Levon Halabelian

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 41

Top Venues

Journal of medicinal chemistry

Nature communications

Communications biology

Biochemistry

University of Toronto

University of Milan (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Feb 01 2019

Canada

Research Associate :: Structural Genomics Consortium

University of Toronto Dec 01 2014 - Jan 31 2019

Canada

PostDoctoral Fellow :: Structural Genomics Consortium (SGC)

Education History

University of Milan Nov 15 2011 - Nov 27 2014

Italy

PHD :: Department of Biosciences

Uppsala University Sep 01 2009 - Jul 30 2011

Sweden

MSC

Publications

Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Jiameng Dan, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature communications 15 (1) (2024)
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo, Sumera Perveen, Pegah Ghiabi, Masoud Vedadi
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions. Biochemistry 63 (10) (2024)
Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Journal of medicinal chemistry (2024)
Merveille Eguida, Guillaume Bret, François Sindt, Fengling Li, Irene Chau, Suzanne Ackloo, Cheryl Arrowsmith, Albina Bolotokova, Pegah Ghiabi, Elisa Gibson, Levon Halabelian, Scott Houliston, Rachel J Harding, Ashley Hutchinson, Peter Loppnau, Sumera Perveen, Almagul Seitova, Hong Zeng, Matthieu Schapira, Didier Rognan
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2. Journal of chemical information and modeling (2024)
Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology (2024)
Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Hong Zeng, Yanjun Li, Peter Loppnau, Tony Mei, Yen-Yen Li, Alma Seitova, Aaron N Patrick, Jean-Francois Brazeau, Charu Chaudhry, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian
Probing the CRL4 DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons. PNAS nexus 3 (4) (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Jiameng Dan, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature communications 15 (1) (2024)
Matthieu Schapira, Levon Halabelian, Cheryl H Arrowsmith, Rachel J Harding
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design. Nature chemical biology 20 (8) (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials". Journal of medicinal chemistry 67 (14) (2024)
Merveille Eguida, Guillaume Bret, François Sindt, Fengling Li, Irene Chau, Suzanne Ackloo, Cheryl Arrowsmith, Albina Bolotokova, Pegah Ghiabi, Elisa Gibson, Levon Halabelian, Scott Houliston, Rachel J Harding, Ashley Hutchinson, Peter Loppnau, Sumera Perveen, Almagul Seitova, Hong Zeng, Matthieu Schapira, Didier Rognan
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2. Journal of chemical information and modeling 64 (13) (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Journal of medicinal chemistry 67 (5) (2024)
Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Hong Zeng, Yanjun Li, Peter Loppnau, Tony Mei, Yen-Yen Li, Alma Seitova, Aaron N Patrick, Jean-Francois Brazeau, Charu Chaudhry, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian
Probing the CRL4 DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons. PNAS nexus 3 (4) (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Journal of medicinal chemistry 67 (5) (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo, Sumera Perveen, Pegah Ghiabi, Masoud Vedadi
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions. Biochemistry (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. Journal of medicinal chemistry 67 (5) (2024)
Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Jiameng Dan, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature communications 15 (1) (2024)
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo, Sumera Perveen, Pegah Ghiabi, Masoud Vedadi
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions. Biochemistry 63 (10) (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials". Journal of medicinal chemistry 67 (14) (2024)
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo, Sumera Perveen, Pegah Ghiabi, Masoud Vedadi
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions. Biochemistry 63 (10) (2024)
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo, Sumera Perveen, Pegah Ghiabi, Masoud Vedadi
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions. Biochemistry 63 (10) (2024)
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Edward B Miller, Ashley Hutchinson, Aiping Dong, Alma Seitova, Mariana Laureano De Souza, David Augeri, Levon Halabelian, John Siekierka, David P Rotella, John Gordon, Wayne E Childers, Mark C Grier, Bart L Staker, Jacques Y Roberge, Purnima Bhanot
Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials". Journal of medicinal chemistry (2024)
