Cheryl H Arrowsmith (Cheryl Arrowsmith)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 71

Top Venues

Journal of medicinal chemistry

Nature communications

Nature chemical biology

Communications biology

University of Toronto

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Jul 01 2003

Canada

Chief Scientist :: Structural Genomics Consortium

University of Toronto Jul 01 2001

Canada

Professor :: Medical Biophysics

University Health Network Jul 01 2001

Canada

Senior Scientist :: Princess Margaret Cancer Centre

University of Toronto Jul 01 1996 - Jun 30 2001

Canada

Associate Professor :: Medical Biophysics

Ontario Cancer Institute Jul 01 1996 - Jun 30 2001

Canada

Senior Scientist :: Research

Ontario Cancer Institute Jul 01 1991 - Jun 30 1996

Canada

Senior Scientist :: Research

University of Toronto Jul 01 1991 - Jun 30 1996

Canada

Assistant Professor :: Medical Biophysics

Stanford University Jul 01 1986 - Jun 30 1991

United States

Postdoctoral Affiliate/Research Associate (Oleg Jardetzky, supervisor) :: Stanford Magnetic Resonance Lab

Education History

University of Toronto Sep 01 1981 - Jun 01 1986

Canada

PHD :: Physical Organic Chemistry

Allegheny College Sep 01 1979 - Jun 01 1981

United States

BSC :: Honors in Chemistry, Magna Cum Laude

Publications

Cheryl H Arrowsmith
Structure-guided drug discovery: back to the future. Nature structural & molecular biology 31 (3) (2024)
Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen Lester Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith
Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles. Science advances 10 (29) (2024)
Cheryl H Arrowsmith
Structure-guided drug discovery: back to the future. Nature structural & molecular biology (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology 20 (9) (2024)
Joseph Walton, Angel S N Ng, Karen Arevalo, Anthony Apostoli, Jalna Meens, Christina Karamboulas, Jonathan St-Germain, Panagiotis Prinos, Julia Dmytryshyn, Eric X Chen, Cheryl H Arrowsmith, Brian Raught, Laurie Ailles
PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma. Nature communications 15 (1) (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology 20 (9) (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M Szewczyk, Matthew F Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S Dowling, Emel Ficici, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Grzegorz J Skrzypek, Tuan P Tran, Matthew D Troutman, Feng Wang, Jennifer A Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J Brown, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Masoud Vedadi, Dafydd R Owen
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex. RSC medicinal chemistry 15 (3) (2024)
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin Peter Schwalm, Raquel Arminda Carvalho Machado, Nicolas Bauer, Xu Wang, Magdalena M Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F Calabrese, Matthew S Dowling, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Chakrapani Subramanyam, Feng Wang, Ella C Adamson, Matthieu Schapira, Matthias Gstaiger, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A Lajoie, Dalia Barsyte-Lovejoy, Dafydd R Owen, Caroline Schild-Poulter, Cheryl H Arrowsmith
A chemical probe to modulate human GID4 Pro/N-degron interactions. Nature chemical biology (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
Cheryl H Arrowsmith
Structure-guided drug discovery: back to the future. Nature structural & molecular biology 31 (3) (2024)
David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M Szewczyk, Matthew F Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S Dowling, Emel Ficici, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Grzegorz J Skrzypek, Tuan P Tran, Matthew D Troutman, Feng Wang, Jennifer A Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J Brown, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Masoud Vedadi, Dafydd R Owen
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex. RSC medicinal chemistry 15 (3) (2024)
Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen Lester Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith
Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles. Science advances 10 (29) (2024)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nature communications 14 (1) (2023)
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nature communications 14 (1) (2023)
Ronan P Hanley, David Y Nie, John R Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M Szewczyk, Peter J Brown, Dalia Barsyte-Lovejoy, Laura E Herring, Gang Greg Wang, Jonathan D Licht, Masoud Vedadi, Cheryl H Arrowsmith, Lindsey I James
