Philip D Kiser

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 33

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature chemical biology

Nature communications

The Journal of biological chemistry

University of California Irvine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of California Irvine

United States

Assistant Professor :: Physiology and Biophysics

Publications

Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser
Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nature chemical biology 20 (6) (2024)
Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser
Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nature chemical biology 20 (6) (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser
Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nature chemical biology 20 (6) (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser
Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nature chemical biology (2024)
Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser
Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nature chemical biology (2024)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Marco Bassetto, Jordan Zaluski, Bowen Li, Jianye Zhang, Mohsen Badiee, Philip D Kiser, Gregory P Tochtrop
Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif. Journal of medicinal chemistry (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Arum Wu, David Salom, John D Hong, Aleksander Tworak, Kohei Watanabe, Els Pardon, Jan Steyaert, Hideki Kandori, Kota Katayama, Philip D Kiser, Krzysztof Palczewski
Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nature communications 14 (1) (2023)
John D Hong, David Salom, Michał Andrzej Kochman, Adam Kubas, Philip D Kiser, Krzysztof Palczewski
Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proceedings of the National Academy of Sciences of the United States of America 119 (45) (2022)
Christopher Lane Sander, Avery E Sears, Antonio F M Pinto, Elliot H Choi, Shirin Kahremany, Fangyuan Gao, David Salom, Hui Jin, Els Pardon, Susie Suh, Zhiqian Dong, Jan Steyaert, Alan Saghatelian, Dorota Skowronska-Krawczyk, Philip D Kiser, Krzysztof Palczewski
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. The Journal of cell biology 220 (8) (2021)
Eliav Blum, Jianye Zhang, Jordan Zaluski, David E Einstein, Edward E Korshin, Adam Kubas, Arie Gruzman, Gregory P Tochtrop, Philip D Kiser, Krzysztof Palczewski
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. Journal of medicinal chemistry 64 (12) (2021)
Anahita Daruwalla, Jianye Zhang, Ho Jun Lee, Nimesh Khadka, Erik R Farquhar, Wuxian Shi, Johannes von Lintig, Philip D Kiser
Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proceedings of the National Academy of Sciences of the United States of America 117 (33) (2020)
Krzysztof Palczewski, Philip D Kiser
Shedding new light on the generation of the visual chromophore. Proceedings of the National Academy of Sciences of the United States of America 117 (33) (2020)
Susie Suh, Elliot H Choi, Henri Leinonen, Andrzej T Foik, Gregory A Newby, Wei-Hsi Yeh, Zhiqian Dong, Philip D Kiser, David C Lyon, David R Liu, Krzysztof Palczewski
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature biomedical engineering 5 (2) (2020)
Josie A Silvaroli, Made Airanthi K Widjaja-Adhi, Thomas Trischman, Sylwia Chelstowska, Samantha Horwitz, Surajit Banerjee, Philip D Kiser, William S Blaner, Marcin Golczak
Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1. ACS chemical biology 14 (3) (2019)
Jianye Zhang, Elliot H Choi, Aleksander Tworak, David Salom, Henri Leinonen, Christopher Lane Sander, Thanh V Hoang, James T Handa, Seth Blackshaw, Grazyna Palczewska, Philip D Kiser, Krzysztof Palczewski
Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. The Journal of biological chemistry 294 (50) (2019)
Nimesh Khadka, Erik R Farquhar, Hannah E Hill, Wuxian Shi, Johannes von Lintig, Philip D Kiser
Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. The Journal of biological chemistry 294 (27) (2019)
Mary E Kelly, Srinivasagan Ramkumar, Weizhong Sun, Crystal Colon Ortiz, Philip D Kiser, Marcin Golczak, Johannes von Lintig
The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin. ACS chemical biology 13 (8) (2018)
Philip D Kiser, Jianye Zhang, Aditya Sharma, Juan M Angueyra, Alexander V Kolesnikov, Mohsen Badiee, Gregory P Tochtrop, Junzo Kinoshita, Neal S Peachey, Wei Li, Vladimir J Kefalov, Krzysztof Palczewski
Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. The Journal of general physiology 150 (4) (2018)
Sahil Gulati, Beata Jastrzebska, Surajit Banerjee, Ángel L Placeres, Przemyslaw Miszta, Songqi Gao, Karl Gunderson, Gregory P Tochtrop, Sławomir Filipek, Kota Katayama, Philip D Kiser, Muneto Mogi, Phoebe L Stewart, Krzysztof Palczewski
Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proceedings of the National Academy of Sciences of the United States of America 114 (13) (2017)
Josie A Silvaroli, Matthew J Pleshinger, Surajit Banerjee, Philip D Kiser, Marcin Golczak
Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa. ACS chemical biology 12 (9) (2017)
Philip D Kiser
Reappraisal of dioxygen binding in NOV1 crystal structures. Proceedings of the National Academy of Sciences of the United States of America 114 (30) (2017)
Xuewu Sui, Andrew C Weitz, Erik R Farquhar, Mohsen Badiee, Surajit Banerjee, Johannes von Lintig, Gregory P Tochtrop, Krzysztof Palczewski, Michael P Hendrich, Philip D Kiser
Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry 56 (22) (2017)
Xuewu Sui, Jianye Zhang, Marcin Golczak, Krzysztof Palczewski, Philip D Kiser
Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. The Journal of biological chemistry 291 (37) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Philip D Kiser