Shabbir Ahmad, Jin Xu, Jianwen A Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi, Aiping Dong, Paolo A Centrella, Matthew A Clark, Marie-Aude Guié, John P Guilinger, Anthony D Keefe, Ying Zhang, Thomas Cerruti, John W Cuozzo, Moritz von Rechenberg, Albina Bolotokova, Yanjun Li, Peter Loppnau, Alma Seitova, Yen-Yen Li, Vijayaratnam Santhakumar, Peter J Brown, Suzanne Ackloo, Levon Halabelian
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. Journal of medicinal chemistry (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Devan J Shell, Caroline A Foley, Qinhong Wang, Chelsea M Smith, Shiva K R Guduru, Hong Zeng, Aiping Dong, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Gaorav Gupta, Levon Halabelian, Stephen V Frye, Lindsey I James, Kenneth H Pearce
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. Journal of medicinal chemistry (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S Disch, Christopher J Mulhern, Belinda L Slakman, John W Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D Keefe, Peter J Brown, Levon Halabelian, Rima Al-Awar, Masoud Vedadi
Discovery of Nanomolar DCAF1 Small Molecule Ligands. Journal of medicinal chemistry (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Serah W Kimani, Julie Owen, Stuart R Green, Fengling Li, Yanjun Li, Aiping Dong, Peter J Brown, Suzanne Ackloo, David Kuter, Cindy Yang, Miranda MacAskill, Stephen Scott MacKinnon, Cheryl H Arrowsmith, Matthieu Schapira, Vijay Shahani, Levon Halabelian
Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. Journal of chemical information and modeling (2023)
Bryan J Fraser, Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li, Daniel Kwon, Ruiyan Tan, Ryan P Wilson, Karoline Leopold, Sriram Subramaniam, Levon Halabelian, Cheryl H Arrowsmith, François Bénard
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nature chemical biology 18 (9) (2022)
Kyle Delaney, Min-Jia Tan, Zhesi Zhu, Jinjun Gao, Lunzhi Dai, Sunjoo Kim, Jun Ding, Maomao He, Levon Halabelian, Lu Yang, Prabakaran Nagarajan, Mark Robert Parthun, Sangkyu Lee, Saadi Khochbin, Yujun George Zheng, Yingming Zhao
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2. Cell discovery 7 (1) (2021)
Kenji Sugata, Yukiko Matsunaga, Yuki Yamashita, Munehide Nakatsugawa, Tingxi Guo, Levon Halabelian, Yota Ohashi, Kayoko Saso, Muhammed A Rahman, Mark Anczurowski, Chung-Hsi Wang, Kenji Murata, Hiroshi Saijo, Yuki Kagoya, Dalam Ly, Brian D Burt, Marcus O Butler, Tak W Mak, Naoto Hirano
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Nature biotechnology 39 (8) (2021)
Yudao Shen, Fengling Li, Magdalena M Szewczyk, Levon Halabelian, Irene Chau, Mohammad S Eram, Carlo Dela Seña, Kwang-Su Park, Fanye Meng, He Chen, Hong Zeng, Aiping Dong, Hong Wu, Viacheslav V Trush, David McLeod, Carlos A Zepeda-Velázquez, Robert M Campbell, Mary M Mader, Brian M Watson, Matthieu Schapira, Cheryl H Arrowsmith, Rima Al-Awar, Dalia Barsyte-Lovejoy, Husnu Ümit Kaniskan, Peter J Brown, Masoud Vedadi, Jian Jin
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry 64 (7) (2021)
Levon Halabelian, Dalia Barsyte-Lovejoy
Structure and Function of Protein Arginine Methyltransferase PRMT7. Life (Basel, Switzerland) 11 (8) (2021)
Magdalena M Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C Dela Seña, Tsukasa Sugo, Kozo Hayashi, David A McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Éric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H Arrowsmith, Masoud Vedadi, Peter J Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications 11 (1) (2020)
Magdalena M Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C Dela Seña, Tsukasa Sugo, Kozo Hayashi, David A McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Éric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H Arrowsmith, Masoud Vedadi, Peter J Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature communications 11 (1) (2020)
Levon Halabelian, Mani Ravichandran, Yanjun Li, Hong Zeng, Anjana Rao, L Aravind, Cheryl H Arrowsmith
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Nature structural & molecular biology 26 (7) (2019)
Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P H Gay, Fengling Li, Levi Blazer, Mohammad S Eram, Levon Halabelian, David Dilworth, Genna M Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S Zakiah A Talib, Peter J Brown, Matthieu Schapira, Philipp Kaldis, Ronan C O'Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, John M Sanders, Solomon D Kattar, David Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Discovery of a chemical probe for PRDM9. Nature communications 10 (1) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Levon Halabelian