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Journal of the American Chemical Society (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Rachel J Harding, Ivan Franzoni, Mandeep K Mann, Magdalena M Szewczyk, Bijan Mirabi, Renato Ferreira de Freitas, Dominic D G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A Juarez-Ornelas, Randy Sanichar, Rachel J Baker, Christian Dank, Peter J Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H Arrowsmith
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6. Journal of medicinal chemistry (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells. ACS chemical biology (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nature communications 14 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S Disch, Christopher J Mulhern, Belinda L Slakman, John W Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D Keefe, Peter J Brown, Levon Halabelian, Rima Al-Awar, Masoud Vedadi
Discovery of Nanomolar DCAF1 Small Molecule Ligands. Journal of medicinal chemistry (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells. bioRxiv : the preprint server for biology (2023)
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nature communications 14 (1) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry (2023)
Kate M MacDonald, Shirony Nicholson-Puthenveedu, Maha M Tageldein, Sarika Khasnis, Cheryl H Arrowsmith, Shane M Harding
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nature communications 14 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Serah W Kimani, Julie Owen, Stuart R Green, Fengling Li, Yanjun Li, Aiping Dong, Peter J Brown, Suzanne Ackloo, David Kuter, Cindy Yang, Miranda MacAskill, Stephen Scott MacKinnon, Cheryl H Arrowsmith, Matthieu Schapira, Vijay Shahani, Levon Halabelian
Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. Journal of chemical information and modeling (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Qin Wu, David Y Nie, Wail Ba-Alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A Marhon, Parinaz Mehdipour, Magdalena M Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagiotis Prinos, Katlin B Massirer, Dalia Barsyte-Lovejoy, Jian Jin, Daniel D De Carvalho, Benjamin Haibe-Kains, XiaoJia Wang, David W Cescon, Mathieu Lupien, Cheryl H Arrowsmith
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nature chemical biology 18 (8) (2022)
Tamuka M Chidyausiku, Soraia R Mendes, Jason C Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K Haddox, Adam Moyer, Cheryl H Arrowsmith, Francesc Xavier Gomis-Rüth, Julien S Baker, Enrique Marcos
De novo design of immunoglobulin-like domains. Nature communications 13 (1) (2022)
Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M G Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David William Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H Arrowsmith, Linda Z Penn
The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Nucleic acids research 50 (6) (2022)
Bryan J Fraser, Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li, Daniel Kwon, Ruiyan Tan, Ryan P Wilson, Karoline Leopold, Sriram Subramaniam, Levon Halabelian, Cheryl H Arrowsmith, François Bénard
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nature chemical biology 18 (9) (2022)
Samir H Barghout, Mandeep K Mann, Ahmed M Aman, Yifan Yu, Matthew G Alteen, Aaron D Schimmer, Matthieu Schapira, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy
Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. ACS chemical biology 17 (10) (2022)
Patty Sachamitr, Jolene Caifeng Ho, Felipe E Ciamponi, Wail Ba-Alawi, Fiona J Coutinho, Paul Guilhamon, Michelle M Kushida, Florence M G Cavalli, Lilian Lee, Naghmeh Rastegar, Victoria Vu, Maria Sánchez-Osuna, Jasmin Coulombe-Huntington, Evgeny Kanshin, Heather Whetstone, Mathieu Durand, Philippe Thibault, Kirsten Hart, Maria Mangos, Joseph Veyhl, Wenjun Chen, Nhat Tran, Bang-Chi Duong, Ahmed M Aman, Xinghui Che, Xiaoyang Lan, Owen Whitley, Olga Zaslaver, Dalia Barsyte-Lovejoy, Laura M Richards, Ian J Restall, Amy A Caudy, Hannes L Röst, Zahid Quyoom Bonday, Mark Bernstein, Sunit Das, Michael D Cusimano, Julian Spears, Gary D Baider, Trevor J Pugh, Mike Tyers, Mathieu Lupien, Benjamin Haibe-Kains, H Artee Luchman, Samuel Weiss, Katlin B Massirer, Panagiotis Prinos, Cheryl H Arrowsmith, Peter B Dirks
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature communications 12 (1) (2021)
Mandeep K Mann, Carlos A Zepeda-Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Ahmed M Aman, Peter Loppnau, Yanjun Li, Brian Wilson, Cheryl H Arrowsmith, Rima Al-Awar, Rachel J Harding, Matthieu Schapira
Structure-Activity Relationship of USP5 Inhibitors. Journal of medicinal chemistry 64 (20) (2021)
Xiangda Peng, Michael Baxa, Nabil Faruk, Joseph R Sachleben, Sebastian Pintscher, Isabelle A Gagnon, Scott Houliston, Cheryl H Arrowsmith, Karl F Freed, Gabriel J Rocklin, Tobin R Sosnick
Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence. Journal of chemical theory and computation 18 (1) (2021)
Yudao Shen, Fengling Li, Magdalena M Szewczyk, Levon Halabelian, Irene Chau, Mohammad S Eram, Carlo Dela Seña, Kwang-Su Park, Fanye Meng, He Chen, Hong Zeng, Aiping Dong, Hong Wu, Viacheslav V Trush, David McLeod, Carlos A Zepeda-Velázquez, Robert M Campbell, Mary M Mader, Brian M Watson, Matthieu Schapira, Cheryl H Arrowsmith, Rima Al-Awar, Dalia Barsyte-Lovejoy, Husnu Ümit Kaniskan, Peter J Brown, Masoud Vedadi, Jian Jin
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry 64 (7) (2021)
David Dilworth, Ronan P Hanley, Renato Ferreira de Freitas, Abdellah Allali-Hassani, Mengqi Zhou, Naimee Mehta, Matthew R Marunde, Suzanne Ackloo, Raquel Arminda Carvalho Machado, Aliakbar Khalili Yazdi, Dominic D G Owens, Victoria Vu, David Y Nie, Mona Alqazzaz, Edyta Marcon, Fengling Li, Irene Chau, Albina Bolotokova, Su Qin, Ming Lei, Yanli Liu, Magdalena M Szewczyk, Aiping Dong, Sina Kazemzadeh, Tigran Abramyan, Irina K Popova, Nathan W Hall, Matthew J Meiners, Marcus A Cheek, Elisa Gibson, Dmitri B Kireev, Jack F Greenblatt, Michael-Christopher Keogh, Jinrong Min, Peter J Brown, Masoud Vedadi, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Lindsey I James, Matthieu Schapira
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology (2021)
Mandeep K Mann, Carlos A Zepeda-Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Ahmed M Aman, Peter Loppnau, Yanjun Li, Brian Wilson, Cheryl H Arrowsmith, Rima Al-Awar, Rachel J Harding, Matthieu Schapira
Correction to "Structure-Activity Relationship of USP5 Inhibitors". Journal of medicinal chemistry 65 (1) (2021)
Corey Lourenco, Diana Resetca, Cornelia Redel, Peter Lin, Alannah S MacDonald, Roberto Ciaccio, Tristan M G Kenney, Yong Wei, David W Andrews, Maria Sunnerhagen, Cheryl H Arrowsmith, Brian Raught, Linda Z Penn
MYC protein interactors in gene transcription and cancer. Nature reviews. Cancer 21 (9) (2021)
Renato Ferreira de Freitas, Yanli Liu, Magdalena M Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P Hanley, Elisa Gibson, Peter J Brown, Rima Al-Awar, Lindsey I James, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira, Abdellah Allali-Hassani
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry 64 (3) (2021)
Anja Dölle, Bikash Adhikari, Andreas Krämer, Janik Weckesser, Nicola Berner, Lena Marie Berger, Mathias Diebold, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Jakob Gebel, Frank Loehr, Volker Dötsch, Martin Eilers, Stephanie Wilhelm, Bernhard Kuster, Christoph A Sotriffer, Elmar Wolf, Stefan Knapp
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry 64 (15) (2021)
Qin Wu, Matthieu Schapira, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy
Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature reviews. Drug discovery 20 (7) (2021)
Rachel J Harding, Justin C Deme, Johannes F Hevler, Sem Tamara, Alexander Lemak, Jeffrey P Cantle, Magdalena M Szewczyk, Nola Begeja, Siobhan Goss, Xiao-Bing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B Carroll, Albert J R Heck, Susan M Lea, Cheryl H Arrowsmith
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Communications biology 4 (1) (2021)
Magdalena M Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C Dela Seña, Tsukasa Sugo, Kozo Hayashi, David A McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Éric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H Arrowsmith, Masoud Vedadi, Peter J Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications 11 (1) (2020)
Magdalena M Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C Dela Seña, Tsukasa Sugo, Kozo Hayashi, David A McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Éric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H Arrowsmith, Masoud Vedadi, Peter J Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications 11 (1) (2020)
Stuart J Conway, Paola Arimondo, Cheryl H Arrowsmith, Jian Jin, Cheng Luo, Nicholas A Meanwell, Wendy B Young, Gunda I Georg, Shaomeng Wang
Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers. Journal of medicinal chemistry 63 (21) (2020)
Qin Wu, Wail Ba-Alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie N Fortier, Hellen Kuasne, Trevor D McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G Wouters, Peter B Dirks, Susan J Done, Morag Park, David W Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H Arrowsmith
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. Nature communications 11 (1) (2020)
Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, Anne-Marie Fortier, Paul Savage, Alexandra N Fedor, Xiaojing Liu, Paul Guilhamon, Evelyne Lima-Fernandes, Alex Murison, Hellen Kuasne, Wail Ba-Alawi, David W Cescon, Cheryl H Arrowsmith, Daniel D De Carvalho, Benjamin Haibe-Kains, Jason W Locasale, Morag Park, Mathieu Lupien
