos, Lindsey A Knight, Jan Schlötzer, Yesid A Ramirez, Kevin Schwickert, Markus Zehe, Thomas B Adler, Tanja Schirmeister, Caroline Kisker, Christoph Sotriffer, Martin Conda Sheridan, Michael Decker
Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis . Journal of medicinal chemistry (2024)
Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Maurice
The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics 30 (6) (2024)
Antonios Drakopoulos, Zsombor Koszegi, Kerstin Seier, Harald Hübner, Damien Maurel, Rémy Sounier, Sébastien Granier, Peter Gmeiner, Davide Calebiro, Michael Decker
Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors. Journal of medicinal chemistry 67 (15) (2024)
Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe Pol Stove, Barbara Monti, Tangui Maurice, Michael Decker
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 66 (9) (2023)
Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe Pol Stove, Barbara Monti, Tangui Maurice, Michael Decker
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 66 (9) (2023)
Anna Tutov, Xinyu Chen, Rudolf A Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, Takahiro Higuchi
Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter. Pharmaceutics 15 (2) (2023)
Anna Tutov, Xinyu Chen, Rudolf A Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, Takahiro Higuchi
Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter. Pharmaceutics 15 (2) (2023)
Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe Pol Stove, Barbara Monti, Tangui Maurice, Michael Decker
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 66 (9) (2023)
Madeline Günther, Samentha Dabare, Jennifer Fuchs, Sandra Gunesch, Julian Hofmann, Michael Decker, Carsten Culmsee
Flavonoid-Phenolic Acid Hybrids Are Potent Inhibitors of Ferroptosis via Attenuation of Mitochondrial Impairment. Antioxidants (Basel, Switzerland) 13 (1) (2023)
Anna Tutov, Xinyu Chen, Rudolf A Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, Takahiro Higuchi
Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter. Pharmaceutics 15 (2) (2023)
Sophie A M Steinmüller, Anna Tutov, James N Hislop, Michael Decker
Bridging the Binding Sites 2.0: Photoswitchable Dualsteric Ligands for the Cannabinoid 2 Receptor. ACS chemical neuroscience (2023)
Madeline Günther, Samentha Dabare, Jennifer Fuchs, Sandra Gunesch, Julian Hofmann, Michael Decker, Carsten Culmsee
Flavonoid-Phenolic Acid Hybrids Are Potent Inhibitors of Ferroptosis via Attenuation of Mitochondrial Impairment. Antioxidants (Basel, Switzerland) 13 (1) (2023)
Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe Pol Stove, Barbara Monti, Tangui Maurice, Michael Decker
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 66 (9) (2023)
Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe Pol Stove, Barbara Monti, Tangui Maurice, Michael Decker
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry (2023)
Anna Tutov, Xinyu Chen, Rudolf A Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, Takahiro Higuchi
Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter. Pharmaceutics 15 (2) (2023)
Julian Hofmann, Philipp Spatz, Rasmus Walther, Marcus Gutmann, Tangui Maurice, Michael Decker
Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (39) (2022)
Philipp Spatz, Thomas Zimmermann, Sophie A M Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decker
Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC medicinal chemistry 13 (8) (2022)
Matthias Scheiner, Alexandra Sink, Matthias Hoffmann, Cassandre Vrigneau, Erik Endres, Allison Carles, Christoph A Sotriffer, Tangui Maurice, Michael Decker
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation. Journal of the American Chemical Society 144 (7) (2022)
Hubert Gerwe, Feng He, Eline Pottie, Christophe Pol Stove, Michael Decker
Enlightening the "Spirit Molecule": Photomodulation of the 5-HT 2A Receptor by a Light-Controllable N,N-Dimethyltryptamine Derivative. Angewandte Chemie (International ed. in English) 61 (26) (2022)
Antonios Drakopoulos, Dimitrios Moianos, Georgia-Myrto Prifti, Grigoris Zoidis, Michael Decker
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype. ChemMedChem 17 (14) (2022)
Diego A Rodríguez-Soacha, Sophie A M Steinmüller, Ali Işbilir, Julia Fender, Marie H Deventer, Yesid A Ramírez, Anna Tutov, Christoph Sotriffer, Christophe Pol Stove, Kristina Lorenz, Martin J Lohse, James N Hislop, Michael Decker
Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB 1 R) "Cis-On" Agonist. ACS chemical neuroscience 13 (16) (2022)
Christian Gentzsch, Matthias Hoffmann, Yasuhiro Ohshima, Naoko Nose, Xinyu Chen, Takahiro Higuchi, Michael Decker
Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer. ChemMedChem 16 (9) (2021)
Feng He, C James Chou, Matthias Scheiner, Eleonora Poeta, Natalia Yuan Chen, Sandra Gunesch, Matthias Hoffmann, Christoph Sotriffer, Barbara Monti, Tangui Maurice, Michael Decker
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 64 (7) (2021)
Diego A Rodríguez-Soacha, Julia Fender, Yesid A Ramírez, Juan Antonio Collado, Eduardo Muñoz, Rangan Maitra, Christoph Sotriffer, Kristina Lorenz, Michael Decker
