Krzysztof Palczewski

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 62

Top Topics

Age Related Macular Degeneration

Estrogen Receptor

Diabetic Retinopathy

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature biotechnology

The Journal of biological chemistry

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Luis Felipe L P Marinho, Janice Querubin, Alexander V Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T Lee, Elliott E Einstein, David E Einstein, Zhiqian Dong, Philip D Kiser, Seth Blackshaw, Vladimir J Kefalov, Marcin Tabaka, Andrzej T Foik, Simon M Petersen-Jones, Krzysztof Palczewski
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nature communications 15 (1) (2024)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Samuel W Du, Krzysztof Palczewski
Eye on genome editing. The Journal of experimental medicine 220 (5) (2023)
Samuel W Du, Krzysztof Palczewski
Eye on genome editing. The Journal of experimental medicine 220 (5) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
John D Hong, Krzysztof Palczewski
A short story on how chromophore is hydrolyzed from rhodopsin for recycling. BioEssays : news and reviews in molecular, cellular and developmental biology (2023)
Samuel W Du, Krzysztof Palczewski
Eye on genome editing. The Journal of experimental medicine 220 (5) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Samuel W Du, Krzysztof Palczewski
Eye on genome editing. The Journal of experimental medicine 220 (5) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Zachary J Engfer, Dominik Lewandowski, Zhiqian Dong, Grazyna Palczewska, Jianye Zhang, Katarzyna Kordecka, Jagoda Płaczkiewicz, Damian Panas, Andrzej T Foik, Marcin Tabaka, Krzysztof Palczewski
Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Jennings Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Arum Wu, David Salom, John D Hong, Aleksander Tworak, Kohei Watanabe, Els Pardon, Jan Steyaert, Hideki Kandori, Kota Katayama, Philip D Kiser, Krzysztof Palczewski
Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nature communications 14 (1) (2023)
Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis
Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis
Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Elliot H Choi, Susie Suh, Andrzej T Foik, Henri Leinonen, Gregory A Newby, Xin D Gao, Samagya Banskota, Thanh Hoang, Samuel W Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C Lyon, David R Liu, Krzysztof Palczewski
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature communications 13 (1) (2022)
Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis
Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Susie Suh, Elliot H Choi, Aditya Raguram, David R Liu, Krzysztof Palczewski
Precision genome editing in the eye. Proceedings of the National Academy of Sciences of the United States of America 119 (39) (2022)
Nastaran Tarban, Hajnalka Halász, Péter Gogolák, Éva Garabuczi, Alexander R Moise, Krzysztof Palczewski, Zsolt Sarang, Zsuzsa Szondy
Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells 11 (8) (2022)
Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis
Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Siyun Chen, Tamar Getter, David Salom, Di Wu, Daniel Quetschlich, Dror S Chorev, Krzysztof Palczewski, Carol V Robinson
Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature 604 (7905) (2022)
Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis
Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
John D Hong, David Salom, Michał Andrzej Kochman, Adam Kubas, Philip D Kiser, Krzysztof Palczewski
Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proceedings of the National Academy of Sciences of the United States of America 119 (45) (2022)
Christopher Lane Sander, Avery E Sears, Antonio F M Pinto, Elliot H Choi, Shirin Kahremany, Fangyuan Gao, David Salom, Hui Jin, Els Pardon, Susie Suh, Zhiqian Dong, Jan Steyaert, Alan Saghatelian, Dorota Skowronska-Krawczyk, Philip D Kiser, Krzysztof Palczewski
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. The Journal of cell biology 220 (8) (2021)
Michał Andrzej Kochman, Krzysztof Palczewski, Adam Kubas
Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. The journal of physical chemistry. A 125 (38) (2021)
Laurence M Occelli, Anahita Daruwalla, Samantha R De Silva, Paige A Winkler, Kelian Sun, Nathanial Pasmanter, Andrea Minella, Janice Querubin, Leslie A Lyons, Lives Consortium, Anthony G Robson, Elise Heon, Michel Michaelides, Andrew R Webster, Krzysztof Palczewski, Ajoy Vincent, Omar A Mahroo, Philip D Kiser, Simon M Petersen-Jones
A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Human molecular genetics (2021)
Guanping Yu, Song-Qi Gao, Zhiqian Dong, Li Sheng, Da Sun, Ning Zhang, Jianye Zhang, Seunghee Margeivicus, Pingfu Fu, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu
Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjugate chemistry 32 (3) (2021)
Eliav Blum, Jianye Zhang, Jordan Zaluski, David E Einstein, Edward E Korshin, Adam Kubas, Arie Gruzman, Gregory P Tochtrop, Philip D Kiser, Krzysztof Palczewski
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. Journal of medicinal chemistry 64 (12) (2021)
Matthias Pöge, Julia Mahamid, Sanae S Imanishi, Juergen M Plitzko, Krzysztof Palczewski, Wolfgang Baumeister
Determinants shaping the nanoscale architecture of the mouse rod outer segment. eLife 10 (2021)
