Chun-Wei David Chen (Chun-Wei Chen, Chun Wei Chen, Chunwei Chen)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 34

Top Venues

Science advances

Nature structural & molecular biology

Nature communications

Cancer discovery

Beckman Research Institute, City of Hope

University of Rochester (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Beckman Research Institute, City of Hope Jun 26 2017

United States

Director :: Division of Epigenetics and Transcriptional Engineering

Beckman Research Institute, City of Hope Jun 26 2017

United States

Assistant Professor :: Systems Biology

Dana Farber Cancer Institute - Harvard Medical School Jun 05 2016 - Jun 25 2017

United States

Instructor :: Pediatric Oncology

Memorial Sloan Kettering Cancer Center Aug 01 2012 - Jun 04 2016

United States

Senior Research Scientist :: Cancer Biology and Genetics

Children's Hospital Boston - Harvard Medical School Jun 07 2011 - Jul 31 2012

United States

Postdoc :: Hematology Oncology

Education History

University of Rochester

United States

PHD :: Pathology

National Taiwan University

Taiwan

MSC :: Bioindustrial Chemistry

National Taiwan University

Taiwan

BSC :: Biochemistry

Publications

Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology (2024)
Changyu Zhu, Yadira M Soto-Feliciano, John P Morris, Chun-Hao Huang, Richard P Koche, Yu-Jui Ho, Ana Banito, Chun-Wei David Chen, Aditya Shroff, Sha Tian, Geulah Livshits, Chi-Chao Chen, Myles Fennell, Scott A Armstrong, C David Allis, Darjus F Tschaharganeh, Scott W Lowe
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. eLife 12 (2023)
Mingli Li, Lu Yang, Anthony K N Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen-Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J R Bishop, Chun-Wei David Chen
Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Mingli Li, Leisi Zhang, Chun-Wei David Chen
Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond. Cells 12 (18) (2023)
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla B Heavican-Foral, Elisa Mandato, Huiyun Liu, Geoffrey M Nelson, Lu Yang, Renee Chen, Katherine Aleisha Donovan, Marcus Kenneth Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit J Nirmal, Salvia Jain, Catharine Leahy, Kristen L Jones, Kristen E Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing C Chan, Shannan Ho Sui, Samuel Y Ng, Andrew L Feldman, Steven M Horwitz, Karen Adelman, Eric S Fischer, Chun-Wei David Chen, David M Weinstock, Myles A Brown
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. Science translational medicine 15 (714) (2023)
Eitan Kugler, Shreyas Madiwale, Darren Yong, Julie A I Thoms, Yehudit Birger, David Brian Sykes, Johannes Schmoellerl, Aneta Drakul, Valdemar Priebe, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei David Chen, Brian Raught, Qiao Liu, Heather Ogana, Elisabeth Liedke, Jean-Pierre Bourquin, Johannes Zuber, Michael Milyavsky, John E Pimanda, Gilbert G Privé, Shai Izraeli
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Nature communications 14 (1) (2023)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Sara Canovas Nunes, Serena De Vita, Andrew Anighoro, François Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A Williams, Haiming Xu
Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood cancer journal 12 (4) (2022)
Ifat Geron, Angela Maria Savino, Hila Fishman, Noa Tal, John Brown, Virginia A Turati, Chela James, Jolanda Sarno, Michal Hameiri-Grossman, Yu Nee Lee, Avigail Rein, Hillary Maniriho, Yehudit Birger, Anna Zemlyansky, Inna Muler, Kara L Davis, Victoria Marcu-Malina, Nicole Mattson, Oren Parnas, Rabea Wagener, Ute Fischer, Joao T Barata, Catriona H M Jamieson, Markus Müschen, Chun-Wei David Chen, Arndt Borkhardt, Ilan Richard Kirsch, Arnon Nagler, Tariq Enver, Shai Izraeli
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia. Nature communications 13 (1) (2022)
Mingli Li, Chun-Wei David Chen
Regulation of Metastasis in Ewing Sarcoma. Cancers 14 (19) (2022)
Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei David Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade. Blood 139 (26) (2022)
Xiaobao Xu, Anthony K C Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Müschen, Steven T Rosen, Jianjun Chen, Lu Yang, Chun-Wei David Chen
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 8 (51) (2022)
Mingli Li, Chun-Wei David Chen