"Photo-Rimonabant": Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar "Cis-On" CB1R Antagonist. ACS chemical neuroscience 12 (9) (2021)
Julian C Schmid, Kerstin Frey, Matthias Scheiner, Jaime Felipe Guerrero Garzón, Luise Stafforst, Jan-Niklas Fricke, Michaela Schuppe, Hajo Schiewe, Axel Zeeck, Tilmann Weber, Isabel Usón, Ralf Kemkemer, Michael Decker, Stephanie Grond
The Structure of Cyclodecatriene Collinolactone, its Biosynthesis, and Semisynthetic Analogues: Effects of Monoastral Phenotype and Protection from Intracellular Oxidative Stress. Angewandte Chemie (International ed. in English) 60 (43) (2021)
Julian Hofmann, Tiziana Ginex, Alba Espargaró, Matthias Scheiner, Sandra Gunesch, Marc Aragó, Christian Stigloher, Raimon Sabaté, F Javier Luque, Michael Decker
Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (19) (2021)
Matthias Scheiner, Matthias Hoffmann, Feng He, Eleonora Poeta, Arnaud Chatonnet, Barbara Monti, Tangui Maurice, Michael Decker
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 64 (13) (2021)
Christian Gentzsch, Xinyu Chen, Philipp Spatz, Urban Košak, Damijan Knez, Naoko Nose, Stanislav Gobec, Takahiro Higuchi, Michael Decker
Synthesis and Initial Characterization of a Reversible, Selective 18F-Labeled Radiotracer for Human Butyrylcholinesterase. Molecular imaging and biology 23 (4) (2021)
Antonios Drakopoulos, Michael Decker
Development and Biological Applications of Fluorescent Opioid Ligands. ChemPlusChem 85 (6) (2021)
Christian Gentzsch, Kerstin Seier, Antonios Drakopoulos, Marie-Lise Jobin, Yann Lanoiselée, Zsombor Koszegi, Damien Maurel, Rémy Sounier, Harald Hübner, Peter Gmeiner, Sébastien Granier, Davide Calebiro, Michael Decker
Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of μ-Opioid Receptor Dimerization. Angewandte Chemie (International ed. in English) 59 (15) (2020)
Antonios Drakopoulos, Zsombor Koszegi, Yann Lanoiselée, Harald Hübner, Peter Gmeiner, Davide Calebiro, Michael Decker
Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes. Journal of medicinal chemistry 63 (7) (2020)
Filippo Basagni, Michela Rosini, Michael Decker
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes. ChemMedChem 15 (15) (2020)
Julian Hofmann, Shaimaa Fayez, Matthias Scheiner, Matthias Hoffmann, Sabrina Oerter, Antje Appelt-Menzel, Pamela Maher, Tangui Maurice, Gerhard Bringmann, Michael Decker
Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (32) (2020)
Sandra Gunesch, David Soriano-Castell, Stephanie Lamer, Andreas Schlosser, Pamela Maher, Michael Decker
Development and Application of a Chemical Probe Based on a Neuroprotective Flavonoid Hybrid for Target Identification Using Activity-Based Protein Profiling. ACS chemical neuroscience 11 (22) (2020)
Matthias Hoffmann, Carina Stiller, Erik Endres, Matthias Scheiner, Sandra Gunesch, Christoph Sotriffer, Tangui Maurice, Michael Decker
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model. Journal of medicinal chemistry 62 (20) (2019)
Matthias Scheiner, Dominik Dolles, Sandra Gunesch, Matthias Hoffmann, Massimo Nabissi, Oliviero Marinelli, Marina Naldi, Manuela Bartolini, Sabrina Petralla, Eleonora Poeta, Barbara Monti, Christina Falkeis, Michael Vieth, Harald Hübner, Peter Gmeiner, Rangan Maitra, Tangui Maurice, Michael Decker
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo. Journal of medicinal chemistry 62 (20) (2019)
Luca Agnetta, Marcel Bermudez, Fabio Riefolo, Carlo Matera, Enrique Claro, Regina Messerer, Timo Littmann, Gerhard Wolber, Gerhard Bringmann, Michael Decker
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties. Journal of medicinal chemistry 62 (6) (2019)
Simon Schramm, Luca Agnetta, Marcel Bermudez, Hubert Gerwe, Matthias Irmen, Janine Holze, Timo Littmann, Gerhard Wolber, Christian Tränkle, Michael Decker
Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism. ChemMedChem 14 (14) (2019)
Fabio Riefolo, Carlo Matera, Aida Garrido-Charles, Alexandre M J Gomila, Rosalba Sortino, Luca Agnetta, Enrique Claro, Roser Masgrau, Gerhard Bringmann, Montserrat Batlle, Michael Decker, Eduard Guasch, Pau Gorostiza
Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist. Journal of the American Chemical Society 141 (18) (2019)
Matthias Hoffmann, Xinyu Chen, Mitsuru Hirano, Kenji Arimitsu, Hiroyuki Kimura, Takahiro Higuchi, Michael Decker
18 F-Labeled Derivatives of Irbesartan for Angiotensin II Receptor PET Imaging. ChemMedChem 13 (23) (2018)
Dominik Dolles, Matthias Hoffmann, Sandra Gunesch, Oliviero Marinelli, Jan Möller, Giorgio Santoni, Arnaud Chatonnet, Martin J Lohse, Hans-Joachim Wittmann, Andrea Strasser, Massimo Nabissi, Tangui Maurice, Michael Decker
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of medicinal chemistry 61 (4) (2018)
Simon Schramm, Sandra Gunesch, Florian Lang, Marco Saedtler, Lorenz Meinel, Petra Högger, Michael Decker
Investigations into neuroprotectivity, stability, and water solubility of 7-O-cinnamoylsilibinin, its hemisuccinate and dehydro derivatives. Archiv der Pharmazie 351 (11) (2018)
Luca Agnetta, Michael Kauk, Maria Consuelo Alonso Canizal, Regina Messerer, Gerhard Bringmann, Carsten Hoffmann, Michael Decker
A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy. Angewandte Chemie (International ed. in English) 56 (25) (2017)