Grazyna Palczewska, Jakub Boguslawski, Patrycjusz Stremplewski, Lukasz Kornaszewski, Jianye Zhang, Zhiqian Dong, Xiao-Xuan Liang, Enrico Gratton, Alfred Vogel, Maciej Wojtkowski, Krzysztof Palczewski
Noninvasive two-photon optical biopsy of retinal fluorophores. Proceedings of the National Academy of Sciences of the United States of America 117 (36) (2020)
Krzysztof Palczewski, Philip D Kiser
Shedding new light on the generation of the visual chromophore. Proceedings of the National Academy of Sciences of the United States of America 117 (33) (2020)
Henri Leinonen, Nguyen C Pham, Taylor Boyd, Johanes Santoso, Krzysztof Palczewski, Frans Vinberg
Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. eLife 9 (2020)
Julio C Corral-Serrano, Ideke J C Lamers, Jeroen van Reeuwijk, Lonneke Duijkers, Anita D M Hoogendoorn, Adem Yildirim, Nikoleta Argyrou, Renate A A Ruigrok, Stef J F Letteboer, Rossano Butcher, Max D van Essen, Sanae Sakami, Sylvia E C van Beersum, Krzysztof Palczewski, Michael E Cheetham, Qin Liu, Karsten Boldt, Uwe Wolfrum, Marius Ueffing, Alejandro Garanto, Ronald Roepman, Rob W J Collin
PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proceedings of the National Academy of Sciences of the United States of America 117 (18) (2020)
Susie Suh, Elliot H Choi, Henri Leinonen, Andrzej T Foik, Gregory A Newby, Wei-Hsi Yeh, Zhiqian Dong, Philip D Kiser, David C Lyon, David R Liu, Krzysztof Palczewski
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature biomedical engineering 5 (2) (2020)
Les Kallestad, Seth Blackshaw, Ahmad M Khalil, Krzysztof Palczewski
Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Scientific reports 9 (1) (2019)
Dorothy Yanling Zhao, Matthias Pöge, Takefumi Morizumi, Sahil Gulati, Ned Van Eps, Jianye Zhang, Przemyslaw Miszta, Slawomir Filipek, Julia Mahamid, Jürgen M Plitzko, Wolfgang Baumeister, Oliver P Ernst, Krzysztof Palczewski
Cryo-EM structure of the native rhodopsin dimer in nanodiscs. The Journal of biological chemistry 294 (39) (2019)
Debarshi Mustafi, Amirmohsen Arbabi, Hossein Ameri, Krzysztof Palczewski
Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel, Switzerland) 12 (2) (2019)
Jianye Zhang, Elliot H Choi, Aleksander Tworak, David Salom, Henri Leinonen, Christopher Lane Sander, Thanh V Hoang, James T Handa, Seth Blackshaw, Grazyna Palczewska, Philip D Kiser, Krzysztof Palczewski
Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. The Journal of biological chemistry 294 (50) (2019)
Shirin Kahremany, Christopher Lane Sander, Gregory P Tochtrop, Adam Kubas, Krzysztof Palczewski
Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Organic & biomolecular chemistry 17 (35) (2019)
Zsolt Sarang, Tibor Sághy, Zsófia Budai, László Ujlaky-Nagy, Judit Bedekovics, Lívia Beke, Gábor Méhes, Gábor Nagy, Ralph Rühl, Alexander R Moise, Krzysztof Palczewski, Zsuzsa Szondy
Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules 9 (11) (2019)
Sahil Gulati, Krzysztof Palczewski, Andreas Engel, Henning Stahlberg, Lubomír Kováčik
Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Science advances 5 (2) (2019)
Tamar Getter, Susie Suh, Thanh Hoang, James T Handa, Zhiqian Dong, Xiuli Ma, Yuanyuan Chen, Seth Blackshaw, Krzysztof Palczewski
The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. The Journal of biological chemistry 294 (24) (2019)
Jennings Luu, Krzysztof Palczewski
Human aging and disease: Lessons from age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 115 (12) (2018)
Timothy S Owen, David Salom, Wenyu Sun, Krzysztof Palczewski
Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry 57 (6) (2018)
Philip D Kiser, Jianye Zhang, Aditya Sharma, Juan M Angueyra, Alexander V Kolesnikov, Mohsen Badiee, Gregory P Tochtrop, Junzo Kinoshita, Neal S Peachey, Wei Li, Vladimir J Kefalov, Krzysztof Palczewski
Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. The Journal of general physiology 150 (4) (2018)
Anahita Daruwalla, Elliot H Choi, Krzysztof Palczewski, Philip D Kiser
Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. The Biochemical journal 475 (20) (2018)
Alexander V Kolesnikov, Tivadar Orban, Hui Jin, Celine Brooks, Lukas Hofmann, Zhiqian Dong, Maxim Sokolov, Krzysztof Palczewski, Vladimir J Kefalov
Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proceedings of the National Academy of Sciences of the United States of America 114 (45) (2017)
Sahil Gulati, Beata Jastrzebska, Surajit Banerjee, Ángel L Placeres, Przemyslaw Miszta, Songqi Gao, Karl Gunderson, Gregory P Tochtrop, Sławomir Filipek, Kota Katayama, Philip D Kiser, Muneto Mogi, Phoebe L Stewart, Krzysztof Palczewski
Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proceedings of the National Academy of Sciences of the United States of America 114 (13) (2017)
Cheng-Kang Chiang, Aleksander Tworak, Brian M Kevany, Bo Xu, Janice Mayne, Zhibin Ning, Daniel Figeys, Krzysztof Palczewski
Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. The Journal of biological chemistry 292 (48) (2017)
Lukas Hofmann, Nathan S Alexander, Wenyu Sun, Jianye Zhang, Tivadar Orban, Krzysztof Palczewski
Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry 56 (17) (2017)
Xuewu Sui, Andrew C Weitz, Erik R Farquhar, Mohsen Badiee, Surajit Banerjee, Johannes von Lintig, Gregory P Tochtrop, Krzysztof Palczewski, Michael P Hendrich, Philip D Kiser
Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry 56 (22) (2017)
Xuewu Sui, Jianye Zhang, Marcin Golczak, Krzysztof Palczewski, Philip D Kiser
Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. The Journal of biological chemistry 291 (37) (2016)