Epigenetic and Transcriptional Signaling in Ewing Sarcoma-Disease Etiology and Therapeutic Opportunities. Biomedicines 10 (6) (2022)
Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric M Wong, Charles Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J C Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei David Chen, Scott A Armstrong
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia. Cancer discovery (2022)
Rui Su, Lei Dong, Yangchan Li, Min Gao, P Cody He, Wei Liu, Jiangbo Wei, Zhicong Zhao, Lei Gao, Li Han, Xiaolan Deng, Chenying Li, Emily Prince, Brandon Tan, Ying Qing, Xi Qin, Chao Shen, Meilin Xue, Keren Zhou, Zhenhua Chen, Jianhuang Xue, Wei Li, Hanjun Qin, Xiwei Wu, Miao Sun, Yunsun Nam, Chun-Wei David Chen, Wendong Huang, David Horne, Steven T Rosen, Chuan He, Jianjun Chen
METTL16 exerts an m 6 A-independent function to facilitate translation and tumorigenesis. Nature cell biology 24 (2) (2022)
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R Barrett, Leila Mahdavi, Hangpeng Li, Sylvia Tang, Tanweer A Khan, Mayako Michino, Connor M Hill, Lele Song, Lu Yang, Yuanyuan Li, Sheela Pangeni Pokharel, Andrew W Stamford, Nigel Liverton, Louis M Renzetti, Simon J Taylor, Gillian F Watt, Tammy Ladduwahetty, Stacia Kargman, Peter T Meinke, Michael A Foley, Junwei Shi, Haitao Li, Martin P Carroll, Chun-Wei David Chen, Alessandro Gardini, Ivan P Maillard, David J Huggins, Kathrin Maria Bernt, Liling Wan
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia. Cancer discovery 12 (11) (2022)
Tina M Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna M Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G Kellaway, Anetta Ptasinska, Elizabeth S Ng, Edouard G Stanley, Andrew G Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei David Chen, Olaf Heidenreich, Matthias Mann, Steven W Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H Heidel
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood (2021)
Lu Yang, Anthony K N Chan, Kazuya Miyashita, Christopher D Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A Armstrong, Chun-Wei David Chen
High-resolution characterization of gene function using single-cell CRISPR tiling screen. Nature communications 12 (1) (2021)
Cosimo Di Raimondo, Zhen Han, Chingyu Su, Xiwei Wu, Hanjun Qin, James F Sanchez, Yate-Ching Yuan, Xochiquetzal Martinez, Farah Abdulla, Jasmine Zain, Chun-Wei David Chen, Steven T Rosen, Christiane Querfeld
Identification of a Distinct miRNA Regulatory Network in the Tumor Microenvironment of Transformed Mycosis Fungoides. Cancers 13 (22) (2021)
Qiao Liu, Anthony K N Chan, Wen-Han Chang, Lu Yang, Sheela Pangeni Pokharel, Kazuya Miyashita, Nicole Mattson, Xiaobao Xu, Mingli Li, Wei Lu, Ren-Jang Lin, Shao-Yuan Wang, Chun-Wei David Chen
3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia. Leukemia (2021)
Jaewoong Lee, Mark E Robinson, Ning Ma, Dewan Artadji, Mohamed A Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N Chan, Kohei Kume, Teemu P Miettinen, Ye Zhang, Matthew A Nix, Lars Klemm, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U Jung, David M Weinstock, Scott R Manalis, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature 588 (7838) (2020)
Hong Qin, Zhenyuan Dong, Xiuli Wang, Wesley A Cheng, Feng Wen, Weili Xue, Han Sun, Miriam Walter, Guowei Wei, D Lynne Smith, Xiuhua Sun, Fan Fei, Jianming Xie, Theano I Panagopoulou, Chun-Wei David Chen, Joo Y Song, Ibrahim Aldoss, Clarisse Kayembe, Luisa Sarno, Markus Müschen, Giorgio G Inghirami, Stephen J Forman, Larry W Kwak
CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies. Science translational medicine 11 (511) (2020)
Sheng F Cai, S Haihua Chu, Aaron D Goldberg, Salma Parvin, Richard P Koche, Jacob L Glass, Eytan M Stein, Martin S Tallman, Filiz Sen, Christopher A Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei David Chen, Lihua Zou, Keith B Cordner, Nicole L DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S Tian, Johannes Zuber, Timour Baslan, Scott W Lowe, Hugh Y Rienhoff, Anthony Letai, Ross L Levine, Scott A Armstrong
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition. Cancer discovery 10 (10) (2020)

Chun-Wei David Chen.css-eqlu8i{font-size:small;padding-left:4px;} (Chun-Wei Chen, Chun Wei Chen, Chunwei Chen)

Publication Activity (10 Years)

Top Topics

Top Venues

Chun-Wei David Chen (Chun-Wei Chen, Chun Wei Chen, Chunwei Chen)