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer. Cancer discovery 10 (9) (2020)
Yudao Shen, Fengling Li, Magdalena M Szewczyk, Levon Halabelian, Kwang-Su Park, Irene Chau, Aiping Dong, Hong Zeng, He Chen, Fanye Meng, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Peter J Brown, Jing Liu, Masoud Vedadi, Jian Jin
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of medicinal chemistry 63 (10) (2020)
Levon Halabelian, Mani Ravichandran, Yanjun Li, Hong Zeng, Anjana Rao, L Aravind, Cheryl H Arrowsmith
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Nature structural & molecular biology 26 (7) (2019)
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Mark Petronczki, Markus Zeeb, Nikolai Mischerikow, Abdellah Allali-Hassani, Magdalena M Szewczyk, Fengling Li, Steven Kennedy, Masoud Vedadi, Dalia Barsyte-Lovejoy, Peter J Brown, Kilian V M Huber, Catherine M Rogers, Carrow I Wells, Oleg Fedorov, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Heribert Arnhof, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Maja Corcokovic, Bernadette Sharps, Sandra Winkler, Daniela Häring, Xiao-Ling Cockcroft, Julian E Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Thomas Gerstberger, Guido Boehmelt, Christopher R Vakoc, Cheryl H Arrowsmith, Mark Pearson, Darryl B McConnell
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology 15 (8) (2019)
Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P H Gay, Fengling Li, Levi Blazer, Mohammad S Eram, Levon Halabelian, David Dilworth, Genna M Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S Zakiah A Talib, Peter J Brown, Matthieu Schapira, Philipp Kaldis, Ronan C O'Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, John M Sanders, Solomon D Kattar, David Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Discovery of a chemical probe for PRDM9. Nature communications 10 (1) (2019)
Alexandria P Taylor, Magdalena Swewczyk, Steven Kennedy, Viacheslav V Trush, Hong Wu, Hong Zeng, Aiping Dong, Renato Ferreira de Freitas, John Tatlock, Robert A Kumpf, Martin Wythes, Agustin Casimiro-Garcia, Rajiah Aldrin Denny, Mihir D Parikh, Fengling Li, Dalia Barsyte-Lovejoy, Matthieu Schapira, Masoud Vedadi, Peter J Brown, Cheryl H Arrowsmith, Dafydd R Owen
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. Journal of medicinal chemistry 62 (17) (2019)
Cheryl H Arrowsmith, Matthieu Schapira
Targeting non-bromodomain chromatin readers. Nature structural & molecular biology 26 (10) (2019)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Johannes Bacher, Kwang-Su Park, Nicolas Babault, Michael Martini, Vincent Fagan, Fengling Li, Irene Chau, Thomas Christott, David Dilworth, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Paul E Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of medicinal chemistry 62 (20) (2019)
Mandeep K Mann, Ivan Franzoni, Renato Ferreira de Freitas, Wolfram Tempel, Scott Houliston, Leanna Smith, Masoud Vedadi, Cheryl H Arrowsmith, Rachel J Harding, Matthieu Schapira
Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. Journal of medicinal chemistry 62 (22) (2019)
Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl H Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan, Udo Oppermann
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. Journal of medicinal chemistry 62 (20) (2019)
H Ümit Kaniskan, Mohammad S Eram, Kehao Zhao, Magdalena M Szewczyk, Xiaobao Yang, Keith Schmidt, Xiao Luo, Sean Xiao, Miao Dai, Feng He, Irene Zang, Ying Lin, Fengling Li, Elena Dobrovetsky, David Smil, Sun-Joon Min, Jennifer Lin-Jones, Matthieu Schapira, Peter Atadja, En Li, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Peter J Brown, Feng Liu, Zhengtian Yu, Masoud Vedadi, Jian Jin
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry 61 (3) (2018)
Gabriel J Rocklin, Tamuka M Chidyausiku, Inna Goreshnik, Alex Ford, Scott Houliston, Alexander Lemak, Lauren Carter, Rashmi Ravichandran, Vikram Khipple Mulligan, Aaron Chevalier, Cheryl H Arrowsmith, Julien S Baker
Global analysis of protein folding using massively parallel design, synthesis, and testing. Science (New York, N.Y.) 357 (6347) (2018)
Rachel J Harding, Renato Ferreira de Freitas, Patrick M Collins, Ivan Franzoni, Mani Ravichandran, Hui Ouyang, Kevin A Juarez-Ornelas, Mark Lautens, Matthieu Schapira, Frank von Delft, Vjayaratnam Santhakumar, Cheryl H Arrowsmith
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. Journal of medicinal chemistry 60 (21) (2017)

Cheryl H Arrowsmith.css-eqlu8i{font-size:small;padding-left:4px;} (Cheryl Arrowsmith)

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Cheryl H Arrowsmith (Cheryl Arrowsmith)